Editors' Note:

Introducing CCR Translations

Carlos L. Arteaga and Jerome Ritz
Clin Cancer Res 2008 14: 4681 doi: 10.1158/1078-0432.CCR-14-15-ED [Full Text] [PDF]  

CCR Translations:

Moving Toward Individualized Cancer Therapies

Giovanni Tonon and Kenneth C. Anderson
Clin Cancer Res 2008 14: 4682-4684 doi: 10.1158/1078-0432.CCR-08-1134 [Abstract] [Full Text] [PDF] Related Article  

Perspectives:

Erythropoiesis-Stimulating Agent Use in Cancer: Preclinical and Clinical Perspectives

Murat O. Arcasoy
Clin Cancer Res 2008 14: 4685-4690 doi: 10.1158/1078-0432.CCR-08-0264 [Abstract] [Full Text] [PDF]  

The Genetics of Castration-Resistant Prostate Cancer: What Can the Germline Tell Us?

Nima Sharifi, William L. Dahut, and William D. Figg
Clin Cancer Res 2008 14: 4691-4693 doi: 10.1158/1078-0432.CCR-08-0453 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Loss of Protein Inhibitors of Activated STAT-3 Expression in Glioblastoma Multiforme Tumors: Implications for STAT-3 Activation and Gene Expression

Emily C. Brantley, L. Burton Nabors, G. Yancey Gillespie, Youn-Hee Choi, Cheryl Ann Palmer, Keith Harrison, Kevin Roarty, and Etty N. Benveniste
Clin Cancer Res 2008 14: 4694-4704 doi: 10.1158/1078-0432.CCR-08-0618 [Abstract] [Full Text] [PDF] Supplementary Data  

Human Papillomavirus Type 16/18 Up-Regulates the Expression of Interleukin-6 and Antiapoptotic Mcl-1 in Non–Small Cell Lung Cancer

Ya-Wen Cheng, Huei Lee, Ming-Yuh Shiau, Tzu-Chin Wu, Tsung-Teng Huang, and Yih-Hsin Chang
Clin Cancer Res 2008 14: 4705-4712 doi: 10.1158/1078-0432.CCR-07-4675 [Abstract] [Full Text] [PDF]  

OPG Is Regulated by β-Catenin and Mediates Resistance to TRAIL-Induced Apoptosis in Colon Cancer

Enrico N. De Toni, Susanne E. Thieme, Andreas Herbst, Andrea Behrens, Petra Stieber, Andreas Jung, Helmut Blum, Burkhard Göke, and Frank T. Kolligs
Clin Cancer Res 2008 14: 4713-4718 doi: 10.1158/1078-0432.CCR-07-5019 [Abstract] [Full Text] [PDF]  

Delineation of TMPRSS2-ERG Splice Variants in Prostate Cancer

Ying Hu, Albert Dobi, Taduru Sreenath, Christopher Cook, Atekelt Y. Tadase, Lakshmi Ravindranath, Jennifer Cullen, Bungo Furusato, Yongmei Chen, Rajesh L. Thangapazham, Ahmed Mohamed, Chen Sun, Isabell A. Sesterhenn, David G. McLeod, Gyorgy Petrovics, and Shiv Srivastava
Clin Cancer Res 2008 14: 4719-4725 doi: 10.1158/1078-0432.CCR-08-0531 [Abstract] [Full Text] [PDF] Supplementary Data  

Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors

Michael L. Nickerson, Erich Jaeger, Yangu Shi, Jeffrey A. Durocher, Sunil Mahurkar, David Zaridze, Vsevolod Matveev, Vladimir Janout, Hellena Kollarova, Vladimir Bencko, Marie Navratilova, Neonilia Szeszenia-Dabrowska, Dana Mates, Anush Mukeria, Ivana Holcatova, Laura S. Schmidt, Jorge R. Toro, Sara Karami, Rayjean Hung, Gary F. Gerard, W. Marston Linehan, Maria Merino, Berton Zbar, Paolo Boffetta, Paul Brennan, Nathaniel Rothman, Wong-Ho Chow, Frederic M. Waldman, and Lee E. Moore
Clin Cancer Res 2008 14: 4726-4734 doi: 10.1158/1078-0432.CCR-07-4921 [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Expression Profiling of Papillary Thyroid Carcinoma Identifies Transcripts Correlated with BRAF Mutational Status and Lymph Node Metastasis

