The Biology Behind:

Nucleotide Excision Repair, Oxidative Damage, DNA Sequence Polymorphisms, and Cancer Treatment

Stephanie Q. Hutsell and Aziz Sancar
Clin Cancer Res 2005 11: 1355-1357. [Full Text] [PDF]  

Editorials:

Histologic Evaluation of Bronchial Squamous Lesions: Any Role in Lung Cancer Risk Assessment?

Ignacio I. Wistuba
Clin Cancer Res 2005 11: 1358-1360. [Full Text] [PDF]  

Perspective:

Thrombopoietic Factors in Chronic Bone Marrow Failure States: The Platelet Problem Revisited

Razelle Kurzrock
Clin Cancer Res 2005 11: 1361-1367. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Somatic Mutations of Epidermal Growth Factor Receptor in Colorectal Carcinoma

Hisashi Nagahara, Koshi Mimori, Mitsuhiko Ohta, Tohru Utsunomiya, Hiroshi Inoue, Graham F. Barnard, Masaichi Ohira, Kosei Hirakawa, and Masaki Mori
Clin Cancer Res 2005 11: 1368-1371. [Abstract] [Full Text] [PDF]  

Characterization of CEBPA Mutations in Acute Myeloid Leukemia: Most Patients with CEBPA Mutations Have Biallelic Mutations and Show a Distinct Immunophenotype of the Leukemic Cells

Liang-In Lin, Chien-Yuan Chen, Dong-Tsamn Lin, Woei Tsay, Jih-Luh Tang, You-Chia Yeh, Hwei-Ling Shen, Fang-Hsien Su, Ming Yao, Sheng-Yi Huang, and Hwei-Fang Tien
Clin Cancer Res 2005 11: 1372-1379. [Abstract] [Full Text] [PDF]  

Down-Regulation of LATS1 and LATS2 mRNA Expression by Promoter Hypermethylation and Its Association with Biologically Aggressive Phenotype in Human Breast Cancers

Yuri Takahashi, Yasuo Miyoshi, Chie Takahata, Natsumi Irahara, Tetsuya Taguchi, Yasuhiro Tamaki, and Shinzaburo Noguchi
Clin Cancer Res 2005 11: 1380-1385. [Abstract] [Full Text] [PDF]  

Expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Expression of Vascular Endothelial Growth Factor in and Angiogenic Phenotype of Human Gastric Cancer

Weida Gong, Liwei Wang, James C. Yao, Jaffer A. Ajani, Daoyan Wei, Kenneth D. Aldape, Keping Xie, Raymond Sawaya, and Suyun Huang
Clin Cancer Res 2005 11: 1386-1393. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Prospective Study of Quantitation of Plasma DNA Levels in the Diagnosis of Malignant versus Benign Prostate Disease

Jane L. Boddy, Shira Gal, Peter R. Malone, Adrian L. Harris, and Jim S. Wainscoat
Clin Cancer Res 2005 11: 1394-1399. [Abstract] [Full Text] [PDF]  

Alteration of Gene Expression in Macroscopically Normal Colonic Mucosa from Individuals with a Family History of Sporadic Colon Cancer

Chun-Yi Hao, Dan H. Moore, Patrick Wong, James L. Bennington, Nancy M. Lee, and Ling-Chun Chen
Clin Cancer Res 2005 11: 1400-1407. [Abstract] [Full Text] [PDF]  

Nucleotide Excision Repair Gene Polymorphisms and Recurrence after Treatment for Superficial Bladder Cancer

Jian Gu, Hua Zhao, Colin P. Dinney, Yong Zhu, Dan Leibovici, Carlos E. Bermejo, H. Barton Grossman, and Xifeng Wu
Clin Cancer Res 2005 11: 1408-1415. [Abstract] [Full Text] [PDF]  

Risk Assessment in Patients with Acute Myeloid Leukemia and a Normal Karyotype

Marianne Bienz, Madleina Ludwig, Beatrice U. Mueller, Elisabeth Oppliger Leibundgut, Daniel Ratschiller, Max Solenthaler, Martin F. Fey, and Thomas Pabst
Clin Cancer Res 2005 11: 1416-1424. [Abstract] [Full Text] [PDF]  

Pathologic Assessment of Melanoma Sentinel Nodes: A Role for Molecular Analysis Using Quantitative Real-Time Reverse Transcription-PCR for MART-1 and Tyrosinase Messenger RNA

Helene Nortvig Abrahamsen, Boe Sandahl Sorensen, Ebba Nexo, Stephen J. Hamilton-Dutoit, Jørn Larsen, and Torben Steiniche
Clin Cancer Res 2005 11: 1425-1433. [Abstract] [Full Text] [PDF]  

