Editorials:

Taming Clinical Research's Paper Tigers

John I. Gallin
Clin Cancer Res 2006 12: 4131. [Full Text] [PDF]  

The Biology Behind:

Selective TRAIL-Induced Apoptosis in Dysplastic Neoplasia of the Colon May Lead to New Neoadjuvant or Adjuvant Therapies

Niklas Finnberg and Wafik S. El-Deiry
Clin Cancer Res 2006 12: 4132-4136. [Full Text] [PDF]  

CCR Drug Updates:

Genetic Testing in Cancer Therapeutics

Hany H. Ezzeldin and Robert B. Diasio
Clin Cancer Res 2006 12: 4137-4141. [Full Text] [PDF]  

Molecular Pathways:

Inhibition of Transforming Growth Factor-ß Signaling in Human Cancer: Targeting a Tumor Suppressor Network as a Therapeutic Strategy

Swati Biswas, Tracy L. Criswell, Shizhen Emily Wang, and Carlos L. Arteaga
Clin Cancer Res 2006 12: 4142-4146. [Full Text] [PDF]  

Review:

Chronic Oxaliplatin Resistance Induces Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cell Lines

Anthony D. Yang, Fan Fan, E. Ramsay Camp, George van Buren, Wenbiao Liu, Ray Somcio, Michael J. Gray, Haiyun Cheng, Paulo M. Hoff, and Lee M. Ellis
Clin Cancer Res 2006 12: 4147-4153. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

c-Met Ectodomain Shedding Rate Correlates with Malignant Potential

Gagani Athauda, Alessio Giubellino, Jonathan A. Coleman, Christine Horak, Patricia S. Steeg, Ming-Jung Lee, Jane Trepel, Jennifer Wimberly, Jan Sun, Angela Coxon, Teresa L. Burgess, and Donald P. Bottaro
Clin Cancer Res 2006 12: 4154-4162. [Abstract] [Full Text] [PDF]  

Unexpected Abundance of HLA Class II Presented Peptides in Primary Renal Cell Carcinomas

Jörn Dengjel, Maria-Dorothea Nastke, Cécile Gouttefangeas, Gitsios Gitsioudis, Oliver Schoor, Florian Altenberend, Margret Müller, Björn Krämer, Anna Missiou, Martina Sauter, Jörg Hennenlotter, Dorothee Wernet, Arnulf Stenzl, Hans-Georg Rammensee, Karin Klingel, and Stefan Stevanovic
Clin Cancer Res 2006 12: 4163-4170. [Abstract] [Full Text] [PDF] Supplementary Data  

Hypomethylated P4 Promoter Induces Expression of the Insulin-Like Growth Factor-II Gene in Hepatocellular Carcinoma in a Chinese Population

Shao Hui Tang, Dong Hua Yang, Wei Huang, Hong Ke Zhou, Xiao Hua Lu, and Gang Ye
Clin Cancer Res 2006 12: 4171-4177. [Abstract] [Full Text] [PDF]  

Isolation of Human Prostatic Epithelial Plasma Membranes for Proteomics Using Mirror Image Tissue Banking of Radical Prostatectomy Specimens

Kanishka Sircar, Louis Gaboury, Lydia Ouadi, Melanie Mecteau, Eleonora Scarlata, Fred Saad, Armen Aprikian, Simon Tanguay, Steven Lapointe, Christian Lussier, Tina Miletti, and Joel Lanoix
Clin Cancer Res 2006 12: 4178-4184. [Abstract] [Full Text] [PDF]  

Basoluminal Carcinoma: A New Biologically and Prognostically Distinct Entity Between Basal and Luminal Breast Cancer

Mervi Laakso, Minna Tanner, Jonas Nilsson, Tom Wiklund, Björn Erikstein, Pirkko Kellokumpu-Lehtinen, Per Malmström, Nils Wilking, Jonas Bergh, and Jorma Isola
Clin Cancer Res 2006 12: 4185-4191. [Abstract] [Full Text] [PDF]  

PC Cell–Derived Growth Factor Stimulates Proliferation and Confers Trastuzumab Resistance to Her-2-Overexpressing Breast Cancer Cells

Wes E. Kim and Ginette Serrero
Clin Cancer Res 2006 12: 4192-4199. [Abstract] [Full Text] [PDF]  

Peroxisome Proliferator-Activated Receptor and Growth Inhibition by Its Ligands in Uterine Endometrial Carcinoma

Kyoko Ota, Kiyoshi Ito, Takashi Suzuki, Sumika Saito, Mitsutoshi Tamura, Shin-ichi Hayashi, Kunihiro Okamura, Hironobu Sasano, and Nobuo Yaegashi
Clin Cancer Res 2006 12: 4200-4208. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Electron Paramagnetic Resonance Oxygen Images Correlate Spatially and Quantitatively with Oxylite Oxygen Measurements

