The Biology Behind:

Well-Defined Melanoma Antigens as Progression Markers for Melanoma: Insights into Differential Expression and Host Response Based on Stage

F. Stephen Hodi
Clin Cancer Res 2006 12: 673-678. [Full Text] [PDF]  

Review:

Handicapping the Race to Develop Inhibitors of the Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin Pathway

Courtney A. Granville, Regan M. Memmott, Joell J. Gills, and Phillip A. Dennis
Clin Cancer Res 2006 12: 679-689. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Expression Profiling of Mucinous Tumors of the Ovary Identifies Genes of Clinicopathologic Importance

Fred W. Wamunyokoli, Tomas Bonome, Ji-Young Lee, Colleen M. Feltmate, William R. Welch, Mike Radonovich, Cindy Pise-Masison, John Brady, Ke Hao, Ross S. Berkowitz, Samuel Mok, and Michael J. Birrer
Clin Cancer Res 2006 12: 690-700. [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Expression Differences Associated with Human Papillomavirus Status in Head and Neck Squamous Cell Carcinoma

Robbert J.C. Slebos, Yajun Yi, Kim Ely, Jesse Carter, Amy Evjen, Xueqiong Zhang, Yu Shyr, Barbara M. Murphy, Anthony J. Cmelak, Brian B. Burkey, James L. Netterville, Shawn Levy, Wendell G. Yarbrough, and Christine H. Chung
Clin Cancer Res 2006 12: 701-709. [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Context of the EGFR Mutations: Evidence for the Activation of mTOR/S6K Signaling

Esther Conde, Barbara Angulo, Moying Tang, Manuel Morente, Juan Torres-Lanzas, Angel Lopez-Encuentra, Fernando Lopez-Rios, and Montserrat Sanchez-Cespedes
Clin Cancer Res 2006 12: 710-717. [Abstract] [Full Text] [PDF]  

Cytotoxic Markers and Frequency Predict Functional Capacity of Natural Killer Cells Infiltrating Renal Cell Carcinoma

Julia S. Schleypen, Nicole Baur, Robert Kammerer, Peter J. Nelson, Karl Rohrmann, Elisabeth F. Gröne, Markus Hohenfellner, Axel Haferkamp, Heike Pohla, Dolores J. Schendel, Christine S. Falk, and Elfriede Noessner
Clin Cancer Res 2006 12: 718-725. [Abstract] [Full Text] [PDF]  

ZAP-70 Expression in Normal Pro/Pre B Cells, Mature B Cells, and in B-Cell Acute Lymphoblastic Leukemia

Marta Crespo, Neus Villamor, Eva Giné, Ana Muntañola, Dolors Colomer, Teresa Marafioti, Margaret Jones, Mireia Camós, Elias Campo, Emili Montserrat, and Francesc Bosch
Clin Cancer Res 2006 12: 726-734. [Abstract] [Full Text] [PDF]  

Homeodomain-Interacting Protein Kinase-2 Restrains Cytosolic Phospholipase A₂–Dependent Prostaglandin E₂ Generation in Human Colorectal Cancer Cells

Gabriella D'Orazi, Maria Gina Sciulli, Valeria Di Stefano, Sabrina Riccioni, Milo Frattini, Rita Falcioni, Lucio Bertario, Ada Sacchi, and Paola Patrignani
Clin Cancer Res 2006 12: 735-741. [Abstract] [Full Text] [PDF]  

Purification and Characterization of Human Kallikrein 11, a Candidate Prostate and Ovarian Cancer Biomarker, from Seminal Plasma

Liu-Ying Luo, Shannon J.C. Shan, Marc B. Elliott, Antoninus Soosaipillai, and Eleftherios P. Diamandis
Clin Cancer Res 2006 12: 742-750. [Abstract] [Full Text] [PDF]  

A Rapid and Sensitive Enzymatic Method for Epidermal Growth Factor Receptor Mutation Screening

Pasi A. Jänne, Ana M. Borras, Yanan Kuang, Andrew M. Rogers, Victoria A. Joshi, Hema Liyanage, Neal Lindeman, Jeffrey C. Lee, Balazs Halmos, Elizabeth A. Maher, Robert J. Distel, Matthew Meyerson, and Bruce E. Johnson
Clin Cancer Res 2006 12: 751-758. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

