Editorials:

Testing the Wrong Hypothesis in Phase II Oncology Trials: There Is a Better Alternative

Mark J. Ratain and Theodore G. Karrison
Clin Cancer Res 2007 13: 781-782 doi: 10.1158/1078-0432.CCR-06-2533 [Full Text] [PDF]  

Phase 0 Trials: Are They Ethically Challenged?

T. Patrick Hill
Clin Cancer Res 2007 13: 783-784 doi: 10.1158/1078-0432.CCR-06-2365 [Full Text] [PDF]  

The Biology Behind:

Anti–CTL-Associated Antigen 4: Are Regulatory T Cells a Target?

Emmanuel M. Gabriel and Edmund C. Lattime
Clin Cancer Res 2007 13: 785 -788 doi: 10.1158/1078-0432.CCR-06-2820 [Full Text] [PDF]  

Molecular Pathways:

Reactive Oxygen Species: A Breath of Life or Death?

John P. Fruehauf and Frank L. Meyskens, Jr.
Clin Cancer Res 2007 13: 789-794 doi: 10.1158/1078-0432.CCR-06-2082 [Abstract] [Full Text] [PDF]  

Nitric Oxide and Its Gatekeeper Thrombospondin-1 in Tumor Angiogenesis

David D. Roberts, Jeffery S. Isenberg, Lisa A. Ridnour, and David A. Wink
Clin Cancer Res 2007 13: 795-798 doi: 10.1158/1078-0432.CCR-06-1758 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Proteomic Signature Corresponding to the Response to Gefitinib (Iressa, ZD1839), an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Lung Adenocarcinoma

Tetsuya Okano, Tadashi Kondo, Kiyonaga Fujii, Toshihide Nishimura, Toshimi Takano, Yuichiro Ohe, Koji Tsuta, Yoshihiro Matsuno, Akihiko Gemma, Harbumi Kato, Shoji Kudoh, and Setsuo Hirohashi
Clin Cancer Res 2007 13: 799-805 doi: 10.1158/1078-0432.CCR-06-1654 [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Expression Signatures for Tumor Progression, Tumor Subtype, and Tumor Thickness in Laser-Microdissected Melanoma Tissues

Jochen Jaeger, Dirk Koczan, Hans-Juergen Thiesen, Saleh M. Ibrahim, Gerd Gross, Rainer Spang, and Manfred Kunz
Clin Cancer Res 2007 13: 806-815 doi: 10.1158/1078-0432.CCR-06-1820 [Abstract] [Full Text] [PDF] Supplementary Data  

Myeloma Cell-Osteoclast Interaction Enhances Angiogenesis Together with Bone Resorption: A Role for Vascular Endothelial Cell Growth Factor and Osteopontin

Yoichi Tanaka, Masahiro Abe, Masahiro Hiasa, Asuka Oda, Hiroe Amou, Ayako Nakano, Kyoko Takeuchi, Kenichi Kitazoe, Shinsuke Kido, Daisuke Inoue, Keiji Moriyama, Toshihiro Hashimoto, Shuji Ozaki, and Toshio Matsumoto
Clin Cancer Res 2007 13: 816-823 doi: 10.1158/1078-0432.CCR-06-2258 [Abstract] [Full Text] [PDF]  

Expression of Voltage-Gated Potassium Channels in Human and Mouse Colonic Carcinoma

Jiraporn Ousingsawat, Melanie Spitzner, Supaporn Puntheeranurak, Luigi Terracciano, Luigi Tornillo, Lukas Bubendorf, Karl Kunzelmann, and Rainer Schreiber
Clin Cancer Res 2007 13: 824-831 doi: 10.1158/1078-0432.CCR-06-1940 [Abstract] [Full Text] [PDF]  

Epigenetic Inactivation of the Chromosomal Stability Control Genes BRCA1, BRCA2, and XRCC5 in Non–Small Cell Lung Cancer

Ming-Ni Lee, Ruo-Chia Tseng, Han-Shui Hsu, Jia-Yang Chen, Ching Tzao, William L. Ho, and Yi-Ching Wang
Clin Cancer Res 2007 13: 832-838 doi: 10.1158/1078-0432.CCR-05-2694 [Abstract] [Full Text] [PDF]  

