Molecular Pathways:

Targeting Ras in Myeloid Leukemias

Benjamin S. Braun and Kevin Shannon
Clin Cancer Res 2008 14: 2249-2252 doi: 10.1158/1078-0432.CCR-07-1005 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Epidermal Growth Factor Receptor Controls Flat Dysplastic Aberrant Crypt Foci Development and Colon Cancer Progression in the Rat Azoxymethane Model

Urszula Dougherty, Amikar Sehdev, Sonia Cerda, Reba Mustafi, Nathaniel Little, Weihua Yuan, Sujatha Jagadeeswaran, Anusara Chumsangsri, Jorge Delgado, Maria Tretiakova, Loren Joseph, John Hart, Ezra E.W. Cohen, Lata Aluri, Alessandro Fichera, and Marc Bissonnette
Clin Cancer Res 2008 14: 2253-2262 doi: 10.1158/1078-0432.CCR-07-4926 [Abstract] [Full Text] [PDF] Supplementary Data  

Endometrial Glandular Dysplasia with Frequent p53 Gene Mutation: A Genetic Evidence Supporting Its Precancer Nature for Endometrial Serous Carcinoma

Lin Jia, Yongjuan Liu, Xiaofang Yi, Alexander Miron, Christopher P. Crum, Beihua Kong, and Wenxin Zheng
Clin Cancer Res 2008 14: 2263-2269 Published Online First March 27, 2008. doi: 10.1158/1078-0432.CCR-07-4837 [Abstract] [Full Text] [PDF]  

Loss of Complex I due to Mitochondrial DNA Mutations in Renal Oncocytoma

Johannes A. Mayr, David Meierhofer, Franz Zimmermann, Rene Feichtinger, Christian Kögler, Manfred Ratschek, Nikolaus Schmeller, Wolfgang Sperl, and Barbara Kofler
Clin Cancer Res 2008 14: 2270-2275 doi: 10.1158/1078-0432.CCR-07-4131 [Abstract] [Full Text] [PDF] Supplementary Data  

Disrupted Expression of CXCL5 in Colorectal Cancer Is Associated with Rapid Tumor Formation in Rats and Poor Prognosis in Patients

Frank M. Speetjens, Peter J.K. Kuppen, Maro H. Sandel, Anand G. Menon, Danny Burg, Cornelis J.H. van de Velde, Rob A.E.M. Tollenaar, Hans J.G.M. de Bont, and J. Fred Nagelkerke
Clin Cancer Res 2008 14: 2276-2284 doi: 10.1158/1078-0432.CCR-07-4045 [Abstract] [Full Text] [PDF]  

KIT Mutations Induce Intracellular Retention and Activation of an Immature Form of the KIT Protein in Gastrointestinal Stromal Tumors

Séverine Tabone-Eglinger, Frédéric Subra, Hiba El Sayadi, Laurent Alberti, Eric Tabone, Jean-Philippe Michot, Nathalie Théou-Anton, Antoinette Lemoine, Jean-Yves Blay, and Jean-François Emile
Clin Cancer Res 2008 14: 2285-2294 doi: 10.1158/1078-0432.CCR-07-4102 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Escherichia coli Nissle 1917 Facilitates Tumor Detection by Positron Emission Tomography and Optical Imaging

Peter Brader, Jochen Stritzker, Christopher C. Riedl, Pat Zanzonico, Shangde Cai, Eva M. Burnazi, E.Rashid Ghani, Hedvig Hricak, Aladar A. Szalay, Yuman Fong, and Ronald Blasberg
Clin Cancer Res 2008 14: 2295-2302 Published Online First March 27, 2008. doi: 10.1158/1078-0432.CCR-07-4254 [Abstract] [Full Text] [PDF]  

Ornithine Decarboxylase G316A Genotype Is Prognostic for Colorectal Adenoma Recurrence and Predicts Efficacy of Aspirin Chemoprevention

Richard A. Hubner, Kenneth R. Muir, Jo-Fen Liu, Richard F.A. Logan, Matthew J. Grainge, Richard S. Houlston Members of the UKCAP Consortium
Clin Cancer Res 2008 14: 2303-2309 doi: 10.1158/1078-0432.CCR-07-4599 [Abstract] [Full Text] [PDF]  

