Molecular Pathways:

Molecular Pathways Mediating Liver Metastasis in Patients with Uveal Melanoma

Silvin Bakalian, Jean-Claude Marshall, Patrick Logan, Dana Faingold, Shawn Maloney, Sebastian Di Cesare, Claudia Martins, Bruno F. Fernandes, and Miguel N. Burnier, Jr.
Clin Cancer Res 2008 14: 951-956 doi: 10.1158/1078-0432.CCR-06-2630 [Abstract] [Full Text] [PDF]  

Perspective:

Epidermal Growth Factor Receptor Inhibitors in Neuro-oncology: Hopes and Disappointments

Alba A. Brandes, Enrico Franceschi, Alicia Tosoni, Monika E. Hegi, and Roger Stupp
Clin Cancer Res 2008 14: 957-960 doi: 10.1158/1078-0432.CCR-07-1810 [Abstract] [Full Text] [PDF]  

Reviews:

Identifying Breast Cancer Druggable Oncogenic Alterations: Lessons Learned and Future Targeted Options

Alberto Ocaña and Atanasio Pandiella
Clin Cancer Res 2008 14: 961-970 doi: 10.1158/1078-0432.CCR-07-1630 [Abstract] [Full Text] [PDF]  

Medulloblastoma: From Molecular Pathology to Therapy

Alessandra Rossi, Valentina Caracciolo, Giuseppe Russo, Krzysztof Reiss, and Antonio Giordano
Clin Cancer Res 2008 14: 971-976 doi: 10.1158/1078-0432.CCR-07-2072 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

ETV6-NCOA2: A Novel Fusion Gene in Acute Leukemia Associated with Coexpression of T-Lymphoid and Myeloid Markers and Frequent NOTCH1 Mutations

Sabine Strehl, Karin Nebral, Margit König, Jochen Harbott, Herbert Strobl, Richard Ratei, Stephanie Struski, Bella Bielorai, Michel Lessard, Martin Zimmermann, Oskar A. Haas, and Shai Izraeli
Clin Cancer Res 2008 14: 977-983 doi: 10.1158/1078-0432.CCR-07-4022 [Abstract] [Full Text] [PDF]  

Nuclear Factor-Y and Epstein Barr Virus in Nasopharyngeal Cancer

Marie C. Chia, Abby Leung, Tiffany Krushel, Nehad M. Alajez, Kwok W. Lo, Pierre Busson, Henry J. Klamut, Carlo Bastianutto, and Fei-Fei Liu
Clin Cancer Res 2008 14: 984-994 doi: 10.1158/1078-0432.CCR-07-0828 [Abstract] [Full Text] [PDF]  

Differential Wnt Pathway Gene Expression and E-Cadherin Truncation in Sporadic Colorectal Cancers with and without Microsatellite Instability

Paloma Ortega, Alberto Morán, Carmen de Juan, Cristina Frías, Susana Hernández, Jose-Antonio López-Asenjo, Andrés Sánchez-Pernaute, Antonio Torres, Pilar Iniesta, and Manuel Benito
Clin Cancer Res 2008 14: 995-1001 doi: 10.1158/1078-0432.CCR-07-1588 [Abstract] [Full Text] [PDF]  

Proteomic Analysis of Laser-Captured Paraffin-Embedded Tissues: A Molecular Portrait of Head and Neck Cancer Progression

Vyomesh Patel, Brian L. Hood, Alfredo A. Molinolo, Norman H. Lee, Thomas P. Conrads, John C. Braisted, David B. Krizman, Timothy D. Veenstra, and J. Silvio Gutkind
Clin Cancer Res 2008 14: 1002-1014 doi: 10.1158/1078-0432.CCR-07-1497 [Abstract] [Full Text] [PDF] Supplementary Data  

High-Resolution DNA Copy Number Profiling of Malignant Peripheral Nerve Sheath Tumors Using Targeted Microarray-Based Comparative Genomic Hybridization

Kiran K. Mantripragada, Gillian Spurlock, Lan Kluwe, Nadia Chuzhanova, Rosalie E. Ferner, Ian M. Frayling, Jan P. Dumanski, Abhijit Guha, Victor Mautner, and Meena Upadhyaya
Clin Cancer Res 2008 14: 1015-1024 doi: 10.1158/1078-0432.CCR-07-1305 [Abstract] [Full Text] [PDF] Supplementary Data  

