Molecular Pathways:

Transforming Growth Factor-ß and the Immune Response to Malignant Disease

Beverly A. Teicher
Clin Cancer Res 2007 13: 6247-6251 doi: 10.1158/1078-0432.CCR-07-1654 [Abstract] [Full Text] [PDF]  

Targeting Poly(ADP-Ribose) Polymerase: A Two-Armed Strategy for Cancer Therapy

Elizabeth Ruth Plummer and Hilary Calvert
Clin Cancer Res 2007 13: 6252-6256 doi: 10.1158/1078-0432.CCR-07-0617 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Amplicon Mapping and Expression Profiling Identify the Fas-Associated Death Domain Gene as a New Driver in the 11q13.3 Amplicon in Laryngeal/Pharyngeal Cancer

Johan H. Gibcus, Lorian Menkema, Mirjam F. Mastik, Mario A. Hermsen, Geertruida H. de Bock, Marie-Louise F. van Velthuysen, Robert P. Takes, Klaas Kok, Cesar A. Álvarez Marcos, Bernard F.A.M. van der Laan, Michiel W.M. van den Brekel, Johannes A. Langendijk, Philip M. Kluin, Jacqueline E. van der Wal, and Ed Schuuring
Clin Cancer Res 2007 13: 6257-6266 doi: 10.1158/1078-0432.CCR-07-1247 [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of a Novel Cancer-Testis Antigen CRT2 Frequently Expressed in Various Cancers Using Representational Differential Analysis

Emiko Hayashi, Yuriko Matsuzaki, Go Hasegawa, Tomonori Yaguchi, Sachiko Kurihara, Tomonobu Fujita, Toshiro Kageshita, Makoto Sano, and Yutaka Kawakami
Clin Cancer Res 2007 13: 6267-6274 doi: 10.1158/1078-0432.CCR-07-1374 [Abstract] [Full Text] [PDF]  

Identification and Validation of a Novel Gene Signature Associated with the Recurrence of Human Hepatocellular Carcinoma

Suk Mei Wang, London Lucien P.J. Ooi, and Kam M. Hui
Clin Cancer Res 2007 13: 6275-6283 doi: 10.1158/1078-0432.CCR-06-2236 [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Expression Profiling from Formalin-Fixed Paraffin-Embedded Tumors of Pediatric Glioblastoma

Takrima Haque, Damien Faury, Steffen Albrecht, Enrique Lopez-Aguilar, Péter Hauser, Miklós Garami, Zoltán Hanzély, László Bognár, Rolando F. Del Maestro, Jeffrey Atkinson, Andre Nantel, and Nada Jabado
Clin Cancer Res 2007 13: 6284-6292 doi: 10.1158/1078-0432.CCR-07-0525 [Abstract] [Full Text] [PDF]  

Hypermethylation of Tachykinin-1 Is a Potential Biomarker in Human Esophageal Cancer

Zhe Jin, Alexandru Olaru, Jian Yang, Fumiaki Sato, Yulan Cheng, Takatsugu Kan, Yuriko Mori, Carmit Mantzur, Bogdan Paun, James P. Hamilton, Tetsuo Ito, Suna Wang, Stefan David, Rachana Agarwal, David G. Beer, John M. Abraham, and Stephen J. Meltzer
Clin Cancer Res 2007 13: 6293-6300 doi: 10.1158/1078-0432.CCR-07-0818 [Abstract] [Full Text] [PDF] Supplementary Data  

The Frequency and Suppressor Function of CD4⁺CD25^highFoxp3⁺ T Cells in the Circulation of Patients with Squamous Cell Carcinoma of the Head and Neck

Laura Strauss, Christoph Bergmann, William Gooding, Jonas T. Johnson, and Theresa L. Whiteside
Clin Cancer Res 2007 13: 6301-6311 doi: 10.1158/1078-0432.CCR-07-1403 [Abstract] [Full Text] [PDF]  

Expression of Prenylated Rab Acceptor 1 Domain Family, Member 2 (PRAF2) in Neuroblastoma: Correlation with Clinical Features, Cellular Localization, and Cerulenin-Mediated Apoptosis Regulation

Dirk Geerts, Christopher J. Wallick, Dana-Lynn T. Koomoa, Jan Koster, Rogier Versteeg, Ramon Christopher V. Go, and André S. Bachmann
Clin Cancer Res 2007 13: 6312-6319 doi: 10.1158/1078-0432.CCR-07-0829 [Abstract] [Full Text] [PDF] Supplementary Data  