Germline Mutations in the BRCA2 Gene and Susceptibility to Hereditary Prostate Cancer

Ilir Agalliu, Erika M. Kwon, Daniel Zadory, Laura McIntosh, Joseph Thompson, Janet L. Stanford, and Elaine A. Ostrander
Clin Cancer Res 2007 13: 839-843 doi: 10.1158/1078-0432.CCR-06-2164 [Abstract] [Full Text] [PDF]  

Somatic TP53 Mutations Are Relatively Rare among Adrenocortical Cancers with the Frequent 17p13 Loss of Heterozygosity

Rossella Libè, Lionel Groussin, Frédérique Tissier, Caroline Elie, Fernande René-Corail, Amato Fratticci, Eric Jullian, Paolo Beck-Peccoz, Xavier Bertagna, Christine Gicquel, and Jérôme Bertherat
Clin Cancer Res 2007 13: 844-850 doi: 10.1158/1078-0432.CCR-06-2085 [Abstract] [Full Text] [PDF]  

Radiation-Induced Hepatitis B Virus Reactivation in Liver Mediated by the Bystander Effect from Irradiated Endothelial Cells

Chia Hung Chou, Pei-Jer Chen, Po-Huang Lee, Ann-Lii Cheng, Hui-Chen Hsu, and Jason Chia-Hsien Cheng
Clin Cancer Res 2007 13: 851-857 doi: 10.1158/1078-0432.CCR-06-2459 [Abstract] [Full Text] [PDF]  

NF-Y–Dependent Cyclin B2 Expression in Colorectal Adenocarcinoma

Seon-Hwa Park, Gyung-Ran Yu, Woo-Ho Kim, Woo-Sung Moon, Jong-Hun Kim, and Dae-Ghon Kim
Clin Cancer Res 2007 13: 858-867 doi: 10.1158/1078-0432.CCR-06-1461 [Abstract] [Full Text] [PDF]  

Implications of Endocrine Gland–Derived Vascular Endothelial Growth Factor/Prokineticin-1 Signaling in Human Neuroblastoma Progression

Elly S.W. Ngan, Francesco Y.L. Sit, King Liu Lee, Xiaoping Miao, Zhengwei Yuan, Weilin Wang, John M. Nicholls, Kenneth K.Y. Wong, Mercè Garcia-Barcelo, Vincent C.H. Lui, and Paul K.H. Tam
Clin Cancer Res 2007 13: 868-875 doi: 10.1158/1078-0432.CCR-06-2176 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

1-Antitrypsin Precursor in Gastric Juice Is a Novel Biomarker for Gastric Cancer and Ulcer

Ping-I Hsu, Chung-Hsuan Chen, Chieu-Shia Hsieh, Wei-Chao Chang, Kwok-Hung Lai, Gin-Ho Lo, Ping-Ning Hsu, Feng-Woei Tsay, Yu-Shan Chen, Michael Hsiao, Hui-Chun Chen, and Pei-Jung Lu
Clin Cancer Res 2007 13: 876-883 doi: 10.1158/1078-0432.CCR-06-1404 [Abstract] [Full Text] [PDF]  

WWOX Expression in Different Histologic Types and Subtypes of Non–Small Cell Lung Cancer

Valentina Donati, Gabriella Fontanini, Matteo Dell'Omodarme, Maria Cristina Prati, Simona Nuti, Marco Lucchi, Alfredo Mussi, Muller Fabbri, Fulvio Basolo, Carlo Maria Croce, and Rami Ishaq Aqeilan
Clin Cancer Res 2007 13: 884-891 doi: 10.1158/1078-0432.CCR-06-2016 [Abstract] [Full Text] [PDF]  

Increased Expression of SIM2-s Protein Is a Novel Marker of Aggressive Prostate Cancer

Ole Johan Halvorsen, Kari Rostad, Anne Margrete Øyan, Hanne Puntervoll, Trond Hellem Bø, Laila Stordrange, Sue Olsen, Svein Andreas Haukaas, Leroy Hood, Inge Jonassen, Karl-Henning Kalland, and Lars Andreas Akslen
Clin Cancer Res 2007 13: 892-897 doi: 10.1158/1078-0432.CCR-06-1207 [Abstract] [Full Text] [PDF] Supplementary Data  

