Perspective:

Progress and Promise of FDG-PET Imaging for Cancer Patient Management and Oncologic Drug Development

Gary J. Kelloff, John M. Hoffman, Bruce Johnson, Howard I. Scher, Barry A. Siegel, Edward Y. Cheng, Bruce D. Cheson, Joyce O'Shaughnessy, Kathryn Z. Guyton, David A. Mankoff, Lalitha Shankar, Steven M. Larson, Caroline C. Sigman, Richard L. Schilsky, and Daniel C. Sullivan
Clin Cancer Res 2005 11: 2785-2808. [Abstract] [Full Text] [PDF]  

Reviews:

Aromatase Inhibition: Translation into a Successful Therapeutic Approach

Jürgen Geisler and Per Eystein Lønning
Clin Cancer Res 2005 11: 2809-2821. [Abstract] [Full Text] [PDF]  

The Clinical Relevance of Steroid Hormone Receptor Corepressors

Rakesh Kumar, Anupama E. Gururaj, Ratna K. Vadlamudi, and Suresh K. Rayala
Clin Cancer Res 2005 11: 2822-2831. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Lack of Telomerase Activity in Lung Carcinoids Is Dependent on Human Telomerase Reverse Transcriptase Transcription and Alternative Splicing and Is Associated with Long Telomeres

Nadia Zaffaroni, Raffaella Villa, Ugo Pastorino, Rosalia Cirincione, Matteo Incarbone, Marco Alloisio, Maria Curto, Silvana Pilotti, and Maria Grazia Daidone
Clin Cancer Res 2005 11: 2832-2839. [Abstract] [Full Text] [PDF]  

Colocalization of the Tetraspanins, CO-029 and CD151, with Integrins in Human Pancreatic Adenocarcinoma: Impact on Cell Motility

Sabine Gesierich, Claudia Paret, Dagmar Hildebrand, Jürgen Weitz, Kaspar Zgraggen, Friedrich H. Schmitz-Winnenthal, Vaclav Horejsi, Osamu Yoshie, Dorothee Herlyn, Leonie K. Ashman, and Margot Zöller
Clin Cancer Res 2005 11: 2840-2852. [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data  

Identification of HLA-DRB1*1501–Restricted T-cell Epitopes from Prostate-Specific Antigen

Elena N. Klyushnenkova, Jason Link, Warren T. Oberle, James Kodak, Cathleen Rich, Arthur A. Vandenbark, and Richard B. Alexander
Clin Cancer Res 2005 11: 2853-2861. [Abstract] [Full Text] [PDF]  

Colorectal Papillomavirus Infection in Patients with Colorectal Cancer

Sohrab Bodaghi, Koji Yamanegi, Shu-Yuan Xiao, Maria Da Costa, Joel M. Palefsky, and Zhi-Ming Zheng
Clin Cancer Res 2005 11: 2862-2867. [Abstract] [Full Text] [PDF]  

Growth Factor Regulation of a 26S Proteasomal Subunit in Breast Cancer

Christopher J. Barnes, Feng Li, Amjad H. Talukder, and Rakesh Kumar
Clin Cancer Res 2005 11: 2868-2874. [Abstract] [Full Text] [PDF]  

Frequent Mutation of the PIK3CA Gene in Ovarian and Breast Cancers

Douglas A. Levine, Faina Bogomolniy, Cindy J. Yee, Alex Lash, Richard R. Barakat, Patrick I. Borgen, and Jeff Boyd
Clin Cancer Res 2005 11: 2875-2878. [Abstract] [Full Text] [PDF]  

Somatic Mutations of EGFR Gene in Squamous Cell Carcinoma of the Head and Neck

Jong Woo Lee, Young Hwa Soung, Su Young Kim, Hyo Kyung Nam, Won Sang Park, Suk Woo Nam, Min Sik Kim, Dong Il Sun, Youn Soo Lee, Ja June Jang, Jung Young Lee, Nam Jin Yoo, and Sug Hyung Lee
Clin Cancer Res 2005 11: 2879-2882. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Stronger Association between Obesity and Biochemical Progression after Radical Prostatectomy among Men Treated in the Last 10 Years