Martyna Elas, Kang-Hyun Ahn, Adrian Parasca, Eugene D. Barth, David Lee, Chad Haney, and Howard J. Halpern
Clin Cancer Res 2006 12: 4209-4217. [Abstract] [Full Text] [PDF]  

Circulating Tumor Cells at Each Follow-up Time Point during Therapy of Metastatic Breast Cancer Patients Predict Progression-Free and Overall Survival

Daniel F. Hayes, Massimo Cristofanilli, G. Thomas Budd, Matthew J. Ellis, Alison Stopeck, M. Craig Miller, Jeri Matera, W. Jeffrey Allard, Gerald V. Doyle, and Leon W.W.M. Terstappen
Clin Cancer Res 2006 12: 4218-4224. [Abstract] [Full Text] [PDF]  

Megakaryocyte Potentiation Factor Cleaved from Mesothelin Precursor Is a Useful Tumor Marker in the Serum of Patients with Mesothelioma

Masanori Onda, Satoshi Nagata, Mitchell Ho, Tapan K. Bera, Raffit Hassan, Richard H. Alexander, and Ira Pastan
Clin Cancer Res 2006 12: 4225-4231. [Abstract] [Full Text] [PDF]  

High Fluorodeoxyglucose Uptake on Positron Emission Tomography in Patients with Advanced Non–Small Cell Lung Cancer on Platinum-Based Combination Chemotherapy

Kyung-Hun Lee, Se-Hoon Lee, Dong-Wan Kim, Won Jun Kang, June-Key Chung, Seock-Ah Im, Tae-You Kim, Young Whan Kim, Yung-Jue Bang, and Dae Seog Heo
Clin Cancer Res 2006 12: 4232-4236. [Abstract] [Full Text] [PDF]  

High WT1 Expression Is Associated with Very Poor Survival of Patients with Osteogenic Sarcoma Metastasis

Alok Srivastava, Bruno Fuchs, Kunbo Zhang, Ming Ruan, Chandralekha Halder, Eric Mahlum, Kristin Weber, Mark E. Bolander, and Gobinda Sarkar
Clin Cancer Res 2006 12: 4237-4243. [Abstract] [Full Text] [PDF] Supplementary Data  

Inverse Effects of Mucin on Survival of Matched Hereditary Nonpolyposis Colorectal Cancer and Sporadic Colorectal Cancer Patients

Jeng-Fu You, Ling-Ling Hsieh, Chung Rong Changchien, Jinn-Shiun Chen, Jim-Ray Chen, Jy-Ming Chiang, Chien Yuh Yeh, Pao-Shiu Hsieh, Chung-Wei Fan, Chun-Ting Liu, and Reiping Tang
Clin Cancer Res 2006 12: 4244-4250. [Abstract] [Full Text] [PDF]  

An Immunohistochemical Study of Morules in Endometrioid Lesions of the Female Genital Tract: CD10 Is a Characteristic Marker of Morular Metaplasia

Silvia Chiarelli, Catalina Buriticá, Piero Litta, Susana Ciani, Rosa Guarch, and Francisco F. Nogales
Clin Cancer Res 2006 12: 4251-4256. [Abstract] [Full Text] [PDF]  

MUC4 Is a Novel Prognostic Factor of Extrahepatic Bile Duct Carcinoma

Shugo Tamada, Hiroaki Shibahara, Michiyo Higashi, Masamichi Goto, Surinder K. Batra, Kohzoh Imai, and Suguru Yonezawa
Clin Cancer Res 2006 12: 4257-4264. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Clinical and Biological Effects of Recombinant Human Interleukin-18 Administered by Intravenous Infusion to Patients with Advanced Cancer

Michael J. Robertson, James W. Mier, Theodore Logan, Michael Atkins, Henry Koon, Kevin M. Koch, Steven Kathman, Lini N. Pandite, Coreen Oei, Lyndon C. Kirby, Roxanne C. Jewell, William N. Bell, Linda M. Thurmond, Jill Weisenbach, Suzanne Roberts, and Mohammed M. Dar
Clin Cancer Res 2006 12: 4265-4273. [Abstract] [Full Text] [PDF]  

A Phase I Clinical and Pharmacokinetic Study of Oral CI-1033 in Combination with Docetaxel in Patients with Advanced Solid Tumors

Linda L. Garland, Manuel Hidalgo, David S. Mendelson, David P. Ryan, Banu K. Arun, Jennifer L. Lovalvo, Irene A. Eiseman, Stephen C. Olson, Peter F. Lenehan, and Joseph P. Eder
Clin Cancer Res 2006 12: 4274-4282. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor Kinase Domain Mutations in Esophageal and Pancreatic Adenocarcinomas

