Editor's Note:

Introducing CCR Focus

Susan E. Bates
Clin Cancer Res 2006 12: 5255. [Full Text] [PDF]  

Editorials:

The Impact of Genetics on Sarcoma Diagnosis: An Evolving Science

Frederic G. Barr and Paul J. Zhang
Clin Cancer Res 2006 12: 5256-5257. [Full Text] [PDF]  

Challenges of Chemosensitivity Testing

Patrick Hwu, Agop Y. Bedikian, and Elizabeth A. Grimm
Clin Cancer Res 2006 12: 5258-5259. [Full Text] [PDF]  

The Biology Behind:

Tumor Hypoxia Imaging

Inna Serganova, John Humm, Clifton Ling, and Ronald Blasberg
Clin Cancer Res 2006 12: 5260-5264. [Full Text] [PDF]  

Studying Human Regulatory T Cells In vivo

Emmanuel Zorn and Jerome Ritz
Clin Cancer Res 2006 12: 5265-5267. [Full Text] [PDF]  

Molecular Pathways:

The Epidermal Growth Factor Receptor Pathway: A Model for Targeted Therapy

Maurizio Scaltriti and José Baselga
Clin Cancer Res 2006 12: 5268-5272. [Abstract] [Full Text] [PDF]  

CCR Focus:

A New Generation of Mouse Models of Cancer for Translational Research

Cory Abate-Shen
Clin Cancer Res 2006 12: 5274-5276. [Full Text] [PDF]  

The Use of Targeted Mouse Models for Preclinical Testing of Novel Cancer Therapeutics

Kenneth P. Olive and David A. Tuveson
Clin Cancer Res 2006 12: 5277-5287. [Abstract] [Full Text] [PDF]  

Mouse Models of Brain Tumors and Their Applications in Preclinical Trials

Elena I. Fomchenko and Eric C. Holland
Clin Cancer Res 2006 12: 5288-5297. [Abstract] [Full Text] [PDF]  

A Mouse Model System to Genetically Dissect the Molecular Mechanisms Regulating Tumorigenesis

Kurt Degenhardt and Eileen White
Clin Cancer Res 2006 12: 5296-5304. [Abstract] [Full Text] [PDF]  

Mouse Modeling in Oncologic Preclinical and Translational Research

Brett S. Carver and Pier P. Pandolfi
Clin Cancer Res 2006 12: 5305-5311. [Abstract] [Full Text] [PDF]  

Using Genetically Engineered Mouse Models of Cancer to Aid Drug Development: An Industry Perspective

Mallika Singh and Leisa Johnson
Clin Cancer Res 2006 12: 5312-5328. [Abstract] [Full Text] [PDF]  

Report from the FDA:

Approval Summary: Nelarabine for the Treatment of T-Cell Lymphoblastic Leukemia/Lymphoma

Martin H. Cohen, John R. Johnson, Tristan Massie, Rajeshwari Sridhara, W. David McGuinn, Jr., Sophia Abraham, Brian P. Booth, M. Anwar Goheer, David Morse, Xiao H. Chen, Nallaperumal Chidambaram, Leslie Kenna, Jogarao V. Gobburu, Robert Justice, and Richard Pazdur
Clin Cancer Res 2006 12: 5329-5335. [Abstract] [Full Text] [PDF]  

Review:

Protein Kinase C as a Therapeutic Target

Beverly A. Teicher
Clin Cancer Res 2006 12: 5336-5345. [Full Text] [PDF]  

Human Cancer Biology:

Curcumin Inhibits Neurotensin-Mediated Interleukin-8 Production and Migration of HCT116 Human Colon Cancer Cells

Xiaofu Wang, Qingding Wang, Kirk L. Ives, and B. Mark Evers
Clin Cancer Res 2006 12: 5346-5355. [Abstract] [Full Text] [PDF]  

EWS-CREB1: A Recurrent Variant Fusion in Clear Cell Sarcoma—Association with Gastrointestinal Location and Absence of Melanocytic Differentiation

Cristina R. Antonescu, Khedoudja Nafa, Neil H. Segal, Paola Dal Cin, and Marc Ladanyi
Clin Cancer Res 2006 12: 5356-5362. [Abstract] [Full Text] [PDF] Supplementary Data  

Overexpression of Cyclase-Associated Protein 2 in Multistage Hepatocarcinogenesis

Rie Shibata, Taisuke Mori, Wenlin Du, Makoto Chuma, Masahiro Gotoh, Motohide Shimazu, Masakazu Ueda, Setsuo Hirohashi, and Michiie Sakamoto
Clin Cancer Res 2006 12: 5363-5368. [Abstract] [Full Text] [PDF]  