Decreased ID2 Promotes Metastatic Potentials of Hepatocellular Carcinoma by Altering Secretion of Vascular Endothelial Growth Factor

Ryouichi Tsunedomi, Norio Iizuka, Takao Tamesa, Kazuhiko Sakamoto, Takashi Hamaguchi, Hideaki Somura, Mamoru Yamada, and Masaaki Oka
Clin Cancer Res 2008 14: 1025-1031 doi: 10.1158/1078-0432.CCR-07-1116 [Abstract] [Full Text] [PDF] Supplementary Data  

Enhanced Functionality of CD4⁺CD25^highFoxP3⁺ Regulatory T Cells in the Peripheral Blood of Patients with Prostate Cancer

Junko Yokokawa, Vittore Cereda, Cinzia Remondo, James L. Gulley, Philip M. Arlen, Jeffrey Schlom, and Kwong Y. Tsang
Clin Cancer Res 2008 14: 1032-1040 doi: 10.1158/1078-0432.CCR-07-2056 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Reduced hGC-1 Protein Expression Is Associated with Malignant Progression of Colon Carcinoma

Wenli Liu, Yueqin Liu, Jianqiong Zhu, Elizabeth Wright, Ivan Ding, and Griffin P. Rodgers
Clin Cancer Res 2008 14: 1041-1049 doi: 10.1158/1078-0432.CCR-07-4125 [Abstract] [Full Text] [PDF]  

Analysis of Integrin β4 Expression in Human Breast Cancer: Association with Basal-like Tumors and Prognostic Significance

Shaolei Lu, Karl Simin, Ashraf Khan, and Arthur M. Mercurio
Clin Cancer Res 2008 14: 1050-1058 doi: 10.1158/1078-0432.CCR-07-4116 [Abstract] [Full Text] [PDF]  

Thymidylate Synthase Expression in Gastroenteropancreatic and Pulmonary Neuroendocrine Tumors

Paolo Ceppi, Marco Volante, Anna Ferrero, Luisella Righi, Ida Rapa, Rosj Rosas, Alfredo Berruti, Luigi Dogliotti, Giorgio V. Scagliotti, and Mauro Papotti
Clin Cancer Res 2008 14: 1059-1064 doi: 10.1158/1078-0432.CCR-07-1513 [Abstract] [Full Text] [PDF]  

Diagnostic Markers for Early Detection of Ovarian Cancer

Irene Visintin, Ziding Feng, Gary Longton, David C. Ward, Ayesha B. Alvero, Yinglei Lai, Jeannette Tenthorey, Aliza Leiser, Ruben Flores-Saaib, Herbert Yu, Masoud Azori, Thomas Rutherford, Peter E. Schwartz, and Gil Mor
Clin Cancer Res 2008 14: 1065-1072 Published Online First February 7, 2008. doi: 10.1158/1078-0432.CCR-07-1569 [Abstract] [Full Text] [PDF] {Supplementary Data} Correction 10/17/2008  

Epithelial Human Leukocyte Antigen-DR Expression Predicts Reduced Recurrence Rates and Prolonged Survival in Rectal Cancer Patients

Elza C. de Bruin, Cornelis J.H. van de Velde, J. Han J.M. van Krieken, Corrie A.M. Marijnen, and Jan Paul Medema
Clin Cancer Res 2008 14: 1073-1079 doi: 10.1158/1078-0432.CCR-07-1597 [Abstract] [Full Text] [PDF]  

Identification of Cystatin B as a Potential Serum Marker in Hepatocellular Carcinoma

Mi-Jin Lee, Gyung-Ran Yu, Seon-Hwa Park, Baik-Hwan Cho, Jong-Seong Ahn, Hae-Joon Park, Eun-Young Song, and Dae-Ghon Kim
Clin Cancer Res 2008 14: 1080-1089 doi: 10.1158/1078-0432.CCR-07-1615 [Abstract] [Full Text] [PDF]  

Effects of Common Germ-Line Genetic Variation in Cell Cycle Genes on Ovarian Cancer Survival

