The Biology Behind:

Does Prostate-Specific Antigen Contribute to Bone Metastases?

John M. Chirgwin and Theresa A. Guise
Clin Cancer Res 2006 12: 1395-1397. [Full Text] [PDF]  

Molecular Pathways:

Treatment for Advanced Tumors: Src Reclaims Center Stage

Justin M. Summy and Gary E. Gallick
Clin Cancer Res 2006 12: 1398-1401. [Full Text] [PDF]  

Human Cancer Biology:

Oncogenic Property of Acrogranin in Human Uterine Leiomyosarcoma: Direct Evidence of Genetic Contribution in In vivo Tumorigenesis

Noriomi Matsumura, Masaki Mandai, Masanori Miyanishi, Ken Fukuhara, Tsukasa Baba, Toshihiro Higuchi, Masatoshi Kariya, Kenji Takakura, and Shingo Fujii
Clin Cancer Res 2006 12: 1402-1411. [Abstract] [Full Text] [PDF]  

Aberrant Methylation and Deacetylation of Deleted in Liver Cancer-1 Gene in Prostate Cancer: Potential Clinical Applications

Ming Guan, Xiaoling Zhou, Nikolaos Soulitzis, Demetrios A. Spandidos, and Nicholas C. Popescu
Clin Cancer Res 2006 12: 1412-1419. [Abstract] [Full Text] [PDF]  

Prostate-Specific Antigen Modulates Genes Involved in Bone Remodeling and Induces Osteoblast Differentiation of Human Osteosarcoma Cell Line SaOS-2

Nagalakshmi Nadiminty, Wei Lou, Soo Ok Lee, Farideh Mehraein-Ghomi, Jason S. Kirk, Jeffrey M. Conroy, Haitao Zhang, and Allen C. Gao
Clin Cancer Res 2006 12: 1420-1430. [Abstract] [Full Text] [PDF] Supplementary Data  

Kinetics of Metastatic Breast Cancer Cell Trafficking in Bone

Pushkar A. Phadke, Robyn R. Mercer, John F. Harms, Yujiang Jia, Andra R. Frost, Jennifer L. Jewell, Karen M. Bussard, Shakira Nelson, Cynthia Moore, John C. Kappes, Carol V. Gay, Andrea M. Mastro, and Danny R. Welch
Clin Cancer Res 2006 12: 1431-1440. [Abstract] [Full Text] [PDF]  

PIK3CA Mutations in Head and Neck Squamous Cell Carcinoma

Wanglong Qiu, Frank Schönleben, Xiaojun Li, Daniel J. Ho, Lanny G. Close, Spiros Manolidis, Boyce P. Bennett, and Gloria H. Su
Clin Cancer Res 2006 12: 1441-1446. [Abstract] [Full Text] [PDF]  

Increased Expression of Leptin and the Leptin Receptor as a Marker of Breast Cancer Progression: Possible Role of Obesity-Related Stimuli

Cecilia Garofalo, Mariusz Koda, Sandra Cascio, Mariola Sulkowska, Luiza Kanczuga-Koda, Jolanta Golaszewska, Antonio Russo, Stanislaw Sulkowski, and Eva Surmacz
Clin Cancer Res 2006 12: 1447-1453. [Abstract] [Full Text] [PDF]  

Refinement of the 22q12-q13 Breast Cancer–Associated Region: Evidence of TMPRSS6 as a Candidate Gene in an Eastern Finnish Population

Jaana M. Hartikainen, Hanna Tuhkanen, Vesa Kataja, Matti Eskelinen, Matti Uusitupa, Veli-Matti Kosma, and Arto Mannermaa
Clin Cancer Res 2006 12: 1454-1462. [Abstract] [Full Text] [PDF]  

The Lysyl Oxidase LOX Is Absent in Basal and Squamous Cell Carcinomas and Its Knockdown Induces an Invading Phenotype in a Skin Equivalent Model

Charbel Bouez, Caroline Reynaud, Emmanuelle Noblesse, Amélie Thépot, Claudine Gleyzal, Jean Kanitakis, Eric Perrier, Odile Damour, and Pascal Sommer
Clin Cancer Res 2006 12: 1463-1469. [Abstract] [Full Text] [PDF]  