Prognostic Significance of Vascular Endothelial Growth Factor Immunohistochemical Expression in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis

Panayiotis A. Kyzas, Isabella W. Cunha, and John P.A. Ioannidis
Clin Cancer Res 2005 11: 1434-1440. [Abstract] [Full Text] [PDF]  

Serum Mannan-Binding Lectin-Associated Serine Protease 2 Levels in Colorectal Cancer: Relation to Recurrence and Mortality

Henriette Ytting, Ib Jarle Christensen, Steffen Thiel, Jens Christian Jensenius, and Hans Jørgen Nielsen
Clin Cancer Res 2005 11: 1441-1446. [Abstract] [Full Text] [PDF]  

Combined Evaluation of Expressions of Cyclin E and p53 Proteins as Prognostic Factors for Patients with Gastric Cancer

Kamal E. Bani-Hani, Nidal M. Almasri, Yousef S. Khader, Fawzi M. Sheyab, and Hanan N. Karam
Clin Cancer Res 2005 11: 1447-1453. [Abstract] [Full Text] [PDF]  

An ¹⁹F Magnetic Resonance–Based In Vivo Assay of Solid Tumor Methotrexate Resistance: Proof of Principle

William M. Spees, Terence P.F. Gade, Guangli Yang, William P. Tong, William G. Bornmann, Richard Gorlick, and Jason A. Koutcher
Clin Cancer Res 2005 11: 1454-1461. [Abstract] [Full Text] [PDF]  

Prognostic Effect of Epidermal Growth Factor Receptor and EGFRvIII in Glioblastoma Multiforme Patients

Amy B. Heimberger, Roman Hlatky, Dima Suki, David Yang, Jeff Weinberg, Mark Gilbert, Raymond Sawaya, and Kenneth Aldape
Clin Cancer Res 2005 11: 1462-1466. [Abstract] [Full Text] [PDF]  

Outcome in Hodgkin's Lymphoma Can Be Predicted from the Presence of Accompanying Cytotoxic and Regulatory T Cells

Tomás Álvaro, Marylène Lejeune, M^a Teresa Salvadó, Ramón Bosch, Juan F. García, Joaquín Jaén, Alison H. Banham, Giovanna Roncador, Carlos Montalbán, and Miguel A. Piris
Clin Cancer Res 2005 11: 1467-1473. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

A Potent Immunogenic General Cancer Vaccine That Targets Survivin, an Inhibitor of Apoptosis Proteins

Satomi Idenoue, Yoshihiko Hirohashi, Toshihiko Torigoe, Yuriko Sato, Yasuaki Tamura, Hiroyuki Hariu, Masaaki Yamamoto, Takehiro Kurotaki, Tetsuhiro Tsuruma, Hiroko Asanuma, Takayuki Kanaseki, Hideyuki Ikeda, Kiyoteru Kashiwagi, Minoru Okazaki, Kazuaki Sasaki, Takashi Sato, Tousei Ohmura, Fumitake Hata, Koji Yamaguchi, Koichi Hirata, and Noriyuki Sato
Clin Cancer Res 2005 11: 1474-1482. [Abstract] [Full Text] [PDF]  

In vivo Radioiodide Imaging and Treatment of Breast Cancer Xenografts after MUC1-Driven Expression of the Sodium Iodide Symporter

Roisin M. Dwyer, Elizabeth R. Bergert, Michael K. O'Connor, Sandra J. Gendler, and John C. Morris
Clin Cancer Res 2005 11: 1483-1489. [Abstract] [Full Text] [PDF]  

B-Cell Lymphomas Differ in their Responsiveness to CpG Oligodeoxynucleotides

Bernd Jahrsdorfer, Lars Mühlenhoff, Sue E. Blackwell, Moritz Wagner, Hendrik Poeck, Evelyn Hartmann, Ralf Jox, Thomas Giese, Bertold Emmerich, Stefan Endres, George J. Weiner, and Gunther Hartmann
Clin Cancer Res 2005 11: 1490-1499. [Abstract] [Full Text] [PDF]  

Endocrine Effects of Tamoxifen Plus Exemestane in Postmenopausal Women with Breast Cancer

Richard R. Love, Paul R. Hutson, Thomas C. Havighurst, and James F. Cleary
Clin Cancer Res 2005 11: 1500-1503. [Abstract] [Full Text] [PDF]  

Phase I Pharmacokinetic, Food Effect, and Pharmacogenetic Study of Oral Irinotecan Given as Semisolid Matrix Capsules in Patients with Solid Tumors