Honglin Song, Estrid Hogdall, Susan J. Ramus, Richard A. DiCioccio, Claus Hogdall, Lydia Quaye, Valerie McGuire, Alice S. Whittemore, Mitul Shah, David Greenberg, Douglas F. Easton, Susanne Kruger Kjaer, Paul D.P. Pharoah, and Simon A. Gayther
Clin Cancer Res 2008 14: 1090-1095 doi: 10.1158/1078-0432.CCR-07-1195 [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Therapy: Clinical:

Hypoxia-Selective Targeting by the Bioreductive Prodrug AQ4N in Patients with Solid Tumors: Results of a Phase I Study

Mark R. Albertella, Paul M. Loadman, Philip H. Jones, Roger M. Phillips, Roy Rampling, Neil Burnet, Chris Alcock, Alan Anthoney, Egils Vjaters, Chris R. Dunk, Peter A. Harris, Alvin Wong, Alshad S. Lalani, and Chris J. Twelves
Clin Cancer Res 2008 14: 1096-1104 doi: 10.1158/1078-0432.CCR-07-4020 [Abstract] [Full Text] [PDF] Supplementary Data  

Phase I Clinical Study of Atacicept in Patients with Relapsed and Refractory B-Cell Non–Hodgkin's Lymphoma

Stephen M. Ansell, Thomas E. Witzig, David J. Inwards, Luis F. Porrata, Arnaud Ythier, Lee Ferrande, Ivan Nestorov, Todd DeVries, Stacey R. Dillon, Diana Hausman, and Anne J. Novak
Clin Cancer Res 2008 14: 1105-1110 doi: 10.1158/1078-0432.CCR-07-4435 [Abstract] [Full Text] [PDF]  

A Phase I Study of ABT-751, an Orally Bioavailable Tubulin Inhibitor, Administered Daily for 21 Days Every 28 Days in Pediatric Patients with Solid Tumors

Elizabeth Fox, John M. Maris, Brigitte C. Widemann, Wendy Goodspeed, Anne Goodwin, Marie Kromplewski, Molly E. Fouts, Diane Medina, Susan L. Cohn, Andrew Krivoshik, Anne E. Hagey, Peter C. Adamson, and Frank M. Balis
Clin Cancer Res 2008 14: 1111-1115 doi: 10.1158/1078-0432.CCR-07-4097 [Abstract] [Full Text] [PDF]  

Phase I Clinical and Pharmacokinetic Study of Kahalalide F Administered Weekly as a 1-Hour Infusion to Patients with Advanced Solid Tumors

Beatriz Pardo, Luis Paz-Ares, Josep Tabernero, Eva Ciruelos, Margarita García, Ramón Salazar, Ana López, María Blanco, Antonio Nieto, José Jimeno, Miguel Ángel Izquierdo, and José Manuel Trigo
Clin Cancer Res 2008 14: 1116-1123 doi: 10.1158/1078-0432.CCR-07-4366 [Abstract] [Full Text] [PDF]  

Phase I Trial of VNP40101M (Cloretazine) in Children with Recurrent Brain Tumors: A Pediatric Brain Tumor Consortium Study

Sridharan Gururangan, Christopher D. Turner, Clinton F. Stewart, Melinda O'Shaughnessy, Mehmet Kocak, Tina Young Poussaint, Peter C. Phillips, Stewart Goldman, Roger Packer, Ian F. Pollack, Susan M. Blaney, Verena Karsten, Stanton L. Gerson, James M. Boyett, Henry S. Friedman, and Larry E. Kun
Clin Cancer Res 2008 14: 1124-1130 doi: 10.1158/1078-0432.CCR-07-4242 [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacokinetic Trial of Erlotinib in Combination with Weekly Docetaxel in Patients with Taxane-Naive Malignancies

E. Gabriela Chiorean, Jennifer M. Porter, Anne E. Foster, Amal S.H. Al Omari, Christy A. Yoder, Karen L. Fife, R. Matthew Strother, Daryl J. Murry, Menggang Yu, David R. Jones, and Christopher J. Sweeney
Clin Cancer Res 2008 14: 1131-1137 doi: 10.1158/1078-0432.CCR-07-0437 [Abstract] [Full Text] [PDF]  

Enhanced Immune System Regeneration in Humans Following Allogeneic or Autologous Hemopoietic Stem Cell Transplantation by Temporary Sex Steroid Blockade

