The Biology Behind:

Antisense to Cyclin D1 Inhibits VEGF-Stimulated Growth of Vascular Endothelial Cells: Implication of Tumor Vascularization

Richard G. Pestell and Zhiping Li
Clin Cancer Res 2006 12: 4459 -4462 doi: 10.1158/1078-0432.CCR-06-0614 [Full Text] [PDF]  

Molecular Pathways:

Targeting the Double-Strand DNA Break Repair Pathway as a Therapeutic Strategy

Christopher J. Lord, Michelle D. Garrett, and Alan Ashworth
Clin Cancer Res 2006 12: 4463-4468 doi: 10.1158/1078-0432.CCR-06-1269 [Abstract] [Full Text] [PDF]  

Reviews:

Statistical Analysis of DNA Microarray Data in Cancer Research

Jianqing Fan and Yi Ren
Clin Cancer Res 2006 12: 4469-4473 doi: 10.1158/1078-0432.CCR-06-1033 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

The Chemokine CCL5 as a Potential Prognostic Factor Predicting Disease Progression in Stage II Breast Cancer Patients

Neora Yaal-Hahoshen, Sima Shina, Leonor Leider-Trejo, Itay Barnea, Esther L. Shabtai, Elina Azenshtein, Iulia Greenberg, Iafa Keydar, and Adit Ben-Baruch
Clin Cancer Res 2006 12: 4474-4480 doi: 10.1158/1078-0432.CCR-06-0074 [Abstract] [Full Text] [PDF]  

Oxaliplatin and Axonal Na⁺ Channel Function In vivo

Arun V. Krishnan, David Goldstein, Michael Friedlander, and Matthew C. Kiernan
Clin Cancer Res 2006 12: 4481-4484 doi: 10.1158/1078-0432.CCR-06-0694 [Abstract] [Full Text] [PDF]  

RhoC GTPase Expression as a Potential Marker of Lymph Node Metastasis in Squamous Cell Carcinomas of the Head and Neck

Celina G. Kleer, Theodoros N. Teknos, Mozaffarul Islam, Benjamin Marcus, Julia Shin-Jung Lee, Quintin Pan, and Sofia D. Merajver
Clin Cancer Res 2006 12: 4485-4490 doi: 10.1158/1078-0432.CCR-06-0376 [Abstract] [Full Text] [PDF]  

Induction of Interleukin-6 by Hepatitis C Virus Core Protein in Hepatitis C–Associated Mixed Cryoglobulinemia and B-Cell Non–Hodgkin's Lymphoma

Georg Feldmann, Hans Dieter Nischalke, Jacob Nattermann, Brigitte Banas, Thomas Berg, Christian Teschendorf, Wolff Schmiegel, Ulrich Dührsen, Juliane Halangk, Agathe Iwan, Tilman Sauerbruch, Wolfgang H. Caselmann, and Ulrich Spengler
Clin Cancer Res 2006 12: 4491-4498 doi: 10.1158/1078-0432.CCR-06-0154 [Abstract] [Full Text] [PDF] Supplementary Data  

Cutaneous Melanoma Subtypes Show Different BRAF and NRAS Mutation Frequencies

Gerald Saldanha, Linda Potter, Philip DaForno, and J. Howard Pringle
Clin Cancer Res 2006 12: 4499-4505 doi: 10.1158/1078-0432.CCR-05-2447 [Abstract] [Full Text] [PDF]  

Hypoxia-Inducible Factor-1 and Hypoxia-Inducible Factor-2 Are Expressed in Kaposi Sarcoma and Modulated by Insulin-like Growth Factor-I

Sergiu-Bogdan Catrina, Ileana Ruxandra Botusan, Anja Rantanen, Anca Irinel Catrina, Pawan Pyakurel, Octavian Savu, Magnus Axelson, Peter Biberfeld, Lorenz Poellinger, and Kerstin Brismar
Clin Cancer Res 2006 12: 4506-4514 doi: 10.1158/1078-0432.CCR-05-2473 [Abstract] [Full Text] [PDF] Supplementary Data  

Accumulation of Promoter Methylation Suggests Epigenetic Progression in Squamous Cell Carcinoma of the Esophagus

Mingzhou Guo, Jingli Ren, Michael G. House, Yu Qi, Malcolm V. Brock, and James G. Herman
Clin Cancer Res 2006 12: 4515-4522 doi: 10.1158/1078-0432.CCR-05-2858 [Abstract] [Full Text] [PDF]  

In vitro Drug Response and Molecular Markers Associated with Drug Resistance in Malignant Gliomas

