CCR Drug Updates:

Nilotinib

Michael W. Deininger
Clin Cancer Res 2008 14: 4027-4031 doi: 10.1158/1078-0432.CCR-07-5015 [Full Text] [PDF]  

Molecular Pathways:

DNA Damage Detection and Repair Pathways—Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy

Susan Ashwell and Sonya Zabludoff
Clin Cancer Res 2008 14: 4032-4037 doi: 10.1158/1078-0432.CCR-07-5138 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Genetic Changes of Wnt Pathway Genes Are Common Events in Metaplastic Carcinomas of the Breast

Michael J. Hayes, Dafydd Thomas, Agnieszka Emmons, Thomas J. Giordano, and Celina G. Kleer
Clin Cancer Res 2008 14: 4038-4044 doi: 10.1158/1078-0432.CCR-07-4379 [Abstract] [Full Text] [PDF]  

Overexpression of Jab1 in Hepatocellular Carcinoma and Its Inhibition by Peroxisome Proliferator-Activated Receptor Ligands In vitro and In vivo

Ming-Chuan Hsu, Chao-Cheng Huang, Hui-Chiu Chang, Tsung-Hui Hu, and Wen-Chun Hung
Clin Cancer Res 2008 14: 4045-4052 doi: 10.1158/1078-0432.CCR-07-5040 [Abstract] [Full Text] [PDF]  

Mutations in the Nijmegen Breakage Syndrome Gene in Medulloblastomas

Jian Huang, Michael A. Grotzer, Takuya Watanabe, Ekkehard Hewer, Torsten Pietsch, Stefan Rutkowski, and Hiroko Ohgaki
Clin Cancer Res 2008 14: 4053-4058 doi: 10.1158/1078-0432.CCR-08-0098 [Abstract] [Full Text] [PDF]  

Activation of Notch Signaling in a Xenograft Model of Brain Metastasis

Do-Hyun Nam, Hye-Min Jeon, Shiyeon Kim, Mi Hyun Kim, Young-Ju Lee, Min Su Lee, Hyunggee Kim, Kyeung Min Joo, Dong-Sup Lee, Janet E. Price, Sa Ik Bang, and Woong-Yang Park
Clin Cancer Res 2008 14: 4059-4066 doi: 10.1158/1078-0432.CCR-07-4039 [Abstract] [Full Text] [PDF]  

Gene Expression Profiles of Luteal Phase Fallopian Tube Epithelium from BRCA Mutation Carriers Resemble High-Grade Serous Carcinoma

Alicia A. Tone, Heather Begley, Monika Sharma, Joan Murphy, Barry Rosen, Theodore J. Brown, and Patricia A. Shaw
Clin Cancer Res 2008 14: 4067-4078 doi: 10.1158/1078-0432.CCR-07-4959 [Abstract] [Full Text] [PDF]  

Increased Prevalence of EGFR-Mutant Lung Cancer in Women and in East Asian Populations: Analysis of Estrogen-Related Polymorphisms

Daphne W. Bell, Brian W. Brannigan, Keitaro Matsuo, Dianne M. Finkelstein, Raffaella Sordella, Jeff Settleman, Tetsuya Mitsudomi, and Daniel A. Haber
Clin Cancer Res 2008 14: 4079-4084 doi: 10.1158/1078-0432.CCR-07-5030 [Abstract] [Full Text] [PDF]  

Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High-Grade Oral Squamous Cell Carcinoma

Shih-Hwa Chiou, Cheng-Chia Yu, Chi-Yang Huang, Shu-Chun Lin, Chung-Ji Liu, Tung-Hu Tsai, Shiu-Huey Chou, Chian-Shiu Chien, Hung-Hai Ku, and Jeng-Fan Lo
Clin Cancer Res 2008 14: 4085-4095 doi: 10.1158/1078-0432.CCR-07-4404 [Abstract] [Full Text] [PDF]  

Mitogen-Activated Protein Kinase Activation in Lung Adenocarcinoma: A Comparative Study between Ever Smokers and Never Smokers

Giannis Mountzios, David Planchard, Benjamin Besse, Pierre Validire, Philippe Girard, Christine Devisme, Meletios-Athanasios Dimopoulos, Jean-Charles Soria, and Pierre Fouret
Clin Cancer Res 2008 14: 4096-4102 doi: 10.1158/1078-0432.CCR-07-4150 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Molecular Subtypes of Breast Cancers Detected in Mammography Screening and Outside of Screening

