Editorials:

Drug Safety and Drug Efficacy: Two Sides of the Same Coin

Robert C. Young, Michael A. Friedman, Richard L. Schilsky, and Ellen V. Sigal
Clin Cancer Res 2007 13: 2533-2534 doi: 10.1158/1078-0432.CCR-07-0608 [Full Text] [PDF]  

Biomarkers in Gastrointestinal Stromal Tumor: Should We Equate Blood-Based Pharmacodynamics with Tumor Biology and Clinical Outcomes?

John C. McAuliffe and Jonathan C. Trent
Clin Cancer Res 2007 13: 2535-2536 doi: 10.1158/1078-0432.CCR-07-0364 [Full Text] [PDF]  

Molecular Pathways:

The Unfolded Protein Response and Integrated Stress Response to Anoxia

Tomasz Rzymski and Adrian L. Harris
Clin Cancer Res 2007 13: 2537-2540 doi: 10.1158/1078-0432.CCR-06-2126 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Epigenetic Modifications of RASSF1A Gene through Chromatin Remodeling in Prostate Cancer

Ken Kawamoto, Steven T. Okino, Robert F. Place, Shinji Urakami, Hiroshi Hirata, Nobuyuki Kikuno, Toshifumi Kawakami, Yuichiro Tanaka, Deepa Pookot, Zhong Chen, Shahana Majid, Hideki Enokida, Masayuki Nakagawa, and Rajvir Dahiya
Clin Cancer Res 2007 13: 2541-2548 doi: 10.1158/1078-0432.CCR-06-2225 [Abstract] [Full Text] [PDF]  

T-Cell Distribution and Adhesion Receptor Expression in Metastatic Melanoma

Carsten Weishaupt, Karla N. Munoz, Elizabeth Buzney, Thomas S. Kupper, and Robert C. Fuhlbrigge
Clin Cancer Res 2007 13: 2549-2556 doi: 10.1158/1078-0432.CCR-06-2450 [Abstract] [Full Text] [PDF] Supplementary Data, Weishaupt, et al.  

The Folate Receptor Is Frequently Overexpressed in Osteosarcoma Samples and Plays a Role in the Uptake of the Physiologic Substrate 5-Methyltetrahydrofolate

Rui Yang, E. Anders Kolb, Jing Qin, Alexander Chou, Rebecca Sowers, Bang Hoang, John H. Healey, Andrew G. Huvos, Paul A. Meyers, and Richard Gorlick
Clin Cancer Res 2007 13: 2557-2567 doi: 10.1158/1078-0432.CCR-06-1343 [Abstract] [Full Text] [PDF]  

Overexpression of Human Papillomavirus Type 16 Oncoproteins Enhances Hypoxia-Inducible Factor 1 Protein Accumulation and Vascular Endothelial Growth Factor Expression in Human Cervical Carcinoma Cells

Xudong Tang, Qunzhou Zhang, Junko Nishitani, Jimmy Brown, Shihong Shi, and Anh D. Le
Clin Cancer Res 2007 13: 2568-2576 doi: 10.1158/1078-0432.CCR-06-2704 [Abstract] [Full Text] [PDF]  

Expression of a Peroxisome Proliferator-Activated Receptor 1 Splice Variant that Was Identified in Human Lung Cancers Suppresses Cell Death Induced by Cisplatin and Oxidative Stress

Hyo Jung Kim, Jin-Yong Hwang, Hyun Jun Kim, Wan Sung Choi, Jae Heun Lee, Hye Jung Kim, Ki Churl Chang, Toru Nishinaka, Chihiro Yabe-Nishimura, and Han Geuk Seo
Clin Cancer Res 2007 13: 2577-2583 doi: 10.1158/1078-0432.CCR-06-2062 [Abstract] [Full Text] [PDF]  

Clinical Significance of CD99 Down-Regulation in Gastric Adenocarcinoma

Jung Hyun Lee, Seok-Hyung Kim, Li-Hui Wang, Yoon-La Choi, Young Chul Kim, Jin Hee Kim, Tae Sung Park, Yun-Chul Hong, and Young Kee Shin
Clin Cancer Res 2007 13: 2584-2591 doi: 10.1158/1078-0432.CCR-06-1785 [Abstract] [Full Text] [PDF] Supplementary Data, Lee, et al.  

