Editorials:

Unexplored Pharmacokinetic Opportunities with Microdosing in Oncology

Alex Sparreboom
Clin Cancer Res 2007 13: 4033-4034 doi: 10.1158/1078-0432.CCR-07-0540 [Full Text] [PDF]  

CCR Practice of Translational Oncology:

The Convergent Development of Molecular-Targeted Drugs for Cancer Treatment and Prevention

Scott M. Lippman and John V. Heymach
Clin Cancer Res 2007 13: 4035-4041 doi: 10.1158/1078-0432.CCR-07-0063 [Abstract] [Full Text] [PDF]  

Molecular Pathways:

WNT Signaling Pathway and Stem Cell Signaling Network

Masuko Katoh and Masaru Katoh
Clin Cancer Res 2007 13: 4042-4045 doi: 10.1158/1078-0432.CCR-06-2316 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Significance of Immunohistochemical Expression of Estrogen Receptors and ß in Squamous Cell Carcinoma of the Esophagus

Tadahiro Nozoe, Tsunehiro Oyama, Mitsuhiro Takenoyama, Takeshi Hanagiri, Kenji Sugio, and Kosei Yasumoto
Clin Cancer Res 2007 13: 4046-4050 doi: 10.1158/1078-0432.CCR-07-0449 [Abstract] [Full Text] [PDF]  

Intraperitoneal Injection of a Hairpin RNA–Expressing Plasmid Targeting Urokinase-Type Plasminogen Activator (uPA) Receptor and uPA Retards Angiogenesis and Inhibits Intracranial Tumor Growth in Nude Mice

Christopher S. Gondi, Sajani S. Lakka, Dzung H. Dinh, William C. Olivero, Meena Gujrati, and Jasti S. Rao
Clin Cancer Res 2007 13: 4051-4060 doi: 10.1158/1078-0432.CCR-06-3032 [Abstract] [Full Text] [PDF]  

Epigenetic Inactivation Implies Independent Functions for Insulin-like Growth Factor Binding Protein (IGFBP)-Related Protein 1 and the Related IGFBPL1 in Inhibiting Breast Cancer Phenotypes

Paul Smith, Linda J. Nicholson, Nelofer Syed, Annette Payne, Louise Hiller, Ornella Garrone, Marcella Occelli, Milena Gasco, and Tim Crook
Clin Cancer Res 2007 13: 4061-4068 doi: 10.1158/1078-0432.CCR-06-3052 [Abstract] [Full Text] [PDF]  

Tamoxifen Induces Heparanase Expression in Estrogen Receptor–Positive Breast Cancer

Irit Cohen, Bella Maly, Itamar Simon, Amichay Meirovitz, Eli Pikarsky, Eyal Zcharia, Tamar Peretz, Israel Vlodavsky, and Michael Elkin
Clin Cancer Res 2007 13: 4069-4077 doi: 10.1158/1078-0432.CCR-06-2546 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Thirty-Gene Pharmacogenomic Test Correlates with Residual Cancer Burden after Preoperative Chemotherapy for Breast Cancer

Florentia Peintinger, Keith Anderson, Chafika Mazouni, Henry M. Kuerer, Christos Hatzis, Feng Lin, Gabriel N. Hortobagyi, W. Fraser Symmans, and Lajos Pusztai
Clin Cancer Res 2007 13: 4078-4082 doi: 10.1158/1078-0432.CCR-06-2600 [Abstract] [Full Text] [PDF]  

Predictive Value of Aurora-A/STK15 Expression for Late Stage Epithelial Ovarian Cancer Patients Treated by Adjuvant Chemotherapy

Silke Lassmann, Yi Shen, Uta Jütting, Philipp Wiehle, Axel Walch, Gerald Gitsch, Annette Hasenburg, and Martin Werner
Clin Cancer Res 2007 13: 4083-4091 doi: 10.1158/1078-0432.CCR-06-2775 [Abstract] [Full Text] [PDF]  

Neoadjuvant Docetaxel and Capecitabine and the Use of Thymidine Phosphorylase as a Predictive Biomarker in Breast Cancer

Rachel M. Layman, Dafydd G. Thomas, Kent A. Griffith, Jeffrey B. Smerage, Mark A. Helvie, Marilyn A. Roubidoux, Kathleen M. Diehl, Lisa A. Newman, Michael S. Sabel, James A. Hayman, Lori J. Pierce, Daniel F. Hayes, and Anne F. Schott
Clin Cancer Res 2007 13: 4092-4097 doi: 10.1158/1078-0432.CCR-07-0288 [Abstract] [Full Text] [PDF]  

Overexpression of the Centrosomal Protein Aurora-A Kinase is Associated with Poor Prognosis in Epithelial Ovarian Cancer Patients

