Editorials:

Can a Single Pill Replace Doublet Chemotherapy in First-Line Therapy of Advanced Non–Small Cell Lung Cancer?

Paul A. Bunn, Jr.
Clin Cancer Res 2006 12: 5919-5920. [Full Text] [PDF]  

The Biology Behind:

Natural Killer T Cell–Based Cancer Immunotherapy

Hans J.J. van der Vliet, Steven P. Balk, and Mark A. Exley
Clin Cancer Res 2006 12: 5921-5923. [Full Text] [PDF]  

Molecular Pathways:

The Hedgehog Signaling Pathway in Cancer

Marie Evangelista, Hua Tian, and Frederic J. de Sauvage
Clin Cancer Res 2006 12: 5924-5928. [Abstract] [Full Text] [PDF]  

Special Article:

The FLIP-Side of Fas Signaling

Marc L. Hyer, Temesgen Samuel, and John C. Reed
Clin Cancer Res 2006 12: 5929-5931. [Full Text] [PDF]  

Human Cancer Biology:

PIK3CA and PTEN Mutations in Uterine Endometrioid Carcinoma and Complex Atypical Hyperplasia

Monica Prasad Hayes, Hong Wang, Rosanny Espinal-Witter, Wayne Douglas, Garron J. Solomon, Suzanne J. Baker, and Lora Hedrick Ellenson
Clin Cancer Res 2006 12: 5932-5935. [Abstract] [Full Text] [PDF]  

Met Receptor Signaling: A Key Effector in Esophageal Adenocarcinoma

Mark R. Anderson, Rebecca Harrison, Paul A. Atherfold, Moray J. Campbell, S. Jane Darnton, Jolanta Obszynska, and Janusz A.Z Jankowski
Clin Cancer Res 2006 12: 5936-5943. [Abstract] [Full Text] [PDF]  

Gene Expression Signatures Differentiate Ovarian/Peritoneal Serous Carcinoma from Diffuse Malignant Peritoneal Mesothelioma

Ben Davidson, Zhen Zhang, Lilach Kleinberg, Mei Li, Vivi Ann Flørenes, Tian-Li Wang, and Ie-Ming Shih
Clin Cancer Res 2006 12: 5944-5950. [Abstract] [Full Text] [PDF] Supplementary Data  

GRO Is Highly Expressed in Adenocarcinoma of the Colon and Down-Regulates Fibulin-1

Yu Wen, Sarah F. Giardina, David Hamming, Jennifer Greenman, Emmanuel Zachariah, Manny D. Bacolod, Hao Liu, Jinru Shia, Peter S. Amenta, Francis Barany, Phillip Paty, William Gerald, and Daniel Notterman
Clin Cancer Res 2006 12: 5951-5959. [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of a Gene Signature for Rapid Screening of Oral Squamous Cell Carcinoma

Amy F. Ziober, Kirtesh R. Patel, Faizan Alawi, Phyllis Gimotty, Randall S. Weber, Michael M. Feldman, Ara A. Chalian, Gregory S. Weinstein, Jennifer Hunt, and Barry L. Ziober
Clin Cancer Res 2006 12: 5960-5971. [Abstract] [Full Text] [PDF] Supplementary Data  

Carcinoembryonic Antigen Messenger RNA Expression in Blood Predicts Recurrence in Esophageal Cancer

Tetsuro Setoyama, Shoji Natsugoe, Hiroshi Okumura, Masataka Matsumoto, Yasuto Uchikado, Sumiya Ishigami, Tetsuhiro Owaki, Sonshin Takao, and Takashi Aikou
Clin Cancer Res 2006 12: 5972-5977. [Abstract] [Full Text] [PDF]  

The Potential of BORIS Detected in the Leukocytes of Breast Cancer Patients as an Early Marker of Tumorigenesis

Vivien D'Arcy, Ziedulla K. Abdullaev, Naresh Pore, France Docquier, Verónica Torrano, Igor Chernukhin, Melissa Smart, Dawn Farrar, Metodi Metodiev, Nelson Fernandez, Carlos Richard, M. Dolores Delgado, Victor Lobanenkov, and Elena Klenova
Clin Cancer Res 2006 12: 5978-5986. [Abstract] [Full Text] [PDF]  