Gisele Oler, Cléber P. Camacho, Flávio C. Hojaij, Pedro Michaluart, Jr., Gregory J. Riggins, and Janete M. Cerutti
Clin Cancer Res 2008 14: 4735-4742 doi: 10.1158/1078-0432.CCR-07-4372 [Abstract] [Full Text] [PDF]  

Epithelial-Mesenchymal Transition in Cervical Cancer: Correlation with Tumor Progression, Epidermal Growth Factor Receptor Overexpression, and Snail Up-Regulation

Mei-Yi Lee, Cheng-Yang Chou, Ming-Jer Tang, and Meng-Ru Shen
Clin Cancer Res 2008 14: 4743-4750 doi: 10.1158/1078-0432.CCR-08-0234 [Abstract] [Full Text] [PDF] Supplementary Data  

Imaging, Diagnosis, Prognosis:

Prospective Study of the Accuracy of EGFR Mutational Analysis by High-Resolution Melting Analysis in Small Samples Obtained from Patients with Non–Small Cell Lung Cancer

Tomoya Fukui, Yuichiro Ohe, Koji Tsuta, Koh Furuta, Hiromi Sakamoto, Toshimi Takano, Hiroshi Nokihara, Noboru Yamamoto, Ikuo Sekine, Hideo Kunitoh, Hisao Asamura, Takaaki Tsuchida, Masahiro Kaneko, Masahiko Kusumoto, Seiichiro Yamamoto, Teruhiko Yoshida, and Tomohide Tamura
Clin Cancer Res 2008 14: 4751-4757 doi: 10.1158/1078-0432.CCR-07-5207 [Abstract] [Full Text] [PDF]  

Imaging of Urokinase-Type Plasminogen Activator Receptor Expression Using a ⁶⁴Cu-Labeled Linear Peptide Antagonist by microPET

Zi-Bo Li, Gang Niu, Hui Wang, Lina He, Lily Yang, Michael Ploug, and Xiaoyuan Chen
Clin Cancer Res 2008 14: 4758-4766 doi: 10.1158/1078-0432.CCR-07-4434 [Abstract] [Full Text] [PDF]  

Pattern of Serum Autoantibodies Allows Accurate Distinction between a Tumor and Pathologies of the Same Organ

Nicole Ludwig, Andreas Keller, Nicole Comtesse, Stefanie Rheinheimer, Christian Pallasch, Ulrike Fischer, Klaus Fassbender, Wolf Ingo Steudel, Hans-Peter Lenhof, and Eckart Meese
Clin Cancer Res 2008 14: 4767-4774 doi: 10.1158/1078-0432.CCR-07-4715 [Abstract] [Full Text] [PDF] Supplementary Data  

The Retinoblastoma Family Member pRb2/p130 Is an Independent Predictor of Survival in Human Soft Tissue Sarcomas

Valeria Masciullo, Ester Berardengo, Antonella Boglione, Alessandro Sgambato, Amelia Bernardi, Marco Forni, Alessandra Linari, Letizia Cito, Giovanni Scambia, Alessandro Comandone, and Antonio Giordano
Clin Cancer Res 2008 14: 4775-4779 doi: 10.1158/1078-0432.CCR-07-4055 [Abstract] [Full Text] [PDF]  

Prognostic Significance of CD55 Expression in Breast Cancer

Jun-ichiro Ikeda, Eiichi Morii, Yalan Liu, Ying Qiu, Naoto Nakamichi, Ryu Jokoji, Yasuo Miyoshi, Shinzaburo Noguchi, and Katsuyuki Aozasa
Clin Cancer Res 2008 14: 4780-4786 doi: 10.1158/1078-0432.CCR-07-1844 [Abstract] [Full Text] [PDF]  

Genetic Polymorphisms of Metastasis Suppressor Gene NME1 and Breast Cancer Survival

Shimian Qu, Jirong Long, Qiuyin Cai, Xiao-Ou Shu, Hui Cai, Yu-Tang Gao, and Wei Zheng
Clin Cancer Res 2008 14: 4787-4793 doi: 10.1158/1078-0432.CCR-08-0083 [Abstract] [Full Text] [PDF]  

Three-Gene Expression Signature Predicts Survival in Early-Stage Squamous Cell Carcinoma of the Lung

Marcin Skrzypski, Ewa Jassem, Miquel Taron, Jose Javier Sanchez, Pedro Mendez, Witold Rzyman, Grazyna Gulida, Dan Raz, David Jablons, Mariano Provencio, Bartomeu Massuti, Imane Chaib, Laia Perez-Roca, Jacek Jassem, and Rafael Rosell
Clin Cancer Res 2008 14: 4794-4799 doi: 10.1158/1078-0432.CCR-08-0576 [Abstract] [Full Text] [PDF] Supplementary Data  