John P. Fruehauf, Henry Brem, Steven Brem, Andrew Sloan, Geoffrey Barger, Weidong Huang, and Ricardo Parker
Clin Cancer Res 2006 12: 4523-4532 doi: 10.1158/1078-0432.CCR-05-1830 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Prognosis and Gene Expression Profiling of 20q13-Amplified Breast Cancers

Christophe Ginestier, Nathalie Cervera, Pascal Finetti, Séverine Esteyries, Benjamin Esterni, José Adélaïde, Luc Xerri, Patrice Viens, Jocelyne Jacquemier, Emmanuelle Charafe-Jauffret, Max Chaffanet, Daniel Birnbaum, and François Bertucci
Clin Cancer Res 2006 12: 4533-4544 doi: 10.1158/1078-0432.CCR-05-2339 [Abstract] [Full Text] [PDF] Supplementary Data  

A Validated Quantitative Assay to Detect Occult Micrometastases by Reverse Transcriptase-Polymerase Chain Reaction of Guanylyl Cyclase C in Patients with Colorectal Cancer

Stephanie Schulz, Terry Hyslop, Janis Haaf, Christine Bonaccorso, Karl Nielsen, Matthew E. Witek, Ruth Birbe, Juan Palazzo, David Weinberg, and Scott A. Waldman
Clin Cancer Res 2006 12: 4545-4552 doi: 10.1158/1078-0432.CCR-06-0865 [Abstract] [Full Text] [PDF]  

Expression of Late Cell Cycle Genes and an Increased Proliferative Capacity Characterize Very Early Relapse of Childhood Acute Lymphoblastic Leukemia

Renate Kirschner-Schwabe, Claudio Lottaz, Jörn Tödling, Peter Rhein, Leonid Karawajew, Cornelia Eckert, Arend von Stackelberg, Ute Ungethüm, Dennis Kostka, Andreas E. Kulozik, Wolf-Dieter Ludwig, Günter Henze, Rainer Spang, Christian Hagemeier, and Karl Seeger
Clin Cancer Res 2006 12: 4553-4561 doi: 10.1158/1078-0432.CCR-06-0235 [Abstract] [Full Text] [PDF] Supplementary Data  

Hypoxia-Inducible Factor-1 Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer

Daniele Generali, Alfredo Berruti, Maria P. Brizzi, Leticia Campo, Simone Bonardi, Simon Wigfield, Alessandra Bersiga, Giovanni Allevi, Manuela Milani, Sergio Aguggini, Valeria Gandolfi, Luigi Dogliotti, Alberto Bottini, Adrian L. Harris, and Stephen B. Fox
Clin Cancer Res 2006 12: 4562-4568 doi: 10.1158/1078-0432.CCR-05-2690 [Abstract] [Full Text] [PDF]  

DNA Integrity Assay: A Plasma-Based Screening Tool for the Detection of Prostate Cancer

Robert Hanley, Kimberly M. Rieger-Christ, David Canes, Norah R. Emara, Anthony P. Shuber, Kevin A. Boynton, John A. Libertino, and Ian C. Summerhayes
Clin Cancer Res 2006 12: 4569-4574 doi: 10.1158/1078-0432.CCR-06-0130 [Abstract] [Full Text] [PDF]  

Endocan Expression and Relationship with Survival in Human Non–Small Cell Lung Cancer

Bogdan Dragos Grigoriu, Florence Depontieu, Arnaud Scherpereel, Delphine Gourcerol, Patrick Devos, Taoufik Ouatas, Jean-Jacques Lafitte, Marie-Christine Copin, Andre-Bernard Tonnel, Philippe Lassalle, and The Thoracic Oncology Group
Clin Cancer Res 2006 12: 4575-4582 doi: 10.1158/1078-0432.CCR-06-0185 [Abstract] [Full Text] [PDF]  

Predicting Cancer Drug Response by Proteomic Profiling

Yan Ma, Zhenyu Ding, Yong Qian, Xianglin Shi, Vince Castranova, E. James Harner, and Lan Guo
Clin Cancer Res 2006 12: 4583-4589 doi: 10.1158/1078-0432.CCR-06-0290 [Abstract] [Full Text] [PDF] Supplementary Data  

Early Detection of Chemoradioresponse in Esophageal Carcinoma by 3'-Deoxy-3'-³H-Fluorothymidine Using Preclinical Tumor Models