Harri Sihto, Johan Lundin, Tiina Lehtimäki, Maarit Sarlomo-Rikala, Ralf Bützow, Kaija Holli, Liisa Sailas, Vesa Kataja, Mikael Lundin, Taina Turpeenniemi-Hujanen, Jorma Isola, Päivi Heikkilä, and Heikki Joensuu
Clin Cancer Res 2008 14: 4103-4110 doi: 10.1158/1078-0432.CCR-07-5003 [Abstract] [Full Text] [PDF]  

Osteopontin and Interleukin-8 Expression is Independently Associated with Prostate Cancer Recurrence

Daniel J. Caruso, Adrienne J.K. Carmack, Vinata B. Lokeshwar, Robert C. Duncan, Mark S. Soloway, and Bal L. Lokeshwar
Clin Cancer Res 2008 14: 4111-4118 doi: 10.1158/1078-0432.CCR-08-0738 [Abstract] [Full Text] [PDF]  

Clinical Significance of CXC Chemokine Receptor-4 and c-Met in Childhood Rhabdomyosarcoma

Francesca Diomedi-Camassei, Heather P. McDowell, Maria A. De Ioris, Stefania Uccini, Pierluigi Altavista, Giuseppe Raschellà, Roberta Vitali, Olga Mannarino, Luigi De Sio, Denis A. Cozzi, Alberto Donfrancesco, Alessandro Inserra, Francesco Callea, and Carlo Dominici
Clin Cancer Res 2008 14: 4119-4127 doi: 10.1158/1078-0432.CCR-07-4446 [Abstract] [Full Text] [PDF]  

Proapoptotic Bad and Bid Protein Expression Predict Survival in Stages II and III Colon Cancers

Frank A. Sinicrope, Rafaela L. Rego, Nathan R. Foster, Stephen N. Thibodeau, Steven R. Alberts, Harold E. Windschitl, and Daniel J. Sargent
Clin Cancer Res 2008 14: 4128-4133 doi: 10.1158/1078-0432.CCR-07-5160 [Abstract] [Full Text] [PDF]  

Multiple Mechanisms of Telomere Maintenance Exist and Differentially Affect Clinical Outcome in Diffuse Malignant Peritoneal Mesothelioma

Raffaella Villa, Maria Grazia Daidone, Rosita Motta, Lorenza Venturini, Cinzia De Marco, Alberto Vannelli, Shigeki Kusamura, Dario Baratti, Marcello Deraco, Aurora Costa, Roger R. Reddel, and Nadia Zaffaroni
Clin Cancer Res 2008 14: 4134-4140 doi: 10.1158/1078-0432.CCR-08-0099 [Abstract] [Full Text] [PDF]  

Persistent Aberrations in Circulating DNA Integrity after Radiotherapy Are Associated with Poor Prognosis in Nasopharyngeal Carcinoma Patients

K.C. Allen Chan, Sing-Fai Leung, Sze-Wan Yeung, Anthony T.C. Chan, and Y.M. Dennis Lo
Clin Cancer Res 2008 14: 4141-4145 doi: 10.1158/1078-0432.CCR-08-0182 [Abstract] [Full Text] [PDF]  

In vivo Optical Molecular Imaging of Vascular Endothelial Growth Factor for Monitoring Cancer Treatment

Sung K. Chang, Imran Rizvi, Nicolas Solban, and Tayyaba Hasan
Clin Cancer Res 2008 14: 4146-4153 doi: 10.1158/1078-0432.CCR-07-4536 [Abstract] [Full Text] [PDF]  

Molecular Risk Stratification of Medulloblastoma Patients Based on Immunohistochemical Analysis of MYC, LDHB, and CCNB1 Expression

Talitha de Haas, Nancy Hasselt, Dirk Troost, Huib Caron, Mara Popovic, Lorna Zadravec-Zaletel, Wieslawa Grajkowska, Marta Perek, Maria-Chiara Osterheld, David Ellison, Frank Baas, Rogier Versteeg, and Marcel Kool
Clin Cancer Res 2008 14: 4154-4160 doi: 10.1158/1078-0432.CCR-07-4159 [Abstract] [Full Text] [PDF]  

Decreased Expression of Gastrokine 1 and the Trefoil Factor Interacting Protein TFIZ1/GKN2 in Gastric Cancer: Influence of Tumor Histology and Relationship to Prognosis

Steven F. Moss, Jin-Woo Lee, Edmond Sabo, Anna K. Rubin, John Rommel, Bruce R. Westley, Felicity E.B. May, John Gao, Patricia A. Meitner, Rose Tavares, and Murray B. Resnick
Clin Cancer Res 2008 14: 4161-4167 doi: 10.1158/1078-0432.CCR-07-4381 [Abstract] [Full Text] [PDF]  