T-Cell Coregulatory Molecule Expression in Urothelial Cell Carcinoma: Clinicopathologic Correlations and Association with Survival

Stephen A. Boorjian, Yuri Sheinin, Paul L. Crispen, Sara A. Farmer, Christine M. Lohse, Susan M. Kuntz, Bradley C. Leibovich, Eugene D. Kwon, and Igor Frank
Clin Cancer Res 2008 14: 4800-4808 doi: 10.1158/1078-0432.CCR-08-0731 [Abstract] [Full Text] [PDF] Supplementary Data  

Quantitative Analysis of the Transrenal Excretion of Circulating EBV DNA in Nasopharyngeal Carcinoma Patients

K.C. Allen Chan, Sing F. Leung, Sze W. Yeung, Anthony T.C. Chan, and Y.M. Dennis Lo
Clin Cancer Res 2008 14: 4809-4813 doi: 10.1158/1078-0432.CCR-08-1112 [Abstract] [Full Text] [PDF]  

ASPM Is a Novel Marker for Vascular Invasion, Early Recurrence, and Poor Prognosis of Hepatocellular Carcinoma

Shih-Yeh Lin, Hung-Wei Pan, Shu-Hsiang Liu, Yung-Ming Jeng, Fu-Chang Hu, Shian-Yang Peng, Po-Lin Lai, and Hey-Chi Hsu
Clin Cancer Res 2008 14: 4814-4820 doi: 10.1158/1078-0432.CCR-07-5262 [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Therapy: Clinical:

Tumor Cell Gene Expression Changes Following Short-term In vivo Exposure to Single Agent Chemotherapeutics are Related to Survival in Multiple Myeloma

Bart Burington, Bart Barlogie, Fenghuang Zhan, John Crowley, and John D. Shaughnessy, Jr.
Clin Cancer Res 2008 14: 4821-4829 doi: 10.1158/1078-0432.CCR-07-4568 [Abstract] [Full Text] [PDF] CCR Translation on this Article  

K-Ras Mutations and Treatment Outcome in Colorectal Cancer Patients Receiving Exclusive Fluoropyrimidine Therapy

Marie-Christine Etienne-Grimaldi, Jean-Louis Formento, Mireille Francoual, Eric François, Patricia Formento, Nicole Renée, Pierre Laurent-Puig, Maurice Chazal, Daniel Benchimol, Jean-Robert Delpero, Christian Letoublon, Denis Pezet, Jean-François Seitz, and Gérard Milano
Clin Cancer Res 2008 14: 4830-4835 doi: 10.1158/1078-0432.CCR-07-4906 [Abstract] [Full Text] [PDF]  

A Phase I Trial of the Oral, Multikinase Inhibitor Sorafenib in Combination with Carboplatin and Paclitaxel

Keith T. Flaherty, Joan Schiller, Lynn M. Schuchter, Glenn Liu, David A. Tuveson, Maryann Redlinger, Chetan Lathia, Chenghua Xia, Oana Petrenciuc, Sunil R. Hingorani, Michael A. Jacobetz, Patricia A. Van Belle, David Elder, Marcia S. Brose, Barbara L. Weber, Mark R. Albertini, and Peter J. O'Dwyer
Clin Cancer Res 2008 14: 4836-4842 doi: 10.1158/1078-0432.CCR-07-4123 [Abstract] [Full Text] [PDF]  

Combination Chemotherapy and ALVAC-CEA/B7.1 Vaccine in Patients with Metastatic Colorectal Cancer

Howard L. Kaufman, Heinz-Josef Lenz, John Marshall, Deepti Singh, Chris Garett, Christine Cripps, Malcolm Moore, Margaret von Mehren, Richard Dalfen, William J. Heim, Robert M. Conry, Walter J. Urba, Al B. Benson, III, Maria Yu, Judy Caterini, Seunghee Kim-Schulze, Mark DeBenedette, Danielle Salha, Thorsten Vogel, Ileana Elias, and Neil L. Berinstein
Clin Cancer Res 2008 14: 4843-4849 doi: 10.1158/1078-0432.CCR-08-0276 [Abstract] [Full Text] [PDF]  

A Pilot Study of Consolidative Immunotherapy in Patients with High-Risk Pediatric Sarcomas