Stephen J. Freedland, William B. Isaacs, Leslie A. Mangold, Sindy K. Yiu, Kelly A. Grubb, Alan W. Partin, Jonathan I. Epstein, Patrick C. Walsh, and Elizabeth A. Platz
Clin Cancer Res 2005 11: 2883-2888. [Abstract] [Full Text] [PDF]  

Clinical Significance of Human Kallikrein Gene 6 Messenger RNA Expression in Colorectal Cancer

Kazuhiko Ogawa, Tohru Utsunomiya, Koshi Mimori, Fumiaki Tanaka, Hiroshi Inoue, Hisashi Nagahara, Sadayuki Murayama, and Masaki Mori
Clin Cancer Res 2005 11: 2889-2893. [Abstract] [Full Text] [PDF]  

High Mutagen Sensitivity in Peripheral Blood Lymphocytes Predicts Poor Overall and Disease-Specific Survival in Patients with Stage III Non–Small Cell Lung Cancer Treated with Radiotherapy and Chemotherapy

Joe Y. Chang, Ritsuko Komaki, Ryohei Sasaki, Zhongxing Liao, Craig W. Stevens, Charles Lu, Frank V. Fossella, Pamela K. Allen, James D. Cox, Margaret R. Spitz, and Xifeng Wu
Clin Cancer Res 2005 11: 2894-2898. [Abstract] [Full Text] [PDF]  

Heparanase Expression at the Invasion Front of Human Head and Neck Cancers and Correlation with Poor Prognosis

Philipp Beckhove, Burkhard M. Helmke, Yvonne Ziouta, Mariana Bucur, Wolfgang Dörner, Carolin Mogler, Gerhard Dyckhoff, and Christel Herold-Mende
Clin Cancer Res 2005 11: 2899-2906. [Abstract] [Full Text] [PDF]  

Array Comparative Genomic Hybridization Identifies Genetic Subgroups in Grade 4 Human Astrocytoma

Anjan Misra, Malgorzata Pellarin, Janice Nigro, Ivan Smirnov, Dan Moore, Kathleen R. Lamborn, Daniel Pinkel, Donna G. Albertson, and Burt G. Feuerstein
Clin Cancer Res 2005 11: 2907-2918. [Abstract] [Full Text] [PDF]  

Detection of Human Papillomavirus Infection of the Cervix in Very Elderly Women Using PCR

Kaiyo Takubo, Naotaka Shimomura-Izumiyama, Hidemi Koiwai, Naoko Honma, Yukiyoshi Esaki, Tomomi Yoshida, Takashi Nakajima, Motoji Sawabe, and Tomio Arai
Clin Cancer Res 2005 11: 2919-2923. [Abstract] [Full Text] [PDF]  

EGFR Mutation Status in Japanese Lung Cancer Patients: Genotyping Analysis Using LightCycler

Hidefumi Sasaki, Katsuhiko Endo, Akimitsu Konishi, Minoru Takada, Masaaki Kawahara, Keiji Iuchi, Akihide Matsumura, Meinoshin Okumura, Hisaichi Tanaka, Tomoya Kawaguchi, Toshiki Shimizu, Hiroshi Takeuchi, Motoki Yano, Ichiro Fukai, and Yoshitaka Fujii
Clin Cancer Res 2005 11: 2924-2929. [Abstract] [Full Text] [PDF]  

Phospho-Akt Expression Is Associated with a Favorable Outcome in Non–Small Cell Lung Cancer

Amit Shah, William A. Swain, Donna Richardson, John Edwards, Duncan J. Stewart, Catherine M. Richardson, Daniel E.B. Swinson, Dipika Patel, J. Louise Jones, and Kenneth J. O'Byrne
Clin Cancer Res 2005 11: 2930-2936. [Abstract] [Full Text] [PDF]  

Expression of CXCR4 and Its Down-Regulation by IFN- in Head and Neck Squamous Cell Carcinoma