Imaging, Diagnosis, Prognosis:

Relationship between Survival and Edema in Malignant Gliomas: Role of Vascular Endothelial Growth Factor and Neuronal Pentraxin 2

Marc R.J. Carlson, Whitney B. Pope, Steve Horvath, Jerome G. Braunstein, Phioanh Nghiemphu, Cho-Lea Tso, Ingo Mellinghoff, Albert Lai, Linda M. Liau, Paul S. Mischel, Jun Dong, Stanley F. Nelson, and Timothy F. Cloughesy
Clin Cancer Res 2007 13: 2592-2598 doi: 10.1158/1078-0432.CCR-06-2772 [Abstract] [Full Text] [PDF]  

A Cross-sectional Study of a Prototype Carcinogenic Human Papillomavirus E6/E7 Messenger RNA Assay for Detection of Cervical Precancer and Cancer

Philip E. Castle, Janel Dockter, Cristina Giachetti, Francisco A.R. Garcia, Mary Kay McCormick, Amy L. Mitchell, E. Blair Holladay, and Daniel P. Kolk
Clin Cancer Res 2007 13: 2599-2605 doi: 10.1158/1078-0432.CCR-06-2881 [Abstract] [Full Text] [PDF]  

Methylation of O⁶-Methylguanine DNA Methyltransferase and Loss of Heterozygosity on 19q and/or 17p Are Overlapping Features of Secondary Glioblastomas with Prolonged Survival

Marica Eoli, Francesca Menghi, Maria Grazia Bruzzone, Tiziana De Simone, Lorella Valletta, Bianca Pollo, Lorena Bissola, Antonio Silvani, Donatella Bianchessi, Ludovico D'Incerti, Graziella Filippini, Giovanni Broggi, Amerigo Boiardi, and Gaetano Finocchiaro
Clin Cancer Res 2007 13: 2606-2613 doi: 10.1158/1078-0432.CCR-06-2184 [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinase Polymorphisms Are Associated with Bladder Cancer Invasiveness

A. Karim Kader, Jun Liu, Lina Shao, Colin P. Dinney, Jie Lin, Yunfei Wang, Jian Gu, H. Barton Grossman, and Xifeng Wu
Clin Cancer Res 2007 13: 2614-2620 doi: 10.1158/1078-0432.CCR-06-1187 [Abstract] [Full Text] [PDF]  

Association between Functional EGF+61 Polymorphism and Glioma Risk

Bruno Marques Costa, Paulo Ferreira, Sandra Costa, Paulo Canedo, Pedro Oliveira, Ana Silva, Fernando Pardal, Gianpaolo Suriano, José Carlos Machado, José Manuel Lopes, and Rui Manuel Reis
Clin Cancer Res 2007 13: 2621-2626 doi: 10.1158/1078-0432.CCR-06-2606 [Abstract] [Full Text] [PDF]  

MDM2 Promoter SNP309 Is Associated with Risk of Occurrence and Advanced Lymph Node Metastasis of Nasopharyngeal Carcinoma in Chinese Population

Gangqiao Zhou, Yun Zhai, Ying Cui, Xiumei Zhang, Xiaojia Dong, Hao Yang, Ying He, Kaitai Yao, Hongxing Zhang, Lianteng Zhi, Xiaoyan Yuan, Wei Qiu, Xiaoai Zhang, Yan Shen, Boqing Qiang, and Fuchu He
Clin Cancer Res 2007 13: 2627-2633 doi: 10.1158/1078-0432.CCR-06-2281 [Abstract] [Full Text] [PDF]  

Collagen XXIII Expression Is Associated with Prostate Cancer Recurrence and Distant Metastases

Jacqueline Banyard, Lere Bao, Matthias D. Hofer, David Zurakowski, Kristin A. Spivey, Adam S. Feldman, Lloyd M. Hutchinson, Rainer Kuefer, Mark A. Rubin, and Bruce R. Zetter
Clin Cancer Res 2007 13: 2634-2642 doi: 10.1158/1078-0432.CCR-06-2163 [Abstract] [Full Text] [PDF] Supplementary Data, Banyard, et al.  