Jayne S. Sutherland, Lisa Spyroglou, Jennifer L. Muirhead, Tracy S. Heng, Adria Prieto-Hinojosa, H. Miles Prince, Ann P. Chidgey, Anthony P. Schwarer, and Richard L. Boyd
Clin Cancer Res 2008 14: 1138-1149 doi: 10.1158/1078-0432.CCR-07-1784 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Methylseleninic Acid Enhances Taxane Drug Efficacy against Human Prostate Cancer and Down-Regulates Antiapoptotic Proteins Bcl-XL and Survivin

Hongbo Hu, Guang-xun Li, Lei Wang, Jennifer Watts, Gerald F. Combs, Jr., and Junxuan Lü
Clin Cancer Res 2008 14: 1150-1158 doi: 10.1158/1078-0432.CCR-07-4037 [Abstract] [Full Text] [PDF]  

Enhancement of Antitumor Radiation Efficacy and Consistent Induction of the Abscopal Effect in Mice by ECI301, an Active Variant of Macrophage Inflammatory Protein-1

Kenshiro Shiraishi, Yoshiro Ishiwata, Keiichi Nakagawa, Shoji Yokochi, Chiho Taruki, Teruo Akuta, Kuni Ohtomo, Kouji Matsushima, Takuya Tamatani, and Shiro Kanegasaki
Clin Cancer Res 2008 14: 1159-1166 doi: 10.1158/1078-0432.CCR-07-4485 [Abstract] [Full Text] [PDF]  

Suppression of Peutz-Jeghers Polyposis by Targeting Mammalian Target of Rapamycin Signaling

Chongjuan Wei, Christopher I. Amos, Nianxiang Zhang, Xiaopei Wang, Asif Rashid, Cheryl L. Walker, Richard R. Behringer, and Marsha L. Frazier
Clin Cancer Res 2008 14: 1167-1171 doi: 10.1158/1078-0432.CCR-07-4007 [Abstract] [Full Text] [PDF]  

Targeting the Phosphoinositide 3-Kinase Isoform p110 Impairs Growth and Survival in Neuroblastoma Cells

Danielle Boller, Alexander Schramm, Kathrin T. Doepfner, Tarek Shalaby, André O. von Bueren, Angelika Eggert, Michael A. Grotzer, and Alexandre Arcaro
Clin Cancer Res 2008 14: 1172-1181 doi: 10.1158/1078-0432.CCR-07-0737 [Abstract] [Full Text] [PDF] Supplementary Data  

TACE/ADAM-17: A Component of the Epidermal Growth Factor Receptor Axis and a Promising Therapeutic Target in Colorectal Cancer

Nipun B. Merchant, Igor Voskresensky, Christopher M. Rogers, Bonnie LaFleur, Peter J. Dempsey, Ramona Graves-Deal, Frank Revetta, A. Coe Foutch, Mace L. Rothenberg, Mary K. Washington, and Robert J. Coffey
Clin Cancer Res 2008 14: 1182-1191 doi: 10.1158/1078-0432.CCR-07-1216 [Abstract] [Full Text] [PDF]  

Trastuzumab Activates Allogeneic or Autologous Antibody-Dependent Cellular Cytotoxicity against Malignant Rhabdoid Tumor Cells and Interleukin-2 Augments the Cytotoxicity

Yoshiki Katsumi, Yasumichi Kuwahara, Shinichi Tamura, Ken Kikuchi, Osamu Otabe, Kunihiko Tsuchiya, Tomoko Iehara, Hiroshi Kuroda, Hajime Hosoi, and Tohru Sugimoto
Clin Cancer Res 2008 14: 1192-1199 doi: 10.1158/1078-0432.CCR-07-1661 [Abstract] [Full Text] [PDF] Supplementary Data  

Effect of Trans-2,3-Dimethoxycinnamoyl Azide on Enhancing Antitumor Activity of Romidepsin on Human Bladder Cancer

Jinhai Fan, Jennifer Stanfield, Yi Guo, Jose A. Karam, Eugene Frenkel, Xiankai Sun, and Jer-Tsong Hsieh
Clin Cancer Res 2008 14: 1200-1207 doi: 10.1158/1078-0432.CCR-07-1656 [Abstract] [Full Text] [PDF] Supplementary Data  

Irinophore C: A Liposome Formulation of Irinotecan with Substantially Improved Therapeutic Efficacy against a Panel of Human Xenograft Tumors