Otto Soepenberg, Herlinde Dumez, Jaap Verweij, Floris A. de Jong, Maja J.A. de Jonge, José Thomas, Ferry A.L.M. Eskens, Ron H.N. van Schaik, Johan Selleslach, Judith ter Steeg, Patricia Lefebvre, Sylvie Assadourian, Ger-Jan Sanderink, Alex Sparreboom, and Allan T. van Oosterom
Clin Cancer Res 2005 11: 1504-1511. [Abstract] [Full Text] [PDF]  

Phase I Study of MetXia-P450 Gene Therapy and Oral Cyclophosphamide for Patients with Advanced Breast Cancer or Melanoma

Jeremy P. Braybrooke, Andrew Slade, Gael Deplanque, Richard Harrop, Srinivasan Madhusudan, Martin D. Forster, Rachel Gibson, Andreas Makris, Denis C. Talbot, Jan Steiner, Linda White, On Kan, Stuart Naylor, Miles W. Carroll, Sue M. Kingsman, and Adrian L. Harris
Clin Cancer Res 2005 11: 1512-1520. [Abstract] [Full Text] [PDF]  

T Cell–Dependent Antibody Responses against Aberrantly Expressed Cyclin B1 Protein in Patients with Cancer and Premalignant Disease

Hiroyuki Suzuki, Daniel F. Graziano, John McKolanis, and Olivera J. Finn
Clin Cancer Res 2005 11: 1521-1526. [Abstract] [Full Text] [PDF]  

Phase I Trial of Combretastatin A-4 Phosphate with Carboplatin

Joshua H. Bilenker, Keith T. Flaherty, Mark Rosen, Lisa Davis, Maryann Gallagher, James P. Stevenson, Weijing Sun, David Vaughn, Bruce Giantonio, Ross Zimmer, Mitchell Schnall, and Peter J. O'Dwyer
Clin Cancer Res 2005 11: 1527-1533. [Abstract] [Full Text] [PDF]  

Polymorphisms in ERCC1 and Grade 3 or 4 Toxicity in Non–Small Cell Lung Cancer Patients

Rebecca Suk, Sarada Gurubhagavatula, Sohee Park, Wei Zhou, Li Su, Thomas J. Lynch, John C. Wain, Donna Neuberg, Geoffrey Liu, and David C. Christiani
Clin Cancer Res 2005 11: 1534-1538. [Abstract] [Full Text] [PDF]  

Promoter Hypermethylation of Mismatch Repair Gene hMLH1 Predicts the Clinical Response of Malignant Astrocytomas to Nitrosourea

Takao Fukushima, Yoichi Katayama, Takao Watanabe, Atsuo Yoshino, Akiyoshi Ogino, Takashi Ohta, and Chiaki Komine
Clin Cancer Res 2005 11: 1539-1544. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

HA22 (R490A) Is a Recombinant Immunotoxin with Increased Antitumor Activity without an Increase in Animal Toxicity

SookHee Bang, Satoshi Nagata, Masanori Onda, Robert J. Kreitman, and Ira Pastan
Clin Cancer Res 2005 11: 1545-1550. [Abstract] [Full Text] [PDF]  

Antitumor Effects of a Monoclonal Antibody that Binds Anionic Phospholipids on the Surface of Tumor Blood Vessels in Mice

Sophia Ran, Jin He, Xianming Huang, Melina Soares, Douglas Scothorn, and Philip E. Thorpe
Clin Cancer Res 2005 11: 1551-1562. [Abstract] [Full Text] [PDF]  

The Insulin-Like Growth Factor-I Receptor Kinase Inhibitor, NVP-ADW742, Sensitizes Small Cell Lung Cancer Cell Lines to the Effects of Chemotherapy

G. Sakuntala Warshamana-Greene, Julie Litz, Elisabeth Buchdunger, Carlos García-Echeverría, Francesco Hofmann, and Geoffrey W. Krystal
Clin Cancer Res 2005 11: 1563-1571. [Abstract] [Full Text] [PDF]  

Enhanced Sensitivity to the HER1/Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Erlotinib Hydrochloride in Chemotherapy-Resistant Tumor Cell Lines

Qun Dai, Yi-He Ling, Marie Lia, Yi-Yu Zou, Glenn Kroog, Kenneth K. Iwata, and Roman Perez-Soler
Clin Cancer Res 2005 11: 1572-1578. [Abstract] [Full Text] [PDF]  

In vitro Canine Distemper Virus Infection of Canine Lymphoid Cells: A Prelude to Oncolytic Therapy for Lymphoma

Steven E. Suter, May B. Chein, Veronika von Messling, Becky Yip, Roberto Cattaneo, William Vernau, Bruce R. Madewell, and Cheryl A. London
Clin Cancer Res 2005 11: 1579-1587. [Abstract] [Full Text] [PDF]  

Patupilone Acts as Radiosensitizing Agent in Multidrug-Resistant Cancer Cells In vitro and In vivo

