Editors Note:

Introducing CCR Practice of Translational Oncology

James L. Abbruzzese
Clin Cancer Res 2006 12: 1657. [Full Text] [PDF]  

CCR Practice of Translational Oncology:

From Bedside to Bench to Bedside to Clinical Practice: An Odyssey with Irinotecan

Mark J. Ratain
Clin Cancer Res 2006 12: 1658-1660. [Full Text] [PDF]  

The Biology Behind:

Is BRAF the Achilles' Heel of Thyroid Cancer?

Antonio Chiloeches and Richard Marais
Clin Cancer Res 2006 12: 1661-1664. [Full Text] [PDF]  

Molecular Pathways:

Mechanisms Underlying the Development of Androgen-Independent Prostate Cancer

Kenneth J. Pienta and Deborah Bradley
Clin Cancer Res 2006 12: 1665-1671. [Full Text] [PDF]  

Human Cancer Biology:

Structural and Functional Features of the B-Cell Receptor in IgG-Positive Chronic Lymphocytic Leukemia

Kathleen N. Potter, C. Ian Mockridge, Louise Neville, Isla Wheatley, Michael Schenk, Jennifer Orchard, Andrew S. Duncombe, Graham Packham, and Freda K. Stevenson
Clin Cancer Res 2006 12: 1672-1679. [Abstract] [Full Text] [PDF]  

Somatic Mutations of Epidermal Growth Factor Receptor in Bile Duct and Gallbladder Carcinoma

Francesco Leone, Giuliana Cavalloni, Ymera Pignochino, Ivana Sarotto, Renato Ferraris, Wanda Piacibello, Tiziana Venesio, Lorenzo Capussotti, Mauro Risio, and Massimo Aglietta
Clin Cancer Res 2006 12: 1680-1685. [Abstract] [Full Text] [PDF]  

Cyclooxygenase 2 Expression in Colorectal Cancer with DNA Mismatch Repair Deficiency

Antoni Castells, Artemio Payá, Cristina Alenda, Francisco Rodríguez-Moranta, Rubén Agrelo, Montserrat Andreu, Virgínia Piñol, Sergi Castellví-Bel, Rodrigo Jover, Xavier Llor, Elisenda Pons, J. Ignasi Elizalde, Xavier Bessa, Javier Alcedo, Joan Saló, Enrique Medina, Antonio Naranjo, Manel Esteller, Josep M. Piqué for the Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Clin Cancer Res 2006 12: 1686-1692. [Abstract] [Full Text] [PDF]  

Characterization of Familial Non-BRCA1/2 Breast Tumors by Loss of Heterozygosity and Immunophenotyping

Rogier A. Oldenburg, Karin Kroeze-Jansema, Hanne Meijers-Heijboer, Cristi J. van Asperen, Nicoline Hoogerbrugge, Inge van Leeuwen, Hans F.A. Vasen, Anne-Marie Cleton-Jansen, Jaennelle Kraan, Jeanine J. Houwing-Duistermaat, Hans Morreau, Cees J. Cornelisse, and Peter Devilee
Clin Cancer Res 2006 12: 1693-1700. [Abstract] [Full Text] [PDF]  

Neosquamous Epithelium Does Not Typically Arise from Barrett's Epithelium

Thomas G. Paulson, Lianjun Xu, Carissa Sanchez, Patricia L. Blount, Kamran Ayub, Robert D. Odze, and Brian J. Reid
Clin Cancer Res 2006 12: 1701-1706. [Abstract] [Full Text] [PDF]  

The Clinical Relevance of Stromal Matrix Metalloproteinase Expression in Ovarian Cancer

Aparna A. Kamat, Mavis Fletcher, Lynn M. Gruman, Peter Mueller, Adriana Lopez, Charles N. Landen, Jr., Liz Han, David M. Gershenson, and Anil K. Sood
Clin Cancer Res 2006 12: 1707-1714. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

HER2-Positive Circulating Tumor Cells Indicate Poor Clinical Outcome in Stage I to III Breast Cancer Patients

Pia Wülfing, Julia Borchard, Horst Buerger, Stefan Heidl, Kurt S. Zänker, Ludwig Kiesel, and Burkhard Brandt
Clin Cancer Res 2006 12: 1715-1720. [Abstract] [Full Text] [PDF]  

Reproducibility of Gene Expression Signature–Based Predictions in Replicate Experiments

Keith Anderson, Kenneth R. Hess, Mini Kapoor, Stephen Tirrell, Jean Courtemanche, Bailiang Wang, Yun Wu, Yun Gong, Gabriel N. Hortobagyi, W. Fraser Symmans, and Lajos Pusztai
Clin Cancer Res 2006 12: 1721-1727. [Abstract] [Full Text] [PDF] Supplementary Data  

