Editorials:

Circulating Tumor Cells in Breast Cancer: Blood Will Tell

George W. Sledge, Jr.
Clin Cancer Res 2006 12: 6321-6322. [Full Text] [PDF]  

The Biology Behind:

Is the Type I Insulin-Like Growth Factor Receptor a Therapeutic Target in Endometrial Cancer?

Hua Zhang and Douglas Yee
Clin Cancer Res 2006 12: 6323-6325. [Full Text] [PDF]  

Molecular Pathways:

Advances in Targeting Human Epidermal Growth Factor Receptor-2 Signaling for Cancer Therapy

Funda Meric-Bernstam and Mien-Chie Hung
Clin Cancer Res 2006 12: 6326-6330. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Attractin Is Elevated in the Cerebrospinal Fluid of Patients with Malignant Astrocytoma and Mediates Glioma Cell Migration

Fatima W. Khwaja, Jonathan S. Duke-Cohan, Daniel J. Brat, and Erwin G. Van Meir
Clin Cancer Res 2006 12: 6331-6336. [Abstract] [Full Text] [PDF] Supplementary Data  

Metastasis-Suppressing Potential of Ribonucleotide Reductase Small Subunit p53R2 in Human Cancer Cells

Xiyong Liu, Bingsen Zhou, Lijun Xue, Jennifer Shih, Karen Tye, Wesley Lin, Christina Qi, Peiguo Chu, Frank Un, Wei Wen, and Yun Yen
Clin Cancer Res 2006 12: 6337-6344. [Abstract] [Full Text] [PDF]  

Acceleration of Telomere Loss by Chemotherapy Is Greater in Older Patients with Locally Advanced Head and Neck Cancer

Brad M. Unryn, Desiree Hao, Stefan Glück, and Karl T. Riabowol
Clin Cancer Res 2006 12: 6345-6350. [Abstract] [Full Text] [PDF]  

Activation of Hypoxia-Inducible Factor-1 Is Necessary for Lysophosphatidic Acid–Induced Vascular Endothelial Growth Factor Expression

Jangsoon Lee, Soon Young Park, Eun Kyung Lee, Chang Gyo Park, Hyun Cheol Chung, Sun Young Rha, Yong Kee Kim, Gyu-Un Bae, Bum Kyeong Kim, Jeung-Whan Han, and Hoi Young Lee
Clin Cancer Res 2006 12: 6351-6358. [Abstract] [Full Text] [PDF] Supplementary Data  

Distribution of GPR30, a Seven Membrane–Spanning Estrogen Receptor, in Primary Breast Cancer and its Association with Clinicopathologic Determinants of Tumor Progression

Edward J. Filardo, Carl T. Graeber, Jeffrey A. Quinn, Murray B. Resnick, Dilip Giri, Ronald A. DeLellis, Margaret M. Steinhoff, and Edmond Sabo
Clin Cancer Res 2006 12: 6359-6366. [Abstract] [Full Text] [PDF]  

Identification of the Decay-Accelerating Factor CD55 as a Peanut Agglutinin–Binding Protein and Its Alteration in Non–Small Cell Lung Cancers

Mitsunori Higuchi, Yuichi Endo, Hiroyuki Suzuki, Fumihiko Osuka, Yutaka Shio, Koichi Fujiu, Ryuzo Kanno, Akio Oishi, Teizo Fujita, and Mitsukazu Gotoh
Clin Cancer Res 2006 12: 6367-6372. [Abstract] [Full Text] [PDF]  

Overexpression of the Insulin-Like Growth Factor I Receptor and Activation of the AKT Pathway in Hyperplastic Endometrium

Adrienne S. McCampbell, Russell R. Broaddus, David S. Loose, and Peter J.A. Davies
Clin Cancer Res 2006 12: 6373-6378. [Abstract] [Full Text] [PDF]  

Chromosomal Instability in Microsatellite-Unstable and Stable Colon Cancer

Karolin Trautmann, Jonathan P. Terdiman, Amy J. French, Ritu Roydasgupta, Nancy Sein, Sanjay Kakar, Jane Fridlyand, Antoine M. Snijders, Donna G. Albertson, Stephen N. Thibodeau, and Frederic M. Waldman
Clin Cancer Res 2006 12: 6379-6385. [Abstract] [Full Text] [PDF] Supplementary Data  