Crystal L. Mackall, Eunice H. Rhee, Elizabeth J. Read, Hanh M. Khuu, Susan F. Leitman, Donna Bernstein, Merertu Tesso, Lauren M. Long, David Grindler, Margret Merino, William Kopp, Maria Tsokos, Jay A. Berzofsky, and Lee J. Helman
Clin Cancer Res 2008 14: 4850-4858 doi: 10.1158/1078-0432.CCR-07-4065 [Abstract] [Full Text] [PDF] Supplementary Data  

Mismatch Repair Deficiency Does Not Mediate Clinical Resistance to Temozolomide in Malignant Glioma

Jill A. Maxwell, Stewart P. Johnson, Roger E. McLendon, David W. Lister, Krystle S. Horne, Ahmed Rasheed, Jennifer A. Quinn, Francis Ali-Osman, Allan H. Friedman, Paul L. Modrich, Darell D. Bigner, and Henry S. Friedman
Clin Cancer Res 2008 14: 4859-4868 doi: 10.1158/1078-0432.CCR-07-4807 [Abstract] [Full Text] [PDF]  

Motexafin Lutetium-Photodynamic Therapy of Prostate Cancer: Short- and Long-Term Effects on Prostate-Specific Antigen

Hiral Patel, Rosemarie Mick, Jarod Finlay, Timothy C. Zhu, Elizabeth Rickter, Keith A. Cengel, S. Bruce Malkowicz, Stephen M. Hahn, and Theresa M. Busch
Clin Cancer Res 2008 14: 4869-4876 doi: 10.1158/1078-0432.CCR-08-0317 [Abstract] [Full Text] [PDF]  

Lung Cancer with Epidermal Growth Factor Receptor Exon 20 Mutations Is Associated with Poor Gefitinib Treatment Response

Jenn-Yu Wu, Shang-Gin Wu, Chih-Hsin Yang, Chien-Hung Gow, Yih-Leong Chang, Chong-Jen Yu, Jin-Yuan Shih, and Pan-Chyr Yang
Clin Cancer Res 2008 14: 4877-4882 doi: 10.1158/1078-0432.CCR-07-5123 [Abstract] [Full Text] [PDF]  

T-Cell Responses to Survivin in Cancer Patients Undergoing Radiation Therapy

Dörthe Schaue, Begonya Comin-Anduix, Antoni Ribas, Li Zhang, Lee Goodglick, James W. Sayre, Annelies Debucquoy, Karin Haustermans, and William H. McBride
Clin Cancer Res 2008 14: 4883-4890 doi: 10.1158/1078-0432.CCR-07-4462 [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Therapy: Preclinical:

Efficacy of Systemically Administered Mutant Vesicular Stomatitis Virus (VSV51) Combined with Radiation for Nasopharyngeal Carcinoma

Nehad M. Alajez, Joseph D. Mocanu, Wei Shi, Marie C. Chia, Caroline J. Breitbach, Angela B.Y. Hui, Shane Knowles, John C. Bell, Pierre Busson, Kenzo Takada, Kwok-Wai Lo, Brian O'Sullivan, Pat Gullane, and Fei-Fei Liu
Clin Cancer Res 2008 14: 4891-4897 doi: 10.1158/1078-0432.CCR-07-4134 [Abstract] [Full Text] [PDF] Supplementary Data  

Oxidation of Ovarian Epithelial Cancer Cells by Hypochlorous Acid Enhances Immunogenicity and Stimulates T Cells that Recognize Autologous Primary Tumor

Cheryl L-L. Chiang, Jonathan A. Ledermann, Egla Aitkens, Elizabeth Benjamin, David R. Katz, and Benjamin M. Chain
Clin Cancer Res 2008 14: 4898-4907 doi: 10.1158/1078-0432.CCR-07-4899 [Abstract] [Full Text] [PDF]  

Sorafenib Potently Inhibits Papillary Thyroid Carcinomas Harboring RET/PTC1 Rearrangement

Ying C. Henderson, Soon-Hyun Ahn, Ya'an Kang, and Gary L. Clayman
Clin Cancer Res 2008 14: 4908-4914 doi: 10.1158/1078-0432.CCR-07-1772 [Abstract] [Full Text] [PDF]  

Radiation-Mediated Up-Regulation of Gene Expression from Replication-Defective Adenoviral Vectors: Implications for Sodium Iodide Symporter Gene Therapy

Mohan Hingorani, Christine L. White, Shane Zaidi, Andrew Merron, Inge Peerlinck, Martin E. Gore, Christopher M. Nutting, Hardev S. Pandha, Alan A. Melcher, Richard G. Vile, Georges Vassaux, and Kevin J. Harrington
Clin Cancer Res 2008 14: 4915-4924 doi: 10.1158/1078-0432.CCR-07-4049 [Abstract] [Full Text] [PDF] Supplementary Data  