Cancer Therapy: Clinical:

Blood-Based Biomarkers of SU11248 Activity and Clinical Outcome in Patients with Metastatic Imatinib-Resistant Gastrointestinal Stromal Tumor

Anat Norden-Zfoni, Jayesh Desai, Judith Manola, Paul Beaudry, Jeremy Force, Robert Maki, Judah Folkman, Carlo Bello, Charles Baum, Sam E. DePrimo, David R. Shalinsky, Goerge D. Demetri, and John V. Heymach
Clin Cancer Res 2007 13: 2643-2650 doi: 10.1158/1078-0432.CCR-06-0919 [Abstract] [Full Text] [PDF]  

Prognostic Relevance of Clinical and Biological Risk Factors in Childhood Medulloblastoma: Results of Patients Treated in the Prospective Multicenter Trial HIT'91

Stefan Rutkowski, André von Bueren, Katja von Hoff, Wolfgang Hartmann, Tarek Shalaby, Frank Deinlein, Monika Warmuth-Metz, Niels Soerensen, Angela Emser, Udo Bode, Uwe Mittler, Christian Urban, Martin Benesch, Rolf D. Kortmann, Paul G. Schlegel, Joachim Kuehl, Torsten Pietsch, and Michael Grotzer
Clin Cancer Res 2007 13: 2651-2657 doi: 10.1158/1078-0432.CCR-06-1779 [Abstract] [Full Text] [PDF]  

Bcl-2 and Glutathione Depletion Sensitizes B16 Melanoma to Combination Therapy and Eliminates Metastatic Disease

Salvador Mena, María Benlloch, Angel Ortega, Julian Carretero, Elena Obrador, Miguel Asensi, Ignacio Petschen, Bob D. Brown, and José M. Estrela
Clin Cancer Res 2007 13: 2658-2666 doi: 10.1158/1078-0432.CCR-06-2642 [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetic Study of 7-Hydroxystaurosporine and Carboplatin in Advanced Solid Tumors

Martin J. Edelman, Kenneth S. Bauer, Jr., Suhlan Wu, Ruth Smith, Sonia Bisacia, and Janet Dancey
Clin Cancer Res 2007 13: 2667-2674 doi: 10.1158/1078-0432.CCR-06-1832 [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetic Study of Pemetrexed with High-Dose Folic Acid Supplementation or Multivitamin Supplementation in Patients with Locally Advanced or Metastatic Cancer

Chris H. Takimoto, Lisa A. Hammond-Thelin, Jane E. Latz, Leonardo Forero, Muralidhar Beeram, Bahram Forouzesh, Johann de Bono, Anthony W. Tolcher, Amita Patnaik, Pamela Monroe, Leslie Wood, Karen B. Schneck, Romnee Clark, and Eric K. Rowinsky
Clin Cancer Res 2007 13: 2675-2683 doi: 10.1158/1078-0432.CCR-06-2393 [Abstract] [Full Text] [PDF]  

Phase I Trial of Sorafenib in Combination with Gefitinib in Patients with Refractory or Recurrent Non–Small Cell Lung Cancer

Alex A. Adjei, Julian R. Molina, Sumithra J. Mandrekar, Randolph Marks, Joel R. Reid, Gary Croghan, Lorelei J. Hanson, James R. Jett, Chenghua Xia, Chetan Lathia, and Ronit Simantov
Clin Cancer Res 2007 13: 2684-2691 doi: 10.1158/1078-0432.CCR-06-2889 [Abstract] [Full Text] [PDF]  

A Phase 1 Study of Pralatrexate in Combination with Paclitaxel or Docetaxel in Patients with Advanced Solid Tumors

Christopher G. Azzoli, Lee M. Krug, Jorge Gomez, Vincent A. Miller, Mark G. Kris, Michelle S. Ginsberg, Roxanne Henry, Jessica Jones, Leslie Tyson, Megan Dunne, Barbara Pizzo, Amy Farmer, Ennapadam Venkatraman, Robert Steffen, and F.M. Sirotnak
Clin Cancer Res 2007 13: 2692-2698 doi: 10.1158/1078-0432.CCR-06-1754 [Abstract] [Full Text] [PDF]  

Insulin Treatment in Cancer Cachexia: Effects on Survival, Metabolism, and Physical Functioning

Kent Lundholm, Ulla Körner, Lena Gunnebo, Petra Sixt-Ammilon, Marita Fouladiun, Peter Daneryd, and Ingvar Bosaeus
Clin Cancer Res 2007 13: 2699-2706 doi: 10.1158/1078-0432.CCR-06-2720 [Abstract] [Full Text] [PDF]  

