Editor's Note:

Introducing The Clinical Connection

Kenneth C. Anderson
Clin Cancer Res 2007 13: 3761 doi: 10.1158/1078-0432.CCR-07-1410 [Full Text] [PDF]  

The Clinical Connection:

Triggering Tumor Immunity through Angiogenesis Targeting

Masahisa Jinushi and Glenn Dranoff
Clin Cancer Res 2007 13: 3762-3764 doi: 10.1158/1078-0432.CCR-07-0880 [Full Text] [PDF]  

CCR Drug Updates:

CCR Drug Updates: Sorafenib and Sunitinib in Renal Cell Carcinoma

Mark N. Stein and Keith T. Flaherty
Clin Cancer Res 2007 13: 3765-3770 doi: 10.1158/1078-0432.CCR-06-2844 [Full Text] [PDF]  

Molecular Pathways:

Targeting the Phosphatidylinositol 3-Kinase Pathway in Multiple Myeloma

Hashem Younes, Xavier Leleu, Evdoxia Hatjiharissi, Anne-Sophie Moreau, Teru Hideshima, Paul Richardson, Kenneth C. Anderson, and Irene M. Ghobrial
Clin Cancer Res 2007 13: 3771-3775 doi: 10.1158/1078-0432.CCR-06-2921 [Abstract] [Full Text] [PDF]  

Review:

Cancer Vaccines: Moving Beyond Current Paradigms

Jeffrey Schlom, Philip M. Arlen, and James L. Gulley
Clin Cancer Res 2007 13: 3776-3782 doi: 10.1158/1078-0432.CCR-07-0588 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Cytochrome P450 17A1 and Catechol O-Methyltransferase Polymorphisms and Age at Lynch Syndrome Colon Cancer Onset in Newfoundland

Peter T. Campbell, Laura Edwards, John R. McLaughlin, Jane Green, H. Banfield Younghusband, and Michael O. Woods
Clin Cancer Res 2007 13: 3783-3788 doi: 10.1158/1078-0432.CCR-06-2987 [Abstract] [Full Text] [PDF]  

Transcriptional Functionality of Germ Line p53 Mutants Influences Cancer Phenotype

Paola Monti, Yari Ciribilli, Jennifer Jordan, Paola Menichini, David M. Umbach, Michael A. Resnick, Lucio Luzzatto, Alberto Inga, and Gilberto Fronza
Clin Cancer Res 2007 13: 3789-3795 doi: 10.1158/1078-0432.CCR-06-2545 [Abstract] [Full Text] [PDF] Supplementary Data  

Age-Related DNA Methylation Changes in Normal Human Prostate Tissues

Bernard Kwabi-Addo, Woonbok Chung, Lanlan Shen, Michael Ittmann, Thomas Wheeler, Jaroslav Jelinek, and Jean-Pierre J. Issa
Clin Cancer Res 2007 13: 3796-3802 doi: 10.1158/1078-0432.CCR-07-0085 [Abstract] [Full Text] [PDF]  

Expression of Ral GTPases, Their Effectors, and Activators in Human Bladder Cancer

Steven Christopher Smith, Gary Oxford, Alexander S. Baras, Charles Owens, Dmytro Havaleshko, David L. Brautigan, Martin K. Safo, and Dan Theodorescu
Clin Cancer Res 2007 13: 3803-3813 doi: 10.1158/1078-0432.CCR-06-2419 [Abstract] [Full Text] [PDF]  

Identification and Clinical Significance of Mobilized Endothelial Progenitor Cells in Tumor Vasculogenesis of Hepatocellular Carcinoma

Decai Yu, Xitai Sun, Yudong Qiu, Jianxing Zhou, Yafu Wu, Lingyuan Zhuang, Jun Chen, and Yitao Ding
Clin Cancer Res 2007 13: 3814-3824 doi: 10.1158/1078-0432.CCR-06-2594 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Long-Term Protective Effect of Mature DC-LAMP⁺ Dendritic Cell Accumulation in Sentinel Lymph Nodes Containing Micrometastatic Melanoma

Bruce Elliott, Richard A. Scolyer, Stefan Suciu, Serge Lebecque, Donata Rimoldi, Oliver Gugerli, Elena Musat, Raghwa N. Sharma, Danielle Lienard, Ulrich Keilholz, Alessandro Testori, Alexander Eggermont, Rona MacKie, Caroline Robert, Martin Cook, John F. Thompson, Eric Angevin, Alain Spatz on behalf of the European Organization for Research and Treatment of Cancer Melanoma Group
Clin Cancer Res 2007 13: 3825-3830 doi: 10.1158/1078-0432.CCR-07-0358 [Abstract] [Full Text] [PDF]  