Radiation Therapy with Tositumomab (B1) Anti-CD20 Monoclonal Antibody Initiates Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase–Dependent Cell Death that Overcomes Resistance to Apoptosis

Andrey Ivanov, Sergei Krysov, Mark S. Cragg, and Tim Illidge
Clin Cancer Res 2008 14: 4925-4934 doi: 10.1158/1078-0432.CCR-07-5072 [Abstract] [Full Text] [PDF]  

Suppression of Tumor Formation by a Cyclooxygenase-2 Inhibitor and a Peroxisome Proliferator-Activated Receptor Agonist in an In vivo Mouse Model of Spontaneous Breast Cancer

Aladdin Mustafa and Warren D. Kruger
Clin Cancer Res 2008 14: 4935-4942 doi: 10.1158/1078-0432.CCR-08-0958 [Abstract] [Full Text] [PDF]  

Human Mena^+11a Isoform Serves as a Marker of Epithelial Phenotype and Sensitivity to Epidermal Growth Factor Receptor Inhibition in Human Pancreatic Cancer Cell Lines

Maria S. Pino, Michele Balsamo, Francesca Di Modugno, Marcella Mottolese, Massimo Alessio, Elisa Melucci, Michele Milella, David J. McConkey, Ulrike Philippar, Frank B. Gertler, Pier Giorgio Natali, and Paola Nisticò
Clin Cancer Res 2008 14: 4943-4950 doi: 10.1158/1078-0432.CCR-08-0436 [Abstract] [Full Text] [PDF]  

The Targeted Immunocytokine L19-IL2 Efficiently Inhibits the Growth of Orthotopic Pancreatic Cancer

Karola Wagner, Petra Schulz, Arne Scholz, Bertram Wiedenmann, and Andreas Menrad
Clin Cancer Res 2008 14: 4951-4960 doi: 10.1158/1078-0432.CCR-08-0157 [Abstract] [Full Text] [PDF]  

Silencing of Transforming Growth Factor-β1 In situ by RNA Interference for Breast Cancer: Implications for Proliferation and Migration In vitro and Metastasis In vivo

Lakisha D. Moore, Tatyana Isayeva, Gene P. Siegal, and Selvarangan Ponnazhagan
Clin Cancer Res 2008 14: 4961-4970 doi: 10.1158/1078-0432.CCR-07-4604 [Abstract] [Full Text] [PDF] Supplementary Data  

Telomere Maintenance in Laser Capture Microdissection–Purified Barrett's Adenocarcinoma Cells and Effect of Telomerase Inhibition In vivo

Masood A. Shammas, Aamer Qazi, Ramesh B. Batchu, Robert C. Bertheau, Jason Y.Y. Wong, Manjula Y. Rao, Madhu Prasad, Diptiman Chanda, Selvarangan Ponnazhagan, Kenneth C. Anderson, Christopher P. Steffes, Nikhil C. Munshi, Immaculata De Vivo, David G. Beer, Sergei Gryaznov, Donald W. Weaver, and Raj K. Goyal
Clin Cancer Res 2008 14: 4971-4980 doi: 10.1158/1078-0432.CCR-08-0473 [Abstract] [Full Text] [PDF]  

Cancer Prevention and Susceptibility:

Synergistic Inhibition of Lung Tumorigenesis by a Combination of Green Tea Polyphenols and Atorvastatin

Gang Lu, Hang Xiao, Hui You, Yong Lin, Huanyu Jin, Blake Snagaski, and Chung S. Yang
Clin Cancer Res 2008 14: 4981-4988 doi: 10.1158/1078-0432.CCR-07-1860 [Abstract] [Full Text] [PDF]  

CHEK2 1100delC Is a Susceptibility Allele for HNPCC-Related Colorectal Cancer

Marijke Wasielewski, Hans Vasen, Juul Wijnen, Maartje Hooning, Dennis Dooijes, Carli Tops, Jan G.M. Klijn, Hanne Meijers-Heijboer, and Mieke Schutte
Clin Cancer Res 2008 14: 4989-4994 doi: 10.1158/1078-0432.CCR-08-0389 [Abstract] [Full Text] [PDF]  

Corrections:

Correction: Article on Prognostic Implications of Stem Cell Marker Nestin and c-jun NH₂- Terminal Kinases

Clin Cancer Res 2008 14: 4995-4996 doi: 10.1158/1078-0432.CCR-14-15-COR [Full Text] [PDF]  

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