Smith Apisarnthanarax, Mian M. Alauddin, Firas Mourtada, Hisanori Ariga, Uma Raju, Osama Mawlawi, Dongmei Han, William G. Bornmann, Jaffer A. Ajani, Luka Milas, Juri G. Gelovani, and K.S. Clifford Chao
Clin Cancer Res 2006 12: 4590-4597 doi: 10.1158/1078-0432.CCR-05-2720 [Abstract] [Full Text] [PDF]  

Expression of Annexin A1 in Esophageal and Esophagogastric Junction Adenocarcinomas: Association with Poor Outcome

Kim L. Wang, Tsung-Teh Wu, Erika Resetkova, Huamin Wang, Arlene M. Correa, Wayne L. Hofstetter, Stephen G. Swisher, Jaffer A. Ajani, Asif Rashid, Stanley R. Hamilton, and Constance T. Albarracin
Clin Cancer Res 2006 12: 4598-4604 doi: 10.1158/1078-0432.CCR-06-0483 [Abstract] [Full Text] [PDF]  

The Prognostic Value of Circulating Tumor Cells in Patients with Melanoma: A Systematic Review and Meta-analysis

Simone Mocellin, Dave Hoon, Alessandro Ambrosi, Donato Nitti, and Carlo Riccardo Rossi
Clin Cancer Res 2006 12: 4605-4613 doi: 10.1158/1078-0432.CCR-06-0823 [Abstract] [Full Text] [PDF] Supplementary Data  

High Progesterone Receptor Expression Correlates to the Effect of Adjuvant Tamoxifen in Premenopausal Breast Cancer Patients

Maria Stendahl, Lisa Rydén, Bo Nordenskjöld, Per Ebbe Jönsson, Göran Landberg, and Karin Jirström
Clin Cancer Res 2006 12: 4614-4618 doi: 10.1158/1078-0432.CCR-06-0248 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Phase I Trial of Sequential Low-Dose 5-Aza-2'-Deoxycytidine Plus High-Dose Intravenous Bolus Interleukin-2 in Patients with Melanoma or Renal Cell Carcinoma

Jared A. Gollob, Catherine J. Sciambi, Bercedis L. Peterson, Tina Richmond, Monica Thoreson, Kelly Moran, Holly K. Dressman, Jaroslav Jelinek, and Jean-Pierre J. Issa
Clin Cancer Res 2006 12: 4619-4627 doi: 10.1158/1078-0432.CCR-06-0883 [Abstract] [Full Text] [PDF]  

A Phase I Study of Intravenous LBH589, a Novel Cinnamic Hydroxamic Acid Analogue Histone Deacetylase Inhibitor, in Patients with Refractory Hematologic Malignancies

Francis Giles, Thomas Fischer, Jorge Cortes, Guillermo Garcia-Manero, Joachim Beck, Farhad Ravandi, Eric Masson, Patricia Rae, Glen Laird, Sunil Sharma, Hagop Kantarjian, Margaret Dugan, Maher Albitar, and Kapil Bhalla
Clin Cancer Res 2006 12: 4628-4635 doi: 10.1158/1078-0432.CCR-06-0511 [Abstract] [Full Text] [PDF]  

Influence of Garlic (Allium sativum) on the Pharmacokinetics of Docetaxel

Michael C. Cox, Jennifer Low, James Lee, Janice Walshe, Neelima Denduluri, Arlene Berman, Matthew G. Permenter, William P. Petros, Douglas K. Price, William D. Figg, Alex Sparreboom, and Sandra M. Swain
Clin Cancer Res 2006 12: 4636-4640 doi: 10.1158/1078-0432.CCR-06-0388 [Abstract] [Full Text] [PDF]  

Effect of Human Leukocyte Antigen Class I Expression of Tumor Cells on Outcome of Intravesical Instillation of Bacillus Calmette-Guerin Immunotherapy for Bladder Cancer

Hiroshi Kitamura, Toshihiko Torigoe, Ichiya Honma, Eiji Sato, Hiroko Asanuma, Yoshihiko Hirohashi, Noriyuki Sato, and Taiji Tsukamoto
Clin Cancer Res 2006 12: 4641-4644 doi: 10.1158/1078-0432.CCR-06-0595 [Abstract] [Full Text] [PDF]  

Increased Bioavailability of Intravenous Versus Oral CI-1033, a Pan erbB Tyrosine Kinase Inhibitor: Results of a Phase I Pharmacokinetic Study

George R. Simon, Christopher R. Garrett, Stephen C. Olson, Michael Langevin, Irene A. Eiseman, John J. Mahany, Charles C. Williams, Richard Lush, Adil Daud, Pamela Munster, Alberto Chiappori, Mayer Fishman, Gerold Bepler, Peter F. Lenehan, and Daniel M. Sullivan
Clin Cancer Res 2006 12: 4645-4651 doi: 10.1158/1078-0432.CCR-05-2379 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