Reduced Likelihood of Metastases in Patients with Microsatellite-Unstable Colorectal Cancer

Alberto Malesci, Luigi Laghi, Paolo Bianchi, Gabriele Delconte, Ann Randolph, Valter Torri, Carlo Carnaghi, Roberto Doci, Riccardo Rosati, Marco Montorsi, Massimo Roncalli, Leandro Gennari, and Armando Santoro
Clin Cancer Res 2007 13: 3831-3839 doi: 10.1158/1078-0432.CCR-07-0366 [Abstract] [Full Text] [PDF]  

Detection of MAGE-A Transcripts in Bone Marrow Is an Independent Prognostic Factor in Operable Non–Small-Cell Lung Cancer

Wulf Sienel, Ingo Mecklenburg, Sebastian Dango, Peter Ehrhardt, Andreas Kirschbaum, Bernward Passlick, and Klaus Pantel
Clin Cancer Res 2007 13: 3840-3847 doi: 10.1158/1078-0432.CCR-06-2507 [Abstract] [Full Text] [PDF]  

Up-regulation of Tumor Susceptibility Gene 101 Conveys Poor Prognosis through Suppression of p21 Expression in Ovarian Cancer

Travis W. Young, Daniel G. Rosen, Fang C. Mei, Nan Li, Jinsong Liu, Xiao-Fan Wang, and Xiaodong Cheng
Clin Cancer Res 2007 13: 3848-3854 doi: 10.1158/1078-0432.CCR-07-0337 [Abstract] [Full Text] [PDF]  

Excision Repair Cross Complementation Group 1 Immunohistochemical Expression Predicts Objective Response and Cancer-Specific Survival in Patients Treated by Cisplatin-Based Induction Chemotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma

Adriana Handra-Luca, Juana Hernandez, Giannis Mountzios, Estelle Taranchon, Jean Lacau-St-Guily, Jean-Charles Soria, and Pierre Fouret
Clin Cancer Res 2007 13: 3855-3859 doi: 10.1158/1078-0432.CCR-07-0252 [Abstract] [Full Text] [PDF]  

Determining Risk of Biochemical Recurrence in Prostate Cancer by Immunohistochemical Detection of PTEN Expression and Akt Activation

Roble Bedolla, Thomas J. Prihoda, Jeffrey I. Kreisberg, Shazli N. Malik, Naveen K. Krishnegowda, Dean A. Troyer, and Paramita M. Ghosh
Clin Cancer Res 2007 13: 3860-3867 doi: 10.1158/1078-0432.CCR-07-0091 [Abstract] [Full Text] [PDF]  

Prognostic Significance of the Immunohistochemical Staining of Cleaved Caspase-3, an Activated Form of Caspase-3, in Gliomas

Tatsuya Kobayashi, Junya Masumoto, Tsuyoshi Tada, Tetsuo Nomiyama, Kazuhiro Hongo, and Jun Nakayama
Clin Cancer Res 2007 13: 3868-3874 doi: 10.1158/1078-0432.CCR-06-2730 [Abstract] [Full Text] [PDF]  

Elevated Peroxiredoxin 1, but not NF-E2–Related Factor 2, Is an Independent Prognostic Factor for Disease Recurrence and Reduced Survival in Stage I Non–Small Cell Lung Cancer

Joo-Heon Kim, Paul N. Bogner, Nithya Ramnath, Yoorim Park, Jihnhee Yu, and Young-Mee Park
Clin Cancer Res 2007 13: 3875-3882 doi: 10.1158/1078-0432.CCR-06-2893 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Granulocyte Macrophage Colony-Stimulating Factor–Secreting Allogeneic Cellular Immunotherapy for Hormone-Refractory Prostate Cancer

Eric J. Small, Natalie Sacks, John Nemunaitis, Walter J. Urba, Eugene Dula, Arthur S. Centeno, William G. Nelson, Dale Ando, Catherine Howard, Flavia Borellini, Minh Nguyen, Kristen Hege, and Jonathan W. Simons
Clin Cancer Res 2007 13: 3883-3891 doi: 10.1158/1078-0432.CCR-06-2937 [Abstract] [Full Text] [PDF]  

Multidrug Resistance Proteins Do Not Predict Benefit of Adjuvant Chemotherapy in Patients with Completely Resected Non–Small Cell Lung Cancer: International Adjuvant Lung Cancer Trial Biologic Program