Inverse Correlation between Tumoral Indoleamine 2,3-Dioxygenase Expression and Tumor-Infiltrating Lymphocytes in Endometrial Cancer: Its Association with Disease Progression and Survival

Kazuhiko Ino, Eiko Yamamoto, Kiyosumi Shibata, Hiroaki Kajiyama, Norio Yoshida, Mikio Terauchi, Akihiro Nawa, Tetsuro Nagasaka, Osamu Takikawa, and Fumitaka Kikkawa
Clin Cancer Res 2008 14: 2310-2317 doi: 10.1158/1078-0432.CCR-07-4144 [Abstract] [Full Text] [PDF]  

Increased Expression of Id Family Proteins in Small Cell Lung Cancer and its Prognostic Significance

Laleh Kamalian, John R. Gosney, Shiva S. Forootan, Christopher S. Foster, Zheng Z. Bao, Carol Beesley, and Youqiang Ke
Clin Cancer Res 2008 14: 2318-2325 doi: 10.1158/1078-0432.CCR-07-4716 [Abstract] [Full Text] [PDF]  

Up-Regulation of Peroxiredoxin 1 in Lung Cancer and Its Implication as a Prognostic and Therapeutic Target

Joo-Heon Kim, Paul N. Bogner, Sun-Hee Baek, Nithya Ramnath, Ping Liang, Hak-Ryul Kim, Chris Andrews, and Young-Mee Park
Clin Cancer Res 2008 14: 2326-2333 doi: 10.1158/1078-0432.CCR-07-4457 [Abstract] [Full Text] [PDF]  

Clinical Significance of High Mobility Group A2 in Human Gastric Cancer and Its Relationship to let-7 MicroRNA Family

Kazuo Motoyama, Hiroshi Inoue, Yoshito Nakamura, Hiroyuki Uetake, Kenichi Sugihara, and Masaki Mori
Clin Cancer Res 2008 14: 2334-2340 doi: 10.1158/1078-0432.CCR-07-4667 [Abstract] [Full Text] [PDF]  

Vascularization in Primary Breast Carcinomas: Its Prognostic Significance and Relationship with Tumor Cell Dissemination

Hari Prasad Dhakal, Bjørn Naume, Marit Synnestvedt, Elin Borgen, Rolf Kaaresen, Ellen Schlichting, Gro Wiedswang, Assia Bassarova, Karl-Erik Giercksky, and Jahn M. Nesland
Clin Cancer Res 2008 14: 2341-2350 doi: 10.1158/1078-0432.CCR-07-4214 [Abstract] [Full Text] [PDF]  

Amphiregulin Is a Promising Prognostic Marker for Liver Metastases of Colorectal Cancer

Michiyo Yamada, Yasushi Ichikawa, Shigeru Yamagishi, Nobuyoshi Momiyama, Mitsuyoshi Ota, Syoichi Fujii, Kuniya Tanaka, Shinji Togo, Shigeo Ohki, and Hiroshi Shimada
Clin Cancer Res 2008 14: 2351-2356 doi: 10.1158/1078-0432.CCR-07-4499 [Abstract] [Full Text] [PDF]  

The Use of Magnetic Resonance Imaging to Noninvasively Detect Genetic Signatures in Oligodendroglioma

Robert Brown, Magdalena Zlatescu, Angelique Sijben, Gloria Roldan, Jay Easaw, Peter Forsyth, Ian Parney, Robert Sevick, Elizabeth Yan, Douglas Demetrick, David Schiff, Gregory Cairncross, and Ross Mitchell
Clin Cancer Res 2008 14: 2357-2362 doi: 10.1158/1078-0432.CCR-07-1964 [Abstract] [Full Text] [PDF]  

Activation of Placenta-Specific Transcription Factor Distal-less Homeobox 5 Predicts Clinical Outcome in Primary Lung Cancer Patients