Expression of Stress Response Protein Grp78 Is Associated with the Development of Castration-Resistant Prostate Cancer

Llana Pootrakul, Ram H. Datar, Shan-Rong Shi, Jie Cai, Debra Hawes, Susan G. Groshen, Amy S. Lee, and Richard J. Cote
Clin Cancer Res 2006 12: 5987-5993. [Abstract] [Full Text] [PDF]  

Biological Role of Estrogen Receptor ß in Salivary Gland Adenocarcinoma Cells

Kazufumi Ohshiro, Suresh K. Rayala, Michelle D. Williams, Rakesh Kumar, and Adel K. El-Naggar
Clin Cancer Res 2006 12: 5994-5999. [Abstract] [Full Text] [PDF]  

The Novel p21 Polymorphism p21^G251A Is Associated with Locally Advanced Breast Cancer

Vidar Staalesen, Stian Knappskog, Ranjan Chrisanthar, Silje H. Nordgard, Erik Løkkevik, Gun Anker, Bjørn Østenstad, Steinar Lundgren, Terje Risberg, Ingvil Mjaaland, Inger Torhild Gram, Vessela N. Kristensen, Anne-Lise Børresen-Dale, Johan Richard Lillehaug, and Per Eystein Lønning
Clin Cancer Res 2006 12: 6000-6004. [Abstract] [Full Text] [PDF]  

A Homeobox Protein, Prox1, Is Involved in the Differentiation, Proliferation, and Prognosis in Hepatocellular Carcinoma

Masayuki Shimoda, Meiko Takahashi, Takanobu Yoshimoto, Tomoya Kono, Iwao Ikai, and Hajime Kubo
Clin Cancer Res 2006 12: 6005-6011. [Abstract] [Full Text] [PDF]  

Glucocorticoids Suppress Tumor Lymphangiogenesis of Prostate Cancer Cells

Akihiro Yano, Yasuhisa Fujii, Aki Iwai, Satoru Kawakami, Yukio Kageyama, and Kazunori Kihara
Clin Cancer Res 2006 12: 6012-6017. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Prognostic Value of Prostate Secretory Protein of 94 Amino Acids and its Binding Protein after Radical Prostatectomy

Jonathan R. Reeves, Hélène Dulude, Chandra Panchal, Luc Daigneault, and Dharam M. Ramnani
Clin Cancer Res 2006 12: 6018-6022. [Abstract] [Full Text] [PDF]  

Reverse Transcription-PCR for t(11;18)(q21;q21) Staging and Monitoring in Mucosa-Associated Lymphoid Tissue Lymphoma

Berthold Streubel, Daniela Huber, Stefan Wöhrer, Andreas Chott, and Markus Raderer
Clin Cancer Res 2006 12: 6023-6028. [Abstract] [Full Text] [PDF]  

The p53 Pathway and Outcome among Patients with T1G3 Bladder Tumors

Elena López-Knowles, Silvia Hernández, Manolis Kogevinas, Josep Lloreta, Alex Amorós, Adonina Tardón, Alfredo Carrato, Sirish Kishore, Consol Serra, Núria Malats, Francisco X. Real on behalf of the EPICURO Study Investigators
Clin Cancer Res 2006 12: 6029-6036. [Abstract] [Full Text] [PDF] Supplementary Data  

Functional Plasminogen Activator Inhibitor-1 Gene Variants and Breast Cancer Survival

Xianglan Zhang, Xiao-Ou Shu, Qiuyin Cai, ZhiXian Ruan, Yu-Tang Gao, and Wei Zheng
Clin Cancer Res 2006 12: 6037-6042. [Abstract] [Full Text] [PDF]  

Hepatoma-Derived Growth Factor Is a Novel Prognostic Factor for Patients with Pancreatic Cancer

Hirokazu Uyama, Yasuhiko Tomita, Hideji Nakamura, Shoji Nakamori, Binglin Zhang, Yoshihiko Hoshida, Hirayuki Enomoto, Yorihide Okuda, Masato Sakon, Katsuyuki Aozasa, Ichiro Kawase, Norio Hayashi, and Morito Monden
Clin Cancer Res 2006 12: 6043-6048. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Erlotinib for Frontline Treatment of Advanced Non–Small Cell Lung Cancer: a Phase II Study