Prognostic Effect of Basal-Like Breast Cancers Is Time Dependent: Evidence from Tissue Microarray Studies on a Lymph Node–Negative Cohort

Anna Marie Mulligan, Dushanthi Pinnaduwage, Shelley B. Bull, Frances P. O'Malley, and Irene L. Andrulis
Clin Cancer Res 2008 14: 4168-4174 doi: 10.1158/1078-0432.CCR-07-4543 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Bortezomib-Induced Apoptosis with Limited Clinical Response Is Accompanied by Inhibition of Canonical but not Alternative Nuclear Factor-B Subunits in Head and Neck Cancer

Clint Allen, Kunal Saigal, Liesl Nottingham, Pattatheyil Arun, Zhong Chen, and Carter Van Waes
Clin Cancer Res 2008 14: 4175-4185 doi: 10.1158/1078-0432.CCR-07-4470 [Abstract] [Full Text] [PDF] Supplementary Data  

Effect of Food on the Pharmacokinetic Behavior of the Potent Oral Taxane BMS-275183

Linda E. Bröker, Manual Valdivieso, Mary Jo Pilat, Pamela DeLuca, Xiaofei Zhou, Susan Parker, Giuseppe Giaccone, and Patricia M. LoRusso
Clin Cancer Res 2008 14: 4186-4191 doi: 10.1158/1078-0432.CCR-07-4594 [Abstract] [Full Text] [PDF]  

Immunity Feedback and Clinical Outcome in Colon Cancer Patients Undergoing Chemoimmunotherapy with Gemcitabine + FOLFOX followed by Subcutaneous Granulocyte Macrophage Colony-Stimulating Factor and Aldesleukin (GOLFIG-1 Trial)

Pierpaolo Correale, Pierosandro Tagliaferri, Antonella Fioravanti, Maria Teresa Del Vecchio, Cinzia Remondo, Francesco Montagnani, Maria Saveria Rotundo, Chiara Ginanneschi, Ignazio Martellucci, Edoardo Francini, Maria Grazia Cusi, Pierfrancesco Tassone, and Guido Francini
Clin Cancer Res 2008 14: 4192-4199 doi: 10.1158/1078-0432.CCR-07-5278 [Abstract] [Full Text] [PDF]  

Randomized Crossover Pharmacokinetic Study of Solvent-Based Paclitaxel and nab-Paclitaxel

Erin R. Gardner, William L. Dahut, Charity D. Scripture, Jacquin Jones, Jeanny B. Aragon-Ching, Neil Desai, Michael J. Hawkins, Alex Sparreboom, and William D. Figg
Clin Cancer Res 2008 14: 4200-4205 doi: 10.1158/1078-0432.CCR-07-4592 [Abstract] [Full Text] [PDF]  

Efficacy and Safety of Two Doses of Pemetrexed Supplemented with Folic Acid and Vitamin B₁₂ in Previously Treated Patients with Non-Small Cell Lung Cancer

Yuichiro Ohe, Yukito Ichinose, Kazuhiko Nakagawa, Tomohide Tamura, Kaoru Kubota, Nobuyuki Yamamoto, Susumu Adachi, Yoshihiro Nambu, Toshio Fujimoto, Yutaka Nishiwaki, Nagahiro Saijo, and Masahiro Fukuoka
Clin Cancer Res 2008 14: 4206-4212 doi: 10.1158/1078-0432.CCR-07-5143 [Abstract] [Full Text] [PDF]  

A Pharmacodynamic Model for the Time Course of Tumor Shrinkage by Gemcitabine + Carboplatin in Non–Small Cell Lung Cancer Patients

Lai-San Tham, Lingzhi Wang, Ross A. Soo, Soo-Chin Lee, How-Sung Lee, Wei-Peng Yong, Boon-Cher Goh, and Nicholas H.G. Holford
Clin Cancer Res 2008 14: 4213-4218 doi: 10.1158/1078-0432.CCR-07-4754 [Abstract] [Full Text] [PDF]  

Early Magnesium Reduction in Advanced Colorectal Cancer Patients Treated with Cetuximab Plus Irinotecan as Predictive Factor of Efficacy and Outcome

Bruno Vincenzi, Daniele Santini, Sara Galluzzo, Antonio Russo, Fabio Fulfaro, Marianna Silletta, Fabrizio Battistoni, Laura Rocci, Bruno Beomonte Zobel, Vincenzo Adamo, Giordano Dicuonzo, and Giuseppe Tonini
Clin Cancer Res 2008 14: 4219-4224 doi: 10.1158/1078-0432.CCR-08-0077 [Abstract] [Full Text] [PDF]  