The Cytoskeleton Regulatory Protein hMena (ENAH) Is Overexpressed in Human Benign Breast Lesions with High Risk of Transformation and Human Epidermal Growth Factor Receptor-2–Positive/Hormonal Receptor–Negative Tumors

Francesca Di Modugno, Marcella Mottolese, Anna Di Benedetto, Andrea Conidi, Flavia Novelli, Letizia Perracchio, Irene Venturo, Claudio Botti, Elke Jager, Angela Santoni, Pier Giorgio Natali, and Paola Nisticò
Clin Cancer Res 2006 12: 1470-1478. [Abstract] [Full Text] [PDF] Supplementary Data  

Metastasis Tumor Antigen Family Proteins during Breast Cancer Progression and Metastasis in a Reliable Mouse Model for Human Breast Cancer

Hao Zhang, L. Clifton Stephens, and Rakesh Kumar
Clin Cancer Res 2006 12: 1479-1486. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Human Kallikrein 8 Protein Is a Favorable Prognostic Marker in Ovarian Cancer

Carla A. Borgoño, Tadaaki Kishi, Andreas Scorilas, Nadia Harbeck, Julia Dorn, Barbara Schmalfeldt, Manfred Schmitt, and Eleftherios P. Diamandis
Clin Cancer Res 2006 12: 1487-1493. [Abstract] [Full Text] [PDF]  

Expression of DNA Double-Strand Break Repair Proteins ATM and BRCA1 Predicts Survival in Colorectal Cancer

Heike Grabsch, Mit Dattani, Lisa Barker, Nicola Maughan, Karen Maude, Olaf Hansen, Helmut E. Gabbert, Phil Quirke, and Wolfram Mueller
Clin Cancer Res 2006 12: 1494-1500. [Abstract] [Full Text] [PDF]  

Changes of Topoisomerase II Expression in Breast Tumors after Neoadjuvant Chemotherapy Predicts Relapse-Free Survival

Nicola Tinari, Rossano Lattanzio, Clara Natoli, Ettore Cianchetti, Domenico Angelucci, Enrico Ricevuto, Corrado Ficorella, Paolo Marchetti, Saverio Alberti, Mauro Piantelli, Stefano Iacobelli on behalf of the Consorzio Interuniversitario Nazionale per la Bioncologia
Clin Cancer Res 2006 12: 1501-1506. [Abstract] [Full Text] [PDF]  

An Evaluation of Tumor Oxygenation and Gene Expression in Patients with Early Stage Non–Small Cell Lung Cancers

Quynh-Thu Le, Eunice Chen, Ali Salim, Hongbin Cao, Christina S. Kong, Richard Whyte, Jessica Donington, Walter Cannon, Heather Wakelee, Robert Tibshirani, John D. Mitchell, Donna Richardson, Ken J. O'Byrne, Albert C. Koong, and Amato J. Giaccia
Clin Cancer Res 2006 12: 1507-1514. [Abstract] [Full Text] [PDF]  

Defective Antitumor Function of Monocyte-Derived Macrophages from Epithelial Ovarian Cancer Patients

Ilyssa O. Gordon and Ralph S. Freedman
Clin Cancer Res 2006 12: 1515-1524. [Abstract] [Full Text] [PDF]  

Inhibition of Vascular Endothelial Growth Factor (VEGF)-A Causes a Paradoxical Increase in Tumor Blood Flow and Up-Regulation of VEGF-D

Bradford A. Moffat, Mark Chen, Muhammed S.T. Kariaapper, Daniel A. Hamstra, Daniel E. Hall, Jadranka Stojanovska, Timothy D. Johnson, Mila Blaivas, Mahesh Kumar, Thomas L. Chenevert, Alnawaz Rehemtulla, and Brian D. Ross
Clin Cancer Res 2006 12: 1525-1532. [Abstract] [Full Text] [PDF]  

Prognostic Significance of Basal-Like Phenotype and Fascin Expression in Node-Negative Invasive Breast Carcinomas