The GNAS1 T393C Polymorphism Predicts Survival in Patients with Clear Cell Renal Cell Carcinoma

Ulrich H. Frey, Gerd Lümmen, Tobias Jäger, Karl-Heinz Jöckel, Kurt W. Schmid, Herbert Rübben, Norbert Müller, Winfried Siffert, and Andreas Eisenhardt
Clin Cancer Res 2006 12: 759-763. [Abstract] [Full Text] [PDF]  

Tumor Antigen Expression in Melanoma Varies According to Antigen and Stage

Catherine Barrow, Judy Browning, Duncan MacGregor, Ian D. Davis, Sue Sturrock, Achim A. Jungbluth, and Jonathan Cebon
Clin Cancer Res 2006 12: 764-771. [Abstract] [Full Text] [PDF]  

The Cytogenetic Relationship between Primary and Recurrent Meningiomas Points to the Need for New Treatment Strategies in Cases at High Risk of Relapse

Ana Belén Espinosa, María Dolores Tabernero, Angel Maíllo, José María Sayagués, Juana Ciudad, Marta Merino, Maria Carmen Alguero, Anne Marie Lubombo, Pablo Sousa, Angel Santos-Briz, and Alberto Orfao
Clin Cancer Res 2006 12: 772-780. [Abstract] [Full Text] [PDF]  

Molecular Subtyping of Breast Cancer from Traditional Tumor Marker Profiles Using Parallel Clustering Methods

Federico Ambrogi, Elia Biganzoli, Patrizia Querzoli, Stefano Ferretti, Patrizia Boracchi, Saverio Alberti, Ettore Marubini, and Italo Nenci
Clin Cancer Res 2006 12: 781-790. [Abstract] [Full Text] [PDF]  

Proteomic Analysis of Malignant Ovarian Cancer Effusions as a Tool for Biologic and Prognostic Profiling

Ben Davidson, Virginia Espina, Seth M. Steinberg, Vivi Ann Flørenes, Lance A. Liotta, Gunnar B. Kristensen, Claes G. Tropé, Aasmund Berner, and Elise C. Kohn
Clin Cancer Res 2006 12: 791-799. [Abstract] [Full Text] [PDF] Supplementary Data  

Lymphangiogenesis and Angiogenesis in Bladder Cancer: Prognostic Implications and Regulation by Vascular Endothelial Growth Factors-A, -C, and -D

Yasuyoshi Miyata, Shigeru Kanda, Kojiro Ohba, Koichiro Nomata, Yasushi Hayashida, Jiro Eguchi, Tomayoshi Hayashi, and Hiroshi Kanetake
Clin Cancer Res 2006 12: 800-806. [Abstract] [Full Text] [PDF]  

Plasma Levels of Trefoil Factors are Increased in Patients with Advanced Prostate Cancer

Else Marie Vestergaard, Michael Borre, Steen Seier Poulsen, Ebba Nexø, and Niels Tørring
Clin Cancer Res 2006 12: 807-812. [Abstract] [Full Text] [PDF] Supplementary Data  

Optical Coherence Tomography: Real-time Imaging of Bronchial Airways Microstructure and Detection of Inflammatory/Neoplastic Morphologic Changes

Suzanne C. Whiteman, Ying Yang, Daniel Gey van Pittius, Mark Stephens, Jitendra Parmer, and Monica A. Spiteri
Clin Cancer Res 2006 12: 813-818. [Abstract] [Full Text] [PDF]  

Gene Expression Profiles of Multiple Breast Cancer Phenotypes and Response to Neoadjuvant Chemotherapy

Holly K. Dressman, Christopher Hans, Andrea Bild, John A. Olson, Eric Rosen, P. Kelly Marcom, Vlayka B. Liotcheva, Ellen L. Jones, Zeljko Vujaskovic, Jeffrey Marks, Mark W. Dewhirst, Mike West, Joseph R. Nevins, and Kimberly Blackwell
Clin Cancer Res 2006 12: 819-826. [Abstract] [Full Text] [PDF] Supplementary Data  

Diffuse Mesothelin Expression Correlates with Prolonged Patient Survival in Ovarian Serous Carcinoma

M. Jim Yen, Chih-Yi Hsu, Tsui-Lien Mao, T-C. Wu, Richard Roden, Tian-Li Wang, and Ie-Ming Shih
Clin Cancer Res 2006 12: 827-831. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