Twist Overexpression Correlates with Hepatocellular Carcinoma Metastasis through Induction of Epithelial-Mesenchymal Transition

Terence K. Lee, Ronnie T.P. Poon, Anthony P. Yuen, Ming Tat Ling, Wei Kei Kwok, Xiang Hong Wang, Yong Chuan Wong, Xin Yuan Guan, Kwan Man, King Lok Chau, and Sheung Tat Fan
Clin Cancer Res 2006 12: 5369-5376. [Abstract] [Full Text] [PDF]  

Clonal Origin of Metastatic Testicular Teratomas

Timothy D. Jones, Mingsheng Wang, Ming-Tse Sung, Shaobo Zhang, Thomas M. Ulbright, John N. Eble, Stephen D. Beck, Richard S. Foster, John J. Anagnostou, Jr., Clay Conner, and Liang Cheng
Clin Cancer Res 2006 12: 5377-5383. [Abstract] [Full Text] [PDF]  

Novel Thioredoxin Inhibitors Paradoxically Increase Hypoxia-Inducible Factor- Expression but Decrease Functional Transcriptional Activity, DNA Binding, and Degradation

Dylan T. Jones, Christopher W. Pugh, Simon Wigfield, Malcolm F.G. Stevens, and Adrian L. Harris
Clin Cancer Res 2006 12: 5384-5394. [Abstract] [Full Text] [PDF]  

Snail and Slug Play Distinct Roles during Breast Carcinoma Progression

Christophe Côme, Fabrice Magnino, Frédéric Bibeau, Pascal De Santa Barbara, Karl Friedrich Becker, Charles Theillet, and Pierre Savagner
Clin Cancer Res 2006 12: 5395-5402. [Abstract] [Full Text] [PDF] Supplementary Data  

HATH1 Expression in Mucinous Cancers of the Colorectum and Related Lesions

Eun Taek Park, Hee Kyung Oh, James R. Gum, Jr., Suzanne C. Crawley, Sanjay Kakar, Juan Engel, Ching Ching Leow, Wei-Qiang Gao, and Young S. Kim
Clin Cancer Res 2006 12: 5403-5410. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

S100P Is an Early Developmental Marker of Pancreatic Carcinogenesis

Kenoki Ohuchida, Kazuhiro Mizumoto, Takuya Egami, Hiroshi Yamaguchi, Kei Fujii, Hiroyuki Konomi, Eishi Nagai, Koji Yamaguchi, Masazumi Tsuneyoshi, and Masao Tanaka
Clin Cancer Res 2006 12: 5411-5416. [Abstract] [Full Text] [PDF]  

S100A11, A Putative Tumor Suppressor Gene, Is Overexpressed in Pancreatic Carcinogenesis

Kenoki Ohuchida, Kazuhiro Mizumoto, Seiji Ohhashi, Hiroshi Yamaguchi, Hiroyuki Konomi, Eishi Nagai, Koji Yamaguchi, Masazumi Tsuneyoshi, and Masao Tanaka
Clin Cancer Res 2006 12: 5417-5422. [Abstract] [Full Text] [PDF]  

Prevalence of FOXP3⁺ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions

Nobuyoshi Hiraoka, Kaoru Onozato, Tomoo Kosuge, and Setsuo Hirohashi
Clin Cancer Res 2006 12: 5423-5434. [Abstract] [Full Text] [PDF]  

Tumor Hypoxia Imaging with [F-18] Fluoromisonidazole Positron Emission Tomography in Head and Neck Cancer

Joseph G. Rajendran, David L. Schwartz, Janet O'Sullivan, Lanell M. Peterson, Patrick Ng, Jeffrey Scharnhorst, John R. Grierson, and Kenneth A. Krohn
Clin Cancer Res 2006 12: 5435-5441. [Abstract] [Full Text] [PDF]  

Cancer-Testis Antigens: Expression and Correlation with Survival in Human Urothelial Carcinoma

Padmanee Sharma, Yu Shen, Sijin Wen, Dean F. Bajorin, Victor E. Reuter, Lloyd J. Old, and Achim A. Jungbluth
Clin Cancer Res 2006 12: 5442-5447. [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Therapy: Clinical:

Matrix Metalloproteinase Polymorphisms and Survival in Stage I Non–Small Cell Lung Cancer

Rebecca Suk Heist, Ariela L. Marshall, Geoffrey Liu, Wei Zhou, Li Su, Donna Neuberg, Thomas J. Lynch, John Wain, and David C. Christiani
Clin Cancer Res 2006 12: 5448-5453. [Abstract] [Full Text] [PDF]  