Giuseppe Giaccone, Marielle Gallegos Ruiz, Thierry Le Chevalier, Nick Thatcher, Egbert Smit, Jose Antonio Rodriguez, Pasi Janne, Dalila Oulid-Aissa, and Jean-Charles Soria
Clin Cancer Res 2006 12: 6049-6055. [Abstract] [Full Text] [PDF]  

Randomized Phase II Study of Interleukin-12 in Combination with Rituximab in Previously Treated Non-Hodgkin's Lymphoma Patients

Stephen M. Ansell, Susan M. Geyer, Matthew J. Maurer, Paul J. Kurtin, Ivana N.M. Micallef, Philip Stella, Paul Etzell, Anne J. Novak, Charles Erlichman, and Thomas E. Witzig
Clin Cancer Res 2006 12: 6056-6063. [Abstract] [Full Text] [PDF]  

A Phase I Dose Escalation Study with Anti-CD44v6 Bivatuzumab Mertansine in Patients with Incurable Squamous Cell Carcinoma of the Head and Neck or Esophagus

Bernard M. Tijink, Jan Buter, Remco de Bree, Giuseppe Giaccone, Margreet S. Lang, Alexander Staab, C. René Leemans, and Guus A.M.S. van Dongen
Clin Cancer Res 2006 12: 6064-6072. [Abstract] [Full Text] [PDF]  

Pharmacokinetic-Pharmacodynamic Relationships of Imatinib and Its Main Metabolite in Patients with Advanced Gastrointestinal Stromal Tumors

Catherine Delbaldo, Etienne Chatelut, Micheline Ré, Alain Deroussent, Sophie Séronie-Vivien, Aurore Jambu, Patrice Berthaud, Axel Le Cesne, Jean-Yves Blay, and Gilles Vassal
Clin Cancer Res 2006 12: 6073-6078. [Abstract] [Full Text] [PDF]  

A Phase I Study of In vitro Expanded Natural Killer T Cells in Patients with Advanced and Recurrent Non–Small Cell Lung Cancer

Shinichiro Motohashi, Aki Ishikawa, Eiichi Ishikawa, Mizuto Otsuji, Toshihiko Iizasa, Hideki Hanaoka, Naomi Shimizu, Shigetoshi Horiguchi, Yoshitaka Okamoto, Shin-ichiro Fujii, Masaru Taniguchi, Takehiko Fujisawa, and Toshinori Nakayama
Clin Cancer Res 2006 12: 6079-6086. [Abstract] [Full Text] [PDF]  

A Phase I Trial of Twice-Weekly 17-Allylamino-Demethoxy-Geldanamycin in Patients with Advanced Cancer

Grzegorz S. Nowakowski, Andrea K. McCollum, Matthew M. Ames, Sumithra J. Mandrekar, Joel M. Reid, Alex A. Adjei, David O. Toft, Stephanie L. Safgren, and Charles Erlichman
Clin Cancer Res 2006 12: 6087-6093. [Abstract] [Full Text] [PDF]  

Hoosier Oncology Group Randomized Phase II Study of Docetaxel, Vinorelbine, and Estramustine in Combination in Hormone-Refractory Prostate Cancer with Pharmacogenetic Survival Analysis

Noah M. Hahn, Sharon Marsh, William Fisher, Robert Langdon, Robin Zon, Mark Browning, Cynthia S. Johnson, Tiffany J. Scott-Horton, Lang Li, Howard L. McLeod, and Christopher J. Sweeney
Clin Cancer Res 2006 12: 6094-6099. [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Toxicity of Weekly Docetaxel in Older Patients

Arti Hurria, Mark T. Fleming, Sharyn D. Baker, Wm. Kevin Kelly, Katie Cutchall, Katherine Panageas, James Caravelli, Henry Yeung, Mark G. Kris, Jorge Gomez, Vincent A. Miller, Gabriella D'Andrea, Howard I. Scher, Larry Norton, and Clifford Hudis
Clin Cancer Res 2006 12: 6100-6105. [Abstract] [Full Text] [PDF]  