An In vivo Platform for Translational Drug Development in Pancreatic Cancer

Belen Rubio-Viqueira, Antonio Jimeno, George Cusatis, Xianfeng Zhang, Christine Iacobuzio-Donahue, Collins Karikari, Chanjusn Shi, Kathleen Danenberg, Peter V. Danenberg, Hidekazu Kuramochi, Koji Tanaka, Sharat Singh, Hossein Salimi-Moosavi, Nadia Bouraoud, Maria L. Amador, Soner Altiok, Piotr Kulesza, Charles Yeo, Wells Messersmith, James Eshleman, Ralph H. Hruban, Anirban Maitra, and Manuel Hidalgo
Clin Cancer Res 2006 12: 4652-4661 doi: 10.1158/1078-0432.CCR-06-0113 [Abstract] [Full Text] [PDF] Supplementary Data  

Effect of Altering Dietary -6/-3 Fatty Acid Ratios on Prostate Cancer Membrane Composition, Cyclooxygenase-2, and Prostaglandin E₂

Naoko Kobayashi, R. James Barnard, Susanne M. Henning, David Elashoff, Srinivasa T. Reddy, Pinchas Cohen, Pak Leung, Jenny Hong-Gonzalez, Stephen J. Freedland, Jonathan Said, Dorina Gui, Navindra P. Seeram, Laura M. Popoviciu, Dilprit Bagga, David Heber, John A. Glaspy, and William J. Aronson
Clin Cancer Res 2006 12: 4662-4670 doi: 10.1158/1078-0432.CCR-06-0459 [Abstract] [Full Text] [PDF] Supplementary Data  

Mutations Within the Kinase Domain and Truncations of the Epidermal Growth Factor Receptor Are Rare Events in Bladder Cancer: Implications for Therapy

Kelly N. Blehm, Philippe E. Spiess, Jolanta E. Bondaruk, Melanie E. Dujka, Gabriel J. Villares, Yi-jue Zhao, Oliver Bogler, Kenneth D. Aldape, H. Barton Grossman, Liana Adam, David J. McConkey, Bogdan A. Czerniak, Colin P. Dinney, and Menashe Bar-Eli
Clin Cancer Res 2006 12: 4671-4677 doi: 10.1158/1078-0432.CCR-06-0407 [Abstract] [Full Text] [PDF]  

Intratumoral Therapy with IL13-PE38 Results in Effective CTL-Mediated Suppression of IL-13R2-Expressing Contralateral Tumors

Koji Kawakami, Masaki Terabe, Mitomu Kioi, Jay A. Berzofsky, and Raj K. Puri
Clin Cancer Res 2006 12: 4678-4686 doi: 10.1158/1078-0432.CCR-06-0192 [Abstract] [Full Text] [PDF]  

Valproic Acid Prolongs Survival Time of Severe Combined Immunodeficient Mice Bearing Intracerebellar Orthotopic Medulloblastoma Xenografts

Qin Shu, Barbara Antalffy, Jack Meng Feng Su, Adekunle Adesina, Ching-Nan Ou, Torsten Pietsch, Susan M. Blaney, Ching C. Lau, and Xiao-Nan Li
Clin Cancer Res 2006 12: 4687-4694 doi: 10.1158/1078-0432.CCR-05-2849 [Abstract] [Full Text] [PDF]  

Synergistic Antitumor Activity of Taxol and Immunotoxin SS1P in Tumor-Bearing Mice

YuJian Zhang, Laiman Xiang, Raffit Hassan, Chang H. Paik, Jorge A. Carrasquillo, Beom-su Jang, Nhat Le, Mitchell Ho, and Ira Pastan
Clin Cancer Res 2006 12: 4695-4701 doi: 10.1158/1078-0432.CCR-06-0346 [Abstract] [Full Text] [PDF]  

Minicircle-IFN Induces Antiproliferative and Antitumoral Effects in Human Nasopharyngeal Carcinoma

Jiangxue Wu, Xia Xiao, Peng Zhao, Gang Xue, Yinghui Zhu, Xiaofeng Zhu, Limin Zheng, Yixin Zeng, and Wenlin Huang
Clin Cancer Res 2006 12: 4702-4713 doi: 10.1158/1078-0432.CCR-06-0520 [Abstract] [Full Text] [PDF] Supplementary Data  

Low-Dose Combretastatin A4 Phosphate Enhances the Immune Response of Tumor Hosts to Experimental Colon Carcinoma

