Human Cancer Biology:

Increased Apoptosis in Cervical Intraepithelial Neoplasia Associated with HIV Infection: Implication of Oncogenic Human Papillomavirus, Caspases, and Langerhans Cells

Francine Walker, Homa Adle-Biassette, Patrick Madelenat, Dominique Hénin, and Thérèse Lehy
Clin Cancer Res 2005 11: 2451-2458. [Abstract] [Full Text] [PDF]  

Up-Regulation of Functional Chemokine Receptor CCR3 in Human Renal Cell Carcinoma

Karin Jöhrer, Claudia Zelle-Rieser, Alexander Perathoner, Patrizia Moser, Martina Hager, Reinhold Ramoner, Hubert Gander, Lorenz Höltl, Georg Bartsch, Richard Greil, and Martin Thurnher
Clin Cancer Res 2005 11: 2459-2465. [Abstract] [Full Text] [PDF]  

Differential DNA Hypermethylation of Critical Genes Mediates the Stage-Specific Tobacco Smoke-Induced Neoplastic Progression of Lung Cancer

Andrea L. Russo, Arunthathi Thiagalingam, Hongjie Pan, Joseph Califano, Kuang-hung Cheng, Jose F. Ponte, Dharmaraj Chinnappan, Pratima Nemani, David Sidransky, and Sam Thiagalingam
Clin Cancer Res 2005 11: 2466-2470. [Abstract] [Full Text] [PDF]  

ß-Catenin Functions Mainly as an Adhesion Molecule in Patients with Squamous Cell Cancer of the Head and Neck

Ziwei Yu, Paul M. Weinberger, Elayne Provost, Bruce G. Haffty, Clarence Sasaki, J. Joe, R.L. Camp, D.L. Rimm, and Amanda Psyrri
Clin Cancer Res 2005 11: 2471-2477. [Abstract] [Full Text] [PDF]  

Dedifferentiation Precedes Invasion in the Progression from Barrett's Metaplasia to Esophageal Adenocarcinoma

James Helm, Steven A. Enkemann, Domenico Coppola, James S. Barthel, Scott T. Kelley, and Timothy J. Yeatman
Clin Cancer Res 2005 11: 2478-2485. [Abstract] [Full Text] [PDF]  

Increased Mitochondrial DNA Content in Saliva Associated with Head and Neck Cancer

Wei-Wen Jiang, Brett Masayesva, Marianna Zahurak, Andre Lopes Carvalho, Eli Rosenbaum, Elizabeth Mambo, Shaoyu Zhou, Khalid Minhas, Nicole Benoit, William H. Westra, Anthony Alberg, David Sidransky, Wayne Koch, and Joseph Califano
Clin Cancer Res 2005 11: 2486-2491. [Abstract] [Full Text] [PDF]  

Cleavage of L1 in Exosomes and Apoptotic Membrane Vesicles Released from Ovarian Carcinoma Cells

Paul Gutwein, Alexander Stoeck, Svenja Riedle, Daniela Gast, Steffen Runz, Thomas P. Condon, Alexander Marmé, Minh-Chau Phong, Otwin Linderkamp, Alexander Skorokhod, and Peter Altevogt
Clin Cancer Res 2005 11: 2492-2501. [Abstract] [Full Text] [PDF]  

The p53 Codon 72 Proline Allele Is Associated with p53 Gene Mutations in Non–Small Cell Lung Cancer

Yingchuan Hu, Michael P. McDermott, and Steven A. Ahrendt
Clin Cancer Res 2005 11: 2502-2509. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Mcm2, Geminin, and KI67 Define Proliferative State and are Prognostic Markers in Renal Cell Carcinoma

Tim J. Dudderidge, Kai Stoeber, Marco Loddo, Geraldine Atkinson, Thomas Fanshawe, David F. Griffiths, and Gareth H. Williams
Clin Cancer Res 2005 11: 2510-2517. [Abstract] [Full Text] [PDF]  

Nuclear Factor-B Activation Correlates with Better Prognosis and Akt Activation in Human Gastric Cancer