Charles N. Landen, Jr., Yvonne G. Lin, Anand Immaneni, Michael T. Deavers, William M. Merritt, Whitney A. Spannuth, Diane C. Bodurka, David M. Gershenson, William R. Brinkley, and Anil K. Sood
Clin Cancer Res 2007 13: 4098-4104 doi: 10.1158/1078-0432.CCR-07-0431 [Abstract] [Full Text] [PDF]  

Detection of Circulating Tumor Cells in Early-Stage Breast Cancer Metastasis to Axillary Lymph Nodes

Taku Nakagawa, Steve R. Martinez, Yasufumi Goto, Kazuo Koyanagi, Minoru Kitago, Tatsushi Shingai, David A. Elashoff, Xing Ye, Frederick R. Singer, Armando E. Giuliano, and Dave S.B. Hoon
Clin Cancer Res 2007 13: 4105-4110 doi: 10.1158/1078-0432.CCR-07-0419 [Abstract] [Full Text] [PDF]  

Prognostic Significance of Nuclear ING3 Expression in Human Cutaneous Melanoma

Yemin Wang, Derek L. Dai, Magdalena Martinka, and Gang Li
Clin Cancer Res 2007 13: 4111-4116 doi: 10.1158/1078-0432.CCR-07-0408 [Abstract] [Full Text] [PDF]  

TIMP-1 Is Significantly Associated with Objective Response and Survival in Metastatic Colorectal Cancer Patients Receiving Combination of Irinotecan, 5-Fluorouracil, and Folinic Acid

Nanna M. Sørensen, Per Byström, Ib J. Christensen, Åke Berglund, Hans Jørgen Nielsen, Nils Brünner, and Bengt Glimelius
Clin Cancer Res 2007 13: 4117-4122 doi: 10.1158/1078-0432.CCR-07-0186 [Abstract] [Full Text] [PDF]  

MDM2 SNP309 Polymorphism as Risk Factor for Susceptibility and Poor Prognosis in Renal Cell Carcinoma

Hiroshi Hirata, Yuji Hinoda, Nobuyuki Kikuno, Ken Kawamoto, Yutaka Suehiro, Yuichiro Tanaka, and Rajvir Dahiya
Clin Cancer Res 2007 13: 4123-4129 doi: 10.1158/1078-0432.CCR-07-0609 [Abstract] [Full Text] [PDF]  

Association of Cysteine-Rich Secretory Protein 3 and ß-Microseminoprotein with Outcome after Radical Prostatectomy

Anders S. Bjartell, Hikmat Al-Ahmadie, Angel M. Serio, James A. Eastham, Scott E. Eggener, Samson W. Fine, Lene Udby, William L. Gerald, Andrew J. Vickers, Hans Lilja, Victor E. Reuter, and Peter T. Scardino
Clin Cancer Res 2007 13: 4130-4138 doi: 10.1158/1078-0432.CCR-06-3031 [Abstract] [Full Text] [PDF]  

Loss of IFN Receptor Is an Independent Prognostic Factor in Ovarian Cancer

Timothy J. Duncan, Phil Rolland, Suha Deen, Ian V. Scott, David T.Y. Liu, Ian Spendlove, and Lindy G. Durrant
Clin Cancer Res 2007 13: 4139-4145 doi: 10.1158/1078-0432.CCR-06-2833 [Abstract] [Full Text] [PDF]  

Low Expression of Bax Predicts Poor Prognosis in Patients with Locally Advanced Esophageal Cancer Treated with Definitive Chemoradiotherapy

Seok Yun Kang, Jae Ho Han, Kwang Jae Lee, Jin-Hyuk Choi, Jung Il Park, Hyoung Il Kim, Hyun-Woo Lee, Jun Ho Jang, Joon Seong Park, Hugh Chul Kim, Seunghee Kang, Young Taek Oh, Mison Chun, Jang Hee Kim, Seung Soo Sheen, and Ho-Yeong Lim
Clin Cancer Res 2007 13: 4146-4153 doi: 10.1158/1078-0432.CCR-06-3063 [Abstract] [Full Text] [PDF]  

Protein Expression Profiling and Molecular Classification of Gastric Cancer by the Tissue Array Method

Hye Seung Lee, Sung-Bum Cho, Hee Eun Lee, Min A Kim, Ji Hun Kim, Do Joong Park, Ju Han Kim, Han-Kwang Yang, Byung Lan Lee, and Woo Ho Kim
Clin Cancer Res 2007 13: 4154-4163 doi: 10.1158/1078-0432.CCR-07-0173 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Pharmacokinetic Investigation of Imatinib Using Accelerator Mass Spectrometry in Patients with Chronic Myeloid Leukemia