Wiaam Badn, Suzanne Kalliomäki, Bengt Widegren, and Hans Olov Sjögren
Clin Cancer Res 2006 12: 4714-4719 doi: 10.1158/1078-0432.CCR-05-2807 [Abstract] [Full Text] [PDF]  

Antisense to Cyclin D1 Inhibits Vascular Endothelial Growth Factor–Stimulated Growth of Vascular Endothelial Cells: Implication of Tumor Vascularization

Masayoshi Yasui, Hirofumi Yamamoto, Chew Yee Ngan, Bazarragchaa Damdinsuren, Yurika Sugita, Hiroki Fukunaga, Jinyu Gu, Makiko Maeda, Ichiro Takemasa, Masataka Ikeda, Yasushi Fujio, Mitsugu Sekimoto, Nariaki Matsuura, I. Bernard Weinstein, and Morito Monden
Clin Cancer Res 2006 12: 4720-4729 doi: 10.1158/1078-0432.CCR-05-1213 [Abstract] [Full Text] [PDF]  

The Combination of Ionizing Radiation and Peripheral Vaccination Produces Long-term Survival of Mice Bearing Established Invasive GL261 Gliomas

Elizabeth W. Newcomb, Sandra Demaria, Yevgeniy Lukyanov, Yongzhao Shao, Tona Schnee, Noriko Kawashima, Li Lan, J. Keith Dewyngaert, David Zagzag, William H. McBride, and Silvia C. Formenti
Clin Cancer Res 2006 12: 4730-4737 doi: 10.1158/1078-0432.CCR-06-0593 [Abstract] [Full Text] [PDF]  

Temozolomide-Mediated Radiation Enhancement in Glioblastoma: A Report on Underlying Mechanisms

Arnab Chakravarti, Michael G. Erkkinen, Ulf Nestler, Roger Stupp, Minesh Mehta, Ken Aldape, Mark R. Gilbert, Peter McL. Black, and Jay S. Loeffler
Clin Cancer Res 2006 12: 4738-4746 doi: 10.1158/1078-0432.CCR-06-0596 [Abstract] [Full Text] [PDF]  

Hypoxia-Inducible Factor-1 Inhibition in Combination with Temozolomide Treatment Exhibits Robust Antitumor Efficacy In vivo

Leiming Li, Xiaoyu Lin, Alex R. Shoemaker, Daniel H. Albert, Stephen W. Fesik, and Yu Shen
Clin Cancer Res 2006 12: 4747-4754 doi: 10.1158/1078-0432.CCR-05-2842 [Abstract] [Full Text] [PDF]  

Growth-Inhibitory Effects of Human Anti-Insulin-Like Growth Factor-I Receptor Antibody (A12) in an Orthotopic Nude Mouse Model of Anaplastic Thyroid Carcinoma

Zhuoying Wang, Geetika Chakravarty, Seungwon Kim, Yasemin D. Yazici, Maher N. Younes, Samar A. Jasser, Alfredo A. Santillan, Corazon D. Bucana, Adel K. El-Naggar, and Jeffrey N. Myers
Clin Cancer Res 2006 12: 4755-4765 doi: 10.1158/1078-0432.CCR-05-2691 [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Effects of Long-term Rofecoxib on Gastric Intestinal Metaplasia: Results of a Randomized Controlled Trial

Wai K. Leung, Enders K.W. Ng, Francis K.L. Chan, Wing Y. Chan, Kui-fat Chan, Alex C.M. Auyeung, Candice C.H. Lam, James Y.W. Lau, and Joseph J.Y. Sung
Clin Cancer Res 2006 12: 4766-4772 doi: 10.1158/1078-0432.CCR-06-0693 [Abstract] [Full Text] [PDF]  

Expression of Carcinoembryonic Antigen Cell Adhesion Molecule 6 Oncoprotein in Atypical Ductal Hyperplastic Tissues Is Associated with the Development of Invasive Breast Cancer

Indira Poola, Babok Shokrani, Rakesh Bhatnagar, Robert L. DeWitty, Qingqi Yue, and George Bonney
Clin Cancer Res 2006 12: 4773-4783 doi: 10.1158/1078-0432.CCR-05-2286 [Abstract] [Full Text] [PDF] Supplementary Data  

Letters to the Editor:

Genetic Effect of ERCC1 Codon 118 Polymorphism and Confounding Factors

Jeong Seon Ryu, Jérôme Viguier, and Françoise Praz
Clin Cancer Res 2006 12: 4784-4785 doi: 10.1158/1078-0432.CCR-06-0419 [Full Text] [PDF]  

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