A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer

Michael H. Kershaw, Jennifer A. Westwood, Linda L. Parker, Gang Wang, Zelig Eshhar, Sharon A. Mavroukakis, Donald E. White, John R. Wunderlich, Silvana Canevari, Linda Rogers-Freezer, Clara C. Chen, James C. Yang, Steven A. Rosenberg, and Patrick Hwu
Clin Cancer Res 2006 12: 6106-6115. [Abstract] [Full Text] [PDF]  

Bcl-2 Expression as a Predictive Marker of Hormone-Refractory Prostate Cancer Treated with Taxane-Based Chemotherapy

Tateki Yoshino, Hiroaki Shiina, Shinji Urakami, Nobuyuki Kikuno, Tatsuaki Yoneda, Kazushi Shigeno, and Mikio Igawa
Clin Cancer Res 2006 12: 6116-6124. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Multidrug Resistance Protein 2 Is an Important Determinant of Paclitaxel Pharmacokinetics

Jurjen S. Lagas, Maria L. Vlaming, Olaf van Tellingen, Els Wagenaar, Robert S. Jansen, Hilde Rosing, Jos H. Beijnen, and Alfred H. Schinkel
Clin Cancer Res 2006 12: 6125-6132. [Abstract] [Full Text] [PDF]  

Piroxicam and Cisplatin in a Mouse Model of Peritoneal Mesothelioma

Enrico P. Spugnini, Irene Cardillo, Alessandra Verdina, Stefania Crispi, Silvia Saviozzi, Raffaele Calogero, Angela Nebbioso, Lucia Altucci, Giancarlo Cortese, Rossella Galati, Jeremy Chien, Viji Shridhar, Bruno Vincenzi, Gennaro Citro, Francesco Cognetti, Ada Sacchi, and Alfonso Baldi
Clin Cancer Res 2006 12: 6133-6143. [Abstract] [Full Text] [PDF]  

A Novel One-Armed Anti-c-Met Antibody Inhibits Glioblastoma Growth In vivo

Tobias Martens, Nils-Ole Schmidt, Carmen Eckerich, Regina Fillbrandt, Mark Merchant, Ralph Schwall, Manfred Westphal, and Katrin Lamszus
Clin Cancer Res 2006 12: 6144-6152. [Abstract] [Full Text] [PDF]  

Combined In vivo Effect of A12, a Type 1 Insulin-Like Growth Factor Receptor Antibody, and Docetaxel against Prostate Cancer Tumors

Jennifer D. Wu, Kathy Haugk, Ilsa Coleman, Lillie Woodke, Robert Vessella, Peter Nelson, R. Bruce Montgomery, Dale L. Ludwig, and Stephen R. Plymate
Clin Cancer Res 2006 12: 6153-6160. [Abstract] [Full Text] [PDF]  

Effect of Simultaneous Inhibition of Epidermal Growth Factor Receptor and Cyclooxygenase-2 in HER-2/Neu-Positive Breast Cancer

Susan Lanza-Jacoby, Randy Burd, Francis E. Rosato, Jr., Kandace McGuire, James Little, Noel Nougbilly, and Sheldon Miller
Clin Cancer Res 2006 12: 6161-6169. [Abstract] [Full Text] [PDF]  

The Use of a Tropism-Modified Measles Virus in Folate Receptor–Targeted Virotherapy of Ovarian Cancer

Kosei Hasegawa, Takafumi Nakamura, Mary Harvey, Yasuhiro Ikeda, Ann Oberg, Mariangela Figini, Silvana Canevari, Lynn C. Hartmann, and Kah-Whye Peng
Clin Cancer Res 2006 12: 6170-6178. [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Therapy Using Adenovirus-Mediated Full-length Anti-HER-2 Antibody for HER-2 Overexpression Cancers

Minghong Jiang, Wenfang Shi, Qi Zhang, Xinhua Wang, Minggao Guo, Zhenfu Cui, Changqin Su, Qing Yang, Yuemin Li, Jonathan Sham, Xinyuan Liu, Mengchao Wu, and Qijun Qian
Clin Cancer Res 2006 12: 6179-6185. [Abstract] [Full Text] [PDF]  