Patients with ERCC1-Negative Locally Advanced Esophageal Cancers May Benefit from Preoperative Chemoradiotherapy

Min Kyoung Kim, Kyung-Ja Cho, Gui Young Kwon, Seung-Il Park, Yong Hee Kim, Jong Hoon Kim, Ho-Young Song, Ji Hoon Shin, Hwoon Yong Jung, Gin Hyug Lee, Kee Don Choi, and Sung-Bae Kim
Clin Cancer Res 2008 14: 4225-4231 doi: 10.1158/1078-0432.CCR-07-4848 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Isopentenyl Pyrophosphate–Activated CD56⁺ T Lymphocytes Display Potent Antitumor Activity toward Human Squamous Cell Carcinoma

Alan A.Z. Alexander, Amudhan Maniar, Jean-Saville Cummings, Andrew M. Hebbeler, Dan H. Schulze, Brian R. Gastman, C. David Pauza, Scott E. Strome, and Andrei I. Chapoval
Clin Cancer Res 2008 14: 4232-4240 doi: 10.1158/1078-0432.CCR-07-4912 [Abstract] [Full Text] [PDF]  

The Use of Chelated Radionuclide (Samarium-153-Ethylenediaminetetramethylenephosphonate) to Modulate Phenotype of Tumor Cells and Enhance T Cell–Mediated Killing

Mala Chakraborty, Elizabeth K. Wansley, Jorge A. Carrasquillo, Sarah Yu, Chang H. Paik, Kevin Camphausen, Michael D. Becker, William F. Goeckeler, Jeffrey Schlom, and James W. Hodge
Clin Cancer Res 2008 14: 4241-4249 doi: 10.1158/1078-0432.CCR-08-0335 [Abstract] [Full Text] [PDF]  

Moscatilin Induces Apoptosis in Human Colorectal Cancer Cells: A Crucial Role of c-Jun NH₂-Terminal Protein Kinase Activation Caused by Tubulin Depolymerization and DNA Damage

Tzu-Hsuan Chen, Shiow-Lin Pan, Jih-Hwa Guh, Cho-Hwa Liao, Der-Yi Huang, Chien-Chih Chen, and Che-Ming Teng
Clin Cancer Res 2008 14: 4250-4258 doi: 10.1158/1078-0432.CCR-07-4578 [Abstract] [Full Text] [PDF]  

Attenuated Salmonella Targets Prodrug Activating Enzyme Carboxypeptidase G2 to Mouse Melanoma and Human Breast and Colon Carcinomas for Effective Suicide Gene Therapy

Frank Friedlos, Panos Lehouritis, Lesley Ogilvie, Douglas Hedley, Lawrence Davies, David Bermudes, Ivan King, Jan Martin, Richard Marais, and Caroline J. Springer
Clin Cancer Res 2008 14: 4259-4266 doi: 10.1158/1078-0432.CCR-07-4800 [Abstract] [Full Text] [PDF]  

Honokiol Suppresses Survival Signals Mediated by Ras-Dependent Phospholipase D Activity in Human Cancer Cells

Avalon Garcia, Yang Zheng, Chen Zhao, Alfredo Toschi, Judy Fan, Natalie Shraibman, H. Alex Brown, Dafna Bar-Sagi, David A. Foster, and Jack L. Arbiser
Clin Cancer Res 2008 14: 4267-4274 doi: 10.1158/1078-0432.CCR-08-0102 [Abstract] [Full Text] [PDF]  

EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer

Jussi P. Koivunen, Craig Mermel, Kreshnik Zejnullahu, Carly Murphy, Eugene Lifshits, Alison J. Holmes, Hwan Geun Choi, Jhingook Kim, Derek Chiang, Roman Thomas, Jinseon Lee, William G. Richards, David J. Sugarbaker, Christopher Ducko, Neal Lindeman, J. Paul Marcoux, Jeffrey A. Engelman, Nathanael S. Gray, Charles Lee, Matthew Meyerson, and Pasi A. Jänne
Clin Cancer Res 2008 14: 4275-4283 doi: 10.1158/1078-0432.CCR-08-0168 [Abstract] [Full Text] [PDF]  

Combined Inhibition of c-Src and Epidermal Growth Factor Receptor Abrogates Growth and Invasion of Head and Neck Squamous Cell Carcinoma

Priya Koppikar, Seung-Ho Choi, Ann Marie Egloff, Quan Cai, Shinsuke Suzuki, Maria Freilino, Hiroshi Nozawa, Sufi M. Thomas, William E. Gooding, Jill M. Siegfried, and Jennifer R. Grandis
Clin Cancer Res 2008 14: 4284-4291 doi: 10.1158/1078-0432.CCR-07-5226 [Abstract] [Full Text] [PDF]  