Imaging, Diagnosis, Prognosis:

MCP-1 Promoter Polymorphism at –2518 Is Associated with Metastasis of Nasopharyngeal Carcinoma after Treatment

Ka-Po Tse, Nang-Ming Tsang, Kung-Den Chen, Hsin-Pai Li, Ying Liang, Chuen Hsueh, Kai-Ping Chang, Jau-Song Yu, Sheng-Po Hao, Ling-Ling Hsieh, and Yu-Sun Chang
Clin Cancer Res 2007 13: 6320-6326 doi: 10.1158/1078-0432.CCR-07-1029 [Abstract] [Full Text] [PDF] Supplementary Data  

The Prognostic Biomarkers HOXB13, IL17BR, and CHDH Are Regulated by Estrogen in Breast Cancer

Zuncai Wang, Sonika Dahiya, Heather Provencher, Beth Muir, Erin Carney, Kathryn Coser, Toshi Shioda, Xiao-Jun Ma, and Dennis C. Sgroi
Clin Cancer Res 2007 13: 6327-6334 doi: 10.1158/1078-0432.CCR-07-0310 [Abstract] [Full Text] [PDF]  

A Self-Quenched Galactosamine-Serum Albumin-RhodamineX Conjugate: A "Smart" Fluorescent Molecular Imaging Probe Synthesized with Clinically Applicable Material for Detecting Peritoneal Ovarian Cancer Metastases

Yukihiro Hama, Yasuteru Urano, Yoshinori Koyama, Andrew J. Gunn, Peter L. Choyke, and Hisataka Kobayashi
Clin Cancer Res 2007 13: 6335-6343 doi: 10.1158/1078-0432.CCR-07-1004 [Abstract] [Full Text] [PDF] Supplementary Data  

Microphthalmia-Associated Transcription Factor Gene Amplification in Metastatic Melanoma Is a Prognostic Marker for Patient Survival, But Not a Predictive Marker for Chemosensitivity and Chemotherapy Response

Selma Ugurel, Roland Houben, David Schrama, Heike Voigt, Marc Zapatka, Dirk Schadendorf, Eva B. Bröcker, and Jürgen C. Becker
Clin Cancer Res 2007 13: 6344-6350 doi: 10.1158/1078-0432.CCR-06-2682 [Abstract] [Full Text] [PDF]  

Prognostic Value of LISCH7 mRNA in Plasma and Tumor of Colon Cancer Patients

José M. García, Cristina Peña, Vanesa García, Gemma Domínguez, Concepción Muñoz, Javier Silva, Isabel Millán, Raquel Diaz, Yolanda Lorenzo, Rufo Rodriguez, and Félix Bonilla
Clin Cancer Res 2007 13: 6351-6358 doi: 10.1158/1078-0432.CCR-07-0882 [Abstract] [Full Text] [PDF] Supplementary Data  

Predictive Factors of Oxaliplatin Neurotoxicity: The Involvement of the Oxalate Outcome Pathway

Laurence Gamelin, Olivier Capitain, Alain Morel, Agnes Dumont, Sory Traore, Le Bouil Anne, Simard Gilles, Michele Boisdron-Celle, and Erick Gamelin
Clin Cancer Res 2007 13: 6359-6368 doi: 10.1158/1078-0432.CCR-07-0660 [Abstract] [Full Text] [PDF]  

Fluorine-18--Methyltyrosine Positron Emission Tomography for Diagnosis and Staging of Lung Cancer: A Clinicopathologic Study

Kyoichi Kaira, Noboru Oriuchi, Yoshimi Otani, Kimihiro Shimizu, Shigebumi Tanaka, Hisao Imai, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Tamotsu Ishizuka, Kunio Dobashi, Yoshikatsu Kanai, Hitoshi Endou, Takashi Nakajima, Keigo Endo, and Masatomo Mori
Clin Cancer Res 2007 13: 6369-6378 doi: 10.1158/1078-0432.CCR-07-1294 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Daily Physical-Rest Activities in Relation to Nutritional State, Metabolism, and Quality of Life in Cancer Patients with Progressive Cachexia

Marita Fouladiun, Ulla Körner, Lena Gunnebo, Petra Sixt-Ammilon, Ingvar Bosaeus, and Kent Lundholm
Clin Cancer Res 2007 13: 6379-6385 doi: 10.1158/1078-0432.CCR-07-1147 [Abstract] [Full Text] [PDF]  

