Subject Reviews:

Signal Transducer and Activator of Transcription-3: A Molecular Hub for Signaling Pathways in Gliomas

Emily C. Brantley and Etty N. Benveniste
Mol Cancer Res 2008 6: 675-684 doi: 10.1158/1541-7786.MCR-07-2180 [Abstract] [Full Text] [PDF]  

Zebrafish as a Cancer Model

Harma Feitsma and Edwin Cuppen
Mol Cancer Res 2008 6: 685-694 doi: 10.1158/1541-7786.MCR-07-2167 [Abstract] [Full Text] [PDF]  

Angiogenesis, Metastasis, and the Cellular Microenvironment:

Transforming Growth Factor-β1, Transforming Growth Factor-β2, and Transforming Growth Factor-β3 Enhance Ovarian Cancer Metastatic Potential by Inducing a Smad3-Dependent Epithelial-to-Mesenchymal Transition

Thuy-Vy Do, Lena A. Kubba, Hongyan Du, Charles D. Sturgis, and Teresa K. Woodruff
Mol Cancer Res 2008 6: 695-705 doi: 10.1158/1541-7786.MCR-07-0294 [Abstract] [Full Text] [PDF]  

Imatinib Mesylate Inhibits Proliferation and Exerts an Antifibrotic Effect in Human Breast Stroma Fibroblasts

Vassiliki Gioni, Theodoros Karampinas, Gerassimos Voutsinas, Andreas E. Roussidis, Savvas Papadopoulos, Nikos K. Karamanos, and Dimitris Kletsas
Mol Cancer Res 2008 6: 706-714 doi: 10.1158/1541-7786.MCR-07-0355 [Abstract] [Full Text] [PDF]  

A Suppressive Role of Mitogen Inducible Gene-2 in Mesenchymal Cancer Cell Invasion

Xiaohua Shi and Chuanyue Wu
Mol Cancer Res 2008 6: 715-724 doi: 10.1158/1541-7786.MCR-07-2026 [Abstract] [Full Text] [PDF]  

The Fibroblast Growth Factor–Inducible 14 Receptor Is Highly Expressed in HER2-Positive Breast Tumors and Regulates Breast Cancer Cell Invasive Capacity

Amanda L. Willis, Nhan L. Tran, Julie M. Chatigny, Nichole Charlton, Hong Vu, Sharron A.N. Brown, Michael A. Black, Wendy S. McDonough, Shannon P. Fortin, Joshua R. Niska, Jeffrey A. Winkles, and Heather E. Cunliffe
Mol Cancer Res 2008 6: 725-734 doi: 10.1158/1541-7786.MCR-08-0005 [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Genes and Genomics:

A Functional Screen Identifies miR-34a as a Candidate Neuroblastoma Tumor Suppressor Gene

Kristina A. Cole, Edward F. Attiyeh, Yael P. Mosse, Michael J. Laquaglia, Sharon J. Diskin, Garrett M. Brodeur, and John M. Maris
Mol Cancer Res 2008 6: 735-742 doi: 10.1158/1541-7786.MCR-07-2102 [Abstract] [Full Text] [PDF] Supplementary Data  

HMGA2 Participates in Transformation in Human Lung Cancer

Francescopaolo Di Cello, Joelle Hillion, Alexandra Hristov, Lisa J. Wood, Mita Mukherjee, Andrew Schuldenfrei, Jeanne Kowalski, Raka Bhattacharya, Raheela Ashfaq, and Linda M.S. Resar
Mol Cancer Res 2008 6: 743-750 doi: 10.1158/1541-7786.MCR-07-0095 [Abstract] [Full Text] [PDF] Supplementary Data  

BRAF Silencing by Short Hairpin RNA or Chemical Blockade by PLX4032 Leads to Different Responses in Melanoma and Thyroid Carcinoma Cells

Elisa Sala, Luca Mologni, Silvia Truffa, Carlo Gaetano, Gideon E. Bollag, and Carlo Gambacorti-Passerini
Mol Cancer Res 2008 6: 751-759Published Online First May 5, 2008. doi: 10.1158/1541-7786.MCR-07-2001 [Abstract] [Full Text] [PDF]  

Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases

Lei Xu, Steven S. Shen, Yujin Hoshida, Aravind Subramanian, Ken Ross, Jean-Philippe Brunet, Stephan N. Wagner, Sridhar Ramaswamy, Jill P. Mesirov, and Richard O. Hynes
Mol Cancer Res 2008 6: 760-769 doi: 10.1158/1541-7786.MCR-07-0344 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell Cycle, Cell Death, and Senescence:

Interferon Regulatory Factors IRF5 and IRF7 Inhibit Growth and Induce Senescence in Immortal Li-Fraumeni Fibroblasts