Vascular Endothelial Growth Factor Gene Polymorphisms Are Associated with Prognosis in Ovarian Cancer

Lukas A. Hefler, Alexander Mustea, Dominique Könsgen, Nicole Concin, Berno Tanner, Reiner Strick, Georg Heinze, Christoph Grimm, Eva Schuster, Clemens Tempfer, Alexander Reinthaller, and Robert Zeillinger
Clin Cancer Res 2007 13: 898-901 doi: 10.1158/1078-0432.CCR-06-1008 [Abstract] [Full Text] [PDF]  

FOXP3⁺ Regulatory T Cells Affect the Development and Progression of Hepatocarcinogenesis

Noritoshi Kobayashi, Nobuyoshi Hiraoka, Wataru Yamagami, Hidenori Ojima, Yae Kanai, Tomoo Kosuge, Atsushi Nakajima, and Setsuo Hirohashi
Clin Cancer Res 2007 13: 902-911 doi: 10.1158/1078-0432.CCR-06-2363 [Abstract] [Full Text] [PDF]  

Decreased Expression of Gene Cluster at Chromosome 1q21 Defines Molecular Subgroups of Chemoradiotherapy Response in Esophageal Cancers

Madan G. Luthra, Jaffer A. Ajani, Julie Izzo, Joe Ensor, Tsung-Teh Wu, Asif Rashid, Li Zhang, Alexandria Phan, Norio Fukami, and Rajyalakshmi Luthra
Clin Cancer Res 2007 13: 912-919 doi: 10.1158/1078-0432.CCR-06-1577 [Abstract] [Full Text] [PDF]  

Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Metastatic Breast Cancer: A Validation Study of the CellSearch System

Sabine Riethdorf, Herbert Fritsche, Volkmar Müller, Thomas Rau, Christian Schindlbeck, Brigitte Rack, Wolfgang Janni, Cornelia Coith, Katrin Beck, Fritz Jänicke, Summer Jackson, Terrie Gornet, Massimo Cristofanilli, and Klaus Pantel
Clin Cancer Res 2007 13: 920-928 doi: 10.1158/1078-0432.CCR-06-1695 [Abstract] [Full Text] [PDF]  

The ABCA5 Protein: A Urine Diagnostic Marker for Prostatic Intraepithelial Neoplasia

Youji Hu, Min Wang, Karen Veverka, Fernando U. Garcia, and Mark E. Stearns
Clin Cancer Res 2007 13: 929-938 doi: 10.1158/1078-0432.CCR-06-1718 [Abstract] [Full Text] [PDF]  

The Time-Resolved Fluorescence-Based PCA3 Test on Urinary Sediments after Digital Rectal Examination; a Dutch Multicenter Validation of the Diagnostic Performance

Martijn P.M.Q. van Gils, Daphne Hessels, Onno van Hooij, Sander A. Jannink, W. Pim Peelen, Suzanne L.J. Hanssen, J. Alfred Witjes, Erik B. Cornel, Herbert F.M. Karthaus, Geert A.H.J. Smits, Gerhard A. Dijkman, Peter F.A. Mulders, and Jack A. Schalken
Clin Cancer Res 2007 13: 939-943 doi: 10.1158/1078-0432.CCR-06-2679 [Abstract] [Full Text] [PDF]  

CpG Island Methylator Phenotype Association with Elevated Serum -Fetoprotein Level in Hepatocellular Carcinoma

Changsong Zhang, Zhengyou Li, Yue Cheng, Fengqi Jia, Rong Li, Mengchao Wu, Ke Li, and Lixin Wei
Clin Cancer Res 2007 13: 944-952 doi: 10.1158/1078-0432.CCR-06-2268 [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor Protein Expression and Gene Amplification in Small Cell Carcinoma of the Urinary Bladder

Xiaoyan Wang, Shaobo Zhang, Gregory T. MacLennan, John N. Eble, Antonio Lopez-Beltran, Ximing J. Yang, Chong-Xian Pan, Honghong Zhou, Rodolfo Montironi, and Liang Cheng
Clin Cancer Res 2007 13: 953-957 doi: 10.1158/1078-0432.CCR-06-2167 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