Byung Lan Lee, Hye Seung Lee, Jieun Jung, Sung Jin Cho, Hee-Yong Chung, Woo Ho Kim, Young-Woo Jin, Chong Soon Kim, and Seon Young Nam
Clin Cancer Res 2005 11: 2518-2525. [Abstract] [Full Text] [PDF]  

The Number of Lymph Node Metastases in Gastric Cancer Correlates with the Angiotensin I–Converting Enzyme Gene Insertion/Deletion Polymorphism

Christoph Röcken, Uwe Lendeckel, Jutta Dierkes, Sabine Westphal, Stacy Carl-McGrath, Brigitte Peters, Sabine Krüger, Peter Malfertheiner, Albert Roessner, and Matthias P.A. Ebert
Clin Cancer Res 2005 11: 2526-2530. [Abstract] [Full Text] [PDF]  

Prognostic Significance of Tissue Factor in Pancreatic Ductal Adenocarcinoma

Nobuhiro Nitori, Yoshinori Ino, Yukihiro Nakanishi, Tesshi Yamada, Kazufumi Honda, Kazuyoshi Yanagihara, Tomoo Kosuge, Yae Kanai, Masaki Kitajima, and Setsuo Hirohashi
Clin Cancer Res 2005 11: 2531-2539. [Abstract] [Full Text] [PDF]  

Minimal Residual Disease in Acute Myeloid Leukemia Is Predicted by an Apoptosis-Resistant Protein Profile at Diagnosis

Amber van Stijn, Nicole Feller, Alice Kok, Marjoleine A. van der Pol, Gert J. Ossenkoppele, and Gerrit J. Schuurhuis
Clin Cancer Res 2005 11: 2540-2546. [Abstract] [Full Text] [PDF]  

Molecular Detection of Early-Stage Laryngopharyngeal Squamous Cell Carcinomas

Stephane Temam, Jean Bénard, Christelle Dugas, Martine Trassard, Emmanuelle Gormally, Jean-Charles Soria, Sandrine Faivre, Bernard Luboinski, Patrick Marandas, Pierre Hainaut, Gilbert Lenoir, Li Mao, and François Janot
Clin Cancer Res 2005 11: 2547-2551. [Abstract] [Full Text] [PDF]  

Defects in the Human Leukocyte Antigen Class I Antigen Processing Machinery in Head and Neck Squamous Cell Carcinoma: Association with Clinical Outcome

Markus Meissner, Torsten E. Reichert, Martin Kunkel, William Gooding, Theresa L. Whiteside, Soldano Ferrone, and Barbara Seliger
Clin Cancer Res 2005 11: 2552-2560. [Abstract] [Full Text] [PDF]  

Messenger RNA Expression Levels of CXCR4 Correlate with Metastatic Behavior and Outcome in Patients with Osteosarcoma

Caroline Laverdiere, Bang H. Hoang, Rui Yang, Rebecca Sowers, Jing Qin, Paul A. Meyers, Andrew G. Huvos, John H. Healey, and Richard Gorlick
Clin Cancer Res 2005 11: 2561-2567. [Abstract] [Full Text] [PDF]  

Opposite Roles of Human Pancreatitis-Associated Protein and REG1A Expression in Hepatocellular Carcinoma: Association of Pancreatitis-Associated Protein Expression with Low-Stage Hepatocellular Carcinoma, ß-Catenin Mutation, and Favorable Prognosis

Ray-Hwang Yuan, Yung-Ming Jeng, Hui-Ling Chen, Fon-Jou Hsieh, Ching-Yao Yang, Po-Huang Lee, and Hey-Chi Hsu
Clin Cancer Res 2005 11: 2568-2575. [Abstract] [Full Text] [PDF]  

Prognostic Value of Tumor-Infiltrating Dendritic Cells in Colorectal Cancer: Role of Maturation Status and Intratumoral Localization