Martin Filipits, Vincent Haddad, Katharina Schmid, Anh Huynh, Ariane Dunant, Fabrice André, Elisabeth Brambilla, Rolf Stahel, Jean-Pierre Pignon, Jean-Charles Soria, Helmut H. Popper, Thierry Le Chevalier, and Robert Pirker
Clin Cancer Res 2007 13: 3892-3898 doi: 10.1158/1078-0432.CCR-06-2446 [Abstract] [Full Text] [PDF]  

Effective Relief of Malignant Ascites in Patients with Advanced Ovarian Cancer by a Trifunctional Anti-EpCAM x Anti-CD3 Antibody: A Phase I/II Study

Alexander Burges, Pauline Wimberger, Carolin Kümper, Vera Gorbounova, Harald Sommer, Barbara Schmalfeldt, Jacobus Pfisterer, Michail Lichinitser, Anatoliy Makhson, Vladimir Moiseyenko, Angelika Lahr, Elisabeth Schulze, Michael Jäger, Michael A. Ströhlein, Markus Maria Heiss, Thomas Gottwald, Horst Lindhofer, and Rainer Kimmig
Clin Cancer Res 2007 13: 3899-3905 doi: 10.1158/1078-0432.CCR-06-2769 [Abstract] [Full Text] [PDF]  

A Phase I Safety and Pharmacologic Study of a Twice Weekly Dosing Regimen of the Oral Taxane BMS-275183

Linda E. Bröker, Stephan A. Veltkamp, Elisabeth I. Heath, Bart C. Kuenen, Helen Gall, Ludovic Astier, Susan Parker, Louis Kayitalire, Patricia M. Lorusso, Jan H.M. Schellens, and Giuseppe Giaccone
Clin Cancer Res 2007 13: 3906-3912 doi: 10.1158/1078-0432.CCR-06-2875 [Abstract] [Full Text] [PDF]  

Correlation between Development of Rash and Efficacy in Patients Treated with the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Erlotinib in Two Large Phase III Studies

Bret Wacker, Tina Nagrani, Jacqueline Weinberg, Karsten Witt, Gary Clark, and Pablo J. Cagnoni
Clin Cancer Res 2007 13: 3913-3921 doi: 10.1158/1078-0432.CCR-06-2610 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104

Adam V. Patterson, Dianne M. Ferry, Shelley J. Edmunds, Yongchuan Gu, Rachelle S. Singleton, Kashyap Patel, Susan M. Pullen, Kevin O. Hicks, Sophie P. Syddall, Graham J. Atwell, Shangjin Yang, William A. Denny, and William R. Wilson
Clin Cancer Res 2007 13: 3922-3932 doi: 10.1158/1078-0432.CCR-07-0478 [Abstract] [Full Text] [PDF]  

Histone Deacetylase Inhibitors Affect Dendritic Cell Differentiation and Immunogenicity

Alessio Nencioni, Julia Beck, Daniela Werth, Frank Grünebach, Franco Patrone, Alberto Ballestrero, and Peter Brossart
Clin Cancer Res 2007 13: 3933-3941 doi: 10.1158/1078-0432.CCR-06-2903 [Abstract] [Full Text] [PDF]  

Bevacizumab-Induced Transient Remodeling of the Vasculature in Neuroblastoma Xenografts Results in Improved Delivery and Efficacy of Systemically Administered Chemotherapy

Paxton V. Dickson, John B. Hamner, Thomas L. Sims, Charles H. Fraga, Catherine Y.C. Ng, Surender Rajasekeran, Nikolaus L. Hagedorn, M. Beth McCarville, Clinton F. Stewart, and Andrew M. Davidoff
Clin Cancer Res 2007 13: 3942-3950 doi: 10.1158/1078-0432.CCR-07-0278 [Abstract] [Full Text] [PDF]  

A Vascular Endothelial Growth Factor Receptor-2 Inhibitor Enhances Antitumor Immunity through an Immune-Based Mechanism

Elizabeth A. Manning, John G.M. Ullman, James M. Leatherman, Justin M. Asquith, Timothy R. Hansen, Todd D. Armstrong, Daniel J. Hicklin, Elizabeth M. Jaffee, and Leisha A. Emens
Clin Cancer Res 2007 13: 3951-3959 doi: 10.1158/1078-0432.CCR-07-0374 [Abstract] [Full Text] [PDF]  

An Imageable Metastatic Treatment Model of Nasopharyngeal Carcinoma

Tengfei Liu, Yanqin Ding, Weibing Xie, Zuguo Li, Xiaoyan Bai, Xin Li, Weiyi Fang, Caiping Ren, Shuang Wang, Robert M. Hoffman, and Kaitai Yao
Clin Cancer Res 2007 13: 3960-3967 doi: 10.1158/1078-0432.CCR-07-0089 [Abstract] [Full Text] [PDF]  

