Editorials:

Will Single-Time Tumor Profiling and a "Guilt by Association" Approach Allow Us to Outsmart HER2-Positive Breast Cancer?

Carlos L. Arteaga
Clin Cancer Res 2007 13: 1071-1073 doi: 10.1158/1078-0432.CCR-06-2717 [Full Text] [PDF]  

The Biology Behind:

New Practices in Computational Modeling

William R. Greco
Clin Cancer Res 2007 13: 1074 -1075 doi: 10.1158/1078-0432.CCR-06-2811 [Full Text] [PDF]  

Molecular Pathways:

Nuclear Factor-B in Development, Prevention, and Therapy of Cancer

Carter Van Waes
Clin Cancer Res 2007 13: 1076-1082 doi: 10.1158/1078-0432.CCR-06-2221 [Abstract] [Full Text] [PDF]  

Prospect of Targeting the CD40 Pathway for Cancer Therapy

Robert H. Vonderheide
Clin Cancer Res 2007 13: 1083-1088 doi: 10.1158/1078-0432.CCR-06-1893 [Abstract] [Full Text] [PDF]  

Reviews:

Important Therapeutic Targets in Chronic Myelogenous Leukemia

Hagop M. Kantarjian, Francis Giles, Alfonso Quintás-Cardama, and Jorge Cortes
Clin Cancer Res 2007 13: 1089-1097 doi: 10.1158/1078-0432.CCR-06-2147 [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor–Targeted Therapy in Renal Cell Carcinoma: Current Status and Future Directions

Brian I. Rini
Clin Cancer Res 2007 13: 1098-1106 doi: 10.1158/1078-0432.CCR-06-1989 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

A Susceptibility Gene Set for Early Onset Colorectal Cancer That Integrates Diverse Signaling Pathways: Implication for Tumorigenesis

Yi Hong, Kok Sun Ho, Kong Weng Eu, and Peh Yean Cheah
Clin Cancer Res 2007 13: 1107-1114 doi: 10.1158/1078-0432.CCR-06-1633 [Abstract] [Full Text] [PDF]  

Poor Outcome in Estrogen Receptor–Positive Breast Cancers Predicted by Loss of Plexin B1

Achim Rody, Uwe Holtrich, Regine Gaetje, Mathias Gehrmann, Knut Engels, Gunter von Minckwitz, Sibylle Loibl, Raihanatou Diallo-Danebrock, Eugen Ruckhäberle, Dirk Metzler, Andre Ahr, Christine Solbach, Thomas Karn, and Manfred Kaufmann
Clin Cancer Res 2007 13: 1115-1122 doi: 10.1158/1078-0432.CCR-06-2433 [Abstract] [Full Text] [PDF] Supplementary Data  

Analysis of Specific Transcriptional Regulators as Early Predictors of Independent Prognostic Relevance in Resected Colorectal Cancer

Gabriele D. Maurer, Joerg H. Leupold, Denis M. Schewe, Tobias Biller, Ronald E. Kates, Hans-Martin Hornung, Ulla Lau-Werner, Stefan Post, and Heike Allgayer
Clin Cancer Res 2007 13: 1123-1132 doi: 10.1158/1078-0432.CCR-06-1668 [Abstract] [Full Text] [PDF] Supplementary Data, Maurer, et al.  

Gene Expression Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma

Hu-Liang Jia, Qing-Hai Ye, Lun-Xiu Qin, Anuradha Budhu, Marshonna Forgues, Yidong Chen, Yin-Kun Liu, Hui-Chuan Sun, Lu Wang, Hong-Zhou Lu, Fang Shen, Zhao-You Tang, and Xin Wei Wang
Clin Cancer Res 2007 13: 1133-1139 doi: 10.1158/1078-0432.CCR-06-1025 [Abstract] [Full Text] [PDF] Supplementary Data, Jia, et al.  

Abrogation of MAPK and Akt Signaling by AEE788 Synergistically Potentiates Histone Deacetylase Inhibitor-Induced Apoptosis through Reactive Oxygen Species Generation

Chunrong Yu, Bret B. Friday, Jin-Ping Lai, Andrea McCollum, Peter Atadja, Lewis R. Roberts, and Alex A. Adjei
Clin Cancer Res 2007 13: 1140-1148 doi: 10.1158/1078-0432.CCR-06-1751 [Abstract] [Full Text] [PDF]  

Lack of Apoptotic Protease Activating Factor-1 Expression and Resistance to Hypoxia-Induced Apoptosis in Cervical Cancer