Barbara Hofstetter, Van Vuong, Angela Broggini-Tenzer, Stephan Bodis, Ilja F. Ciernik, Doriano Fabbro, Markus Wartmann, Gerd Folkers, and Martin Pruschy
Clin Cancer Res 2005 11: 1588-1596. [Abstract] [Full Text] [PDF]  

Analyses of Recombinant Vaccinia and Fowlpox Vaccine Vectors Expressing Transgenes for Two Human Tumor Antigens and Three Human Costimulatory Molecules

Kwong Y. Tsang, Claudia Palena, Junko Yokokawa, Philip M. Arlen, James L. Gulley, Gail P. Mazzara, Linda Gritz, Alicia Gómez Yafal, Sandra Ogueta, Patricia Greenhalgh, Kelledy Manson, Dennis Panicali, and Jeffrey Schlom
Clin Cancer Res 2005 11: 1597-1607. [Abstract] [Full Text] [PDF]  

Formation and Antitumor Activity of PNU-159682, A Major Metabolite of Nemorubicin in Human Liver Microsomes

Luigi Quintieri, Cristina Geroni, Marianna Fantin, Rosangela Battaglia, Antonio Rosato, William Speed, Paola Zanovello, and Maura Floreani
Clin Cancer Res 2005 11: 1608-1617. [Abstract] [Full Text] [PDF]  

Effects of Nonselective Cyclooxygenase Inhibition with Low-Dose Ibuprofen on Tumor Growth, Angiogenesis, Metastasis, and Survival in a Mouse Model of Colorectal Cancer

Min Yao, Wei Zhou, Simren Sangha, Andrew Albert, Albert J. Chang, Thomas C. Liu, and M. Michael Wolfe
Clin Cancer Res 2005 11: 1618-1628. [Abstract] [Full Text] [PDF]  

Identification of CD19 and CD20 Peptides for Induction of Antigen-Specific CTLs against B-Cell Malignancies

Jooeun Bae, Jeffrey A. Martinson, and Hans G. Klingemann
Clin Cancer Res 2005 11: 1629-1638. [Abstract] [Full Text] [PDF]  

Induction of T-Cell Apoptosis in Rats by Genetically Engineered Glioma Cells Expressing Granulocyte-Macrophage Colony-Stimulating Factor and B7.1

Sheng-Hong Tseng, Yun Chen, Chun-Jung Chang, Kuo-Feng Tai, Swei-Ming Lin, and Lih-Hwa Hwang
Clin Cancer Res 2005 11: 1639-1649. [Abstract] [Full Text] [PDF]  

MEN4901/T-0128, a New Camptothecin Derivative–Carboxymethyldextran Conjugate, Has Potent Antitumor Activities in a Panel of Human Tumor Xenografts in Nude Mice

Fumiko Fujita, Masako Koike, Masahide Fujita, Yasuo Sakamoto, Satoshi Okuno, Takayuki Kawaguchi, Shigeru Yano, Toshiro Yano, Satoko Kiuchi, Toshihisa Fujiwara, Shinzoh Kudoh, and Masatoshi Kakushima
Clin Cancer Res 2005 11: 1650-1657. [Abstract] [Full Text] [PDF]  

Photochemical Targeting of Epidermal Growth Factor Receptor: A Mechanistic Study

Mark D. Savellano and Tayyaba Hasan
Clin Cancer Res 2005 11: 1658-1668. [Abstract] [Full Text] [PDF]  

Plasma and Cerebrospinal Fluid Pharmacokinetics of Intravenous Oxaliplatin, Cisplatin, and Carboplatin in Nonhuman Primates

Shana S. Jacobs, Elizabeth Fox, Christopher Dennie, Lindsey B. Morgan, Cynthia L. McCully, and Frank M. Balis
Clin Cancer Res 2005 11: 1669-1674. [Abstract] [Full Text] [PDF]  

Green Tea Extract Modulates Actin Remodeling via Rho Activity in an In vitro Multistep Carcinogenic Model

Qing-Yi Lu, Yu-Sheng Jin, Allan Pantuck, Zuo-Feng Zhang, David Heber, Arie Belldegrun, Mai Brooks, Robert Figlin, and JianYu Rao
Clin Cancer Res 2005 11: 1675-1683. [Abstract] [Full Text] [PDF]  

Corrections:

Correction: Article on the In vitro and In vivo Effects of Re-expressing Methylated von Hippel-Lindau Tumor Suppressor Gene with 5-Aza-dCyd

Clin Cancer Res 2005 11: 1684. [Full Text] [PDF]  

Correction: Article on the Characterization and Multiparameter Analysis of Visual Adverse Events in Irofulven Single-Agent Phase I and II Trials

Clin Cancer Res 2005 11: 1684. [Full Text] [PDF]  

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