Alan V. Boddy, Julieann Sludden, Melanie J. Griffin, Colin Garner, John Kendrick, Pritesh Mistry, Catherine Dutreix, David R. Newell, and Stephen G. O'Brien
Clin Cancer Res 2007 13: 4164-4169 doi: 10.1158/1078-0432.CCR-06-2179 [Abstract] [Full Text] [PDF]  

Pilot Study of a Heptavalent Vaccine-Keyhole Limpet Hemocyanin Conjugate plus QS21 in Patients with Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer

Paul J. Sabbatini, Govind Ragupathi, Chandra Hood, Carol A. Aghajanian, Margrit Juretzka, Alexia Iasonos, Martee L. Hensley, Maria K. Spassova, Ouathek Ouerfelli, David R. Spriggs, William P. Tew, Jason Konner, Henrik Clausen, Nadeem Abu Rustum, Samuel J. Dansihefsky, and Philip O. Livingston
Clin Cancer Res 2007 13: 4170-4177 doi: 10.1158/1078-0432.CCR-06-2949 [Abstract] [Full Text] [PDF]  

A Phase Ib and Pharmacokinetic Trial of Patupilone Combined with Carboplatin in Patients with Advanced Cancer

Martin Forster, Stan Kaye, Amit Oza, Ivo Sklenar, Anandhi Johri, Wing Cheung, Sara Zaknoen, and Martin Gore
Clin Cancer Res 2007 13: 4178-4184 doi: 10.1158/1078-0432.CCR-06-1653 [Abstract] [Full Text] [PDF]  

Effect of Tibolone on Breast Cancer Cell Proliferation in Postmenopausal ER+ Patients: Results from STEM Trial

Ernst Kubista, Juan V.M. Planellas Gomez, Mitch Dowsett, Jean-Michel Foidart, Kamil Pohlodek, Rudolphe Serreyn, Michail Nechushkin, Alexey G. Manikhas, Victor F. Semiglazov, Cornelius C.M. Hageluken, and Christian F. Singer
Clin Cancer Res 2007 13: 4185-4190 doi: 10.1158/1078-0432.CCR-06-2700 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Humanized Anti-CD26 Monoclonal Antibody as a Treatment for Malignant Mesothelioma Tumors

Teruo Inamoto, Taketo Yamada, Kei Ohnuma, Shinichiro Kina, Nozomu Takahashi, Tadanori Yamochi, Sakiko Inamoto, Yoji Katsuoka, Osamu Hosono, Hirotoshi Tanaka, Nam H. Dang, and Chikao Morimoto
Clin Cancer Res 2007 13: 4191-4200 doi: 10.1158/1078-0432.CCR-07-0110 [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Trap Blocks Tumor Growth, Metastasis Formation, and Vascular Leakage in an Orthotopic Murine Renal Cell Cancer Model

Henk M.W. Verheul, Hans Hammers, Karen van Erp, Yonfeng Wei, Tolib Sanni, Brenda Salumbides, David Z. Qian, George D. Yancopoulos, and Roberto Pili
Clin Cancer Res 2007 13: 4201-4208 doi: 10.1158/1078-0432.CCR-06-2553 [Abstract] [Full Text] [PDF]  

Dual Targeting of Endothelial Cells and Pericytes in Antivascular Therapy for Ovarian Carcinoma

Chunhua Lu, Aparna A. Kamat, Yvonne G. Lin, William M. Merritt, Charles N. Landen, Tae Jin Kim, Whitney Spannuth, Thiru Arumugam, Liz Y. Han, Nicholas B. Jennings, Craig Logsdon, Robert B. Jaffe, Robert L. Coleman, and Anil K. Sood
Clin Cancer Res 2007 13: 4209-4217 doi: 10.1158/1078-0432.CCR-07-0197 [Abstract] [Full Text] [PDF]  

The Effect of Repeated Administration of Cyclophosphamide on Cytochrome P450 2B in Rats

Parvaneh Afsharian, Ylva Terelius, Zuzana Hassan, Christina Nilsson, Stefan Lundgren, and Moustapha Hassan
Clin Cancer Res 2007 13: 4218-4224 doi: 10.1158/1078-0432.CCR-07-0320 [Abstract] [Full Text] [PDF]  

Effect of Cytarabine and Decitabine in Combination in Human Leukemic Cell Lines

Taichun Qin, Emile M. Youssef, Jaroslav Jelinek, Rong Chen, Allen S. Yang, Guillermo Garcia-Manero, and Jean-Pierre J. Issa
Clin Cancer Res 2007 13: 4225-4232 doi: 10.1158/1078-0432.CCR-06-2762 [Abstract] [Full Text] [PDF]  

Abrogation of Signal Transducer and Activator of Transcription 3 Reactivation after Src Kinase Inhibition Results in Synergistic Antitumor Effects