A Pilot Study of CTLA-4 Blockade after Cancer Vaccine Failure in Patients with Advanced Malignancy

Deirdre O'Mahony, John C. Morris, Cate Quinn, Wendy Gao, Wyndham H. Wilson, Barry Gause, Stefania Pittaluga, Sattva Neelapu, Margaret Brown, Thomas A. Fleisher, James L. Gulley, Jeffrey Schlom, Robert Nussenblatt, Paul Albert, Thomas A. Davis, Israel Lowy, Mike Petrus, Thomas A. Waldmann, and John E. Janik
Clin Cancer Res 2007 13: 958-964 doi: 10.1158/1078-0432.CCR-06-1974 [Abstract] [Full Text] [PDF]  

Celecoxib and Mucosal Protection: Translation from an Animal Model to a Phase I Clinical Trial of Celecoxib, Irinotecan, and 5-Fluorouracil

Milind M. Javle, Shousong Cao, Farukh A. Durrani, Lakshmi Pendyala, David D. Lawrence, Patrick F. Smith, Patrick J. Creaven, Diane C. Noel, Renuka V. Iyer, and Youcef M. Rustum
Clin Cancer Res 2007 13: 965-971 doi: 10.1158/1078-0432.CCR-06-0551 [Abstract] [Full Text] [PDF]  

Setting the Bar in Phase II Trials: The Use of Historical Data for Determining "Go/No Go" Decision for Definitive Phase III Testing

Andrew J. Vickers, Vennus Ballen, and Howard I. Scher
Clin Cancer Res 2007 13: 972-976 Published Online First February 2, 2007. doi: 10.1158/1078-0432.CCR-06-0909 [Abstract] [Full Text] [PDF]  

An Optimized Clinical Regimen for the Oncolytic Virus PV701

Sébastien J. Hotte, Robert M. Lorence, Hal W. Hirte, Susan R. Polawski, Michael K. Bamat, James D. O'Neil, M. Scot Roberts, William S. Groene, and Pierre P. Major
Clin Cancer Res 2007 13: 977-985 doi: 10.1158/1078-0432.CCR-06-1817 [Abstract] [Full Text] [PDF]  

A Phase 1 Escalating Single-Dose and Weekly Fixed-Dose Study of Cetuximab: Pharmacokinetic and Pharmacodynamic Rationale for Dosing

Paula M. Fracasso, Howard Burris, III, Matthew A. Arquette, Ramaswamy Govindan, Feng Gao, Lisa P. Wright, Sherry A. Goodner, F. Anthony Greco, Suzanne F. Jones, Noel Willcut, Catherine Chodkiewicz, Amit Pathak, Gregory M. Springett, George R. Simon, Daniel M. Sullivan, Raphaël Marcelpoil, Shelley D. Mayfield, David Mauro, and Christopher R. Garrett
Clin Cancer Res 2007 13: 986-993 doi: 10.1158/1078-0432.CCR-06-1542 [Abstract] [Full Text] [PDF]  

Class III ß-Tubulin Expression and Benefit from Adjuvant Cisplatin/Vinorelbine Chemotherapy in Operable Non–Small Cell Lung Cancer: Analysis of NCIC JBR.10

Pascal Sève, Raymond Lai, Keyue Ding, Timothy Winton, Charles Butts, John Mackey, Charles Dumontet, Laith Dabbagh, Sarit Aviel-Ronen, Lesley Seymour, Marlo Whitehead, Ming-Sound Tsao, Frances A. Shepherd, and Tony Reiman
Clin Cancer Res 2007 13: 994-999 doi: 10.1158/1078-0432.CCR-06-1503 [Abstract] [Full Text] [PDF]  

Clinical Pharmacodynamic Effects of the Growth Hormone Receptor Antagonist Pegvisomant: Implications for Cancer Therapy

Donghua Yin, Franzanne Vreeland, Larry J. Schaaf, Robert Millham, Barbara A. Duncan, and Amarnath Sharma
Clin Cancer Res 2007 13: 1000-1009 doi: 10.1158/1078-0432.CCR-06-1910 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Cell Type–Specific, Topoisomerase II–Dependent Inhibition of Hypoxia-Inducible Factor-1 Protein Accumulation by NSC 644221