Phase I Evaluation of J591 as a Vascular Targeting Agent in Progressive Solid Tumors

Michael J. Morris, Neeta Pandit-Taskar, Chaitanya R. Divgi, Samantha Bender, Joseph A. O'Donoghue, Angelo Nacca, Peter Smith-Jones, Lawrence Schwartz, Susan Slovin, Ronald Finn, Steven Larson, and Howard I. Scher
Clin Cancer Res 2007 13: 2707-2713 doi: 10.1158/1078-0432.CCR-06-2935 [Abstract] [Full Text] [PDF]  

CD4⁺CD25⁺ Regulatory T-Cell Frequency in HER-2/neu (HER)-Positive and HER-Negative Advanced-Stage Breast Cancer Patients

Sonia A. Perez, Michael V. Karamouzis, Dimosthenes V. Skarlos, Alexandros Ardavanis, Nectaria N. Sotiriadou, Eleni G. Iliopoulou, Maria L. Salagianni, George Orphanos, Constantin N. Baxevanis, Gerasimos Rigatos, and Michael Papamichail
Clin Cancer Res 2007 13: 2714-2721 doi: 10.1158/1078-0432.CCR-06-2347 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Pulsed-High Intensity Focused Ultrasound and Low Temperature–Sensitive Liposomes for Enhanced Targeted Drug Delivery and Antitumor Effect

Sergio Dromi, Victor Frenkel, Alfred Luk, Bryan Traughber, Mary Angstadt, Monica Bur, Jason Poff, Jianwu Xie, Steven K. Libutti, King C.P. Li, and Bradford J. Wood
Clin Cancer Res 2007 13: 2722-2727 doi: 10.1158/1078-0432.CCR-06-2443 [Abstract] [Full Text] [PDF]  

ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

Cherrie K. Donawho, Yan Luo, Yanping Luo, Thomas D. Penning, Joy L. Bauch, Jennifer J. Bouska, Velitchka D. Bontcheva-Diaz, Bryan F. Cox, Theodore L. DeWeese, Larry E. Dillehay, Debra C. Ferguson, Nayereh S. Ghoreishi-Haack, David R. Grimm, Ran Guan, Edward K. Han, Rhonda R. Holley-Shanks, Boris Hristov, Kenneth B. Idler, Ken Jarvis, Eric F. Johnson, Lawrence R. Kleinberg, Vered Klinghofer, Loren M. Lasko, Xuesong Liu, Kennan C. Marsh, Thomas P. McGonigal, Jonathan A. Meulbroek, Amanda M. Olson, Joann P. Palma, Luis E. Rodriguez, Yan Shi, Jason A. Stavropoulos, Alan C. Tsurutani, Gui-Dong Zhu, Saul H. Rosenberg, Vincent L. Giranda, and David J. Frost
Clin Cancer Res 2007 13: 2728-2737 doi: 10.1158/1078-0432.CCR-06-3039 [Abstract] [Full Text] [PDF]  

SOM230, A New Somatostatin Analogue, Is Highly Effective in the Therapy of Growth Hormone/Prolactin-Secreting Pituitary Adenomas

Monica Fedele, Ivana De Martino, Rosario Pivonello, Andrea Ciarmiello, M. Laura Del Basso De Caro, Rosa Visone, Dario Palmieri, Giovanna M. Pierantoni, Claudio Arra, Herbert A. Schmid, Leo Hofland, Gaetano Lombardi, Annamaria Colao, and Alfredo Fusco
Clin Cancer Res 2007 13: 2738-2744 doi: 10.1158/1078-0432.CCR-06-2505 [Abstract] [Full Text] [PDF]  

Recombinant Human Hexamer-Dominant IgM Monoclonal Antibody to Ganglioside GM3 for Treatment of Melanoma

Yumiko Azuma, Yuji Ishikawa, Shigeto Kawai, Toshiaki Tsunenari, Hiroyuki Tsunoda, Tomoyuki Igawa, Shin-ichiro Iida, Masahiko Nanami, Masami Suzuki, Reiko F. Irie, Masayuki Tsuchiya, and Hisafumi Yamada-Okabe
Clin Cancer Res 2007 13: 2745-2750 doi: 10.1158/1078-0432.CCR-06-2919 [Abstract] [Full Text] [PDF]  