Akihiro Katayama, Takeshi Ogino, Nobuyuki Bandoh, Satoshi Nonaka, and Yasuaki Harabuchi
Clin Cancer Res 2005 11: 2937-2946. [Abstract] [Full Text] [PDF]  

Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer

Yuichiro Ohigashi, Masayuki Sho, Yukishige Yamada, Yoshikazu Tsurui, Kaoru Hamada, Naoya Ikeda, Takashi Mizuno, Ryo Yoriki, Hisanori Kashizuka, Katsunari Yane, Fumihiko Tsushima, Noriko Otsuki, Hideo Yagita, Miyuki Azuma, and Yoshiyuki Nakajima
Clin Cancer Res 2005 11: 2947-2953. [Abstract] [Full Text] [PDF]  

Promoter Methylation of DAL-1/4.1B Predicts Poor Prognosis in Non–Small Cell Lung Cancer

Shinji Kikuchi, Daisuke Yamada, Takeshi Fukami, Mari Masuda, Mika Sakurai-Yageta, Yuko N. Williams, Tomoko Maruyama, Hisao Asamura, Yoshihiro Matsuno, Masataka Onizuka, and Yoshinori Murakami
Clin Cancer Res 2005 11: 2954-2961. [Abstract] [Full Text] [PDF]  

Galectin-9 as a Prognostic Factor with Antimetastatic Potential in Breast Cancer

Akemi Irie, Akira Yamauchi, Keiichi Kontani, Minoru Kihara, Dage Liu, Yukako Shirato, Masako Seki, Nozomu Nishi, Takanori Nakamura, Hiroyasu Yokomise, and Mitsuomi Hirashima
Clin Cancer Res 2005 11: 2962-2968. [Abstract] [Full Text] [PDF]  

ß1,6-Branched Oligosaccharides Are Increased in Lymph Node Metastases and Predict Poor Outcome in Breast Carcinoma

Tamara Handerson, Robert Camp, Malini Harigopal, David Rimm, and John Pawelek
Clin Cancer Res 2005 11: 2969-2973. [Abstract] [Full Text] [PDF]  

Expression Levels of TEL, AML1, and the Fusion Products TEL-AML1 and AML1-TEL versus Drug Sensitivity and Clinical Outcome in t(12;21)-Positive Pediatric Acute Lymphoblastic Leukemia

Wendy A.G. Stams, Monique L. den Boer, H. Berna Beverloo, Jules P.P. Meijerink, Elisabeth R. van Wering, Gritta E. Janka-Schaub, and Rob Pieters
Clin Cancer Res 2005 11: 2974-2980. [Abstract] [Full Text] [PDF]  

Single Nucleotide Polymorphism of Pi-Class Glutathione S-Transferase and Susceptibility to Endometrial Carcinoma

Queeny K.Y. Chan, Ui-Soon Khoo, Hextan Y.S. Ngan, Chong-Qing Yang, Wei-Cheng Xue, Kelvin Y.K. Chan, Pui-Man Chiu, Philip P.C. Ip, and Annie N.Y. Cheung
Clin Cancer Res 2005 11: 2981-2985. [Abstract] [Full Text] [PDF]  

N¹,N¹²-Diacetylspermine as a Sensitive and Specific Novel Marker for Early- and Late-Stage Colorectal and Breast Cancers

Kyoko Hiramatsu, Keiichi Takahashi, Taturo Yamaguchi, Hiroshi Matsumoto, Hidenori Miyamoto, Souichi Tanaka, Chikako Tanaka, Yoshiko Tamamori, Mari Imajo, Masashi Kawaguchi, Masakazu Toi, Takeo Mori, and Masao Kawakita
Clin Cancer Res 2005 11: 2986-2990. [Abstract] [Full Text] [PDF]  

Biallelic Deletions in INK4 in Cutaneous Melanoma Are Common and Associated with Decreased Survival

Eva Grafström, Suzanne Egyházi, Ulrik Ringborg, Johan Hansson, and Anton Platz
Clin Cancer Res 2005 11: 2991-2997. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Cellular Uptake and Intracellular Levels of the Bcl-2 Antisense G3139 in Cultured Cells and Treated Patients with Acute Myeloid Leukemia