Euan C. Ramsay, Malathi Anantha, Jason Zastre, Marieke Meijs, Jet Zonderhuis, Dita Strutt, Murray S. Webb, Dawn Waterhouse, and Marcel B. Bally
Clin Cancer Res 2008 14: 1208-1217 doi: 10.1158/1078-0432.CCR-07-0780 [Abstract] [Full Text] [PDF]  

Oncolytic Efficacy of Recombinant Vesicular Stomatitis Virus and Myxoma Virus in Experimental Models of Rhabdoid Tumors

Yushui Wu, Xueqing Lun, Hongyuan Zhou, Limei Wang, Beichen Sun, John C. Bell, John W. Barrett, Grant McFadden, Jaclyn A. Biegel, Donna L. Senger, and Peter A. Forsyth
Clin Cancer Res 2008 14: 1218-1227 doi: 10.1158/1078-0432.CCR-07-1330 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor-Selective Replication of an Oncolytic Adenovirus Carrying Oct-3/4 Response Elements in Murine Metastatic Bladder Cancer Models

Chao-Liang Wu, Gia-Shing Shieh, Chao-Ching Chang, Yi-Te Yo, Chih-Hau Su, Meng-Ya Chang, Yin-Hui Huang, Pensee Wu, and Ai-Li Shiau
Clin Cancer Res 2008 14: 1228-1238 doi: 10.1158/1078-0432.CCR-07-1047 [Abstract] [Full Text] [PDF]  

Yeast-Derived β-Glucan Augments the Therapeutic Efficacy Mediated by Anti–Vascular Endothelial Growth Factor Monoclonal Antibody in Human Carcinoma Xenograft Models

Carolina Salvador, Bing Li, Richard Hansen, Daniel E. Cramer, Maiying Kong, and Jun Yan
Clin Cancer Res 2008 14: 1239-1247 doi: 10.1158/1078-0432.CCR-07-1669 [Abstract] [Full Text] [PDF]  

Honokiol, a Constituent of Oriental Medicinal Herb Magnolia officinalis, Inhibits Growth of PC-3 Xenografts In vivo in Association with Apoptosis Induction

Eun-Ryeong Hahm, Julie A. Arlotti, Stanley W. Marynowski, and Shivendra V. Singh
Clin Cancer Res 2008 14: 1248-1257 doi: 10.1158/1078-0432.CCR-07-1926 [Abstract] [Full Text] [PDF]  

Preclinical Toxicity, Toxicokinetics, and Antitumoral Efficacy Studies of DTS-201, a Tumor-Selective Peptidic Prodrug of Doxorubicin

Denis Ravel, Vincent Dubois, Jérôme Quinonero, Florence Meyer-Losic, JeanPierre Delord, Philippe Rochaix, Céline Nicolazzi, Fabien Ribes, Catherine Mazerolles, Elise Assouly, Karine Vialatte, Inès Hor, Jonathan Kearsey, and André Trouet
Clin Cancer Res 2008 14: 1258-1265 doi: 10.1158/1078-0432.CCR-07-1165 [Abstract] [Full Text] [PDF]  

Gefitinib Radiosensitizes Non–Small Cell Lung Cancer Cells by Suppressing Cellular DNA Repair Capacity

Toshimitsu Tanaka, Anupama Munshi, Colin Brooks, Jenny Liu, Marvette L. Hobbs, and Raymond E. Meyn
Clin Cancer Res 2008 14: 1266-1273 doi: 10.1158/1078-0432.CCR-07-1606 [Abstract] [Full Text] [PDF]  

Cancer Prevention and Susceptibility:

Molecular Risk Assessment for Breast Cancer Development in Patients with Ductal Hyperplasias

Indira Poola, Jessy Abraham, Josephine J. Marshalleck, Qingqi Yue, Vinatha B. Lokeshwar, George Bonney, and Robert L. DeWitty
Clin Cancer Res 2008 14: 1274-1280 doi: 10.1158/1078-0432.CCR-07-4053 [Abstract] [Full Text] [PDF] Supplementary Data  

Corrections:

Correction: Article on Phosphatidylinositol 3-Kinase in Breast Cancer

Clin Cancer Res 2008 14: 1281 doi: 10.1158/1078-0432.CCR-14-4-COR [Full Text] [PDF]  

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