Socorro María Rodríguez-Pinilla, David Sarrió, Emiliano Honrado, David Hardisson, Francisco Calero, Javier Benitez, and José Palacios
Clin Cancer Res 2006 12: 1533-1539. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Phase I Trial of Intrathecal Spartaject Busulfan in Children with Neoplastic Meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004)

Sridharan Gururangan, William P. Petros, Tina Young Poussaint, Michael L. Hancock, Peter C. Phillips, Henry S. Friedman, Lisa Bomgaars, Susan M. Blaney, Larry E. Kun, and James M. Boyett
Clin Cancer Res 2006 12: 1540-1546. [Abstract] [Full Text] [PDF]  

Increased MDR1 Expression in Normal and Malignant Peripheral Blood Mononuclear Cells Obtained from Patients Receiving Depsipeptide (FR901228, FK228, NSC630176)

Robert W. Robey, Zhirong Zhan, Richard L. Piekarz, Ganesh L. Kayastha, Tito Fojo, and Susan E. Bates
Clin Cancer Res 2006 12: 1547-1555. [Abstract] [Full Text] [PDF]  

A Randomized Phase II Trial of the Matrix Metalloproteinase Inhibitor BMS-275291 in Hormone-Refractory Prostate Cancer Patients with Bone Metastases

Primo N. Lara, Jr., Walter M. Stadler, Jeff Longmate, David I. Quinn, Jason Wexler, Marta Van Loan, Przemyslaw Twardowski, Paul H. Gumerlock, Nicholas J. Vogelzang, Everett E. Vokes, Heinz Josef Lenz, James H. Doroshow, and David R. Gandara
Clin Cancer Res 2006 12: 1556-1563. [Abstract] [Full Text] [PDF]  

Decreased Mitochondrial DNA Content in Posttreatment Salivary Rinses from Head and Neck Cancer Patients

Wei-Wen Jiang, Eli Rosenbaum, Elizabeth Mambo, Marianna Zahurak, Brett Masayesva, Andre Lopes Carvalho, Shaoyu Zhou, William H. Westra, Anthony J. Alberg, David Sidransky, Wayne Koch, and Joseph A. Califano
Clin Cancer Res 2006 12: 1564-1569. [Abstract] [Full Text] [PDF]  

Neoadjuvant Concurrent Paclitaxel and Radiation in Stage II/III Breast Cancer

A. Bapsi Chakravarthy, Mark C. Kelley, Bernadette McLaren, Cristina I. Truica, Dean Billheimer, Ingrid A. Mayer, Ana M. Grau, David H. Johnson, Jean F. Simpson, R. Daniel Beauchamp, Catherine Jones, and Jennifer A. Pietenpol
Clin Cancer Res 2006 12: 1570-1576. [Abstract] [Full Text] [PDF]  

Lomeguatrib, a Potent Inhibitor of O⁶-Alkylguanine-DNA-Alkyltransferase: Phase I Safety, Pharmacodynamic, and Pharmacokinetic Trial and Evaluation in Combination with Temozolomide in Patients with Advanced Solid Tumors

Malcolm Ranson, Mark R. Middleton, John Bridgewater, Siow Ming Lee, Martin Dawson, Debra Jowle, Gavin Halbert, Sue Waller, Helen McGrath, Lindsey Gumbrell, R. Stanley McElhinney, Dorothy Donnelly, T. Brian H. McMurry, and Geoffrey P. Margison
Clin Cancer Res 2006 12: 1577-1584. [Abstract] [Full Text] [PDF]  

Phase I Study of STX 64 (667 Coumate) in Breast Cancer Patients: The First Study of a Steroid Sulfatase Inhibitor

Susannah J. Stanway, Atul Purohit, L.W. Lawrence Woo, Saulat Sufi, David Vigushin, Rebecca Ward, Richard H. Wilson, Frank Z. Stanczyk, Nicola Dobbs, Elena Kulinskaya, Moira Elliott, Barry V.L. Potter, Michael J. Reed, and R. Charles Coombes
Clin Cancer Res 2006 12: 1585-1592. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Recombinant Human Mullerian Inhibiting Substance Inhibits Long-term Growth of MIS Type II Receptor–Directed Transgenic Mouse Ovarian Cancers In vivo