Prognostic Relevance of AGR2 Expression in Breast Cancer

Florian Rudolf Fritzsche, Edgar Dahl, Stefan Pahl, Mick Burkhardt, Jun Luo, Empar Mayordomo, Tserenchunt Gansukh, Anja Dankof, Ruth Knuechel, Carsten Denkert, Klaus-Jürgen Winzer, Manfred Dietel, and Glen Kristiansen
Clin Cancer Res 2006 12: 1728-1734. [Abstract] [Full Text] [PDF]  

Computer-Assisted Analysis of Biopsy Specimen Microvessels Predicts the Outcome of Esophageal Cancers Treated with Chemoradiotherapy

Shi-chuan Zhang, Shuichi Hironaka, Atsushi Ohtsu, Shigeaki Yoshida, Takahiro Hasebe, Masashi Fukayama, and Atsushi Ochiai
Clin Cancer Res 2006 12: 1735-1742. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Polyclonal Evolution of Multiple Secondary KIT Mutations in Gastrointestinal Stromal Tumors under Treatment with Imatinib Mesylate

Eva Wardelmann, Sabine Merkelbach-Bruse, Katharina Pauls, Nadja Thomas, Hans-Ulrich Schildhaus, Thomas Heinicke, Nicola Speidel, Torsten Pietsch, Reinhard Buettner, Daniel Pink, Peter Reichardt, and Peter Hohenberger
Clin Cancer Res 2006 12: 1743-1749. [Abstract] [Full Text] [PDF]  

A Phase I Clinical Trial of the hu14.18-IL2 (EMD 273063) as a Treatment for Children with Refractory or Recurrent Neuroblastoma and Melanoma: a Study of the Children's Oncology Group

Kaci L. Osenga, Jacquelyn A. Hank, Mark R. Albertini, Jacek Gan, Adam G. Sternberg, Jens Eickhoff, Robert C. Seeger, Katherine K. Matthay, C. Patrick Reynolds, Clare Twist, Mark Krailo, Peter C. Adamson, Ralph A. Reisfeld, Stephen D. Gillies, and Paul M. Sondel
Clin Cancer Res 2006 12: 1750-1759. [Abstract] [Full Text] [PDF]  

Phase I Trial with BMS-275183, a Novel Oral Taxane with Promising Antitumor Activity

Linda E. Bröker, Filip Y.F.L. de Vos, Cees J. van Groeningen, Bart C. Kuenen, Helen E. Gall, Michael H. Woo, Maurizio Voi, Jourik A. Gietema, Elisabeth G.E. de Vries, and Giuseppe Giaccone
Clin Cancer Res 2006 12: 1760-1767. [Abstract] [Full Text] [PDF]  

A Phase I Trial of Vaccination of CA9-Derived Peptides for HLA-A24-Positive Patients with Cytokine-Refractory Metastatic Renal Cell Carcinoma

Hirotsugu Uemura, Kiyohide Fujimoto, Motoyoshi Tanaka, Motoyoshi Yoshikawa, Yoshihiko Hirao, Shigeya Uejima, Kazuhiro Yoshikawa, and Kyogo Itoh
Clin Cancer Res 2006 12: 1768-1775. [Abstract] [Full Text] [PDF]  

5,6-Dimethylxanthenone-4-Acetic Acid in the Treatment of Refractory Tumors: a Phase I Safety Study of a Vascular Disrupting Agent

Mark J. McKeage, Peter Fong, Mark Jeffery, Bruce C. Baguley, Phil Kestell, Miroslav Ravic, and Michael B. Jameson
Clin Cancer Res 2006 12: 1776-1784. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Inhibitors of Raf Kinase Activity Block Growth of Thyroid Cancer Cells with RET/PTC or BRAF Mutations In vitro and In vivo

Bin Ouyang, Jeffrey A. Knauf, Eric P. Smith, Lei Zhang, Tim Ramsey, Naeem Yusuff, David Batt, and James A. Fagin
Clin Cancer Res 2006 12: 1785-1793. [Abstract] [Full Text] [PDF]  

Gemcitabine Pharmacogenomics: Cytidine Deaminase and Deoxycytidylate Deaminase Gene Resequencing and Functional Genomics

Judith A. Gilbert, Oreste E. Salavaggione, Yuan Ji, Linda L. Pelleymounter, Bruce W. Eckloff, Eric D. Wieben, Matthew M. Ames, and Richard M. Weinshilboum
Clin Cancer Res 2006 12: 1794-1803. [Abstract] [Full Text] [PDF] Supplementary Data  

