Editorials:

Aurora Sheds Light on Head and Neck Squamous Cell Carcinoma

Haiyong Han and Daniel D. Von Hoff
Clin Cancer Res 2006 12: 5003-5004. [Full Text] [PDF]  

Prognostic Biomarkers in Head and Neck Cancer

Jennifer R. Grandis
Clin Cancer Res 2006 12: 5005-5006. [Full Text] [PDF]  

The Biology Behind:

Hypoxia-Inducible Factor-1 and p53: Friends, Acquaintances, or Strangers?

Ester M. Hammond and Amato J. Giaccia
Clin Cancer Res 2006 12: 5007-5009. [Full Text] [PDF]  

The Science of Selective Estrogen Receptor Modulators: Concept to Clinical Practice

V. Craig Jordan
Clin Cancer Res 2006 12: 5010-5013. [Full Text] [PDF]  

CCR Practice of Translational Oncology:

Molecular Screening Testing for Colorectal Cancer

Bernard Levin
Clin Cancer Res 2006 12: 5014-5017. [Full Text] [PDF]  

Molecular Pathways:

Vascular Endothelial Growth Factor Signaling Pathways: Therapeutic Perspective

Marcin Kowanetz and Napoleone Ferrara
Clin Cancer Res 2006 12: 5018-5022. [Abstract] [Full Text] [PDF]  

Review:

Unique Tumor Antigens: Evidence for Immune Control of Genome Integrity and Immunogenic Targets for T Cell–Mediated Patient-Specific Immunotherapy

Marialuisa Sensi and Andrea Anichini
Clin Cancer Res 2006 12: 5023-5032. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Validity of Messenger RNA Expression Analyses of Human Saliva

Shalini V. Kumar, Gregory J. Hurteau, and Simon D. Spivack
Clin Cancer Res 2006 12: 5033-5039. [Abstract] [Full Text] [PDF]  

Promoter Hypermethylation Profile of Kidney Cancer with New Proapoptotic p53 Target Genes and Clinical Implications

Frank Christoph, Steffen Weikert, Carsten Kempkensteffen, Hans Krause, Martin Schostak, Jens Köllermann, Kurt Miller, and Mark Schrader
Clin Cancer Res 2006 12: 5040-5046. [Abstract] [Full Text] [PDF]  

Molecular Heterogeneity of Inflammatory Breast Cancer: A Hyperproliferative Phenotype

Dang M. Nguyen, Kathy Sam, Anna Tsimelzon, Xiaoxian Li, Helen Wong, Syed Mohsin, Gary M. Clark, Susan G. Hilsenbeck, Richard M. Elledge, D. Craig Allred, Peter O'Connell, and Jenny C. Chang
Clin Cancer Res 2006 12: 5047-5054. [Abstract] [Full Text] [PDF]  

Signal Transducers and Activators of Transcription 3 Pathway Activation in Drug-Resistant Ovarian Cancer

Zhenfeng Duan, Rosemary Foster, Debra A. Bell, Jennifer Mahoney, Kathryn Wolak, Ami Vaidya, Constanze Hampel, Hang Lee, and Michael V. Seiden
Clin Cancer Res 2006 12: 5055-5063. [Abstract] [Full Text] [PDF]  

Mutant Epidermal Growth Factor Receptor (EGFRvIII) Contributes to Head and Neck Cancer Growth and Resistance to EGFR Targeting

John C. Sok, Francesca M. Coppelli, Sufi M. Thomas, Miriam N. Lango, Sichuan Xi, Jennifer L. Hunt, Maria L. Freilino, Michael W. Graner, Carol J. Wikstrand, Darell D. Bigner, William E. Gooding, Frank B. Furnari, and Jennifer R. Grandis
Clin Cancer Res 2006 12: 5064-5073. [Abstract] [Full Text] [PDF]  

Aberrant Nuclear Accumulation of Glycogen Synthase Kinase-3ß in Human Pancreatic Cancer: Association with Kinase Activity and Tumor Dedifferentiation