In vitro Drug Sensitivity Predicts Response and Survival after Individualized Sensitivity-Directed Chemotherapy in Metastatic Melanoma: A Multicenter Phase II Trial of the Dermatologic Cooperative Oncology Group

Selma Ugurel, Dirk Schadendorf, Claudia Pföhler, Karsten Neuber, Adina Thoelke, Jens Ulrich, Axel Hauschild, Konstanze Spieth, Martin Kaatz, Werner Rittgen, Stefan Delorme, Wolfgang Tilgen, and Uwe Reinhold
Clin Cancer Res 2006 12: 5454-5463. [Abstract] [Full Text] [PDF] Supplementary Data  

Photofrin Uptake in the Tumor and Normal Tissues of Patients Receiving Intraperitoneal Photodynamic Therapy

Stephen M. Hahn, Mary E. Putt, James Metz, Daniel B. Shin, Elizabeth Rickter, Chandrakala Menon, Debbie Smith, Eli Glatstein, Douglas L. Fraker, and Theresa M. Busch
Clin Cancer Res 2006 12: 5464-5470. [Abstract] [Full Text] [PDF]  

A Phase I Biological and Pharmacologic Study of the Heparanase Inhibitor PI-88 in Patients with Advanced Solid Tumors

Michele Basche, Daniel L. Gustafson, Scott N. Holden, Cindy L. O'Bryant, Lia Gore, Samir Witta, Mary Kay Schultz, Mark Morrow, Adrah Levin, Brian R. Creese, Michael Kangas, Kaye Roberts, Thu Nguyen, Kat Davis, Russell S. Addison, Jane C. Moore, and S. Gail Eckhardt
Clin Cancer Res 2006 12: 5471-5480. [Abstract] [Full Text] [PDF]  

Population Pharmacokinetic-Pharmacodynamic Model for Neutropenia with Patient Subgroup Identification: Comparison across Anticancer Drugs

Charlotte Kloft, Johan Wallin, Anja Henningsson, Etienne Chatelut, and Mats O. Karlsson
Clin Cancer Res 2006 12: 5481-5490. [Abstract] [Full Text] [PDF]  

Increased Prevalence of Dihydropyrimidine Dehydrogenase Deficiency in African-Americans Compared with Caucasians

Lori Kay Mattison, Jeanne Fourie, Renee A. Desmond, Anil Modak, Muhammad Wasif Saif, and Robert B. Diasio
Clin Cancer Res 2006 12: 5491-5495. [Abstract] [Full Text] [PDF]  

Pharmacogenetics of Capecitabine in Advanced Breast Cancer Patients

Rémy Largillier, Marie-Christine Etienne-Grimaldi, Jean-Louis Formento, Joseph Ciccolini, Jean-François Nebbia, Aurélie Ginot, Mireille Francoual, Nicole Renée, Jean-Marc Ferrero, Cyril Foa, Moïse Namer, Bruno Lacarelle, and Gérard Milano
Clin Cancer Res 2006 12: 5496-5502. [Abstract] [Full Text] [PDF]  

Phase I Study of Abagovomab in Patients with Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Paul Sabbatini, Jakob Dupont, Carol Aghajanian, Felicia Derosa, Elizabeth Poynor, Sybil Anderson, Martee Hensley, Phillip Livingston, Alexia Iasonos, David Spriggs, William McGuire, Silke Reinartz, Sally Schneider, Cathy Grande, Shashikant Lele, Kerry Rodabaugh, James Kepner, Soldano Ferrone, and Kunle Odunsi
Clin Cancer Res 2006 12: 5503-5510. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Adjuvanticity of Plasmid DNA Encoding Cytokines Fused to Immunoglobulin Fc Domains

Cristina R. Ferrone, Miguel-Angel Perales, Stacie M. Goldberg, C. Joy Somberg, Daniel Hirschhorn-Cymerman, Polly D. Gregor, Mary Jo Turk, Teresa Ramirez-Montagut, Jason S. Gold, Alan N. Houghton, and Jedd D. Wolchok
Clin Cancer Res 2006 12: 5511-5519. [Abstract] [Full Text] [PDF]  

Human Regulatory T Cells Control Xenogeneic Graft-versus-Host Disease Induced by Autologous T Cells in RAG2^–/–c^–/– Immunodeficient Mice

Tuna Mutis, Rozemarijn S. van Rijn, Elles R. Simonetti, Tineke Aarts-Riemens, Maarten E. Emmelot, Louis van Bloois, Anton Martens, Leo F. Verdonck, and Saskia B. Ebeling
Clin Cancer Res 2006 12: 5520-5525. [Abstract] [Full Text] [PDF]  