Tatsuya Kato, Nagato Sato, Atsushi Takano, Masaki Miyamoto, Hitoshi Nishimura, Eiju Tsuchiya, Satoshi Kondo, Yusuke Nakamura, and Yataro Daigo
Clin Cancer Res 2008 14: 2363-2370 doi: 10.1158/1078-0432.CCR-07-1523 [Abstract] [Full Text] [PDF] Supplementary Data  

A Genotype-Phenotype Examination of Cyclin D1 on Risk and Outcome of Squamous Cell Carcinoma of the Head and Neck

Carmen J. Marsit, Candice C. Black, Marshall R. Posner, and Karl T. Kelsey
Clin Cancer Res 2008 14: 2371-2377 doi: 10.1158/1078-0432.CCR-07-4368 [Abstract] [Full Text] [PDF]  

Urinary Biomarkers Predict Brain Tumor Presence and Response to Therapy

Edward R. Smith, David Zurakowski, Ali Saad, R. Michael Scott, and Marsha A. Moses
Clin Cancer Res 2008 14: 2378-2386 doi: 10.1158/1078-0432.CCR-07-1253 [Abstract] [Full Text] [PDF]  

Clinical, Radiographic, and Biochemical Characterization of Multiple Myeloma Patients with Osteonecrosis of the Jaw

Noopur Raje, Sook-Bin Woo, Karen Hande, Jeffrey T. Yap, Paul G. Richardson, Sonia Vallet, Nathaniel Treister, Teru Hideshima, Niall Sheehy, Shweta Chhetri, Brendan Connell, Wanling Xie, Yu-Tzu Tai, Agnieszka Szot-Barnes, Mei Tian, Robert L. Schlossman, Edie Weller, Nikhil C. Munshi, Annick D. Van Den Abbeele, and Kenneth C. Anderson
Clin Cancer Res 2008 14: 2387-2395 doi: 10.1158/1078-0432.CCR-07-1430 [Abstract] [Full Text] [PDF]  

Understanding the Biological Basis of Autofluorescence Imaging for Oral Cancer Detection: High-Resolution Fluorescence Microscopy in Viable Tissue

Ina Pavlova, Michelle Williams, Adel El-Naggar, Rebecca Richards-Kortum, and Ann Gillenwater
Clin Cancer Res 2008 14: 2396-2404 doi: 10.1158/1078-0432.CCR-07-1609 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Prediction of Broad Spectrum Resistance of Tumors towards Anticancer Drugs

Thomas Efferth, V. Badireenath Konkimalla, Yi-Fen Wang, Axel Sauerbrey, Silke Meinhardt, Felix Zintl, Jürgen Mattern, and Manfred Volm
Clin Cancer Res 2008 14: 2405-2412 doi: 10.1158/1078-0432.CCR-07-4525 [Abstract] [Full Text] [PDF] Supplementary Data  

Pathologic Complete Response to Neoadjuvant Chemotherapy of Breast Carcinoma Is Associated with the Disappearance of Tumor-Infiltrating Foxp3⁺ Regulatory T Cells

Sylvain Ladoire, Laurent Arnould, Lionel Apetoh, Bruno Coudert, Francois Martin, Bruno Chauffert, Pierre Fumoleau, and François Ghiringhelli
Clin Cancer Res 2008 14: 2413-2420 doi: 10.1158/1078-0432.CCR-07-4491 [Abstract] [Full Text] [PDF]  

Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions

Brian S. Shumway, Laura A. Kresty, Peter E. Larsen, Jared C. Zwick, Bo Lu, Henry W. Fields, Russell J. Mumper, Gary D. Stoner, and Susan R. Mallery
Clin Cancer Res 2008 14: 2421-2430 doi: 10.1158/1078-0432.CCR-07-4096 [Abstract] [Full Text] [PDF] Supplementary Data  

Sunitinib for Treatment of Advanced Renal Cell Cancer: Primary Tumor Response

Astrid A.M. van der Veldt, Martijn R. Meijerink, Alfons J.M. van den Eertwegh, Axel Bex, Gijsbert de Gast, John B.A.G. Haanen, and Epie Boven
Clin Cancer Res 2008 14: 2431-2436 doi: 10.1158/1078-0432.CCR-07-4089 [Abstract] [Full Text] [PDF]  

Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer

Steven Attia, Jens Eickhoff, George Wilding, Douglas McNeel, Jules Blank, Harish Ahuja, Alcee Jumonville, Michael Eastman, Daniel Shevrin, Michael Glode, Dona Alberti, Mary Jane Staab, Dottie Horvath, Jane Straus, Rebecca Marnocha, and Glenn Liu
Clin Cancer Res 2008 14: 2437-2443 doi: 10.1158/1078-0432.CCR-07-4274 [Abstract] [Full Text] [PDF]  

A Phase I Biological Study of MG98, an Oligodeoxynucleotide Antisense to DNA Methyltransferase 1, in Patients with High-Risk Myelodysplasia and Acute Myeloid Leukemia

Rebecca B. Klisovic, Wendy Stock, Spero Cataland, Marko I. Klisovic, Shujun Liu, William Blum, Margaret Green, Olatoyosi Odenike, Lucy Godley, Jennifer Vanden Burgt, Emily Van Laar, Michael Cullen, A. Robert Macleod, Jeffrey M. Besterman, Gregory K. Reid, John C. Byrd, and Guido Marcucci
Clin Cancer Res 2008 14: 2444-2449 doi: 10.1158/1078-0432.CCR-07-1320 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Treatment of Cancer with a Novel Dual-Targeted Conditionally Replicative Adenovirus Armed with mda-7/IL-24 Gene

Jingjing Luo, Qingmei Xia, Rui Zhang, Chen Lv, Wei Zhang, Yingxin Wang, Qiang Cui, Li Liu, Rong Cai, and Cheng Qian
Clin Cancer Res 2008 14: 2450-2457 doi: 10.1158/1078-0432.CCR-07-4596 [Abstract] [Full Text] [PDF]  

Inhibiting Fatty Acid Synthase for Chemoprevention of Chemically Induced Lung Tumors

Hajime Orita, Jonathan Coulter, Ellen Tully, Francis P. Kuhajda, and Edward Gabrielson
Clin Cancer Res 2008 14: 2458-2464 doi: 10.1158/1078-0432.CCR-07-4177 [Abstract] [Full Text] [PDF]  

EXEL-7647 Inhibits Mutant Forms of ErbB2 Associated with Lapatinib Resistance and Neoplastic Transformation

Torsten Trowe, Sotiria Boukouvala, Keith Calkins, Richard E. Cutler, Jr., Ryan Fong, Roel Funke, Steven B. Gendreau, Yong D. Kim, Nicole Miller, John R. Woolfrey, Valentina Vysotskaia, Jing Ping Yang, Mary E. Gerritsen, David J. Matthews, Peter Lamb, and Timothy S. Heuer
Clin Cancer Res 2008 14: 2465-2475 doi: 10.1158/1078-0432.CCR-07-4367 [Abstract] [Full Text] [PDF]  

Therapeutic Significance of Elevated Tissue Transglutaminase Expression in Pancreatic Cancer

Amit Verma, Sushovan Guha, Parmeswaran Diagaradjane, Ajaikumar B. Kunnumakkara, Angela M. Sanguino, Gabriel Lopez-Berestein, Anil K. Sood, Bharat B. Aggarwal, Sunil Krishnan, Juri G. Gelovani, and Kapil Mehta
Clin Cancer Res 2008 14: 2476-2483 doi: 10.1158/1078-0432.CCR-07-4529 [Abstract] [Full Text] [PDF]  

Profound Inhibition of Antigen-Specific T-Cell Effector Functions by Dasatinib

Ralf Weichsel, Carolin Dix, Linda Wooldridge, Matthew Clement, Angharad Fenton-May, Andrew K. Sewell, Josef Zezula, Elisabeth Greiner, Emma Gostick, David A. Price, Hermann Einsele, and Ruth Seggewiss
Clin Cancer Res 2008 14: 2484-2491 doi: 10.1158/1078-0432.CCR-07-4393 [Abstract] [Full Text] [PDF] Supplementary Data  