Mobilization of Bone Marrow Stem Cells by Granulocyte Colony-Stimulating Factor Ameliorates Radiation-Induced Damage to Salivary Glands

Isabelle M.A. Lombaert, Pieter K. Wierenga, Tineke Kok, Harm H. Kampinga, Gerald deHaan, and Robert P. Coppes
Clin Cancer Res 2006 12: 1804-1812. [Abstract] [Full Text] [PDF]  

Immunotherapy of Tumors with Protein Vaccine Based on Chicken Homologous Tie-2

Yan Luo, Yan-Jun Wen, Zhen-Yu Ding, Chun-Hua Fu, Yang Wu, Ji-Yan Liu, Qiu Li, Qiu-Ming He, Xia Zhao, Yu Jiang, Jiong Li, Hong-Xin Deng, Bin Kang, Yong-Qiu Mao, and Yu-Quan Wei
Clin Cancer Res 2006 12: 1813-1819. [Abstract] [Full Text] [PDF]  

Ingenuity Network-Assisted Transcription Profiling: Identification of a New Pharmacologic Mechanism for MK886

Anatoly L. Mayburd, Alfredo Martlínez, Daniel Sackett, Huaitian Liu, Joanna Shih, Jordy Tauler, Ingalill Avis, and James L. Mulshine
Clin Cancer Res 2006 12: 1820-1827. [Abstract] [Full Text] [PDF] Supplementary Data  

A Synthetic Triterpenoid, CDDO-Me, Inhibits IB Kinase and Enhances Apoptosis Induced by TNF and Chemotherapeutic Agents through Down-Regulation of Expression of Nuclear Factor B–Regulated Gene Products in Human Leukemic Cells

Shishir Shishodia, Gautam Sethi, Marina Konopleva, Michael Andreeff, and Bharat B. Aggarwal
Clin Cancer Res 2006 12: 1828-1838. [Abstract] [Full Text] [PDF]  

The Vascular Targeting Property of Paclitaxel Is Enhanced by SU6668, a Receptor Tyrosine Kinase Inhibitor, Causing Apoptosis of Endothelial Cells and Inhibition of Angiogenesis

Elitza Naumova, Paolo Ubezio, Angela Garofalo, Patrizia Borsotti, Linda Cassis, Elena Riccardi, Eugenio Scanziani, Suzanne A. Eccles, Maria R. Bani, and Raffaella Giavazzi
Clin Cancer Res 2006 12: 1839-1849. [Abstract] [Full Text] [PDF]  

Irinotecan Inactivation Is Modulated by Epigenetic Silencing of UGT1A1 in Colon Cancer

Jean-François Gagnon, Olivier Bernard, Lyne Villeneuve, Bernard Têtu, and Chantal Guillemette
Clin Cancer Res 2006 12: 1850-1858. [Abstract] [Full Text] [PDF]  

Enhanced Killing of Primary Ovarian Cancer by Retargeting Autologous Cytokine-Induced Killer Cells with Bispecific Antibodies: A Preclinical Study

John K. Chan, Chad A. Hamilton, Michael K. Cheung, Mobin Karimi, Jeanette Baker, Jonathan M. Gall, Stephan Schulz, Steve H. Thorne, Nelson N. Teng, Christopher H. Contag, Lawrence G. Lum, and Robert S. Negrin
Clin Cancer Res 2006 12: 1859-1867. [Abstract] [Full Text] [PDF]  

Dual Therapy of Ovarian Cancer Using Measles Viruses Expressing Carcinoembryonic Antigen and Sodium Iodide Symporter

Kosei Hasegawa, Linh Pham, Michael K. O'Connor, Mark J. Federspiel, Stephen J. Russell, and Kah-Whye Peng
Clin Cancer Res 2006 12: 1868-1875. [Abstract] [Full Text] [PDF]  

Tumor Epithelial Cell Matrix Metalloproteinase 9 Is a Target for Antimetastatic Therapy in Colorectal Cancer

Wilhelm J. Lubbe, Zengyi Y. Zhou, Weili Fu, David Zuzga, Stephanie Schulz, Rafael Fridman, Ruth J. Muschel, Scott A. Waldman, and Giovanni M. Pitari
Clin Cancer Res 2006 12: 1876-1882. [Abstract] [Full Text] [PDF]  

Effects of HIV Protease Inhibitor Ritonavir on Akt-Regulated Cell Proliferation in Breast Cancer