Andrei V. Ougolkov, Martin E. Fernandez-Zapico, Vladimir N. Bilim, Thomas C. Smyrk, Suresh T. Chari, and Daniel D. Billadeau
Clin Cancer Res 2006 12: 5074-5081. [Abstract] [Full Text] [PDF]  

Rac Activation Is Associated with Hepatocellular Carcinoma Metastasis by Up-regulation of Vascular Endothelial Growth Factor Expression

Terence K. Lee, Ronnie T.P. Poon, Anthony P. Yuen, Kwan Man, Zhen Fan Yang, Xin Yuan Guan, and Sheung Tat Fan
Clin Cancer Res 2006 12: 5082-5089. [Abstract] [Full Text] [PDF]  

Fatty Acid Binding Protein 6 Is Overexpressed in Colorectal Cancer

Takahiro Ohmachi, Hiroshi Inoue, Koshi Mimori, Fumiaki Tanaka, Atsushi Sasaki, Tatsuo Kanda, Hiroshi Fujii, Katsuhiko Yanaga, and Masaki Mori
Clin Cancer Res 2006 12: 5090-5095. [Abstract] [Full Text] [PDF]  

The Biological Role of the Low-Affinity p75 Neurotrophin Receptor in Esophageal Squamous Cell Carcinoma

Tomoyuki Okumura, Shigeru Tsunoda, Yukiko Mori, Tetsuo Ito, Keiji Kikuchi, Timothy Cragin Wang, Shigeru Yasumoto, and Yutaka Shimada
Clin Cancer Res 2006 12: 5096-5103. [Abstract] [Full Text] [PDF] Supplementary Data  

DNA Repair Pathway Profiling and Microsatellite Instability in Colorectal Cancer

Jinsheng Yu, Mary A. Mallon, Wanghai Zhang, Robert R. Freimuth, Sharon Marsh, Mark A. Watson, Paul J. Goodfellow, and Howard L. McLeod
Clin Cancer Res 2006 12: 5104-5111. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Overexpression of Hypoxia-Inducible Factor 1 and p53 Is a Marker for an Unfavorable Prognosis in Gastric Cancer

Yasushi Sumiyoshi, Yoshihiro Kakeji, Akinori Egashira, Ken Mizokami, Hiroyuki Orita, and Yoshihiko Maehara
Clin Cancer Res 2006 12: 5112-5117. [Abstract] [Full Text] [PDF]  

Differential Expression of Neuronal Genes Defines Subtypes of Disseminated Neuroblastoma with Favorable and Unfavorable Outcome

Matthias Fischer, André Oberthuer, Benedikt Brors, Yvonne Kahlert, Matthias Skowron, Harald Voth, Patrick Warnat, Karen Ernestus, Barbara Hero, and Frank Berthold
Clin Cancer Res 2006 12: 5118-5128. [Abstract] [Full Text] [PDF] Supplementary Data  

A Molecular Diagnostic Test for Distinguishing Lung Adenocarcinoma from Malignant Mesothelioma Using Cells Collected from Pleural Effusions

Andrew J. Holloway, Dileepa S. Diyagama, Ken Opeskin, Jenette Creaney, Bruce W.S. Robinson, Richard A. Lake, and David D.L. Bowtell
Clin Cancer Res 2006 12: 5129-5135. [Abstract] [Full Text] [PDF] Supplementary Data  

Aurora Kinase A Messenger RNA Overexpression Is Correlated with Tumor Progression and Shortened Survival in Head and Neck Squamous Cell Carcinoma

Rudolf Reiter, Peter Gais, Uta Jütting, Miriam K. Steuer-Vogt, Anja Pickhard, Karin Bink, Sandra Rauser, Silke Lassmann, Heinz Höfler, Martin Werner, and Axel Walch
Clin Cancer Res 2006 12: 5136-5141. [Abstract] [Full Text] [PDF]  