Qunfang Li, Lin Tang, Paul Christopher Roberts, Janice M. Kraniak, Aviva Levine Fridman, Olga I. Kulaeva, Omid S. Tehrani, and Michael A. Tainsky
Mol Cancer Res 2008 6: 770-784 doi: 10.1158/1541-7786.MCR-07-0114 [Abstract] [Full Text] [PDF] Supplementary Data  

Decorin-Induced Growth Inhibition Is Overcome through Protracted Expression and Activation of Epidermal Growth Factor Receptors in Osteosarcoma Cells

Alexandros Zafiropoulos, Dragana Nikitovic, Pavlos Katonis, Aristidis Tsatsakis, Nikos K. Karamanos, and George N. Tzanakakis
Mol Cancer Res 2008 6: 785-794 doi: 10.1158/1541-7786.MCR-07-0165 [Abstract] [Full Text] [PDF]  

DNA Damage and Cellular Stress Responses:

Neutral Sphingomyelinase-3 Is a DNA Damage and Nongenotoxic Stress-Regulated Gene That Is Deregulated in Human Malignancies

Chad A. Corcoran, Qin He, Suriyan Ponnusamy, Besim Ogretmen, Ying Huang, and M. Saeed Sheikh
Mol Cancer Res 2008 6: 795-807 doi: 10.1158/1541-7786.MCR-07-2097 [Abstract] [Full Text] [PDF] Supplementary Data  

Impairment of the DNA Repair and Growth Arrest Pathways by p53R2 Silencing Enhances DNA Damage–Induced Apoptosis in a p53-Dependent Manner in Prostate Cancer Cells

Hong-Lin Devlin, Phillip C. Mack, Rebekah A. Burich, Paul H. Gumerlock, Hsing-Jien Kung, Maria Mudryj, and Ralph W. deVere White
Mol Cancer Res 2008 6: 808-818 doi: 10.1158/1541-7786.MCR-07-2027 [Abstract] [Full Text] [PDF]  

Signaling and Regulation:

Characterization of a Novel Primary Mammary Tumor Cell Line Reveals that Cyclin D1 Is Regulated by the Type I Insulin-Like Growth Factor Receptor

Robert A. Jones, Craig I. Campbell, James J. Petrik, and Roger A. Moorehead
Mol Cancer Res 2008 6: 819-828 doi: 10.1158/1541-7786.MCR-07-2157 [Abstract] [Full Text] [PDF] Supplementary Data  

The Biphasic Role of the Hypoxia-Inducible Factor Prolyl-4-Hydroxylase, PHD2, in Modulating Tumor-Forming Potential

KangAe Lee, Jeremy D. Lynd, Sandra O'Reilly, Matti Kiupel, J. Justin McCormick, and John J. LaPres
Mol Cancer Res 2008 6: 829-842 doi: 10.1158/1541-7786.MCR-07-2113 [Abstract] [Full Text] [PDF]  

Identification and Functional Characterization of the Human Glutathione S-Transferase P1 Gene as a Novel Transcriptional Target of the p53 Tumor Suppressor Gene

Hui-Wen Lo, Lisa Stephenson, Xinyu Cao, Mira Milas, Raphael Pollock, and Francis Ali-Osman
Mol Cancer Res 2008 6: 843-850 doi: 10.1158/1541-7786.MCR-07-2105 [Abstract] [Full Text] [PDF]  

Growth Factor Regulation of Estrogen Receptor Coregulator PELP1 Functions via Protein Kinase A Pathway

Jatin K. Nagpal, Sujit Nair, Dimple Chakravarty, Rajib Rajhans, Saikumar Pothana, Darrell W. Brann, Rajeshwar Rao Tekmal, and Ratna K. Vadlamudi
Mol Cancer Res 2008 6: 851-861 doi: 10.1158/1541-7786.MCR-07-2030 [Abstract] [Full Text] [PDF]  

TLS-ERG Leukemia Fusion Protein Deregulates Cyclin-Dependent Kinase 1 and Blocks Terminal Differentiation of Myeloid Progenitor Cells

Jing Pan, Junhui Zou, Daniel Y. Wu, Rachael S. Roberson, Leah J. Hennings, Xiaoyun Ma, Marwan Yared, Michael L. Blackburn, Howard A. Chansky, and Liu Yang
Mol Cancer Res 2008 6: 862-872 doi: 10.1158/1541-7786.MCR-07-2070 [Abstract] [Full Text] [PDF]  

Inhibition of Histone Deacetylases Promotes Ubiquitin-Dependent Proteasomal Degradation of DNA Methyltransferase 1 in Human Breast Cancer Cells

Qun Zhou, Agoston T. Agoston, Peter Atadja, William G. Nelson, and Nancy E. Davidson
Mol Cancer Res 2008 6: 873-883 doi: 10.1158/1541-7786.MCR-07-0330 [Abstract] [Full Text] [PDF]  

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