Rafael Pieretti-Vanmarcke, Patricia K. Donahoe, Paul Szotek, Thomas Manganaro, Mary K. Lorenzen, James Lorenzen, Denise C. Connolly, Elkan F. Halpern, and David T. MacLaughlin
Clin Cancer Res 2006 12: 1593-1598. [Abstract] [Full Text] [PDF]  

Avidity-Mediated Enhancement of In vivo Tumor Targeting by Single-Chain Fv Dimers

Gregory P. Adams, Mei-Sheng Tai, John E. McCartney, James D. Marks, Walter F. Stafford, III, L.L. Houston, James S. Huston, and Louis M. Weiner
Clin Cancer Res 2006 12: 1599-1605. [Abstract] [Full Text] [PDF]  

Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models

Thomas Schluep, Jungyeong Hwang, Jianjun Cheng, Jeremy D. Heidel, Derek W. Bartlett, Beth Hollister, and Mark E. Davis
Clin Cancer Res 2006 12: 1606-1614. [Abstract] [Full Text] [PDF]  

Radiosensitization of Squamous Cell Carcinoma by the Alkylphospholipid Perifosine in Cell Culture and Xenografts

Stefan R. Vink, Saskia Lagerwerf, Elly Mesman, Jan H.M. Schellens, Adrian C. Begg, Wim J. van Blitterswijk, and Marcel Verheij
Clin Cancer Res 2006 12: 1615-1622. [Abstract] [Full Text] [PDF]  

BRAF Is a Therapeutic Target in Aggressive Thyroid Carcinoma

Giuliana Salvatore, Valentina De Falco, Paolo Salerno, Tito Claudio Nappi, Stefano Pepe, Giancarlo Troncone, Francesca Carlomagno, Rosa Marina Melillo, Scott M. Wilhelm, and Massimo Santoro
Clin Cancer Res 2006 12: 1623-1629. [Abstract] [Full Text] [PDF]  

YM-359445, an Orally Bioavailable Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor, Has Highly Potent Antitumor Activity against Established Tumors

Nobuaki Amino, Yukitaka Ideyama, Mayumi Yamano, Sadao Kuromitsu, Katsuinori Tajinda, Kiyohiro Samizu, Hiroyuki Hisamichi, Akira Matsuhisa, Kenna Shirasuna, Masafumi Kudoh, and Masayuki Shibasaki
Clin Cancer Res 2006 12: 1630-1638. [Abstract] [Full Text] [PDF]  

Stomatin-like Protein 2 Is Overexpressed in Cancer and Involved in Regulating Cell Growth and Cell Adhesion in Human Esophageal Squamous Cell Carcinoma

Liyong Zhang, Fang Ding, Wenfeng Cao, Zhongmin Liu, Wei Liu, Zaicheng Yu, Yu Wu, Wendong Li, Yanda Li, and Zhihua Liu
Clin Cancer Res 2006 12: 1639-1646. [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Prevention:

Distinct Epidermal Growth Factor Receptor and KRAS Mutation Patterns in Non–Small Cell Lung Cancer Patients with Different Tobacco Exposure and Clinicopathologic Features

Issan Yee San Tam, Lap Ping Chung, Wai Sing Suen, Elaine Wang, May C.M. Wong, Kok Keung Ho, Wah Kit Lam, Shui Wah Chiu, Luc Girard, John D. Minna, Adi F. Gazdar, and Maria P. Wong
Clin Cancer Res 2006 12: 1647-1653. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

SMAD4 Levels and Allelic Imbalance in 18q21 in Colorectal Cancer

Toshiaki Watanabe, Takamitsu Kanazawa, Yoshihiro Kazama, Junichiro Tanaka, Toshiaki Tanaka, Soichiro Ishihara, and Hirokazu Nagawa
Clin Cancer Res 2006 12: 1654. [Full Text] [PDF]  

Reply to the Letter to the Editor by Watanabe et al.

Diego Arango, Pia Alhopuro, and Lauri A. Aaltonen
Clin Cancer Res 2006 12: 1654-1655. [Full Text] [PDF]  

Corrections:

Article on Synovial Sarcoma X Antigens in Epithelial Ovarian Cancer

Clin Cancer Res 2006 12: 1656. [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.