The Biology Behind:

Advanced Generation Adenoviral Virotherapy Agents Embody Enhanced Potency Based upon CAR-Independent Tropism

J. Michael Mathis, Phoebe L. Stewart, Zheng B. Zhu, and David T. Curiel
Clin Cancer Res 2006 12: 2651-2656. [Full Text] [PDF]  

Molecular Pathways:

Chk2 Molecular Interaction Map and Rationale for Chk2 Inhibitors

Yves Pommier, John N. Weinstein, Mirit I. Aladjem, and Kurt W. Kohn
Clin Cancer Res 2006 12: 2657-2661. [Abstract] [Full Text] [PDF] Supplementary Data  

Human Cancer Biology:

Ectopic Expression of the Proto-oncogene Mer in Pediatric T-Cell Acute Lymphoblastic Leukemia

Douglas K. Graham, Dana B. Salzberg, Joanne Kurtzberg, Susan Sather, Glenn K. Matsushima, Amy K. Keating, Xiayuan Liang, Mark A. Lovell, Sara A. Williams, Thomas L. Dawson, Michael J. Schell, Adil A. Anwar, H. Ralph Snodgrass, and H. Shelton Earp
Clin Cancer Res 2006 12: 2662-2669. [Abstract] [Full Text] [PDF]  

Presence of Circulating CCR10+ T cells and Elevated Serum CTACK/CCL27 in the Early Stage of Mycosis Fungoides

Yasuyuki Fujita, Riichiro Abe, Mikako Sasaki, Ayumi Honda, Megumi Furuichi, Yukie Asano, Osamu Norisugi, Tadamichi Shimizu, and Hiroshi Shimizu
Clin Cancer Res 2006 12: 2670-2675. [Abstract] [Full Text] [PDF]  

Tumor-Driven Paracrine Platelet-Derived Growth Factor Receptor Signaling Is a Key Determinant of Stromal Cell Recruitment in a Model of Human Lung Carcinoma

Max L. Tejada, Lanlan Yu, Jianying Dong, Kenneth Jung, Gloria Meng, Franklin V. Peale, Gretchen D. Frantz, Linda Hall, XiaoHuan Liang, Hans-Peter Gerber, and Napoleone Ferrara
Clin Cancer Res 2006 12: 2676-2688. [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of HLA-A2- or HLA-A24-Restricted CTL Epitopes Possibly Useful for Glypican-3-Specific Immunotherapy of Hepatocellular Carcinoma

Hiroyuki Komori, Tetsuya Nakatsura, Satoru Senju, Yoshihiro Yoshitake, Yutaka Motomura, Yoshiaki Ikuta, Daiki Fukuma, Kazunori Yokomine, Michiko Harao, Toru Beppu, Masanori Matsui, Toshihiko Torigoe, Noriyuki Sato, Hideo Baba, and Yasuharu Nishimura
Clin Cancer Res 2006 12: 2689-2697. [Abstract] [Full Text] [PDF]  

Mechanisms and Effects of Loss of Human Leukocyte Antigen Class II Expression in Immune-Privileged Site-Associated B-Cell Lymphoma

Marije Booman, Jenny Douwes, Annuska M. Glas, Sietske A. Riemersma, Ekaterina S. Jordanova, Klaas Kok, Andreas Rosenwald, Daphne de Jong, Ed Schuuring, and Philip M. Kluin
Clin Cancer Res 2006 12: 2698-2705. [Abstract] [Full Text] [PDF] Supplementary Data  

Sublethal Irradiation Induces Vascular Endothelial Growth Factor and Promotes Growth of Hepatoma Cells: Implications for Radiotherapy of Hepatocellular Carcinoma

Yih-Lin Chung, James Jer-Min Jian, Skye Hongiun Cheng, Stella Y.C. Tsai, Vincent P. Chuang, Thomas Soong, Yu-Mong Lin, and Cheng-Fang Horng
Clin Cancer Res 2006 12: 2706-2715. [Abstract] [Full Text] [PDF]  

Genomic Alterations in Human Malignant Glioma Cells Associate with the Cell Resistance to the Combination Treatment with Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand and Chemotherapy

Yueh-Chun Li, Ching-Cherng Tzeng, Jin H. Song, Fuu-Jen Tsia, Lie-Jiau Hsieh, Shu-Ju Liao, Chang-Hai Tsai, Erwin G. Van Meir, Chunhai Hao, and Chyi-Chyang Lin
Clin Cancer Res 2006 12: 2716-2729. [Abstract] [Full Text] [PDF]  