RUNX3 Inhibits the Expression of Vascular Endothelial Growth Factor and Reduces the Angiogenesis, Growth, and Metastasis of Human Gastric Cancer

Zhihai Peng, Daoyan Wei, Liwei Wang, Huamei Tang, Jun Zhang, Xiangdong Le, Zhiliang Jia, Qiang Li, and Keping Xie
Clin Cancer Res 2006 12: 6386-6394. [Abstract] [Full Text] [PDF]  

Loss of Krüppel-Like Factor 4 Expression Contributes to Sp1 Overexpression and Human Gastric Cancer Development and Progression

Masashi Kanai, Daoyan Wei, Qiang Li, Zhiliang Jia, Jaffer Ajani, Xiangdong Le, James Yao, and Keping Xie
Clin Cancer Res 2006 12: 6395-6402. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Circulating Tumor Cells versus Imaging—Predicting Overall Survival in Metastatic Breast Cancer

G. Thomas Budd, Massimo Cristofanilli, Mathew J. Ellis, Allison Stopeck, Ernest Borden, M. Craig Miller, Jeri Matera, Madeline Repollet, Gerald V. Doyle, Leon W.M.M. Terstappen, and Daniel F. Hayes
Clin Cancer Res 2006 12: 6403-6409. [Abstract] [Full Text] [PDF]  

Reduced Expression of the Breast Cancer Metastasis Suppressor 1 mRNA Is Correlated with Poor Progress in Breast Cancer

Zhenhuan Zhang, Hiroko Yamashita, Tatsuya Toyama, Yutaka Yamamoto, Teru Kawasoe, and Hirotaka Iwase
Clin Cancer Res 2006 12: 6410-6414. [Abstract] [Full Text] [PDF]  

Proteomics-Based Approach Identifying Autoantibody against Peroxiredoxin VI as a Novel Serum Marker in Esophageal Squamous Cell Carcinoma

Yoshihisa Fujita, Toyofumi Nakanishi, Masako Hiramatsu, Hideaki Mabuchi, Yoshiharu Miyamoto, Akiko Miyamoto, Akira Shimizu, and Nobuhiko Tanigawa
Clin Cancer Res 2006 12: 6415-6420. [Abstract] [Full Text] [PDF]  

CA IX is an Independent Prognostic Marker in Premenopausal Breast Cancer Patients with One to Three Positive Lymph Nodes and a Putative Marker of Radiation Resistance

Donal J. Brennan, Karin Jirstrom, Åsa Kronblad, Robert C. Millikan, Goran Landberg, Michael J. Duffy, Lisa Rydén, William M. Gallagher, and Sallyann L. O'Brien
Clin Cancer Res 2006 12: 6421-6431. [Abstract] [Full Text] [PDF] Supplementary Data  

Prognostic Value of Apoptosis in Rectal Cancer Patients of the Dutch Total Mesorectal Excision Trial: Radiotherapy Is Redundant in Intrinsically High-Apoptotic Tumors

Elza C. de Bruin, Cornelis J.H. van de Velde, Simone van de Pas, Iris D. Nagtegaal, J. Han J.M. van Krieken, Marleen J.E.M. Gosens, Lucy T.C. Peltenburg, Jan Paul Medema, and Corrie A.M. Marijnen
Clin Cancer Res 2006 12: 6432-6436. [Abstract] [Full Text] [PDF]  

Sequential Positron Emission Tomography Using [¹⁸F]Fluorodeoxyglucose for Monitoring Response to Chemotherapy in Metastatic Breast Cancer

Olivier Couturier, Guy Jerusalem, Jean-Michel N'Guyen, and Roland Hustinx
Clin Cancer Res 2006 12: 6437-6443. [Abstract] [Full Text] [PDF]  

Peroxisome Proliferator-Activated Receptor Is Highly Expressed in Pancreatic Cancer and Is Associated With Shorter Overall Survival Times

Glen Kristiansen, Juliane Jacob, Ann-Christin Buckendahl, Robert Grützmann, Ingo Alldinger, Bence Sipos, Günter Klöppel, Marcus Bahra, Jan M. Langrehr, Peter Neuhaus, Manfred Dietel, and Christian Pilarsky
Clin Cancer Res 2006 12: 6444-6451. [Abstract] [Full Text] [PDF]  