Guowei Dai, Kenneth K. Chan, Shujun Liu, Dale Hoyt, Susan Whitman, Marko Klisovic, TianSheng Shen, Michael A. Caligiuri, John Byrd, Michael Grever, and Guido Marcucci
Clin Cancer Res 2005 11: 2998-3008. [Abstract] [Full Text] [PDF]  

Phase II Trial of Karenitecin in Patients with Malignant Melanoma: Clinical and Translational Study

Adil Daud, Nikola Valkov, Barbara Centeno, Jennifer Derderian, Patricia Sullivan, Pamela Munster, Patricia Urbas, Ronald C. DeConti, Elmer Berghorn, Zhenmei Liu, Frederick Hausheer, and Daniel Sullivan
Clin Cancer Res 2005 11: 3009-3016. [Abstract] [Full Text] [PDF]  

Phase I Study of Immunization with Dendritic Cells Modified with Fowlpox Encoding Carcinoembryonic Antigen and Costimulatory Molecules

Michael A. Morse, Timothy M. Clay, Amy C. Hobeika, Takuya Osada, Shubi Khan, Stephen Chui, Donna Niedzwiecki, Dennis Panicali, Jeffrey Schlom, and H. Kim Lyerly
Clin Cancer Res 2005 11: 3017-3024. [Abstract] [Full Text] [PDF]  

Combined GADD45A and Thymidine Phosphorylase Expression Levels Predict Response and Survival of Neoadjuvant-Treated Gastric Cancer Patients

Rudolf Napieralski, Katja Ott, Markus Kremer, Katja Specht, Holger Vogelsang, Karen Becker, Martina Müller, Florian Lordick, Ulrich Fink, Jörg Rüdiger Siewert, Heinz Höfler, and Gisela Keller
Clin Cancer Res 2005 11: 3025-3031. [Abstract] [Full Text] [PDF]  

Gefitinib as a First-Line Therapy of Advanced or Metastatic Adenocarcinoma of the Lung in Never-Smokers

Dae Ho Lee, Ji-Youn Han, Hong Gi Lee, Jae Jin Lee, Eun Kyoung Lee, Hyae Young Kim, Hark Kyun Kim, Eun Kyung Hong, and Jin Soo Lee
Clin Cancer Res 2005 11: 3032-3037. [Abstract] [Full Text] [PDF]  

Serum Cystatin C is a Better Marker of Topotecan Clearance than Serum Creatinine

Antje Hoppe, Sophie Séronie-Vivien, Fabienne Thomas, Jean-Pierre Delord, Laurence Malard, Pierre Canal, and Etienne Chatelut
Clin Cancer Res 2005 11: 3038-3044. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Antitumor Activity of Orally Bioavailable Farnesyltransferase Inhibitor, ABT-100, Is Mediated by Antiproliferative, Proapoptotic, and Antiangiogenic Effects in Xenograft Models

Debra Ferguson, Luis E. Rodriguez, Joann P. Palma, Marion Refici, Kenneth Jarvis, Jacqueline O'Connor, Gerard M. Sullivan, David Frost, Kennan Marsh, Joy Bauch, Haiying Zhang, Nan-Horng Lin, Saul Rosenberg, Hing L. Sham, and Ingrid B.J.K. Joseph
Clin Cancer Res 2005 11: 3045-3054. [Abstract] [Full Text] [PDF]  

Development of ß-Lapachone Prodrugs for Therapy Against Human Cancer Cells with Elevated NAD(P)H:Quinone Oxidoreductase 1 Levels

Kathryn E. Reinicke, Erik A. Bey, Melissa S. Bentle, John J. Pink, Stephen T. Ingalls, Charles L. Hoppel, Rosana I. Misico, Gisela M. Arzac, Gerardo Burton, William G. Bornmann, Damon Sutton, Jinming Gao, and David A. Boothman
Clin Cancer Res 2005 11: 3055-3064. [Abstract] [Full Text] [PDF]  