Anjaiah Srirangam, Ranjana Mitra, Mu Wang, J. Christopher Gorski, Sunil Badve, LeeAnn Baldridge, Justin Hamilton, Hiromitsu Kishimoto, John Hawes, Lang Li, Christie M. Orschell, Edward F. Srour, Janice S. Blum, David Donner, George W. Sledge, Harikrishna Nakshatri, and David A. Potter
Clin Cancer Res 2006 12: 1883-1896. [Abstract] [Full Text] [PDF]  

Combination Chemotherapy and Radiation of Human Squamous Cell Carcinoma of the Head and Neck Augments CTL-Mediated Lysis

Alexander Gelbard, Charlie T. Garnett, Scott I. Abrams, Vyomesh Patel, J. Silvio Gutkind, Claudia Palena, Kwong-Yok Tsang, Jeffrey Schlom, and James W. Hodge
Clin Cancer Res 2006 12: 1897-1905. [Abstract] [Full Text] [PDF]  

Intraperitoneal Immunotherapy for Metastatic Ovarian Carcinoma: Resistance of Intratumoral Collagen to Antibody Penetration

Jaehwa Choi, Kimberly Credit, Karla Henderson, Ravi Deverkadra, Zhi He, Helge Wiig, Heather Vanpelt, and Michael F. Flessner
Clin Cancer Res 2006 12: 1906-1912. [Abstract] [Full Text] [PDF]  

Reduced Toxicity and Superior Therapeutic Activity of a Mitomycin C Lipid-Based Prodrug Incorporated in Pegylated Liposomes

Alberto A. Gabizon, Dinah Tzemach, Aviva T. Horowitz, Hilary Shmeeda, Jerry Yeh, and Samuel Zalipsky
Clin Cancer Res 2006 12: 1913-1920. [Abstract] [Full Text] [PDF]  

In vitro Stimulation of CD8 and CD4 T Cells by Dendritic Cells Loaded with a Complex of Cholesterol-Bearing Hydrophobized Pullulan and NY-ESO-1 Protein: Identification of a New HLA-DR15–Binding CD4 T-Cell Epitope

Kosei Hasegawa, Yuji Noguchi, Fumihito Koizumi, Akiko Uenaka, Motoyuki Tanaka, Michihide Shimono, Hideo Nakamura, Hiroshi Shiku, Sacha Gnjatic, Roger Murphy, Yuji Hiramatsu, Lloyd J. Old, and Eiichi Nakayama
Clin Cancer Res 2006 12: 1921-1927. [Abstract] [Full Text] [PDF]  

Albendazole: a Potent Inhibitor of Vascular Endothelial Growth Factor and Malignant Ascites Formation in OVCAR-3 Tumor-Bearing Nude Mice

Mohammad Hossein Pourgholami, Zhao Yan Cai, Ying Lu, Lisa Wang, and David Lawson Morris
Clin Cancer Res 2006 12: 1928-1935. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Estrogen Receptor ß Polymorphism Is Associated with Prostate Cancer Risk

Camilla Thellenberg-Karlsson, Sara Lindström, Beatrice Malmer, Fredrik Wiklund, Katarina Augustsson-Bälter, Hans-Olov Adami, Par Stattin, Maria Nilsson, Karin Dahlman-Wright, Jan-Åke Gustafsson, and Henrik Grönberg
Clin Cancer Res 2006 12: 1936-1941. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: Cecchin et al., Carboxylesterase Isoform 2 mRNA Expression in Peripheral Blood Mononuclear Cells Is a Predictive Marker of the Irinotecan to SN38 Activation Step in Colorectal Cancer Patients. Clin Cancer Res 2005;11:6901–7

Balram Chowbay, Srinivas Rao Jada, and Darren Lim Wan Teck
Clin Cancer Res 2006 12: 1942. [Full Text] [PDF]  

Reply to the Letter to the Editor from Chowbay et al

Erika Cecchin, Giuseppe Corona, and Giuseppe Toffoli
Clin Cancer Res 2006 12: 1942. [Full Text] [PDF]  

No Universally Applicable Thermal Dose Descriptor

Jacoba van der Zee, Gerard C. van Rhoon, and Paul J.M. Rietveld
Clin Cancer Res 2006 12: 1943-1944. [Full Text] [PDF]  

A Clinically Proven, Prospective, Thermal Dose Descriptor Exists

Donald E. Thrall, Mark W. Dewhirst, Ellen L. Jones, Zeljko Vujaskovic, Daohai Yu, and Oana I. Craciunescu
Clin Cancer Res 2006 12: 1944-1945. [Full Text] [PDF]  

Corrections:

Article on Overexpression of Peptidyl-Prolyl Isomerase Like-1 Association with Colon Cancer Cell Growth

Clin Cancer Res 2006 12: 1947. [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.