The Thalidomide Analogue, CC-4047, Induces Apoptosis Signaling and Growth Arrest in Childhood Acute Lymphoblastic Leukemia Cells In vitro and In vivo

Shabnam Shalapour, Andrea Zelmer, Madlen Pfau, Eva Moderegger, Cristiane Costa-Blechschmidt, Frank K.H. van Landeghem, Tillmann Taube, Iduna Fichtner, Christoph Bührer, Günter Henze, Karl Seeger, and Sven Wellmann
Clin Cancer Res 2006 12: 5526-5532. [Abstract] [Full Text] [PDF]  

The Ras Inhibitor Farnesylthiosalicylic Acid as a Potential Therapy for Neurofibromatosis Type 1

Batya Barkan, Sigal Starinsky, Eitan Friedman, Reuven Stein, and Yoel Kloog
Clin Cancer Res 2006 12: 5533-5542. [Abstract] [Full Text] [PDF]  

In vivo Efficacy of STX213, A Second-Generation Steroid Sulfatase Inhibitor, for Hormone-Dependent Breast Cancer Therapy

Paul A. Foster, Simon P. Newman, Surinder K. Chander, Chloe Stengel, Roma Jhalli, Lawrence L.W. Woo, Barry V.L. Potter, Michael J. Reed, and Atul Purohit
Clin Cancer Res 2006 12: 5543-5549. [Abstract] [Full Text] [PDF]  

Human Neural Stem Cells Target Experimental Intracranial Medulloblastoma and Deliver a Therapeutic Gene Leading to Tumor Regression

Seung-Ki Kim, Seung U. Kim, In Ho Park, Jung Hee Bang, Karen S. Aboody, Kyu-Chang Wang, Byung-Kyu Cho, Manho Kim, Lata G. Menon, Peter M. Black, and Rona S. Carroll
Clin Cancer Res 2006 12: 5550-5556. [Abstract] [Full Text] [PDF]  

Benzethonium Chloride: A Novel Anticancer Agent Identified by Using a Cell-Based Small-Molecule Screen

Kenneth W. Yip, Xinliang Mao, P.Y. Billie Au, David W. Hedley, Sue Chow, Shadi Dalili, Joseph D. Mocanu, Carlo Bastianutto, Aaron Schimmer, and Fei-Fei Liu
Clin Cancer Res 2006 12: 5557-5569. [Abstract] [Full Text] [PDF]  

Antitumor Activity of Suberoylanilide Hydroxamic Acid against Thyroid Cancer Cell Lines In vitro and In vivo

Quang T. Luong, James O'Kelly, Glenn D. Braunstein, Jerome M. Hershman, and H. Phillip Koeffler
Clin Cancer Res 2006 12: 5570-5577. [Abstract] [Full Text] [PDF]  

Interleukin 6, a Nuclear Factor-B Target, Predicts Resistance to Docetaxel in Hormone-Independent Prostate Cancer and Nuclear Factor-B Inhibition by PS-1145 Enhances Docetaxel Antitumor Activity

Josep Domingo-Domenech, Cristina Oliva, Ana Rovira, Jordi Codony-Servat, Marta Bosch, Xavier Filella, Clara Montagut, Marian Tapia, Clara Campás, Lenny Dang, Mark Rolfe, Jeffrey S. Ross, Pere Gascon, Joan Albanell, and Begoña Mellado
Clin Cancer Res 2006 12: 5578-5586. [Abstract] [Full Text] [PDF]  

Bispecific Antibody Pretargeting of Tumor Neovasculature for Improved Systemic Radiotherapy of Solid Tumors

Dieter Moosmayer, Dietmar Berndorff, Chien-Hsing Chang, Robert M. Sharkey, Axel Rother, Sandra Borkowski, Edmund A. Rossi, William J. McBride, Thomas M. Cardillo, David M. Goldenberg, and Ludger M. Dinkelborg
Clin Cancer Res 2006 12: 5587-5595. [Abstract] [Full Text] [PDF]  

Cancer Susceptibility and Prevention:

Polymorphisms of FAS and FAS Ligand Genes Involved in the Death Pathway and Risk and Progression of Squamous Cell Carcinoma of the Head and Neck

Zhengdong Zhang, Li-E Wang, Erich M. Sturgis, Adel K. El-Naggar, Waun K. Hong, Christopher I. Amos, Margaret R. Spitz, and Qingyi Wei
Clin Cancer Res 2006 12: 5596-5602. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Aromatase Inhibitors and Postmenopausal Breast Cancer Patients with Tamoxifen-Induced Endometrial Pathology

Leilani Morales, Robert Paridaens, Dirk Timmerman, and Patrick Neven
Clin Cancer Res 2006 12: 5603. [Full Text] [PDF]  

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