Selective Profiling of Proteins in Lung Cancer Cells from Fine-Needle Aspirates by Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry

Joseph M. Amann, Pierre Chaurand, Adriana Gonzalez, James A. Mobley, Pierre P. Massion, David P. Carbone, and Richard M. Caprioli
Clin Cancer Res 2006 12: 5142-5150. [Abstract] [Full Text] [PDF] Supplementary Data  

Microsatellite DNA Alterations of Gastrointestinal Stromal Tumors Are Predictive for Outcome

Paulus Schurr, Stefan Wolter, Jussuf Kaifi, Uta Reichelt, Helge Kleinhans, Robin Wachowiak, Emre Yekebas, Tim Strate, Viacheslav Kalinin, Ronald Simon, Guido Sauter, Hansjoerg Schaefer, and Jakob Izbicki
Clin Cancer Res 2006 12: 5151-5157. [Abstract] [Full Text] [PDF]  

Identification of Cripto-1 as a Novel Serologic Marker for Breast and Colon Cancer

Caterina Bianco, Luigi Strizzi, Mario Mancino, Aasia Rehman, Shin Hamada, Kazuhide Watanabe, Antonella De Luca, Brenda Jones, Gabriela Balogh, Jose Russo, Daniel Mailo, Raffaele Palaia, Giuseppe D'Aiuto, Gerardo Botti, Francesco Perrone, David S. Salomon, and Nicola Normanno
Clin Cancer Res 2006 12: 5158-5164. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Phase I/II Study of the Mammalian Target of Rapamycin Inhibitor Everolimus (RAD001) in Patients with Relapsed or Refractory Hematologic Malignancies

Karen W.L. Yee, Zhihong Zeng, Marina Konopleva, Srdan Verstovsek, Farhad Ravandi, Alessandra Ferrajoli, Deborah Thomas, William Wierda, Efrosyni Apostolidou, Maher Albitar, Susan O'Brien, Michael Andreeff, and Francis J. Giles
Clin Cancer Res 2006 12: 5165-5173. [Abstract] [Full Text] [PDF]  

The Effect of Enzyme-Inducing Antiseizure Drugs on the Pharmacokinetics and Tolerability of Procarbazine Hydrochloride

Stuart A. Grossman, Kathryn A. Carson, Tracy T. Batchelor, Glenn Lesser, Tom Mikkelsen, Jane B. Alavi, Surasak Phuphanich, Tarek Hammour, Joy D. Fisher, and Jeffrey G. Supko
Clin Cancer Res 2006 12: 5174-5181. [Abstract] [Full Text] [PDF]  

A Phase I Pharmacokinetic Study of HMN-214, a Novel Oral Stilbene Derivative with Polo-Like Kinase-1–Interacting Properties, in Patients with Advanced Solid Tumors

Linda L. Garland, Charles Taylor, Deborah L. Pilkington, Jan L. Cohen, and Daniel D. Von Hoff
Clin Cancer Res 2006 12: 5182-5189. [Abstract] [Full Text] [PDF]  

High-Dose Celecoxib and Metronomic "Low-dose" Cyclophosphamide Is an Effective and Safe Therapy in Patients with Relapsed and Refractory Aggressive Histology Non–Hodgkin's Lymphoma

Rena Buckstein, Robert S. Kerbel, Yuval Shaked, Rakesh Nayar, Cindy Foden, Ruth Turner, Christine R. Lee, Diane Taylor, Liying Zhang, Shan Man, Sylvain Baruchel, Diana Stempak, Francesco Bertolini, and Michael Crump
Clin Cancer Res 2006 12: 5190-5198. [Abstract] [Full Text] [PDF]  

Antitumor Effects of a Novel Phenylbutyrate-Based Histone Deacetylase Inhibitor, (S)-HDAC-42, in Prostate Cancer