Eunice L. Kwak, Janusz Jankowski, Sarah P. Thayer, Gregory Y. Lauwers, Brian W. Brannigan, Patricia L. Harris, Ross A. Okimoto, Sara M. Haserlat, David R. Driscoll, David Ferry, Beth Muir, Jeff Settleman, Charles S. Fuchs, Matthew H. Kulke, David P. Ryan, Jeff W. Clark, Dennis C. Sgroi, Daniel A. Haber, and Daphne W. Bell
Clin Cancer Res 2006 12: 4283-4287. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

The Synthetic Triterpenoid CDDO-Imidazolide Suppresses STAT Phosphorylation and Induces Apoptosis in Myeloma and Lung Cancer Cells

Karen Liby, Nga Voong, Charlotte R. Williams, Renee Risingsong, Darlene B. Royce, Tadashi Honda, Gordon W. Gribble, Michael B. Sporn, and John J. Letterio
Clin Cancer Res 2006 12: 4288-4293. [Abstract] [Full Text] [PDF]  

Systemic Anti-CD25 Monoclonal Antibody Administration Safely Enhances Immunity in Murine Glioma without Eliminating Regulatory T Cells

Peter E. Fecci, Alison E. Sweeney, Peter M. Grossi, Smita K. Nair, Christopher A. Learn, Duane A. Mitchell, Xiuyu Cui, Thomas J. Cummings, Darell D. Bigner, Eli Gilboa, and John H. Sampson
Clin Cancer Res 2006 12: 4294-4305. [Abstract] [Full Text] [PDF]  

Xenografts of Human Hepatocellular Carcinoma: A Useful Model for Testing Drugs

Hung Huynh, Khee Chee Soo, Pierce K.H. Chow, Lawrence Panasci, and Evelyn Tran
Clin Cancer Res 2006 12: 4306-4314. [Abstract] [Full Text] [PDF]  

Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-ß Type I Receptor Kinase In vivo

Rongrong Ge, Vaishali Rajeev, Partha Ray, Edmund Lattime, Susan Rittling, Satya Medicherla, Andy Protter, Alison Murphy, Jit Chakravarty, Sundeep Dugar, George Schreiner, Nicola Barnard, and Michael Reiss
Clin Cancer Res 2006 12: 4315-4330. [Abstract] [Full Text] [PDF] Supplementary Data  

Influence of Formulation Vehicle on Metronomic Taxane Chemotherapy: Albumin-Bound versus Cremophor EL–Based Paclitaxel

Sylvia S.W. Ng, Alex Sparreboom, Yuval Shaked, Christina Lee, Shan Man, Neil Desai, Patrick Soon-Shiong, William D. Figg, and Robert S. Kerbel
Clin Cancer Res 2006 12: 4331-4338. [Abstract] [Full Text] [PDF]  

Overcoming Drug-Resistant Cancer by a Newly Developed Copper Chelate through Host-Protective Cytokine-Mediated Apoptosis

Ananda Mookerjee, Jayati Mookerjee Basu, Pranabananda Dutta, Surajit Majumder, Sankar Bhattacharyya, Jaydip Biswas, Smarajit Pal, Pratima Mukherjee, Sanghamitra Raha, Rathindra N. Baral, Tania Das, Thomas Efferth, Gourisankar Sa, Shyamal Roy, and Soumitra K. Choudhuri
Clin Cancer Res 2006 12: 4339-4349. [Abstract] [Full Text] [PDF]  

TRAIL Induces Apoptosis in Human Colorectal Adenoma Cell Lines and Human Colorectal Adenomas

Mathilde Jalving, Steven de Jong, Jan J. Koornstra, Wytske Boersma-van Ek, Nynke Zwart, Jelle Wesseling, Elisabeth G.E. de Vries, and Jan H. Kleibeuker
Clin Cancer Res 2006 12: 4350-4356. [Abstract] [Full Text] [PDF]  

ABCA3 as a Possible Cause of Drug Resistance in Childhood Acute Myeloid Leukemia

Daniel Steinbach, Jean-Pierre Gillet, Axel Sauerbrey, Bernd Gruhn, Kristin Dawczynski, Vincent Bertholet, Françoise de Longueville, Felix Zintl, Jose Remacle, and Thomas Efferth
Clin Cancer Res 2006 12: 4357-4363. [Abstract] [Full Text] [PDF] Supplementary Data  

Corrections:

Article on Mesenchymal Stem Cell Targeting of Microscopic Tumors

Clin Cancer Res 2006 12: 4364. [Full Text] [PDF]  

Novel Agents in the Treatment of Lung Cancer: Advances in EGFR-Targeted Agents:

Summary Statement: Novel Agents in the Treatment of Lung Cancer: Advances in Epidermal Growth Factor Receptor-Targeted Agents