A Phase II Trial of Pemetrexed in Advanced Breast Cancer: Clinical Response and Association with Molecular Target Expression

Henry L. Gomez, Sergio L. Santillana, Carlos S. Vallejos, Raul Velarde, Juvenal Sanchez, Xinpeng Wang, Nancy L. Bauer, Richard D. Hockett, Victor J. Chen, Clet Niyikiza, and Axel R. Hanauske
Clin Cancer Res 2006 12: 832-838. [Abstract] [Full Text] [PDF]  

Clinical Course of Patients with Non–Small Cell Lung Cancer and Epidermal Growth Factor Receptor Exon 19 and Exon 21 Mutations Treated with Gefitinib or Erlotinib

Gregory J. Riely, William Pao, DuyKhanh Pham, Allan R. Li, Naiyer Rizvi, Ennapadam S. Venkatraman, Maureen F. Zakowski, Mark G. Kris, Marc Ladanyi, and Vincent A. Miller
Clin Cancer Res 2006 12: 839-844. [Abstract] [Full Text] [PDF]  

Herceptin Sensitizes ErbB2–Overexpressing Cells to Apoptosis by Reducing Antiapoptotic Mcl-1 Expression

Elizabeth S. Henson, Xiaojie Hu, and Spencer B. Gibson
Clin Cancer Res 2006 12: 845-853. [Abstract] [Full Text] [PDF]  

mdr-1 Single Nucleotide Polymorphisms in Ovarian Cancer Tissue: G2677T/A Correlates with Response to Paclitaxel Chemotherapy

Henrik Gréen, Peter Söderkvist, Per Rosenberg, György Horvath, and Curt Peterson
Clin Cancer Res 2006 12: 854-859. [Abstract] [Full Text] [PDF]  

Phase 1 Trial of Gefitinib Plus Sirolimus in Adults with Recurrent Malignant Glioma

David A. Reardon, Jennifer A. Quinn, James J. Vredenburgh, Sridharan Gururangan, Allan H. Friedman, Annick Desjardins, Sith Sathornsumetee, James E. Herndon, II, Jeannette M. Dowell, Roger E. McLendon, James M. Provenzale, John H. Sampson, Robert P. Smith, Alan J. Swaisland, Judith S. Ochs, Peggy Lyons, Sandy Tourt-Uhlig, Darell D. Bigner, Henry S. Friedman, and Jeremy N. Rich
Clin Cancer Res 2006 12: 860-868. [Abstract] [Full Text] [PDF]  

Mannan-MUC1–Pulsed Dendritic Cell Immunotherapy: A Phase I Trial in Patients with Adenocarcinoma

Bruce E. Loveland, Anne Zhao, Shane White, Hui Gan, Kate Hamilton, Pei-Xiang Xing, Geoffrey A. Pietersz, Vasso Apostolopoulos, Hilary Vaughan, Vaios Karanikas, Peter Kyriakou, Ian F.C. McKenzie, and Paul L.R. Mitchell
Clin Cancer Res 2006 12: 869-877. [Abstract] [Full Text] [PDF]  

Combination of p53 Cancer Vaccine with Chemotherapy in Patients with Extensive Stage Small Cell Lung Cancer

Scott J. Antonia, Noweeda Mirza, Ingo Fricke, Alberto Chiappori, Patricia Thompson, Nicholas Williams, Gerold Bepler, George Simon, William Janssen, Ji-Hyun Lee, Kerstin Menander, Sunil Chada, and Dmitry I. Gabrilovich
Clin Cancer Res 2006 12: 878-887. [Abstract] [Full Text] [PDF]  

A Metabolic Study of Patients with Lung Cancer and Hyponatremia of Malignancy

John P. Chute, Elizabeth Taylor, John Williams, Frederic Kaye, David Venzon, and Bruce E. Johnson
Clin Cancer Res 2006 12: 888-896. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

²¹³Bi-[DOTA⁰, Tyr³]Octreotide Peptide Receptor Radionuclide Therapy of Pancreatic Tumors in a Preclinical Animal Model

Jeffrey P. Norenberg, Boudewijn J. Krenning, Inge R.H.M. Konings, Donna F. Kusewitt, Tapan K. Nayak, Tamara L. Anderson, Marion de Jong, Kayhan Garmestani, Martin W. Brechbiel, and Larry K. Kvols
Clin Cancer Res 2006 12: 897-903. [Abstract] [Full Text] [PDF]  