Noninvasive Imaging of Apoptosis and Its Application in Cancer Therapeutics

Julia M. Coppola, Brian D. Ross, and Alnawaz Rehemtulla
Clin Cancer Res 2008 14: 2492-2501 doi: 10.1158/1078-0432.CCR-07-0782 [Abstract] [Full Text] [PDF]  

Dopamine Increases the Efficacy of Anticancer Drugs in Breast and Colon Cancer Preclinical Models

Chandrani Sarkar, Debanjan Chakroborty, Uttio Roy Chowdhury, Partha Sarathi Dasgupta, and Sujit Basu
Clin Cancer Res 2008 14: 2502-2510 doi: 10.1158/1078-0432.CCR-07-1778 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Computed Tomography Screening for Lung Cancer

Peter Bach
Clin Cancer Res 2008 14: 2511 doi: 10.1158/1078-0432.CCR-07-4931 [Full Text] [PDF]  

Deaths among Patients with Screen-Detected Lung Cancer

Gerard A. Silvestri
Clin Cancer Res 2008 14: 2511 doi: 10.1158/1078-0432.CCR-07-4416 [Full Text] [PDF]  

Reply to the Letters to the Editor from Bach and Silvestri

Claudia I. Henschke
Clin Cancer Res 2008 14: 2511 doi: 10.1158/1078-0432.CCR-07-5140 [Full Text] [PDF]  

Biomarkers In Early Clinical Trials: the Committed and the Skeptics

Udai Banerji, Johann de Bono, Ian Judson, Stanley Kaye, and Paul Workman
Clin Cancer Res 2008 14: 2512 doi: 10.1158/1078-0432.CCR-07-5224 [Full Text] [PDF]  

Reply to the Letter to the Editor from Banerji et al

Bernardo Goulart, Thomas G. Roberts, Jeffrey Clark, and Bruce A. Chabner
Clin Cancer Res 2008 14: 2513 doi: 10.1158/1078-0432.CCR-08-0248 [Full Text] [PDF]  

Reply to the Letter to the Editor from Banerji et al

Mark J. Ratain and Robert H. Glassman
Clin Cancer Res 2008 14: 2514 doi: 10.1158/1078-0432.CCR-08-0240 [Full Text] [PDF]  

T-Cell Response in B-Cell Lymphomas: Favorable or Unfavorable?

Joost J. Oudejans, Jettie J.F. Muris, Saskia A.G.M. Cillessen, and Chris J.L.M. Meijer
Clin Cancer Res 2008 14: 2514 doi: 10.1158/1078-0432.CCR-07-4979 [Full Text] [PDF]  

Reply to the Letter to the Editor from Oudejans et al

Kung-Chao Chang and Dan Jones
Clin Cancer Res 2008 14: 2515 doi: 10.1158/1078-0432.CCR-07-5178 [Full Text] [PDF]  

Survival in Microsatellite-Unstable Colorectal Cancer

Toshiaki Watanabe, Yoko Yamamoto, Hideki Yamada, Tamuro Hayama, Yoshiko Aoyagi, Keisuke Nakamura, Hajime Shibuya, and Takashi Kobunai
Clin Cancer Res 2008 14: 2516 doi: 10.1158/1078-0432.CCR-07-2197 [Full Text] [PDF]  

Reply to the Letter to the Editor from Watanabe et al

Alberto Malesci, Luigi Laghi, and Paolo Bianchi
Clin Cancer Res 2008 14: 2516 doi: 10.1158/1078-0432.CCR-07-4833 [Full Text] [PDF]  

Population Pharmacokinetc/Pharmacodynamic Modeling of Paclitaxel and Carboplatin in Ovarian Cancer

Merrill J. Egorin
Clin Cancer Res 2008 14: 2517 doi: 10.1158/1078-0432.CCR-07-5049 [Full Text] [PDF]  

Reply to the Letter to the Editor from Egorin

Markus Joerger and Jan H.N. Schelleus
Clin Cancer Res 2008 14: 2517 doi: 10.1158/1078-0432.CCR-08-0189 [Full Text] [PDF]  

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