Expression and Nuclear Localization of ErbB3 in Prostate Cancer

Ismaël Hervé Koumakpayi, Jean-Simon Diallo, Cécile Le Page, Laurent Lessard, Martin Gleave, Louis R. Bégin, Anne-Marie Mes-Masson, and Fred Saad
Clin Cancer Res 2006 12: 2730-2737. [Abstract] [Full Text] [PDF]  

Thymidylate Synthase Expression in Colon Carcinomas with Microsatellite Instability

Frank A. Sinicrope, Rafaela L. Rego, Kevin C. Halling, Nathan R. Foster, Daniel J. Sargent, Betsy La Plant, Amy J. French, Carmen J. Allegra, John A. Laurie, Richard M. Goldberg, Thomas E. Witzig, and Stephen N. Thibodeau
Clin Cancer Res 2006 12: 2738-2744. [Abstract] [Full Text] [PDF]  

Preferential Nuclear and Cytoplasmic NY-BR-1 Protein Expression in Primary Breast Cancer and Lymph Node Metastases

Zsuzsanna Varga, Jean-Philippe Theurillat, Valeriy Filonenko, Bernd Sasse, Bernhard Odermatt, Achim A. Jungbluth, Yao-Tseng Chen, Lloyd J. Old, Alexander Knuth, Dirk Jäger, and Holger Moch
Clin Cancer Res 2006 12: 2745-2751. [Abstract] [Full Text] [PDF]  

Biological Characteristics in Bladder Cancer Depend on the Type of Genetic Instability

Yoshiaki Yamamoto, Hideyasu Matsuyama, Shigeto Kawauchi, Tomoko Furuya, Xiu Ping Liu, Kenzo Ikemoto, Atsunori Oga, Katsusuke Naito, and Kohsuke Sasaki
Clin Cancer Res 2006 12: 2752-2758. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Inflammatory Biomarkers for Persistent Fatigue in Breast Cancer Survivors

Alicia Collado-Hidalgo, Julienne E. Bower, Patricia A. Ganz, Steve W. Cole, and Michael R. Irwin
Clin Cancer Res 2006 12: 2759-2766. [Abstract] [Full Text] [PDF]  

Expression of Novel Molecules, MICAL2-PV (MICAL2 Prostate Cancer Variants), Increases with High Gleason Score and Prostate Cancer Progression

Shingo Ashida, Mutsuo Furihata, Toyomasa Katagiri, Kenji Tamura, Yoshio Anazawa, Hiroki Yoshioka, Tsuneharu Miki, Tomoaki Fujioka, Taro Shuin, Yusuke Nakamura, and Hidewaki Nakagawa
Clin Cancer Res 2006 12: 2767-2773. [Abstract] [Full Text] [PDF]  

Class III ß-Tubulin Overexpression Is a Marker of Poor Clinical Outcome in Advanced Ovarian Cancer Patients

Gabriella Ferrandina, Gian Franco Zannoni, Enrica Martinelli, Amelia Paglia, Valerio Gallotta, Simona Mozzetti, Giovanni Scambia, and Cristiano Ferlini
Clin Cancer Res 2006 12: 2774-2779. [Abstract] [Full Text] [PDF]  

N-Cadherin as a Novel Prognostic Marker of Progression in Superficial Urothelial Tumors

Isabelle Lascombe, Anne Clairotte, Sylvie Fauconnet, Stéphane Bernardini, Hervé Wallerand, Bernadette Kantelip, and Hugues Bittard
Clin Cancer Res 2006 12: 2780-2787. [Abstract] [Full Text] [PDF]  

Prognostic DNA Methylation Biomarkers in Ovarian Cancer

Susan H. Wei, Curtis Balch, Henry H. Paik, Yoo-Sung Kim, Rae Lynn Baldwin, Sandya Liyanarachchi, Lang Li, Zailong Wang, Joseph C. Wan, Ramana V. Davuluri, Beth Y. Karlan, Gillian Gifford, Robert Brown, Sun Kim, Tim H-M. Huang, and Kenneth P. Nephew
Clin Cancer Res 2006 12: 2788-2794. [Abstract] [Full Text] [PDF] Supplementary Data  

Overexpression of Both CXC Chemokine Receptor 4 and Vascular Endothelial Growth Factor Proteins Predicts Early Distant Relapse in Stage II-III Colorectal Cancer Patients