Cornelia Leo, Lars-Christian Horn, Cora Rauscher, Bettina Hentschel, Christine E. Richter, Alexander Schütz, Chandra Paul Leo, and Michael Höckel
Clin Cancer Res 2007 13: 1149-1153 doi: 10.1158/1078-0432.CCR-06-2371 [Abstract] [Full Text] [PDF]  

Toll-like Receptor-4 Is Up-Regulated in Hematopoietic Progenitor Cells and Contributes to Increased Apoptosis in Myelodysplastic Syndromes

Christos I. Maratheftis, Evangelos Andreakos, Haralampos M. Moutsopoulos, and Michael Voulgarelis
Clin Cancer Res 2007 13: 1154-1160 doi: 10.1158/1078-0432.CCR-06-2108 [Abstract] [Full Text] [PDF]  

Genetic Alterations and Their Relationship in the Phosphatidylinositol 3-Kinase/Akt Pathway in Thyroid Cancer

Peng Hou, Dingxie Liu, Yuan Shan, Shuiying Hu, Kimberley Studeman, Stephen Condouris, Yangang Wang, Ariel Trink, Adel K. El-Naggar, Giovanni Tallini, Vasily Vasko, and Mingzhao Xing
Clin Cancer Res 2007 13: 1161-1170 doi: 10.1158/1078-0432.CCR-06-1125 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Circulating Tumor Cells as Prognostic Factor for Distant Metastases and Survival in Patients with Primary Uveal Melanoma

Ronny Schuster, Nikolaos E. Bechrakis, Andrea Stroux, Antonia Busse, Alexander Schmittel, Carmen Scheibenbogen, Eckhard Thiel, Michael H. Foerster, and Ulrich Keilholz
Clin Cancer Res 2007 13: 1171-1178 doi: 10.1158/1078-0432.CCR-06-2329 [Abstract] [Full Text] [PDF]  

Tumor-Specific Methylation in Saliva: A Promising Biomarker for Early Detection of Head and Neck Cancer Recurrence

Christian Adrien Righini, Florence de Fraipont, Jean-François Timsit, Claire Faure, Elisabeth Brambilla, Emile Reyt, and Marie-Christine Favrot
Clin Cancer Res 2007 13: 1179-1185 doi: 10.1158/1078-0432.CCR-06-2027 [Abstract] [Full Text] [PDF] Supplementary Data  

Detection of Human Papillomavirus-16 in Fine-Needle Aspirates to Determine Tumor Origin in Patients with Metastatic Squamous Cell Carcinoma of the Head and Neck

Shahnaz Begum, Maura L. Gillison, Theresa L. Nicol, and William H. Westra
Clin Cancer Res 2007 13: 1186-1191 doi: 10.1158/1078-0432.CCR-06-1690 [Abstract] [Full Text] [PDF]  

Quantitative Detection of Micrometastases in Pelvic Lymph Nodes in Patients with Clinically Localized Prostate Cancer by Real-time Reverse Transcriptase-PCR

Hideaki Miyake, Isao Hara, Toshifumi Kurahashi, Taka-aki Inoue, Hiroshi Eto, and Masato Fujisawa
Clin Cancer Res 2007 13: 1192-1197 doi: 10.1158/1078-0432.CCR-05-2706 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Predictors of Resistance to Preoperative Trastuzumab and Vinorelbine for HER2-Positive Early Breast Cancer

Lyndsay N. Harris, Fanglei You, Stuart J. Schnitt, Agnes Witkiewicz, Xin Lu, Dennis Sgroi, Paula D. Ryan, Steven E. Come, Harold J. Burstein, Beth-Ann Lesnikoski, Madhavi Kamma, Paula N. Friedman, Rebecca Gelman, J. Dirk Iglehart, and Eric P. Winer
Clin Cancer Res 2007 13: 1198-1207 doi: 10.1158/1078-0432.CCR-06-1304 [Abstract] [Full Text] [PDF] Supplementary Data  

Phase I/II Study of Bortezomib Plus Docetaxel in Patients with Advanced Androgen-Independent Prostate Cancer

Robert Dreicer, Daniel Petrylak, David Agus, Iain Webb, and Bruce Roth
Clin Cancer Res 2007 13: 1208-1215 doi: 10.1158/1078-0432.CCR-06-2046 [Abstract] [Full Text] [PDF]  

A Phase I Pharmacokinetic and Pharmacodynamic Study of Intravenous Calcitriol in Combination with Oral Gefitinib in Patients with Advanced Solid Tumors