Inhibition of the Phosphatidylinositol 3-Kinase/Akt Pathway Improves Response of Long-term Estrogen-Deprived Breast Cancer Xenografts to Antiestrogens

Gauri Sabnis, Olga Goloubeva, Danijela Jelovac, Adam Schayowitz, and Angela Brodie
Clin Cancer Res 2007 13: 2751-2757 doi: 10.1158/1078-0432.CCR-06-2466 [Abstract] [Full Text] [PDF]  

Targeted and Untargeted CD137L Fusion Proteins for the Immunotherapy of Experimental Solid Tumors

Nan Zhang, Rebecca E. Sadun, Robyn S. Arias, Meg L. Flanagan, Suzanne M. Sachsman, Yu-Chih Nien, Leslie A. Khawli, Peisheng Hu, and Alan L. Epstein
Clin Cancer Res 2007 13: 2758-2767 Published Online First April 25, 2007. doi: 10.1158/1078-0432.CCR-06-2343 [Abstract] [Full Text] [PDF]  

A Physiologically Based Pharmacokinetic Model of Docetaxel Disposition: from Mouse to Man

Erica L. Bradshaw-Pierce, S. Gail Eckhardt, and Daniel L. Gustafson
Clin Cancer Res 2007 13: 2768-2776 doi: 10.1158/1078-0432.CCR-06-2362 [Abstract] [Full Text] [PDF]  

A Mosaic Fiber Adenovirus Serotype 5 Vector Containing Reovirus 1 and Adenovirus Serotype 3 Knob Fibers Increases Transduction in an Ovarian Cancer Ex vivo System via a Coxsackie and Adenovirus Receptor–Independent Pathway

Yuko Tsuruta, Larisa Pereboeva, Joel N. Glasgow, Daniel T. Rein, Yosuke Kawakami, Ronald D. Alvarez, Rodney P. Rocconi, Gene P. Siegal, Paul Dent, Paul B. Fisher, and David T. Curiel
Clin Cancer Res 2007 13: 2777-2783 doi: 10.1158/1078-0432.CCR-06-2706 [Abstract] [Full Text] [PDF]  

Akt/cAMP-Responsive Element Binding Protein/Cyclin D1 Network: A Novel Target for Prostate Cancer Inhibition in Transgenic Adenocarcinoma of Mouse Prostate Model Mediated by Nexrutine, a Phellodendron Amurense Bark Extract

Addanki P. Kumar, Shylesh Bhaskaran, Manonmani Ganapathy, Katherine Crosby, Michael D. Davis, Peter Kochunov, John Schoolfield, I-Tien Yeh, Dean A. Troyer, and Rita Ghosh
Clin Cancer Res 2007 13: 2784-2794 doi: 10.1158/1078-0432.CCR-06-2974 [Abstract] [Full Text] [PDF]  

Implication of the Insulin-like Growth Factor-IR Pathway in the Resistance of Non–small Cell Lung Cancer Cells to Treatment with Gefitinib

Floriana Morgillo, Woo-Young Kim, Edward S. Kim, Fortunato Ciardiello, Waun Ki Hong, and Ho-Young Lee
Clin Cancer Res 2007 13: 2795-2803 doi: 10.1158/1078-0432.CCR-06-2077 [Abstract] [Full Text] [PDF]  

Limited Tissue Penetration of Taxanes: A Mechanism for Resistance in Solid Tumors

Alastair H. Kyle, Lynsey A. Huxham, Devon M. Yeoman, and Andrew I. Minchinton
Clin Cancer Res 2007 13: 2804-2810 doi: 10.1158/1078-0432.CCR-06-1941 [Abstract] [Full Text] [PDF]  

c-Myc–Induced Chemosensitization Is Mediated by Suppression of Cyclin D1 Expression and Nuclear Factor-B Activity in Pancreatic Cancer Cells

Hector Biliran, Jr., Sanjeev Banerjee, Archana Thakur, Fazlul H. Sarkar, Aliccia Bollig, Fakhara Ahmed, Jiusheng Wu, Yuan Sun, and Joshua D. Liao
Clin Cancer Res 2007 13: 2811-2821 doi: 10.1158/1078-0432.CCR-06-1844 [Abstract] [Full Text] [PDF]  

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