Mark Creighton-Gutteridge, John H. Cardellina, II, Andrew G. Stephen, Annamaria Rapisarda, Badarch Uranchimeg, Karen Hite, William A. Denny, Robert H. Shoemaker, and Giovanni Melillo
Clin Cancer Res 2007 13: 1010-1018 doi: 10.1158/1078-0432.CCR-06-2301 [Abstract] [Full Text] [PDF] Supplementary Data  

Protein Kinase CK2 as an Unfavorable Prognostic Marker and Novel Therapeutic Target in Acute Myeloid Leukemia

Jin Seok Kim, Ju In Eom, June-Won Cheong, Ae Jin Choi, Jin Koo Lee, Woo Ick Yang, and Yoo Hong Min
Clin Cancer Res 2007 13: 1019-1028 doi: 10.1158/1078-0432.CCR-06-1602 [Abstract] [Full Text] [PDF]  

Cyclophosphamide-Using Nonmyeloablative Allogeneic Cell Therapy against Renal Cancer with a Reduced Risk of Graft-versus-Host Disease

Masatoshi Eto, Masahiko Harano, Katsunori Tatsugami, Mamoru Harada, Yoriyuki Kamiryo, Keijiro Kiyoshima, Masumitsu Hamaguchi, Masazumi Tsuneyoshi, Yasunobu Yoshikai, and Seiji Naito
Clin Cancer Res 2007 13: 1029-1035 doi: 10.1158/1078-0432.CCR-06-1578 [Abstract] [Full Text] [PDF]  

Celecoxib Prevents Neuroblastoma Tumor Development and Potentiates the Effect of Chemotherapeutic Drugs In vitro and In vivo

Frida Ponthan, Malin Wickström, Helena Gleissman, Ole M. Fuskevåg, Lova Segerström, Baldur Sveinbjörnsson, Christopher P.F. Redfern, Staffan Eksborg, Per Kogner, and John I. Johnsen
Clin Cancer Res 2007 13: 1036-1044 doi: 10.1158/1078-0432.CCR-06-1908 [Abstract] [Full Text] [PDF]  

Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor: Effects on Gene Expression and Growth of Glioma Cells In vitro and In vivo

Dong Yin, John M. Ong, Jinwei Hu, Julian C. Desmond, Norihiko Kawamata, Bindu M. Konda, Keith L. Black, and H. Phillip Koeffler
Clin Cancer Res 2007 13: 1045-1052 doi: 10.1158/1078-0432.CCR-06-1261 [Abstract] [Full Text] [PDF]  

CD8⁺ T cells Reactive to Survivin Antigen in Patients with Multiple Myeloma

Matthias Grube, Stephanie Moritz, Ellen C. Obermann, Katayoun Rezvani, Andreas Mackensen, Reinhard Andreesen, and Ernst Holler
Clin Cancer Res 2007 13: 1053-1060 doi: 10.1158/1078-0432.CCR-06-1722 [Abstract] [Full Text] [PDF] Supplementary Data  

Flaxseed and Its Lignans Inhibit Estradiol-Induced Growth, Angiogenesis, and Secretion of Vascular Endothelial Growth Factor in Human Breast Cancer Xenografts In vivo

Malin Bergman Jungeström, Lilian U. Thompson, and Charlotta Dabrosin
Clin Cancer Res 2007 13: 1061-1067 doi: 10.1158/1078-0432.CCR-06-1651 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

HDAC Inhibitors and Cardiac Safety

Rhoda Molife, Peter Fong, Michelle Scurr, Ian Judson, Stan Kaye, and Johann de Bono
Clin Cancer Res 2007 13: 1068 doi: 10.1158/1078-0432.CCR-06-1715 [Full Text] [PDF]  

HDAC Inhibitors and Cardiac Safety

Manisha H. Shah, Miguel A. Villalona-Calero, Guido Marcucci, John C. Byrd, and Michael R. Grever
Clin Cancer Res 2007 13: 1068 doi: 10.1158/1078-0432.CCR-06-2380 [Full Text] [PDF]  

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