Marwan G. Fakih, Donald L. Trump, Josephia R. Muindi, Jennifer D. Black, Ronald J. Bernardi, Patrick J. Creaven, James Schwartz, Michael G. Brattain, Alan Hutson, Renee French, and Candace S. Johnson
Clin Cancer Res 2007 13: 1216-1223 doi: 10.1158/1078-0432.CCR-06-1165 [Abstract] [Full Text] [PDF]  

Initial Modulation of the Tumor Microenvironment Accounts for Thalidomide Activity in Prostate Cancer

Eleni Efstathiou, Patricia Troncoso, Sijin Wen, Kim-Anh Do, Curtis A. Pettaway, Louis L. Pisters, Timothy J. McDonnell, and Christopher J. Logothetis
Clin Cancer Res 2007 13: 1224-1231 doi: 10.1158/1078-0432.CCR-06-1938 [Abstract] [Full Text] [PDF]  

Phase I Trial of Intraperitoneal Gemcitabine in the Treatment of Advanced Malignancies Primarily Confined to the Peritoneal Cavity

Robert J. Morgan, Jr., Timothy W. Synold, Bixin Xi, Dean Lim, Stephen Shibata, Kim Margolin, Roderich E. Schwarz, Lucille Leong, George Somlo, Przemyslaw Twardowski, Yun Yen, Warren Chow, Merry Tetef, Paul Lin, Benjamin Paz, Mariana Koczywas, Lawrence Wagman, David Chu, Paul Frankel, Susan Stalter, and James H. Doroshow
Clin Cancer Res 2007 13: 1232-1237 doi: 10.1158/1078-0432.CCR-06-1735 [Abstract] [Full Text] [PDF]  

First Study of the Safety, Tolerability, and Pharmacokinetics of CP-724,714 in Patients with Advanced Malignant Solid HER2-Expressing Tumors

Pamela N. Munster, Carolyn D. Britten, Monica Mita, Karen Gelmon, Susan E. Minton, Stacy Moulder, Dennis J. Slamon, Feng Guo, Stephen P. Letrent, Louis Denis, and Anthony W. Tolcher
Clin Cancer Res 2007 13: 1238-1245 doi: 10.1158/1078-0432.CCR-06-1539 [Abstract] [Full Text] [PDF]  

Phase I Study of Inhaled Doxorubicin for Patients with Metastatic Tumors to the Lungs

Gregory A. Otterson, Miguel A. Villalona-Calero, Sunil Sharma, Mark G. Kris, Anthony Imondi, Mirjam Gerber, Dorothy A. White, Mark J. Ratain, Joan H. Schiller, Alan Sandler, Michael Kraut, Sridhar Mani, and John R. Murren
Clin Cancer Res 2007 13: 1246-1252 doi: 10.1158/1078-0432.CCR-06-1096 [Abstract] [Full Text] [PDF]  

Phase II Trial of Bevacizumab and Irinotecan in Recurrent Malignant Glioma

James J. Vredenburgh, Annick Desjardins, James E. Herndon, II, Jeannette M. Dowell, David A. Reardon, Jennifer A. Quinn, Jeremy N. Rich, Sith Sathornsumetee, Sridharan Gururangan, Melissa Wagner, Darell D. Bigner, Allan H. Friedman, and Henry S. Friedman
Clin Cancer Res 2007 13: 1253-1259 doi: 10.1158/1078-0432.CCR-06-2309 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Molecular Targeting and Treatment of an Epidermal Growth Factor Receptor–Positive Glioma Using Boronated Cetuximab

Gong Wu, Weilian Yang, Rolf F. Barth, Shinji Kawabata, Michele Swindall, Achintya K. Bandyopadhyaya, Werner Tjarks, Behrooz Khorsandi, Thomas E. Blue, Amy K. Ferketich, Ming Yang, Gregory A. Christoforidis, Thomas J. Sferra, Peter J. Binns, Kent J. Riley, Michael J. Ciesielski, and Robert A. Fenstermaker
Clin Cancer Res 2007 13: 1260-1268 doi: 10.1158/1078-0432.CCR-06-2399 [Abstract] [Full Text] [PDF]  

Metabolism and Anticancer Activity of the Curcumin Analogue, Dimethoxycurcumin

Constantin Tamvakopoulos, Konstantinos Dimas, Zacharias D. Sofianos, Sophia Hatziantoniou, Zhiyong Han, Zhong-Li Liu, James H. Wyche, and Panayotis Pantazis
Clin Cancer Res 2007 13: 1269-1277 doi: 10.1158/1078-0432.CCR-06-1839 [Abstract] [Full Text] [PDF]  