Faye M. Johnson, Babita Saigal, Hai Tran, and Nicholas J. Donato
Clin Cancer Res 2007 13: 4233-4244 doi: 10.1158/1078-0432.CCR-06-2981 [Abstract] [Full Text] [PDF]  

Regulation of p53 Expression in Response to 5-Fluorouracil in Human Cancer RKO Cells

Jingfang Ju, John C. Schmitz, Bo Song, Kenji Kudo, and Edward Chu
Clin Cancer Res 2007 13: 4245-4251 doi: 10.1158/1078-0432.CCR-06-2890 [Abstract] [Full Text] [PDF]  

Doxorubicin Directs the Accumulation of Interleukin-12–Induced IFN into Tumors for Enhancing STAT1–Dependent Antitumor Effect

Shiguo Zhu, Marian Waguespack, Steven A. Barker, and Shulin Li
Clin Cancer Res 2007 13: 4252-4260 doi: 10.1158/1078-0432.CCR-06-2894 [Abstract] [Full Text] [PDF]  

RAD001 Inhibits Human Ovarian Cancer Cell Proliferation, Enhances Cisplatin-Induced Apoptosis, and Prolongs Survival in an Ovarian Cancer Model

Seiji Mabuchi, Deborah A. Altomare, Mitchell Cheung, Lili Zhang, Poulikos I. Poulikakos, Harvey H. Hensley, Russell J. Schilder, Robert F. Ozols, and Joseph R. Testa
Clin Cancer Res 2007 13: 4261-4270 doi: 10.1158/1078-0432.CCR-06-2770 [Abstract] [Full Text] [PDF]  

Predicting Human Tumor Drug Concentrations from a Preclinical Pharmacokinetic Model of Temozolomide Brain Disposition

Qingyu Zhou, Ping Guo, Gary D. Kruh, Paolo Vicini, Xiaomin Wang, and James M. Gallo
Clin Cancer Res 2007 13: 4271-4279 doi: 10.1158/1078-0432.CCR-07-0658 [Abstract] [Full Text] [PDF]  

Synergistic Interactions between Vorinostat and Sorafenib in Chronic Myelogenous Leukemia Cells Involve Mcl-1 and p21^CIP1 Down-Regulation

Girija Dasmahapatra, Nitin Yerram, Yun Dai, Paul Dent, and Steven Grant
Clin Cancer Res 2007 13: 4280-4290 doi: 10.1158/1078-0432.CCR-07-0835 [Abstract] [Full Text] [PDF]  

Insulin-like Growth Factor Receptor as a Therapeutic Target in Head and Neck Cancer

Christopher J. Barnes, Kazufumi Ohshiro, Suresh K. Rayala, Adel K. El-Naggar, and Rakesh Kumar
Clin Cancer Res 2007 13: 4291-4299 doi: 10.1158/1078-0432.CCR-06-2040 [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Polymorphic TP53BP1 and TP53 Gene Interactions Associated with Risk of Squamous Cell Carcinoma of the Head and Neck

Kexin Chen, Zhibin Hu, Li-E Wang, Wei Zhang, Adel K. El-Naggar, Erich M. Sturgis, and Qingyi Wei
Clin Cancer Res 2007 13: 4300-4305 doi: 10.1158/1078-0432.CCR-07-0469 [Abstract] [Full Text] [PDF]  

BRCA Mutations in Women with Ductal Carcinoma In situ

Karen Lisa Smith, Muriel Adank, Noah Kauff, Kelly Lafaro, Jeff Boyd, Johanna B. Lee, Clifford Hudis, Kenneth Offit, and Mark Robson
Clin Cancer Res 2007 13: 4306-4310 doi: 10.1158/1078-0432.CCR-07-0146 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Effects of Interleukin-2 Treatment on CD1d-Restricted Natural Killer T Cells

Johan K. Sandberg and Markus Moll
Clin Cancer Res 2007 13: 4311 doi: 10.1158/1078-0432.CCR-07-1043 [Full Text] [PDF]  

Effects of Interleukin-2 Treatment on CD1d-Restricted Natural Killer T Cells

Hans van der Vliet, Henry Koon, and Mark Exley
Clin Cancer Res 2007 13: 4311 doi: 10.1158/1078-0432.CCR-07-1267 [Full Text] [PDF]  

Corrections:

Correction: Article on Deoxycytidine Kinase in Pancreatic Cancer

Clin Cancer Res 2007 13: 4313 doi: 10.1158/1078-0432.CCR-13-14-COR1 [Full Text] [PDF]  

Correction: Article on Oropharyngeal Squamous Cell Carcinoma

Clin Cancer Res 2007 13: 4313 doi: 10.1158/1078-0432.CCR-13-14-COR2 [Full Text] [PDF]  

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