Immunologic and Clinical Outcomes of a Randomized Phase II Trial of Two Multipeptide Vaccines for Melanoma in the Adjuvant Setting

Craig L. Slingluff, Jr., Gina R. Petroni, Kimberly A. Chianese-Bullock, Mark E. Smolkin, Sarah Hibbitts, Cheryl Murphy, Naomi Johansen, William W. Grosh, Galina V. Yamshchikov, Patrice Y. Neese, James W. Patterson, Robyn Fink, and Patrice K. Rehm
Clin Cancer Res 2007 13: 6386-6395 doi: 10.1158/1078-0432.CCR-07-0486 [Abstract] [Full Text] [PDF]  

A Contemporary Prognostic Nomogram for Men with Hormone-Refractory Metastatic Prostate Cancer: A TAX327 Study Analysis

Andrew J. Armstrong, Elizabeth S. Garrett-Mayer, Yi-Chun Ou Yang, Ronald de Wit, Ian F. Tannock, and Mario Eisenberger
Clin Cancer Res 2007 13: 6396-6403 doi: 10.1158/1078-0432.CCR-07-1036 [Abstract] [Full Text] [PDF] Supplementary Data  

Pathologic Complete Response to Trastuzumab-Based Neoadjuvant Therapy Is Related to the Level of HER-2 Amplification

Laurent Arnould, Patrick Arveux, Jerome Couturier, Marion Gelly-Marty, Catherine Loustalot, Francette Ettore, Christine Sagan, Martine Antoine, Frederique Penault-Llorca, Berangere Vasseur, Pierre Fumoleau, and Bruno P. Coudert
Clin Cancer Res 2007 13: 6404-6409 doi: 10.1158/1078-0432.CCR-06-3022 [Abstract] [Full Text] [PDF]  

Population Pharmacokinetics and Pharmacodynamics of Paclitaxel and Carboplatin in Ovarian Cancer Patients: A Study by the European Organization for Research and Treatment of Cancer-Pharmacology and Molecular Mechanisms Group and New Drug Development Group

Markus Joerger, Alwin D.R. Huitema, Dick J. Richel, Christian Dittrich, Nikolas Pavlidis, Evangelos Briasoulis, Jan B. Vermorken, Elena Strocchi, Andrea Martoni, Roberto Sorio, Henk P. Sleeboom, Miguel A. Izquierdo, Duncan I. Jodrell, Hilary Calvert, Alan V. Boddy, Harry Hollema, Regine Féty, Wjf J.F. Van der Vijgh, Georg Hempel, Etienne Chatelut, Mats Karlsson, Justin Wilkins, Brigitte Tranchand, Ad H.G.J. Schrijvers, Christian Twelves, Jos H. Beijnen, and Jan H.M. Schellens
Clin Cancer Res 2007 13: 6410-6418 doi: 10.1158/1078-0432.CCR-07-0064 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

The Activation of Natural Killer Cell Effector Functions by Cetuximab-Coated, Epidermal Growth Factor Receptor–Positive Tumor Cells is Enhanced By Cytokines

Julie M. Roda, Trupti Joshi, Jonathan P. Butchar, Jaclyn W. McAlees, Amy Lehman, Susheela Tridandapani, and William E. Carson, III
Clin Cancer Res 2007 13: 6419-6428 Published Online First October 25, 2007. doi: 10.1158/1078-0432.CCR-07-0865 [Abstract] [Full Text] [PDF]  

An Antibody Targeting the Type I Insulin-like Growth Factor Receptor Enhances the Castration-Induced Response in Androgen-Dependent Prostate Cancer

Stephen R. Plymate, Kathy Haugk, Ilsa Coleman, Lillie Woodke, Robert Vessella, Peter Nelson, R. Bruce Montgomery, Dale L. Ludwig, and Jennifer D. Wu
Clin Cancer Res 2007 13: 6429-6439 doi: 10.1158/1078-0432.CCR-07-0648 [Abstract] [Full Text] [PDF]  

P-Glycoprotein and Breast Cancer Resistance Protein: Two Dominant Transporters Working Together in Limiting the Brain Penetration of Topotecan

Nienke A. de Vries, Jin Zhao, Emily Kroon, Tessa Buckle, Jos H. Beijnen, and Olaf van Tellingen
Clin Cancer Res 2007 13: 6440-6449 doi: 10.1158/1078-0432.CCR-07-1335 [Abstract] [Full Text] [PDF]  