Maro H. Sandel, Alisher R. Dadabayev, Anand G. Menon, Hans Morreau, Cornelis J.M. Melief, Rienk Offringa, Sjoerd H. van der Burg, Connie M. Janssen-van Rhijn, N. Geeske Ensink, Rob A.E.M. Tollenaar, Cornelis J.H. van de Velde, and Peter J.K. Kuppen
Clin Cancer Res 2005 11: 2576-2582. [Abstract] [Full Text] [PDF]  

Expression of Hypoxia-Inducible Factor-1 Protein Predicts Survival in Patients with Transitional Cell Carcinoma of the Upper Urinary Tract

Kuniaki Nakanishi, Sadayuki Hiroi, Susumu Tominaga, Shinsuke Aida, Hiroyasu Kasamatsu, Shigeo Matsuyama, Tomokazu Matsuyama, and Toshiaki Kawai
Clin Cancer Res 2005 11: 2583-2590. [Abstract] [Full Text] [PDF]  

Prostate Stem Cell Antigen Is Overexpressed in Prostate Cancer Metastases

John S. Lam, Joyce Yamashiro, I. Peter Shintaku, Robert L. Vessella, Robert B. Jenkins, Steve Horvath, Jonathan W. Said, and Robert E. Reiter
Clin Cancer Res 2005 11: 2591-2596. [Abstract] [Full Text] [PDF]  

Prognostic Significance of Fascin Overexpression in Human Esophageal Squamous Cell Carcinoma

Yosuke Hashimoto, Tetsuo Ito, Harutaka Inoue, Tomoyuki Okumura, Eiji Tanaka, Shigeru Tsunoda, Motoshige Higashiyama, Go Watanabe, Masayuki Imamura, and Yutaka Shimada
Clin Cancer Res 2005 11: 2597-2605. [Abstract] [Full Text] [PDF]  

SMAD4 as a Prognostic Marker in Colorectal Cancer

Hafid Alazzouzi, Pia Alhopuro, Reijo Salovaara, Heli Sammalkorpi, Heikki Järvinen, Jukka-Pekka Mecklin, Akeseli Hemminki, Simo Schwartz, Jr., Lauri A. Aaltonen, and Diego Arango
Clin Cancer Res 2005 11: 2606-2611. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Variance in the Expression of 5-Fluorouracil Pathway Genes in Colorectal Cancer

Elizabeth A. Kidd, Jinsheng Yu, Xia Li, William D. Shannon, Mark A. Watson, and Howard L. McLeod
Clin Cancer Res 2005 11: 2612-2619. [Abstract] [Full Text] [PDF]  

Severe Drug Toxicity Associated with a Single-Nucleotide Polymorphism of the Cytidine Deaminase Gene in a Japanese Cancer Patient Treated with Gemcitabine plus Cisplatin

Kan Yonemori, Hideki Ueno, Takuji Okusaka, Noboru Yamamoto, Masafumi Ikeda, Nagahiro Saijo, Teruhiko Yoshida, Hiroshi Ishii, Junji Furuse, Emiko Sugiyama, Su-Ryang Kim, Ruri Kikura-Hanajiri, Ryuichi Hasegawa, Yoshiro Saito, Shogo Ozawa, Nahoko Kaniwa, and Jun-ichi Sawada
Clin Cancer Res 2005 11: 2620-2624. [Abstract] [Full Text] [PDF]  

Evasion of a Single-Step, Chemotherapy-Induced Senescence in Breast Cancer Cells: Implications for Treatment Response

Lynne W. Elmore, Xu Di, Catherine Dumur, Shawn E. Holt, and David A. Gewirtz
Clin Cancer Res 2005 11: 2637-2643. [Abstract] [Full Text] [PDF]  

A Phase I Clinical, Pharmacologic, and Biologic Study of Thrombopoietin and Granulocyte Colony-Stimulating Factor in Children Receiving Ifosfamide, Carboplatin, and Etoposide Chemotherapy for Recurrent or Refractory Solid Tumors: A Children's Oncology Group Experience