Alessandro Ottaiano, Renato Franco, Annarita Aiello Talamanca, Giuseppina Liguori, Fabiana Tatangelo, Paolo Delrio, Guglielmo Nasti, Emiddio Barletta, Gaetano Facchini, Bruno Daniele, Arturo Di Blasi, Maria Napolitano, Caterina Ieranò, Rosa Calemma, Enrico Leonardi, Vittorio Albino, Valentina De Angelis, Marzia Falanga, Vincenzo Boccia, Maurizio Capuozzo, Valerio Parisi, Gerardo Botti, Giuseppe Castello, Rosario Vincenzo Iaffaioli, and Stefania Scala
Clin Cancer Res 2006 12: 2795-2803. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Minimal Residual Disease in Hairy Cell Leukemia Patients Assessed by Clone-Specific Polymerase Chain Reaction

Evgeny Arons, Inger Margulies, Lynn Sorbara, Mark Raffeld, Maryalice Stetler-Stevenson, Ira Pastan, and Robert J. Kreitman
Clin Cancer Res 2006 12: 2804-2811. [Abstract] [Full Text] [PDF]  

Effect of Calcitriol on Prostate-Specific Antigen In vitro and in Humans

Tomasz M. Beer, Mark Garzotto, Byung Park, Motomi Mori, Anne Myrthue, Nicole Janeba, David Sauer, and Kristine Eilers
Clin Cancer Res 2006 12: 2812-2816. [Abstract] [Full Text] [PDF]  

A Phase I/II Trial Testing Immunization of Hepatocellular Carcinoma Patients with Dendritic Cells Pulsed with Four -Fetoprotein Peptides

Lisa H. Butterfield, Antoni Ribas, Vivian B. Dissette, Yohan Lee, Jin Quan Yang, Pilar De la Rocha, Sonia D. Duran, Jackie Hernandez, Elisabeth Seja, Douglas M. Potter, William H. McBride, Richard Finn, John A. Glaspy, and James S. Economou
Clin Cancer Res 2006 12: 2817-2825. [Abstract] [Full Text] [PDF]  

Tumor-Specific CD8+ T Cell Reactivity in the Sentinel Lymph Node of GM-CSF–Treated Stage I Melanoma Patients is Associated with High Myeloid Dendritic Cell Content

Ronald J.C.L.M. Vuylsteke, Barbara G. Molenkamp, Paul A.M. van Leeuwen, Sybren Meijer, Pepijn G.J.T.B. Wijnands, John B.A.G. Haanen, Rik J. Scheper, and Tanja D. de Gruijl
Clin Cancer Res 2006 12: 2826-2833. [Abstract] [Full Text] [PDF]  

The Pharmacokinetics and Safety of ABT-751, a Novel, Orally Bioavailable Sulfonamide Antimitotic Agent: Results of a Phase 1 Study

Kenneth R. Hande, Anne Hagey, Jordan Berlin, Yingna Cai, Kysa Meek, Hiro Kobayashi, A. Craig Lockhart, Diane Medina, Jeffrey Sosman, Gary B. Gordon, and Mace L. Rothenberg
Clin Cancer Res 2006 12: 2834-2840. [Abstract] [Full Text] [PDF]  

A Phase I Study of a New Nucleoside Analogue, OSI-7836, Using Two Administration Schedules in Patients with Advanced Solid Malignancies

Chooi P. Lee, Maja J.A. de Jonge, Anne E. O'Donnell, Kristel L. Schothorst, Janet Hanwell, Jon B. Chick, Rik A. Brooimans, Laurel M. Adams, Daniel W. Drolet, Johann S. de Bono, Stan B. Kaye, Ian R. Judson, and Jaap Verweij
Clin Cancer Res 2006 12: 2841-2848. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Antisense Oligonucleotide Inhibition of Tumor Necrosis Factor Receptor 1 Protects the Liver from Radiation-Induced Apoptosis

Xiao W. Huang, Jiong Yang, Aleksandar F. Dragovic, Hong Zhang, Theodore S. Lawrence, and Ming Zhang
Clin Cancer Res 2006 12: 2849-2855. [Abstract] [Full Text] [PDF]  

Antitumor Efficacy of Edotecarin as a Single Agent and in Combination with Chemotherapy Agents in a Xenograft Model

Marina Ciomei, Valter Croci, Antonella Ciavolella, Dario Ballinari, and Enrico Pesenti
Clin Cancer Res 2006 12: 2856-2861. [Abstract] [Full Text] [PDF] Supplementary Data  

Bisphosphonates Inhibit the Growth of Mesothelioma Cells In vitro and In vivo

Savita Wakchoure, Melinda A. Merrell, Wayne Aldrich, Telisha Millender-Swain, Kevin W. Harris, Pierre Triozzi, and Katri S. Selander
Clin Cancer Res 2006 12: 2862-2868. [Abstract] [Full Text] [PDF]  