Preclinical Antitumor Activity of BMS-599626, a pan-HER Kinase Inhibitor That Inhibits HER1/HER2 Homodimer and Heterodimer Signaling

Tai W. Wong, Francis Y. Lee, Chiang Yu, Feng R. Luo, Simone Oppenheimer, Hongjian Zhang, Richard A. Smykla, Harold Mastalerz, Brian E. Fink, John T. Hunt, Ashvinikumar V. Gavai, and Gregory D. Vite
Clin Cancer Res 2006 12: 6186-6193. [Abstract] [Full Text] [PDF]  

Cancer Susceptibility and Prevention:

Grape Seed Extract Inhibits In vitro and In vivo Growth of Human Colorectal Carcinoma Cells

Manjinder Kaur, Rana P. Singh, Mallikarjuna Gu, Rajesh Agarwal, and Chapla Agarwal
Clin Cancer Res 2006 12: 6194-6202. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

The Activity of Sunitinib against Gastrointestinal Stromal Tumor Seems to be Distinct from Its Antiangiogenic Effects

Marco Seandel, Jinru Shia, Irina Linkov, Robert G. Maki, Cristina R. Antonescu, and Jakob Dupont
Clin Cancer Res 2006 12: 6203-6204. [Full Text] [PDF]  

Does MDR-1 G2677T/A Polymorphism Really Associate with Ovarian Cancer Response to Paclitaxel Chemotherapy?

Agnieszka H. Ludwig, Jolanta Kupryjañczyk for the Polish Ovarian Cancer Study Group
Clin Cancer Res 2006 12: 6204. [Full Text] [PDF]  

Polyclonal Resistance in Gastrointestinal Stromal Tumor Treated with Sequential Kinase Inhibitors

Maurice B. Loughrey, Paul M. Waring, Alex Dobrovic, George Demetri, Serge Kovalenko, and Grant McArthur
Clin Cancer Res 2006 12: 6205-6206. [Full Text] [PDF]  

Polyclonal Resistance in Gastrointestinal Stromal Tumor Treated with Sequential Kinase Inhibitors

Eva Wardelmann, Katharina Biermann, Sabine Merkelbach-Bruse, Hans-Ulrich Schildhaus, Nadja Thomas, Reinhard Büttner, Torsten Pietsch, Thomas Heinicke, Nicola Speidel, Daniel Pink, Peter Reichardt, and Peter Hohenberger
Clin Cancer Res 2006 12: 6206. [Full Text] [PDF]  

Advances in Treating Metastatic Bone Cancer:

Advances in Treating Metastatic Bone Cancer: Summary Statement for the First Cambridge Conference

Allan Lipton, James R. Berenson, Jean-Jacques Body, Brendan F. Boyce, Oyvind S. Bruland, Michael A. Carducci, Charles S. Cleeland, Denis R. Clohisy, Robert E. Coleman, Richard J. Cook, Theresa A. Guise, Roger N. Pearse, Trevor J. Powles, Michael J. Rogers, G. David Roodman, Matthew R. Smith, Larry J. Suva, Robert L. Vessella, Katherine N. Weilbaecher, and Laura King
Clin Cancer Res 2006 12: 6209s-6212s. [Abstract] [Full Text] [PDF]  

Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone Metastases

Theresa A. Guise, Khalid S. Mohammad, Gregory Clines, Elizabeth G. Stebbins, Darren H. Wong, Linda S. Higgins, Robert Vessella, Eva Corey, Susan Padalecki, Larry Suva, and John M. Chirgwin
Clin Cancer Res 2006 12: 6213s-6216s. [Abstract] [Full Text] [PDF]  

Genomics and Proteomics of Bone Cancer

Aaron G. Marguiles, V. Suzanne Klimberg, Sudeepa Bhattacharrya, Dana Gaddy, and Larry J. Suva
Clin Cancer Res 2006 12: 6217s-6221s. [Abstract] [Full Text] [PDF]  