In vivo Effects of the Human Type I Insulin-Like Growth Factor Receptor Antibody A12 on Androgen-Dependent and Androgen-Independent Xenograft Human Prostate Tumors

Jennifer D. Wu, Austin Odman, Lily M. Higgins, Kathy Haugk, Robert Vessella, Dale L. Ludwig, and Stephen R. Plymate
Clin Cancer Res 2005 11: 3065-3074. [Abstract] [Full Text] [PDF]  

Role of Intracellular Glutathione in Cell Sensitivity to the Apoptosis Induced by Tumor Necrosis Factor –Related Apoptosis-Inducing Ligand/Anticancer Drug Combinations

Olivier Meurette, Luz Lefeuvre-Orfila, Amélie Rebillard, Dominique Lagadic-Gossmann, and Marie-Thérèse Dimanche-Boitrel
Clin Cancer Res 2005 11: 3075-3083. [Abstract] [Full Text] [PDF]  

NHS76/PEP₂, a Fully Human Vasopermeability-Enhancing Agent to Increase The Uptake and Efficacy of Cancer Chemotherapy

Leslie A. Khawli, Peisheng Hu, and Alan L. Epstein
Clin Cancer Res 2005 11: 3084-3093. [Abstract] [Full Text] [PDF]  

Intrinsic Chemoresistance to Gemcitabine Is Associated with Decreased Expression of BNIP3 in Pancreatic Cancer

Masanori Akada, Tatjana Crnogorac-Jurcevic, Samuel Lattimore, Patrick Mahon, Rita Lopes, Makoto Sunamura, Seiki Matsuno, and Nicholas R. Lemoine
Clin Cancer Res 2005 11: 3094-3101. [Abstract] [Full Text] [PDF]  

Inhibition of Phosphatidylinositol 3'-Kinase/AKT Signaling Promotes Apoptosis of Primary Effusion Lymphoma Cells

Shahab Uddin, Azhar R. Hussain, Khaled A. Al-Hussein, Pulicat S. Manogaran, Amitha Wickrema, Marina I. Gutierrez, and Kishor G. Bhatia
Clin Cancer Res 2005 11: 3102-3108. [Abstract] [Full Text] [PDF]  

Factors That Limit the Effectiveness of Herpes Simplex Virus Type 1 for Treatment of Oral Cancer in Mice

Edward J. Shillitoe and Christopher Pellenz
Clin Cancer Res 2005 11: 3109-3116. [Abstract] [Full Text] [PDF]  

Resistance of Tumor Interstitial Pressure to the Penetration of Intraperitoneally Delivered Antibodies into Metastatic Ovarian Tumors

Michael F. Flessner, Jaewah Choi, Kimberly Credit, Ravi Deverkadra, and Karla Henderson
Clin Cancer Res 2005 11: 3117-3125. [Abstract] [Full Text] [PDF]  

Enhanced Apoptosis and Tumor Regression Induced by a Direct Agonist Antibody to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Receptor 2

Kazuhiro Motoki, Eiji Mori, Atsushi Matsumoto, Mayumi Thomas, Takafumi Tomura, Robin Humphreys, Vivian Albert, Mari Muto, Hitoshi Yoshida, Masami Aoki, Taro Tamada, Ryota Kuroki, Hideaki Yoshida, Isao Ishida, Carl F. Ware, and Shiro Kataoka
Clin Cancer Res 2005 11: 3126-3135. [Abstract] [Full Text] [PDF]  

p38^MAPK-Dependent Sensitivity of Ewing's Sarcoma Family of Tumors to Fenretinide-Induced Cell Death

Stephen S. Myatt, Christopher P.F. Redfern, and Susan A. Burchill
Clin Cancer Res 2005 11: 3136-3148. [Abstract] [Full Text] [PDF]  

Corrections:

Correction: Article on Fibroblast Growth Factor Overexpressed in Urinary Tract Carcinomas

Clin Cancer Res 2005 11: 3149. [Full Text] [PDF]  

Correction: Article on Identification of Gastric-Related Genes Using a cDNA Microarray

Clin Cancer Res 2005 11: 3149. [Full Text] [PDF]  

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