Adeno-Associated Virus–Mediated Antiangiogenic Gene Therapy with Thrombospondin-1 Type 1 Repeats and Endostatin

Xuefeng Zhang, Jianfeng Xu, Jack Lawler, Ernest Terwilliger, and Sareh Parangi
Clin Cancer Res 2007 13: 3968-3976 doi: 10.1158/1078-0432.CCR-07-0245 [Abstract] [Full Text] [PDF]  

Combined Therapeutic Effects of Vinblastine and Rapamycin on Human Neuroblastoma Growth, Apoptosis, and Angiogenesis

Danilo Marimpietri, Chiara Brignole, Beatrice Nico, Fabio Pastorino, Annalisa Pezzolo, Federica Piccardi, Michele Cilli, Daniela Di Paolo, Gabriella Pagnan, Luca Longo, Patrizia Perri, Domenico Ribatti, and Mirco Ponzoni
Clin Cancer Res 2007 13: 3977-3988 doi: 10.1158/1078-0432.CCR-06-2757 [Abstract] [Full Text] [PDF]  

A New Model of Patient Tumor-Derived Breast Cancer Xenografts for Preclinical Assays

Elisabetta Marangoni, Anne Vincent-Salomon, Nathalie Auger, Armelle Degeorges, Franck Assayag, Patricia de Cremoux, Ludmilla de Plater, Charlotte Guyader, Gonzague De Pinieux, Jean-Gabriel Judde, Magali Rebucci, Carine Tran-Perennou, Xavier Sastre-Garau, Brigitte Sigal-Zafrani, Olivier Delattre, Véronique Diéras, and Marie-France Poupon
Clin Cancer Res 2007 13: 3989-3998 doi: 10.1158/1078-0432.CCR-07-0078 [Abstract] [Full Text] [PDF]  

A Novel Alphavirus Vaccine Encoding Prostate-Specific Membrane Antigen Elicits Potent Cellular and Humoral Immune Responses

Robert J. Durso, Sofija Andjelic, Jason P. Gardner, Dennis J. Margitich, Gerald P. Donovan, Robert R. Arrigale, Xinning Wang, Maureen F. Maughan, Todd L. Talarico, Robert A. Olmsted, Warren D.W. Heston, Paul J. Maddon, and William C. Olson
Clin Cancer Res 2007 13: 3999-4008 doi: 10.1158/1078-0432.CCR-06-2202 [Abstract] [Full Text] [PDF]  

Rebuilding Human Leukocyte Antigen Class II–Restricted Minor Histocompatibility Antigen Specificity in Recall Antigen-Specific T Cells by Adoptive T Cell Receptor Transfer: Implications for Adoptive Immunotherapy

Robbert Spaapen, Kelly van den Oudenalder, Roman Ivanov, Andries Bloem, Henk Lokhorst, and Tuna Mutis
Clin Cancer Res 2007 13: 4009-4015 doi: 10.1158/1078-0432.CCR-07-0286 [Abstract] [Full Text] [PDF]  

Immune Signatures of Murine and Human Cancers Reveal Unique Mechanisms of Tumor Escape and New Targets for Cancer Immunotherapy

Rebecca E. Sadun, Suzanne M. Sachsman, Xiaoying Chen, Kamilee W. Christenson, William Z. Morris, Peisheng Hu, and Alan L. Epstein
Clin Cancer Res 2007 13: 4016-4025 doi: 10.1158/1078-0432.CCR-07-0016 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Phase I Study of Abagovomab in Patients with Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Birgit C. Schultes, L. Mary Smith, and Christopher F. Nicodemus
Clin Cancer Res 2007 13: 4026 doi: 10.1158/1078-0432.CCR-06-2664 [Full Text] [PDF]  

Reply to the Letter to the Editor from Schultes et al

Paul Sabbatini and Kunle Odunsi
Clin Cancer Res 2007 13: 4026 doi: 10.1158/1078-0432.CCR-07-0718 [Full Text] [PDF]  

Obesity and Treatment of Prostate Cancer: What Is the Right Dose of Lupron Depot?

Neeraj Agarwal, Deborah Fletcher, and John Ward
Clin Cancer Res 2007 13: 4027 doi: 10.1158/1078-0432.CCR-07-0788 [Full Text] [PDF]  

Corrections:

Article on Recombinant Human Hexamer-Dominant IgM Monoclonal Antibody to Ganglioside GM3 for Treatment of Melanoma

Clin Cancer Res 2007 13: 4029-4031 doi: 10.1158/1078-0432.CCR-13-13-COR [Full Text] [PDF]  

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