Variants of the hK2 Protein Gene (KLK2) Are Associated with Serum hK2 Levels and Predict the Presence of Prostate Cancer at Biopsy

Robert K. Nam, William W. Zhang, Laurence H. Klotz, John Trachtenberg, Michael A.S. Jewett, Joan Sweet, Ants Toi, Seamus Teahan, Vasundara Venkateswaran, Linda Sugar, Andrew Loblaw, Kathy Siminovitch, and Steven A. Narod
Clin Cancer Res 2006 12: 6452-6458. [Abstract] [Full Text] [PDF]  

Classification of Breast Cancer Using Genetic Algorithms and Tissue Microarrays

Marisa Dolled-Filhart, Lisa Rydén, Melissa Cregger, Karin Jirström, Malini Harigopal, Robert L. Camp, and David L. Rimm
Clin Cancer Res 2006 12: 6459-6468. [Abstract] [Full Text] [PDF] Supplementary Data  

Gastric and Intestinal Phenotypic Marker Expression in Early Differentiated-Type Tumors of the Stomach: Clinicopathologic Significance and Genetic Background

Yusuke Tajima, Kimiyasu Yamazaki, Reiko Makino, Nobukazu Nishino, Shigeo Aoki, Masanori Kato, Koji Morohara, Tsutomu Kaetsu, and Mitsuo Kusano
Clin Cancer Res 2006 12: 6469-6479. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Effect of Chemotherapy on Skeletal Health in Male Survivors from Testicular Cancer and Lymphoma

Janet E. Brown, Sue P. Ellis, Paul Silcocks, Aubrey Blumsohn, Sandra A. Gutcher, Clare Radstone, Barry W. Hancock, Matthew Q. Hatton, and Robert E. Coleman
Clin Cancer Res 2006 12: 6480-6486. [Abstract] [Full Text] [PDF]  

Long-term Events in Adult Patients with Clinical Stage IA-IIA Nonbulky Hodgkin's Lymphoma Treated with Four Cycles of Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine and Adjuvant Radiotherapy: A Single-Institution 15-Year Follow-up

Ercole Brusamolino, Ambrogia Baio, Ester Orlandi, Luca Arcaini, Francesco Passamonti, Vassiliki Griva, William Casagrande, Cristiana Pascutto, Pietro Franchini, and Mario Lazzarino
Clin Cancer Res 2006 12: 6487-6493. [Abstract] [Full Text] [PDF]  

Novel D761Y and Common Secondary T790M Mutations in Epidermal Growth Factor Receptor–Mutant Lung Adenocarcinomas with Acquired Resistance to Kinase Inhibitors

Marissa N. Balak, Yixuan Gong, Gregory J. Riely, Romel Somwar, Allan R. Li, Maureen F. Zakowski, Anne Chiang, Guangli Yang, Ouathek Ouerfelli, Mark G. Kris, Marc Ladanyi, Vincent A. Miller, and William Pao
Clin Cancer Res 2006 12: 6494-6501. [Abstract] [Full Text] [PDF] Supplementary Data  

Flat Dosing of Carboplatin Is Justified in Adult Patients with Normal Renal Function

Corine Ekhart, Milly E. de Jonge, Alwin D.R. Huitema, Jan H.M. Schellens, Sjoerd Rodenhuis, and Jos H. Beijnen
Clin Cancer Res 2006 12: 6502-6508. [Abstract] [Full Text] [PDF]  

A Phase I Study of Single Administration of Antibody-Directed Enzyme Prodrug Therapy with the Recombinant Anti–Carcinoembryonic Antigen Antibody-Enzyme Fusion Protein MFECP1 and a Bis-Iodo Phenol Mustard Prodrug

Astrid Mayer, Roslyn J. Francis, Surinder K. Sharma, Berend Tolner, Caroline J. Springer, Jan Martin, Geoff M. Boxer, James Bell, Alan J. Green, John A. Hartley, Clare Cruickshank, Julie Wren, Kerry A. Chester, and Richard H.J. Begent
Clin Cancer Res 2006 12: 6509-6516. [Abstract] [Full Text] [PDF]  

Pharmacokinetics of Cetuximab After Administration of Escalating Single Dosing and Weekly Fixed Dosing in Patients with Solid Tumors