Investigation of Two Dosing Schedules of Vandetanib (ZD6474), an Inhibitor of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor Signaling, in Combination with Irinotecan in a Human Colon Cancer Xenograft Model

Teresa Troiani, Natalie J. Serkova, Daniel L. Gustafson, Thomas K. Henthorn, Owen Lockerbie, Andrea Merz, Michael Long, Mark Morrow, Fortunato Ciardiello, and S. Gail Eckhardt
Clin Cancer Res 2007 13: 6450-6458 doi: 10.1158/1078-0432.CCR-07-1094 [Abstract] [Full Text] [PDF]  

Targeting Heat Shock Protein 90 in Pancreatic Cancer Impairs Insulin-like Growth Factor-I Receptor Signaling, Disrupts an Interleukin-6/Signal-Transducer and Activator of Transcription 3/Hypoxia-Inducible Factor-1 Autocrine Loop, and Reduces Orthotopic Tumor Growth

Sven A. Lang, Christian Moser, Andreas Gaumann, Dagmar Klein, Gabriel Glockzin, Felix C. Popp, Marc H. Dahlke, Pompiliu Piso, Hans J. Schlitt, Edward K. Geissler, and Oliver Stoeltzing
Clin Cancer Res 2007 13: 6459-6468 doi: 10.1158/1078-0432.CCR-07-1104 [Abstract] [Full Text] [PDF]  

Inhibition of Interleukin-6 Signaling with CNTO 328 Enhances the Activity of Bortezomib in Preclinical Models of Multiple Myeloma

Peter M. Voorhees, Qing Chen, Deborah J. Kuhn, George W. Small, Sally A. Hunsucker, John S. Strader, Robert E. Corringham, Mohamed H. Zaki, Jeffrey A. Nemeth, and Robert Z. Orlowski
Clin Cancer Res 2007 13: 6469-6478 doi: 10.1158/1078-0432.CCR-07-1293 [Abstract] [Full Text] [PDF] Supplementary Data  

Nerve-Sparing Therapy with Oncolytic Herpes Virus for Cancers with Neural Invasion

Ziv Gil, Avigail Rein, Peter Brader, Sen Li, Jatin P. Shah, Yuman Fong, and Richard J. Wong
Clin Cancer Res 2007 13: 6479-6485 doi: 10.1158/1078-0432.CCR-07-1639 [Abstract] [Full Text] [PDF]  

A Bispecific Recombinant Cytotoxin (DTEGF13) Targeting Human Interleukin-13 and Epidermal Growth Factor Receptors in a Mouse Xenograft Model of Prostate Cancer

Brad J. Stish, Hua Chen, Yanqun Shu, Angela Panoskaltsis-Mortari, and Daniel A. Vallera
Clin Cancer Res 2007 13: 6486-6493 doi: 10.1158/1078-0432.CCR-07-0938 [Abstract] [Full Text] [PDF]  

Defucosylated Anti–CC Chemokine Receptor 4 Monoclonal Antibody Combined with Immunomodulatory Cytokines: A Novel Immunotherapy for Aggressive/Refractory Mycosis Fungoides and Sézary Syndrome

Hiroki Yano, Takashi Ishida, Atsushi Inagaki, Toshihiko Ishii, Jianmin Ding, Shigeru Kusumoto, Hirokazu Komatsu, Shinsuke Iida, Hiroshi Inagaki, and Ryuzo Ueda
Clin Cancer Res 2007 13: 6494-6500 doi: 10.1158/1078-0432.CCR-07-1324 [Abstract] [Full Text] [PDF]  

Immunization with Mimotopes Prevents Growth of Carcinoembryonic Antigen–Positive Tumors in BALB/c Mice

Kira H. Brämswig, Regina Knittelfelder, Silke Gruber, Eva Untersmayr, Angelika B. Riemer, Krisztina Szalai, Reinhard Horvat, Robert Kammerer, Wolfgang Zimmermann, Christoph C. Zielinski, Otto Scheiner, and Erika Jensen-Jarolim
Clin Cancer Res 2007 13: 6501-6508 doi: 10.1158/1078-0432.CCR-07-0692 [Abstract] [Full Text] [PDF]  

Apicularen A Induces Cell Death through Fas Ligand Up-Regulation and Microtubule Disruption by Tubulin Down-Regulation in HM7 Human Colon Cancer Cells