Thomas J. Lynch, Alex A. Adjei, Paul A. Bunn, Jr., Tim G. Eisen, Jeffrey Engelman, Glenwood D. Goss, Daniel A. Haber, John V. Heymach, Pasi A. Jänne, Bruce E. Johnson, David H. Johnson, Rogerio C. Lilenbaum, Matthew Meyerson, Alan B. Sandler, Lecia V. Sequist, Jeffrey Settleman, Kwok-Kin Wong, and Carol S. Hart
Clin Cancer Res 2006 12: 4365s-4371s. [Full Text] [PDF]  

The Role of the ErbB Family Members in Non–Small Cell Lung Cancers Sensitive to Epidermal Growth Factor Receptor Kinase Inhibitors

Jeffrey A. Engelman and Lewis C. Cantley
Clin Cancer Res 2006 12: 4372s-4376s. [Abstract] [Full Text] [PDF]  

Her2-Targeted Therapies in Non–Small Cell Lung Cancer

Charles Swanton, Andy Futreal, and Tim Eisen
Clin Cancer Res 2006 12: 4377s-4383s. [Abstract] [Full Text] [PDF]  

Genomic Approaches to Lung Cancer

Roman K. Thomas, Barbara Weir, and Matthew Meyerson
Clin Cancer Res 2006 12: 4384s-4391s. [Abstract] [Full Text] [PDF]  

"Oncogenic Shock": Explaining Oncogene Addiction through Differential Signal Attenuation

Sreenath V. Sharma, Michael A. Fischbach, Daniel A. Haber, and Jeffrey Settleman
Clin Cancer Res 2006 12: 4392s-4395s. [Abstract] [Full Text] [PDF]  

Mouse Models of Lung Cancer

Amit Dutt and Kwok-Kin Wong
Clin Cancer Res 2006 12: 4396s-4402s. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor Mutation Testing in the Care of Lung Cancer Patients

Lecia V. Sequist, Victoria A. Joshi, Pasi A. Jänne, Daphne W. Bell, Panos Fidias, Neal I. Lindeman, David N. Louis, Jeffrey C. Lee, Eugene J. Mark, Janina Longtine, Peter Verlander, Raju Kucherlapati, Matthew Meyerson, Daniel A. Haber, Bruce E. Johnson, and Thomas J. Lynch
Clin Cancer Res 2006 12: 4403s-4408s. [Abstract] [Full Text] [PDF]  

Selecting Lung Cancer Patients for Treatment with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors by Immunohistochemistry and Fluorescence In situ Hybridization—Why, When, and How?

Rafal Dziadziuszko, Fred R. Hirsch, Marileila Varella-Garcia, and Paul A. Bunn, Jr.
Clin Cancer Res 2006 12: 4409s-4415s. [Abstract] [Full Text] [PDF]  

Effect of Epidermal Growth Factor Receptor Tyrosine Kinase Domain Mutations on the Outcome of Patients with Non–Small Cell Lung Cancer Treated with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

Pasi A. Jänne and Bruce E. Johnson
Clin Cancer Res 2006 12: 4416s-4420s. [Abstract] [Full Text] [PDF]  

Combining Targeted Agents: Blocking the Epidermal Growth Factor and Vascular Endothelial Growth Factor Pathways

Alan Sandler and Roy Herbst
Clin Cancer Res 2006 12: 4421s-4425s. [Abstract] [Full Text] [PDF]  

Strategies to Enhance Epidermal Growth Factor Inhibition: Targeting the Mevalonate Pathway

Jim Dimitroulakos, Ian A. Lorimer, and Glenwood Goss
Clin Cancer Res 2006 12: 4426s-4431s. [Abstract] [Full Text] [PDF]  

The Evolving Role of Cetuximab in Non–Small Cell Lung Cancer

Rogerio C. Lilenbaum
Clin Cancer Res 2006 12: 4432s-4435s. [Abstract] [Full Text] [PDF]  

Rationale for a Phase II Trial of Pertuzumab, a HER-2 Dimerization Inhibitor, in Patients with Non–Small Cell Lung Cancer

Bruce E. Johnson and Pasi A. Jänne
Clin Cancer Res 2006 12: 4436s-4440s. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor Inhibitors in Development for the Treatment of Non–Small Cell Lung Cancer

John V. Heymach, Monique Nilsson, George Blumenschein, Vassiliki Papadimitrakopoulou, and Roy Herbst
Clin Cancer Res 2006 12: 4441s-4445s. [Abstract] [Full Text] [PDF]  

Novel Combinations Based on Epidermal Growth Factor Receptor Inhibition

Alex A. Adjei
Clin Cancer Res 2006 12: 4446s-4450s. [Abstract] [Full Text] [PDF]  

Targeted Therapies in Combination with Chemotherapy in Non–Small Cell Lung Cancer

David H. Johnson
Clin Cancer Res 2006 12: 4451s-4457s. [Abstract] [Full Text] [PDF]  

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