Enhanced Gene Transfer and Oncolysis of Head and Neck Cancer and Melanoma Cells by Fiber Chimeric Oncolytic Adenoviruses

P. Seshidhar Reddy, Shanthi Ganesh, and De-Chao Yu
Clin Cancer Res 2006 12: 2869-2878. [Abstract] [Full Text] [PDF]  

Nonfucosylated Therapeutic IgG1 Antibody Can Evade the Inhibitory Effect of Serum Immunoglobulin G on Antibody-Dependent Cellular Cytotoxicity through its High Binding to FcRIIIa

Shigeru Iida, Hirofumi Misaka, Miho Inoue, Mami Shibata, Ryosuke Nakano, Naoko Yamane-Ohnuki, Masako Wakitani, Keiichi Yano, Kenya Shitara, and Mitsuo Satoh
Clin Cancer Res 2006 12: 2879-2887. [Abstract] [Full Text] [PDF]  

Angiotensin II Type 1 Receptor Antagonist Candesartan as an Angiogenic Inhibitor in a Xenograft Model of Bladder Cancer

Michio Kosugi, Akira Miyajima, Eiji Kikuchi, Yutaka Horiguchi, and Masaru Murai
Clin Cancer Res 2006 12: 2888-2893. [Abstract] [Full Text] [PDF]  

A Disaccharide-Based Inhibitor of Glycosylation Attenuates Metastatic Tumor Cell Dissemination

Jillian R. Brown, Mark M. Fuster, Ruixia Li, Nissi Varki, Charles A. Glass, and Jeffrey D. Esko
Clin Cancer Res 2006 12: 2894-2901. [Abstract] [Full Text] [PDF]  

The Combination of the Proteasome Inhibitor Bortezomib and the Bcl-2 Antisense Molecule Oblimersen Sensitizes Human B-Cell Lymphomas to Cyclophosphamide

Owen A. O'Connor, Emily A. Smith, Lorraine E. Toner, Julie Teruya-Feldstein, Stanley Frankel, Mark Rolfe, Xiaohui Wei, Shujun Liu, Guido Marcucci, Kenneth K. Chan, and Asher Chanan-Khan
Clin Cancer Res 2006 12: 2902-2911. [Abstract] [Full Text] [PDF]  

In vitro and In vivo Radiosensitization Induced by the Ribonucleotide Reductase Inhibitor Triapine (3-Aminopyridine-2-Carboxaldehyde-Thiosemicarbazone)

Christopher A. Barker, William E. Burgan, Donna J. Carter, David Cerna, David Gius, Melinda G. Hollingshead, Kevin Camphausen, and Philip J. Tofilon
Clin Cancer Res 2006 12: 2912-2918. [Abstract] [Full Text] [PDF]  

Systemic Oncolytic Herpes Virus Therapy of Poorly Immunogenic Prostate Cancer Metastatic to Lung

Susan Varghese, Samuel D. Rabkin, Petur G. Nielsen, Wenzheng Wang, and Robert L. Martuza
Clin Cancer Res 2006 12: 2919-2927. [Abstract] [Full Text] [PDF]  

PUMA Sensitizes Lung Cancer Cells to Chemotherapeutic Agents and Irradiation

Jian Yu, Wen Yue, Bin Wu, and Lin Zhang
Clin Cancer Res 2006 12: 2928-2936. [Abstract] [Full Text] [PDF]  

Gefitinib Inhibits the Growth and Invasion of Urothelial Carcinoma Cell Lines in which Akt and MAPK Activation Is Dependent on Constitutive Epidermal Growth Factor Receptor Activation

Gaëlle Nicolle, Ahmad Daher, Pascale Maillé, Marcel Vermey, Sylvain Loric, Ashraf Bakkar, Hervé Wallerand, Dimitrios Vordos, Francis Vacherot, Sixtina Gil Diez de Medina, Claude C. Abbou, Theodore Van der Kwast, Jean-Paul Thiery, François Radvanyi, and Dominique K. Chopin
Clin Cancer Res 2006 12: 2937-2943. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Pilot Study of Oral Silibinin, a Putative Chemopreventive Agent, in Colorectal Cancer Patients: Silibinin Levels in Plasma, Colorectum, and Liver and Their Pharmacodynamic Consequences

Carmen Hoh, David Boocock, Tim Marczylo, Rajinder Singh, David P. Berry, Ashley R. Dennison, David Hemingway, Andrew Miller, Kevin West, Stephanie Euden, Giuseppe Garcea, Peter B. Farmer, William P. Steward, and Andreas J. Gescher
Clin Cancer Res 2006 12: 2944-2950. [Abstract] [Full Text] [PDF]  

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