Jong-Seok Kim, Young-Chul Lee, Ho-Tak Nam, Ge Li, Eun-Jin Yun, Kyoung-Sub Song, Kang-Sik Seo, Ji-Hoon Park, Jong-Woong Ahn, OkPyo Zee, Jong-Il Park, Wan-Hee Yoon, Kyu Lim, and Byung-Doo Hwang
Clin Cancer Res 2007 13: 6509-6517 doi: 10.1158/1078-0432.CCR-07-1428 [Abstract] [Full Text] [PDF] Supplementary Data  

Buccal Mucosa Cells as In vivo Model to Evaluate Gefitinib Activity in Patients with Advanced Non–Small Cell Lung Cancer

Maura Loprevite, Marcello Tiseo, Maurizio Chiaramondia, Marzia Capelletti, Cecilia Bozzetti, Beatrice Bortesi, Nadia Naldi, Rita Nizzoli, Patrizia Dadati, Annalisa Kunkl, Daniela Zennaro, Costanza Lagrasta, Nicoletta Campanini, Elena Spiritelli, Roberta Camisa, Francesco Grossi, Guido Rindi, Vittorio Franciosi, and Andrea Ardizzoni
Clin Cancer Res 2007 13: 6518-6526 doi: 10.1158/1078-0432.CCR-07-0805 [Abstract] [Full Text] [PDF]  

Cancer Susceptibility and Prevention:

5-Aminosalicylic Acid Given in the Remission Stage of Colitis Suppresses Colitis-Associated Cancer in a Mouse Colitis Model

Ikuko Ikeda, Ayako Tomimoto, Koichiro Wada, Toshio Fujisawa, Koji Fujita, Kyoko Yonemitsu, Yuichi Nozaki, Hiroki Endo, Hirokazu Takahashi, Masato Yoneda, Masahiko Inamori, Kensuke Kubota, Satoru Saito, Yoji Nagashima, Hitoshi Nakagama, and Atsushi Nakajima
Clin Cancer Res 2007 13: 6527-6531 doi: 10.1158/1078-0432.CCR-07-1208 [Abstract] [Full Text] [PDF] Supplementary Data  

Repair Capacity for UV Light–Induced DNA Damage Associated with Risk of Nonmelanoma Skin Cancer and Tumor Progression

Li-E Wang, Chunying Li, Sara S. Strom, Leonard H. Goldberg, Abenaa Brewster, Zhaozheng Guo, Yawei Qiao, Gary L. Clayman, J. Jack Lee, Adel K. El-Naggar, Victor G. Prieto, Madeleine Duvic, Scott M. Lippman, Randal S. Weber, Margaret L. Kripke, and Qingyi Wei
Clin Cancer Res 2007 13: 6532-6539 doi: 10.1158/1078-0432.CCR-07-0969 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Clarification Regarding "Phase II Trials Published in 2002: A Cross-Specialty Comparison Showing Significant Design Differences between Oncology Trials and Other Medical Specialties" and the Accompanying Commentary, "Phase II Cancer Trials: Out of Control?"

Bruce A. Chabner and Mark J. Ratain
Clin Cancer Res 2007 13: 6540 doi: 10.1158/1078-0432.CCR-07-1108 [Full Text] [PDF]  

Bortezomib Sensitizes Human Astrocytoma Cells to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis

Athanassios P. Kyritsis, Fanny Tachmazoglou, Jasti S. Rao, and Vinay K. Puduvalli
Clin Cancer Res 2007 13: 6540 doi: 10.1158/1078-0432.CCR-07-1447 [Full Text] [PDF]  

Bortezomib-Mediated Up-Regulation of TRAIL-R1 and TRAIL-R2 Is Not Necessary for but Contributes to Sensitization of Primary Human Glioma Cells to TRAIL

Ronald Koschny, Jaromir Sykora, Henning Walczak, Tom M. Ganten, Tobias L. Haas, Martin R. Sprick, Heidrum Holland, Peter Ahnert, Wolfgang Krupp, Jürgen Meixensberger, and Manfred Bauer
Clin Cancer Res 2007 13: 6541-6542 doi: 10.1158/1078-0432.CCR-07-1759 [Full Text] [PDF]  

Corrections:

Correction: Article on Bortezomib Inhibition of Nuclear Factor-KB-Dependent Survival

Clin Cancer Res 2007 13: 6543 doi: 10.1158/1078-0432.CCR-13-21-COR1 [Full Text] [PDF]  

Correction: Article on the Tumor Suppression Activities of CMTM5

Clin Cancer Res 2007 13: 6543 doi: 10.1158/1078-0432.CCR-13-21-COR2 [Full Text] [PDF]  

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