Anne L. Angiolillo, Virginia Davenport, Mary Ann Bonilla, Carmella van de Ven, Janet Ayello, Olga Militano, Langdon L. Miller, Mark Krailo, Gregory Reaman, and Mitchell S. Cairo
Clin Cancer Res 2005 11: 2644-2650. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Predicting Response to Methotrexate, Vinblastine, Doxorubicin, and Cisplatin Neoadjuvant Chemotherapy for Bladder Cancers through Genome-Wide Gene Expression Profiling

Ryo Takata, Toyomasa Katagiri, Mitsugu Kanehira, Tatsuhiko Tsunoda, Taro Shuin, Tsuneharu Miki, Mikio Namiki, Kenjiro Kohri, Yasushi Matsushita, Tomoaki Fujioka, and Yusuke Nakamura
Clin Cancer Res 2005 11: 2625-2636. [Abstract] [Full Text] [PDF]  

Anti-Flt1 Peptide, a Vascular Endothelial Growth Factor Receptor 1–Specific Hexapeptide, Inhibits Tumor Growth and Metastasis

Dong-Goo Bae, Tae-Dong Kim, Ge Li, Wan-Hee Yoon, and Chi-Bom Chae
Clin Cancer Res 2005 11: 2651-2661. [Abstract] [Full Text] [PDF]  

A Small Interfering RNA Targeting Vascular Endothelial Growth Factor Inhibits Ewing's Sarcoma Growth in a Xenograft Mouse Model

Hui Guan, Zhichao Zhou, Hua Wang, Shu-Fang Jia, Wenbiao Liu, and Eugenie S. Kleinerman
Clin Cancer Res 2005 11: 2662-2669. [Abstract] [Full Text] [PDF]  

Caspase-Dependent Apoptosis Induction by Phenethyl Isothiocyanate, a Cruciferous Vegetable-Derived Cancer Chemopreventive Agent, Is Mediated by Bak and Bax

Dong Xiao, Yan Zeng, Sunga Choi, Karen L. Lew, Joel B. Nelson, and Shivendra V. Singh
Clin Cancer Res 2005 11: 2670-2679. [Abstract] [Full Text] [PDF]  

Methionine Aminopeptidase 2 Inhibition Is an Effective Treatment Strategy for Neuroblastoma in Preclinical Models

Michael J. Morowitz, Rosalind Barr, Qun Wang, Rebecca King, Nicholas Rhodin, Bruce Pawel, Huaqing Zhao, Scott A. Erickson, George S. Sheppard, Jieyi Wang, John M. Maris, and Suzanne Shusterman
Clin Cancer Res 2005 11: 2680-2685. [Abstract] [Full Text] [PDF]  

Functional Expression of the Angiotensin II Type1 Receptor in Human Ovarian Carcinoma Cells and Its Blockade Therapy Resulting in Suppression of Tumor Invasion, Angiogenesis, and Peritoneal Dissemination

Takayasu Suganuma, Kazuhiko Ino, Kiyosumi Shibata, Hiroaki Kajiyama, Tetsuro Nagasaka, Shigehiko Mizutani, and Fumitaka Kikkawa
Clin Cancer Res 2005 11: 2686-2694. [Abstract] [Full Text] [PDF]  

Preclinical Evaluation of the Pharmacodynamic Properties of 2,5-Diaziridinyl-3-Hydroxymethyl-6-Methyl-1,4-Benzoquinone

Timothy H. Ward, Sarah Danson, Alan T. McGown, Malcolm Ranson, Nic A. Coe, Gordon C. Jayson, Jeff Cummings, Robert H.J. Hargreaves, and John Butler
Clin Cancer Res 2005 11: 2695-2701. [Abstract] [Full Text] [PDF]  

Disruption of Fibroblast Growth Factor Signal Pathway Inhibits the Growth of Synovial Sarcomas: Potential Application of Signal Inhibitors to Molecular Target Therapy

Tatsuya Ishibe, Tomitaka Nakayama, Takeshi Okamoto, Tomoki Aoyama, Koichi Nishijo, Kotaro Roberts Shibata, Yasuko Shima, Satoshi Nagayama, Toyomasa Katagiri, Yusuke Nakamura, Takashi Nakamura, and Junya Toguchida
Clin Cancer Res 2005 11: 2702-2712. [Abstract] [Full Text] [PDF]  