Efficacy of Superoxide Dismutase Mimetic M40403 in Attenuating Radiation-Induced Oral Mucositis in Hamsters

Christopher K. Murphy, Edward G. Fey, Brynmor A. Watkins, Vivien Wong, David Rothstein, and Stephen T. Sonis
Clin Cancer Res 2008 14: 4292-4297 doi: 10.1158/1078-0432.CCR-07-4669 [Abstract] [Full Text] [PDF]  

Dendritic Cell Vaccination with Xenogenic Polypeptide Hormone Induces Tumor Rejection in Neuroendocrine Cancer

Claudia Papewalis, Margret Wuttke, Jochen Seissler, Yvonne Meyer, Caroline Kessler, Benedikt Jacobs, Evelyn Ullrich, Holger S. Willenberg, Sven Schinner, Thomas Baehring, Werner A. Scherbaum, and Matthias Schott
Clin Cancer Res 2008 14: 4298-4305 doi: 10.1158/1078-0432.CCR-08-0587 [Abstract] [Full Text] [PDF]  

Human CD4⁺ T Lymphocytes Recognize a Vascular Endothelial Growth Factor Receptor-2–Derived Epitope in Association with HLA-DR

Yuansheng Sun, Mingxia Song, Elke Jäger, Christina Schwer, Stefan Stevanovic, Sven Flindt, Julia Karbach, Xuan D. Nguyen, Dirk Schadendorf, and Klaus Cichutek
Clin Cancer Res 2008 14: 4306-4315 doi: 10.1158/1078-0432.CCR-07-4849 [Abstract] [Full Text] [PDF]  

Vaccination with a Recombinant Saccharomyces cerevisiae Expressing a Tumor Antigen Breaks Immune Tolerance and Elicits Therapeutic Antitumor Responses

Elizabeth K. Wansley, Mala Chakraborty, Kenneth W. Hance, Michael B. Bernstein, Amanda L. Boehm, Zhimin Guo, Deborah Quick, Alex Franzusoff, John W. Greiner, Jeffrey Schlom, and James W. Hodge
Clin Cancer Res 2008 14: 4316-4325 doi: 10.1158/1078-0432.CCR-08-0393 [Abstract] [Full Text] [PDF]  

Synergistic Inhibition of ErbB Signaling by Combined Treatment with Seliciclib and ErbB-Targeting Agents

Ian N. Fleming, Morag Hogben, Sheelagh Frame, Steven J. McClue, and Simon R. Green
Clin Cancer Res 2008 14: 4326-4335 doi: 10.1158/1078-0432.CCR-07-4633 [Abstract] [Full Text] [PDF]  

Combined Inhibition of PLC-1 and c-Src Abrogates Epidermal Growth Factor Receptor–Mediated Head and Neck Squamous Cell Carcinoma Invasion

Hiroshi Nozawa, Gina Howell, Shinsuke Suzuki, Qing Zhang, Yanjun Qi, Judith Klein-Seetharaman, Alan Wells, Jennifer R. Grandis, and Sufi M. Thomas
Clin Cancer Res 2008 14: 4336-4344 doi: 10.1158/1078-0432.CCR-07-4857 [Abstract] [Full Text] [PDF]  

Cancer Prevention and Susceptibility:

Functional Variants of the NEIL1 and NEIL2 Genes and Risk and Progression of Squamous Cell Carcinoma of the Oral Cavity and Oropharynx

Xiaodong Zhai, Hui Zhao, Zhensheng Liu, Li-E Wang, Adel K. El-Naggar, Erich M. Sturgis, and Qingyi Wei
Clin Cancer Res 2008 14: 4345-4352 doi: 10.1158/1078-0432.CCR-07-5282 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Frontline Therapy for Chronic Lymphocytic Leukemia: The Dilemma Continues

Chadi Nabhan
Clin Cancer Res 2008 14: 4353 doi: 10.1158/1078-0432.CCR-08-0350 [Full Text] [PDF]  

Corrections:

Correction: Article on Cyclooxygenase-2 and Platelet-derived Growth Factors as Targets in Treating Aggressive Fibromatosis

Clin Cancer Res 2008 14: 4354 doi: 10.1158/1078-0432.CCR-14-13-COR1 [Full Text] [PDF]  

Correction: Article on CEACAM6 and Breast Cancer Recurrence

Clin Cancer Res 2008 14: 4355-4356 doi: 10.1158/1078-0432.CCR-14-13-COR2 [Full Text] [PDF]  

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