Molecular Mechanisms of Action of Bisphosphonates: Current Status

Anke J. Roelofs, Keith Thompson, Sharon Gordon, and Michael J. Rogers
Clin Cancer Res 2006 12: 6222s-6230s. [Abstract] [Full Text] [PDF]  

Biology of Bone Cancer Pain

Michael J. Goblirsch, Pawel P. Zwolak, and Denis R. Clohisy
Clin Cancer Res 2006 12: 6231s-6235s. [Abstract] [Full Text] [PDF]  

The Measurement of Pain from Metastatic Bone Disease: Capturing the Patient's Experience

Charles S. Cleeland
Clin Cancer Res 2006 12: 6236s-6242s. [Abstract] [Full Text] [PDF]  

Clinical Features of Metastatic Bone Disease and Risk of Skeletal Morbidity

Robert E. Coleman
Clin Cancer Res 2006 12: 6243s-6249s. [Abstract] [Full Text] [PDF]  

High-Linear Energy Transfer Irradiation Targeted to Skeletal Metastases by the -Emitter ²²³Ra: Adjuvant or Alternative to Conventional Modalities?

Øyvind S. Bruland, Sten Nilsson, Darrell R. Fisher, and Roy H. Larsen
Clin Cancer Res 2006 12: 6250s-6257s. [Abstract] [Full Text] [PDF]  

Breast Cancer: Bisphosphonate Therapy for Metastatic Bone Disease

Jean-Jacques Body
Clin Cancer Res 2006 12: 6258s-6263s. [Abstract] [Full Text] [PDF]  

Multistate Analysis of Skeletal Events in Patients with Bone Metastases

Richard J. Cook and Pierre Major
Clin Cancer Res 2006 12: 6264s-6269s. [Abstract] [Full Text] [PDF]  

New Potential Targets for Treating Myeloma Bone Disease

G. David Roodman
Clin Cancer Res 2006 12: 6270s-6273s. [Abstract] [Full Text] [PDF]  

Wnt Antagonism in Multiple Myeloma: A Potential Cause of Uncoupled Bone Remodeling

Roger N. Pearse
Clin Cancer Res 2006 12: 6274s-6278s. [Abstract] [Full Text] [PDF]  

Treatment for Myeloma Bone Disease

Howard S. Yeh and James R. Berenson
Clin Cancer Res 2006 12: 6279s-6284s. [Abstract] [Full Text] [PDF]  

Targeting Factors Involved in Bone Remodeling as Treatment Strategies in Prostate Cancer Bone Metastasis

Robert L. Vessella and Eva Corey
Clin Cancer Res 2006 12: 6285s-6290s. [Abstract] [Full Text] [PDF]  

Src Inhibitors in Metastatic Bone Disease

Brendan F. Boyce, Lianping Xing, Zhenqiang Yao, Teruhito Yamashita, William C. Shakespeare, Yihan Wang, Chester A. Metcalf, III, Raji Sundaramoorthi, David C. Dalgarno, John D. Iuliucci, and Tomi K. Sawyer
Clin Cancer Res 2006 12: 6291s-6295s. [Abstract] [Full Text] [PDF]  

Targeting Bone Metastasis in Prostate Cancer with Endothelin Receptor Antagonists

Michael A. Carducci and Antonio Jimeno
Clin Cancer Res 2006 12: 6296s-6300s. [Abstract] [Full Text] [PDF]  

Oral Bisphosphonates as Adjuvant Therapy for Operable Breast Cancer

Trevor Powles, Eugene McCroskey, and Alexander Paterson
Clin Cancer Res 2006 12: 6301s-6304s. [Abstract] [Full Text] [PDF]  

Future Treatment of Bone Metastases

Allan Lipton
Clin Cancer Res 2006 12: 6305s-6308s. [Abstract] [Full Text] [PDF]  

Skeletal Complications of Breast Cancer Therapies

Angela Hirbe, Elizabeth A. Morgan, Özge Uluçkan, and Katherine Weilbaecher
Clin Cancer Res 2006 12: 6309s-6314s. [Abstract] [Full Text] [PDF]  

Treatment-Related Osteoporosis in Men with Prostate Cancer

Matthew R. Smith
Clin Cancer Res 2006 12: 6315s-6319s. [Abstract] [Full Text] [PDF]  

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