Effect of YM529 on a Model of Mandibular Invasion by Oral Squamous Cell Carcinoma in Mice

Nianhui Cui, Takeshi Nomura, Hiroyasu Noma, Keiko Yokoo, Ryo Takagi, Sadamitsu Hashimoto, Masato Okamoto, Mitsunobu Sato, Guangyan Yu, Chuanbin Guo, and Takahiko Shibahala
Clin Cancer Res 2005 11: 2713-2719. [Abstract] [Full Text] [PDF]  

Potential Antagonism of Tubulin-Binding Anticancer Agents in Combination Therapies

Giulia Taraboletti, Gianluca Micheletti, Romina Dossi, Patrizia Borsotti, Michele Martinelli, Fabio Fiordaliso, Anderson J. Ryan, and Raffaella Giavazzi
Clin Cancer Res 2005 11: 2720-2726. [Abstract] [Full Text] [PDF]  

Advantage of a Residualizing Iodine Radiolabel in the Therapy of a Colon Cancer Xenograft Targeted with an Anticarcinoembryonic Antigen Monoclonal Antibody

Rhona Stein, Serengulam V. Govindan, Marianne Hayes, Gary L. Griffiths, Hans J. Hansen, Ivan D. Horak, and David M. Goldenberg
Clin Cancer Res 2005 11: 2727-2734. [Abstract] [Full Text] [PDF]  

(–)-Epigallocatechin Gallate and Polyphenon E Inhibit Growth and Activation of the Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor-2 Signaling Pathways in Human Colon Cancer Cells

Masahito Shimizu, Atsuko Deguchi, Jin T.E. Lim, Hisataka Moriwaki, Levy Kopelovich, and I. Bernard Weinstein
Clin Cancer Res 2005 11: 2735-2746. [Abstract] [Full Text] [PDF]  

O⁶-Methylguanine-DNA Methyltransferase, O⁶-Benzylguanine, and Resistance to Clinical Alkylators in Pediatric Primary Brain Tumor Cell Lines

Michael S. Bobola, John R. Silber, Richard G. Ellenbogen, J. Russell Geyer, A. Blank, and Ryan D. Goff
Clin Cancer Res 2005 11: 2747-2755. [Abstract] [Full Text] [PDF]  

Myc Down-Regulation Sensitizes Melanoma Cells to Radiotherapy by Inhibiting MLH1 and MSH2 Mismatch Repair Proteins

Barbara Bucci, Igea D'Agnano, Donatella Amendola, Arianna Citti, Giorgio H. Raza, Roberto Miceli, Ugo De Paula, Rodolfo Marchese, Sonia Albini, Armando Felsani, Ercole Brunetti, and Aldo Vecchione
Clin Cancer Res 2005 11: 2756-2767. [Abstract] [Full Text] [PDF]  

Microregional Expression of Glucose Transporter-1 and Oxygenation Status: Lack of Correlation in Locally Advanced Cervical Cancers

Arnulf Mayer, Michael Höckel, Alexander Wree, and Peter Vaupel
Clin Cancer Res 2005 11: 2768-2773. [Abstract] [Full Text] [PDF]  

Tirapazamine Cytotoxicity for Neuroblastoma Is p53 Dependent

Bo Yang and C. Patrick Reynolds
Clin Cancer Res 2005 11: 2774-2780. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

The dl1520 Virus Is Found Preferentially in Tumor Tissue after Direct Intratumoral Injection in Oral Carcinoma

Scott Wadler, Howard Kaufman, Marshall Horwitz, Stephen Morley, David Kirn, Robert Brown, Stan Kaye, and David Soutar
Clin Cancer Res 2005 11: 2781-2782. [Full Text] [PDF]  

Corrections:

Carbonic Anhydrase IX in Early-Stage Non-Small Cell Lung Cancer

Clin Cancer Res 2005 11: 2783. [Full Text] [PDF]  

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