Antoinette R. Tan, Dirk F. Moore, Manuel Hidalgo, James H. Doroshow, Elizabeth A. Poplin, Susan Goodin, David Mauro, and Eric H. Rubin
Clin Cancer Res 2006 12: 6517-6522. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Increased Safety with Preserved Antitumoral Efficacy on Hepatocellular Carcinoma with Dual-Regulated Oncolytic Adenovirus

Qi Zhang, Guihua Chen, Linhui Peng, Xinghua Wang, Yang Yang, Chen Liu, Wenfang Shi, Changqing Su, Hongping Wu, Xinyuan Liu, Mengchao Wu, and Qijun Qian
Clin Cancer Res 2006 12: 6523-6531. [Abstract] [Full Text] [PDF]  

2-Methoxyestradiol, an Endogenous Mammalian Metabolite, Radiosensitizes Colon Carcinoma Cells through c-Jun NH₂-Terminal Kinase Activation

HuiChao Zou, Masaaki Adachi, Kohzoh Imai, Masato Hareyama, Katsuji Yoshioka, Shiguang Zhao, and Yasuhisa Shinomura
Clin Cancer Res 2006 12: 6532-6539. [Abstract] [Full Text] [PDF]  

Antileukemic Activity of Lysophosphatidic Acid Acyltransferase-ß Inhibitor CT32228 in Chronic Myelogenous Leukemia Sensitive and Resistant to Imatinib

Paul La Rosée, Taiping Jia, Shadmer Demehri, Nicolai Härtel, Peter de Vries, Lynn Bonham, David Hollenback, Jack W. Singer, Junia V. Melo, Brian J. Druker, and Michael W. Deininger
Clin Cancer Res 2006 12: 6540-6546. [Abstract] [Full Text] [PDF] Supplementary Data  

Schedule-Dependent Synergy between the Heat Shock Protein 90 Inhibitor 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin and Doxorubicin Restores Apoptosis to p53-Mutant Lymphoma Cell Lines

Ana I. Robles, Mollie H. Wright, Bheru Gandhi, Steven S. Feis, Christin L. Hanigan, Adrian Wiestner, and Lyuba Varticovski
Clin Cancer Res 2006 12: 6547-6556. [Abstract] [Full Text] [PDF] Supplementary Data  

Synthetic MicroRNA Designed to Target Glioma-Associated Antigen 1 Transcription Factor Inhibits Division and Induces Late Apoptosis in Pancreatic Tumor Cells

Naotake Tsuda, Satoshi Ishiyama, Yufeng Li, Constantin G. Ioannides, James L. Abbruzzese, and David Z. Chang
Clin Cancer Res 2006 12: 6557-6564. [Abstract] [Full Text] [PDF] Supplementary Data  

Hedgehog: an Attribute to Tumor Regrowth after Chemoradiotherapy and a Target to Improve Radiation Response

Jennifer Sims-Mourtada, Julie G. Izzo, Smith Apisarnthanarax, Tsung-Teh Wu, Usha Malhotra, Rajyalashmi Luthra, Zhongxing Liao, Ritsuko Komaki, Albert van der Kogel, Jaffer Ajani, and K.S. Clifford Chao
Clin Cancer Res 2006 12: 6565-6572. [Abstract] [Full Text] [PDF]  

Anti-Vascular Endothelial Growth Factor Receptor-1 Antagonist Antibody as a Therapeutic Agent for Cancer

Yan Wu, Zhaojing Zhong, James Huber, Rajiv Bassi, Bridget Finnerty, Erik Corcoran, Huiling Li, Elizabeth Navarro, Paul Balderes, Xenia Jimenez, Henry Koo, Venkata R.M. Mangalampalli, Dale L. Ludwig, James R. Tonra, and Daniel J. Hicklin
Clin Cancer Res 2006 12: 6573-6584. [Abstract] [Full Text] [PDF]  

Cancer Susceptibility and Prevention:

Genetic Variants of UGT1A6 Influence Risk of Colorectal Adenoma Recurrence

Richard A. Hubner, Kenneth R. Muir, Jo-Fen Liu, Richard F.A. Logan, Matthew Grainge, Nicholas Armitage, Vic Shepherd, Sanjay Popat, Richard S. Houlston the United Kingdom Colorectal Adenoma Prevention Consortium
Clin Cancer Res 2006 12: 6585-6589. [Abstract] [Full Text] [PDF]  

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