Samuel K. Kulp, Chang-Shi Chen, Da-Sheng Wang, Ching-Yu Chen, and Ching-Shih Chen
Clin Cancer Res 2006 12: 5199-5206. [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetic Study of Tasidotin Hydrochloride (ILX651), a Third-Generation Dolastatin-15 Analogue, Administered Weekly for 3 Weeks Every 28 Days in Patients with Advanced Solid Tumors

Alain C. Mita, Lisa A. Hammond, Peter L. Bonate, Geoffrey Weiss, Heather McCreery, Samira Syed, Mitchell Garrison, Quincy S.C. Chu, Johann S. DeBono, Christopher B. Jones, Steve Weitman, and Eric K. Rowinsky
Clin Cancer Res 2006 12: 5207-5215. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Adenovirus-Mediated Calponin h1 Gene Therapy Directed against Peritoneal Dissemination of Ovarian Cancer: Bifunctional Therapeutic Effects on Peritoneal Cell Layer and Cancer Cells

Tomonori Ogura, Hiroaki Kobayashi, Yousuke Ueoka, Kaoru Okugawa, Kiyoko Kato, Toshio Hirakawa, Shigenari Hashimoto, Shun'ichiro Taniguchi, Norio Wake, and Hitoo Nakano
Clin Cancer Res 2006 12: 5216-5223. [Abstract] [Full Text] [PDF]  

Eliminating Established Tumor in nu/nu Nude Mice by a Tumor Necrosis Factor--Related Apoptosis-Inducing Ligand–Armed Oncolytic Adenovirus

Fengqin Dong, Li Wang, John J. Davis, Wenxian Hu, Lidong Zhang, Wei Guo, Fuminori Teraishi, Lin Ji, and Bingliang Fang
Clin Cancer Res 2006 12: 5224-5230. [Abstract] [Full Text] [PDF]  

Preclinical Characterization of AEG35156/GEM 640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis

Eric C. LaCasse, Gabriele G. Cherton-Horvat, Kimberley E. Hewitt, Lori J. Jerome, Stephen J. Morris, Ekambar R. Kandimalla, Dong Yu, Hui Wang, Wei Wang, Ruiwen Zhang, Sudhir Agrawal, John W. Gillard, and Jon P. Durkin
Clin Cancer Res 2006 12: 5231-5241. [Abstract] [Full Text] [PDF]  

Cancer Susceptibility and Prevention:

Effect of Raloxifene on the Incidence of Invasive Breast Cancer in Postmenopausal Women with Osteoporosis Categorized by Breast Cancer Risk

Marc E. Lippman, Steven R. Cummings, Damon P. Disch, John L. Mershon, Sherie A. Dowsett, Jane A. Cauley, and Silvana Martino
Clin Cancer Res 2006 12: 5242-5247. [Abstract] [Full Text] [PDF]  

Liver Intestine-Cadherin (CDH17) Haplotype Is Associated with Increased Risk of Hepatocellular Carcinoma

Xiao Qi Wang, John M. Luk, Mercè Garcia-Barcelo, Xiaoping Miao, Pauline P. Leung, David W. Ho, Siu Tim Cheung, Brian Y. Lam, Cindy K. Cheung, Ashley S. Wong, Silvana S. Lau, Man Ting So, Wan Ching Yu, Qi Cai, Karen S. Liu, Chee Kin Hui, George K. Lau, Ronnie T.P. Poon, John Wong, and Sheung Tat Fan
Clin Cancer Res 2006 12: 5248-5252. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Mononuclear Infiltrates in Osteosarcoma and Chemokine Receptor Expression

Irene von Luettichau, Michaela Nathrath, Stefan Burdach, Ralf Huss, Stephan Segerer, and Peter J. Nelson
Clin Cancer Res 2006 12: 5253-5254. [Full Text] [PDF]  

CXCR4 Expression in Osteosarcoma Cell Lines and Tumor Samples: Evidence for Expression by Tumor Cells

Caroline Laverdière and Richard Gorlick
Clin Cancer Res 2006 12: 5254. [Full Text] [PDF]  

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