Computational Modeling to Predict Effect of Treatment Schedule on Drug Delivery to Prostate in Humans

Leijun Hu, Jessie L-S. Au, and M. Guillaume Wientjes
Clin Cancer Res 2007 13: 1278-1287 doi: 10.1158/1078-0432.CCR-06-1610 [Abstract] [Full Text] [PDF]  

CABYR Is a Novel Cancer-Testis Antigen in Lung Cancer

Chonglin Luo, Xueyuan Xiao, Danhui Liu, Shaosong Chen, Mingying Li, Anjian Xu, Jifu Liu, Shugeng Gao, Shanshan Wu, and Dacheng He
Clin Cancer Res 2007 13: 1288-1297 doi: 10.1158/1078-0432.CCR-06-1742 [Abstract] [Full Text] [PDF]  

Chimmitecan, a Novel 9-Substituted Camptothecin, with Improved Anticancer Pharmacologic Profiles In vitro and In vivo

Min Huang, Heyong Gao, Yi Chen, Hong Zhu, Yujun Cai, Xiongwen Zhang, Zehong Miao, Hualiang Jiang, Jian Zhang, Hongwu Shen, Liping Lin, Wei Lu, and Jian Ding
Clin Cancer Res 2007 13: 1298-1307 Published Online First February 7, 2007. doi: 10.1158/1078-0432.CCR-06-1277 [Abstract] [Full Text] [PDF]  

Docetaxel-Induced Apoptosis of Human Melanoma Is Mediated by Activation of c-Jun NH₂-Terminal Kinase and Inhibited by the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 1/2 Pathway

Nizar M. Mhaidat, Xu Dong Zhang, Chen Chen Jiang, and Peter Hersey
Clin Cancer Res 2007 13: 1308-1314 doi: 10.1158/1078-0432.CCR-06-2216 [Abstract] [Full Text] [PDF]  

DNA Mismatch Repair Initiates 6-Thioguanine–Induced Autophagy through p53 Activation in Human Tumor Cells

Xuehuo Zeng, Tao Yan, Jane E. Schupp, Yuji Seo, and Timothy J. Kinsella
Clin Cancer Res 2007 13: 1315-1321 doi: 10.1158/1078-0432.CCR-06-1517 [Abstract] [Full Text] [PDF]  

Preclinical In vivo Study of New Insulin-Like Growth Factor-I Receptor–Specific Inhibitor in Ewing's Sarcoma

Maria C. Manara, Lorena Landuzzi, Patrizia Nanni, Giordano Nicoletti, Diana Zambelli, Pier Luigi Lollini, Cristina Nanni, Francesco Hofmann, Carlos García-Echeverría, Piero Picci, and Katia Scotlandi
Clin Cancer Res 2007 13: 1322-1330 doi: 10.1158/1078-0432.CCR-06-1518 [Abstract] [Full Text] [PDF]  

The Suppression of Aurora-A/STK15/BTAK Expression Enhances Chemosensitivity to Docetaxel in Human Esophageal Squamous Cell Carcinoma

Eiji Tanaka, Yosuke Hashimoto, Tetsuo Ito, Kan Kondo, Motoshige Higashiyama, Shigeru Tsunoda, Cristian Ortiz, Yoshiharu Sakai, Johji Inazawa, and Yutaka Shimada
Clin Cancer Res 2007 13: 1331-1340 doi: 10.1158/1078-0432.CCR-06-1192 [Abstract] [Full Text] [PDF] Supplementary Data  

Suppression of BRAF/MEK/MAP Kinase Pathway Restores Expression of Iodide-Metabolizing Genes in Thyroid Cells Expressing the V600E BRAF Mutant

Dingxie Liu, Shuiying Hu, Peng Hou, David Jiang, Stephen Condouris, and Mingzhao Xing
Clin Cancer Res 2007 13: 1341-1349 doi: 10.1158/1078-0432.CCR-06-1753 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Validity of Messenger RNA Expression Analyses of Human Saliva

Jack Ballantyne
Clin Cancer Res 2007 13: 1350 doi: 10.1158/1078-0432.CCR-06-2796 [Full Text] [PDF]  

Salivary Transcriptome

David T. Wong
Clin Cancer Res 2007 13: 1350 doi: 10.1158/1078-0432.CCR-06-2227 [Full Text] [PDF]  

Simon D. Spivack
Clin Cancer Res 2007 13: 1351 doi: 10.1158/1078-0432.CCR-06-2888 [Full Text] [PDF]  

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