Strategies for Delaying or Treating In vivo Acquired Resistance to Trastuzumab in Human Breast Cancer Xenografts

Jeanne M. du Manoir, Giulio Francia, Shan Man, Miriam Mossoba, Jeffrey A. Medin, Alicia Viloria-Petit, Daniel J. Hicklin, Urban Emmenegger, and Robert S. Kerbel
Clin Cancer Res 2006 12: 904-916. [Abstract] [Full Text] [PDF]  

Tumor Vascular Permeabilization by Vascular-Targeting Photosensitization: Effects, Mechanism, and Therapeutic Implications

Bin Chen, Brian W. Pogue, Jorge M. Luna, Rulon L. Hardman, P. Jack Hoopes, and Tayyaba Hasan
Clin Cancer Res 2006 12: 917-923. [Abstract] [Full Text] [PDF]  

The Schedule-Dependent Effects of the Novel Antifolate Pralatrexate and Gemcitabine Are Superior to Methotrexate and Cytarabine in Models of Human Non-Hodgkin's Lymphoma

Lorraine E. Toner, Radovan Vrhovac, Emily A. Smith, Jeffrey Gardner, Mark Heaney, Mithat Gonen, Julie Teruya-Feldstein, Frank Sirotnak, and Owen A. O'Connor
Clin Cancer Res 2006 12: 924-932. [Abstract] [Full Text] [PDF]  

Lovastatin Protects Human Endothelial Cells from Killing by Ionizing Radiation without Impairing Induction and Repair of DNA Double-Strand Breaks

Tobias Nübel, Julia Damrot, Wynand P. Roos, Bernd Kaina, and Gerhard Fritz
Clin Cancer Res 2006 12: 933-939. [Abstract] [Full Text] [PDF]  

Histone Deacetylase Inhibitor–Mediated Radiosensitization of Human Cancer Cells: Class Differences and the Potential Influence of p53

In Ah Kim, Jin Hee Shin, Il Han Kim, Jin Ho Kim, Jae Sung Kim, Hong Gyun Wu, Eui Kyu Chie, Sung Whan Ha, Charn Il Park, and Gary D. Kao
Clin Cancer Res 2006 12: 940-949. [Abstract] [Full Text] [PDF] Supplementary Data  

BMS-345541 Targets Inhibitor of B Kinase and Induces Apoptosis in Melanoma: Involvement of Nuclear Factor B and Mitochondria Pathways

Jinming Yang, Katayoun I. Amiri, James R. Burke, Johannes A. Schmid, and Ann Richmond
Clin Cancer Res 2006 12: 950-960. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Risk Stratification of Colon Carcinogenesis through Enhanced Backscattering Spectroscopy Analysis of the Uninvolved Colonic Mucosa

Hemant K. Roy, Young L. Kim, Yang Liu, Ramesh K. Wali, Michael J. Goldberg, Vladimir Turzhitsky, Jonathan Horwitz, and Vadim Backman
Clin Cancer Res 2006 12: 961-968. [Abstract] [Full Text] [PDF]  

Chemoprevention of Skin Carcinogenesis by Phenylretinamides: Retinoid Receptor–Independent Tumor Suppression

Hui Xu, Satish Cheepala, Elisabeth McCauley, Kevin Coombes, Lianchun Xiao, Susan M. Fischer, and John L. Clifford
Clin Cancer Res 2006 12: 969-979. [Abstract] [Full Text] [PDF]  

2-Methoxyestradiol Inhibits Prostate Tumor Development in Transgenic Adenocarcinoma of Mouse Prostate: Role of Tumor Necrosis Factor-–Stimulated Gene 6

Gretchen E. Garcia, Hans-Georg Wisniewski, M. Scott Lucia, Nicole Arevalo, Thomas J. Slaga, Susan L. Kraft, Robert Strange, and Addanki P. Kumar
Clin Cancer Res 2006 12: 980-988. [Abstract] [Full Text] [PDF]  

High Levels of Aberrant DNA Methylation in Helicobacter pylori–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk

Takao Maekita, Kazuyuki Nakazawa, Mami Mihara, Takeshi Nakajima, Kimihiko Yanaoka, Mikitaka Iguchi, Kenji Arii, Atsushi Kaneda, Tetsuya Tsukamoto, Masae Tatematsu, Gen Tamura, Daizo Saito, Takashi Sugimura, Masao Ichinose, and Toshikazu Ushijima
Clin Cancer Res 2006 12: 989-995. [Abstract] [Full Text] [PDF] Supplementary Data  

Corrections:

Article on Quantification of Plasma ß-catenin mRNA

Clin Cancer Res 2006 12: 996. [Full Text] [PDF]  

Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer:

Proceedings of the Fifth International Conference on Recent Advances and Future Directions in Endocrine Therapy for Breast Cancer: Conference Summary Statement

Steven E. Come, Aman U. Buzdar, James N. Ingle, Carlos L. Arteaga, Myles Brown, Mitch Dowsett, Susan G. Hilsenbeck, Rakesh Kumar, Stephen R.D. Johnston, Adrian V. Lee, Soonmyung Paik, Kathleen I. Pritchard, Eric P. Winer, and Carol Hart
Clin Cancer Res 2006 12: 997s-1000s. [Full Text] [PDF]  

Novel Mechanisms of Resistance to Endocrine Therapy: Genomic and Nongenomic Considerations

Anupama E. Gururaj, Suresh K. Rayala, Ratna K. Vadlamudi, and Rakesh Kumar
Clin Cancer Res 2006 12: 1001s-1007s. [Abstract] [Full Text] [PDF]  

ErbB Receptor Signaling and Therapeutic Resistance to Aromatase Inhibitors

Incheol Shin, Todd Miller, and Carlos L. Arteaga
Clin Cancer Res 2006 12: 1008s-1012s. [Abstract] [Full Text] [PDF]  

Progesterone Receptor Loss Correlates with Human Epidermal Growth Factor Receptor 2 Overexpression in Estrogen Receptor–Positive Breast Cancer

Hyun-Jung Kim, Xiaojiang Cui, Susan G. Hilsenbeck, and Adrian V. Lee
Clin Cancer Res 2006 12: 1013s-1018s. [Abstract] [Full Text] [PDF]  

Methods for Gene Expression Profiling in Clinical Trials of Adjuvant Breast Cancer Therapy

Soonmyung Paik
Clin Cancer Res 2006 12: 1019s-1023s. [Abstract] [Full Text] [PDF]  

Proliferation and Apoptosis as Markers of Benefit in Neoadjuvant Endocrine Therapy of Breast Cancer

Mitch Dowsett, Ian E. Smith, Steve R. Ebbs, J. Michael Dixon, Anthony Skene, Clive Griffith, Irene Boeddinghaus, Janine Salter, Simone Detre, Margaret Hills, Susan Ashley, Stephen Francis, Geraldine Walsh, and Roger A'Hern
Clin Cancer Res 2006 12: 1024s-1030s. [Abstract] [Full Text] [PDF]  

Adjuvant Endocrine Therapy for Postmenopausal Women with Early Breast Cancer

James N. Ingle
Clin Cancer Res 2006 12: 1031s-1036s. [Abstract] [Full Text] [PDF]  

Anastrozole as an Adjuvant Endocrine Treatment for Postmenopausal Patients with Breast Cancer: Emerging Data

Aman U. Buzdar and Jack Cuzick
Clin Cancer Res 2006 12: 1037s-1048s. [Abstract] [Full Text] [PDF]  

Is There a Role for Adjuvant Tamoxifen in Progesterone Receptor–Positive Breast Cancer? An In silico Clinical Trial

Susan G. Hilsenbeck and C. Kent Osborne
Clin Cancer Res 2006 12: 1049s-1055s. [Abstract] [Full Text] [PDF]  

Managing Patients on Endocrine Therapy: Focus on Quality-of-Life Issues

Timothy J. Whelan and Kathleen I. Pritchard
Clin Cancer Res 2006 12: 1056s-1060s. [Abstract] [Full Text] [PDF]  

Clinical Efforts to Combine Endocrine Agents with Targeted Therapies against Epidermal Growth Factor Receptor/Human Epidermal Growth Factor Receptor 2 and Mammalian Target of Rapamycin in Breast Cancer

Stephen R.D. Johnston
Clin Cancer Res 2006 12: 1061s-1068s. [Abstract] [Full Text] [PDF]  

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