Editors Note:

Introducing Molecular Pathways

William N. Hait
Clin Cancer Res 2005 11: 8529. [Full Text] [PDF]  

Molecular Pathways:

Intracellular Protein Degradation and Its Therapeutic Implications

Teru Hideshima, James E. Bradner, Dharminder Chauhan, and Kenneth C. Anderson
Clin Cancer Res 2005 11: 8530-8533. [Full Text] [PDF]  

The Biology Behind:

Epithelial to Mesenchymal Transition Tumors: Fallacious or Snail's Pace?

Robert D. Cardiff
Clin Cancer Res 2005 11: 8534-8537. [Full Text] [PDF]  

Human Cancer Biology:

Combination Analysis of Activator Protein-1 Family Members, Sp1 and an Activator Protein-2-Related Factor Binding to Different Regions of the Urokinase Receptor Gene in Resected Colorectal Cancers

Denis Martin Schewe, Tobias Biller, Gabriele Maurer, Irfan A. Asangani, Joerg H. Leupold, Ernst R. Lengyel, Stefan Post, and Heike Allgayer
Clin Cancer Res 2005 11: 8538-8548. [Abstract] [Full Text] [PDF]  

The Putative Tumor Suppressor Cdx2 Is Overexpressed by Human Colorectal Adenocarcinomas

Matthew E. Witek, Karl Nielsen, Rhonda Walters, Terry Hyslop, Juan Palazzo, Stephanie Schulz, and Scott A. Waldman
Clin Cancer Res 2005 11: 8549-8556. [Abstract] [Full Text] [PDF]  

Overexpression of Platelet-Derived Growth Factor Receptor in Endothelial Cells of Hepatocellular Carcinoma Associated with High Metastatic Potential

Ti Zhang, Hui-Chuan Sun, Yang Xu, Ke-Zhi Zhang, Lu Wang, Lun-Xiu Qin, Wei-Zhong Wu, Yin-Kun Liu, Sheng-Long Ye, and Zhao-You Tang
Clin Cancer Res 2005 11: 8557-8563. [Abstract] [Full Text] [PDF]  

The Relationship between Global Methylation Level, Loss of Heterozygosity, and Microsatellite Instability in Sporadic Colorectal Cancer

Koji Matsuzaki, Guoren Deng, Hirofumi Tanaka, Sanjay Kakar, Soichiro Miura, and Young S. Kim
Clin Cancer Res 2005 11: 8564-8569. [Abstract] [Full Text] [PDF]  

Increased Expression of the Polycomb Group Gene, EZH2, in Transitional Cell Carcinoma of the Bladder

Jay D. Raman, Nigel P. Mongan, Satish K. Tickoo, Stephen A. Boorjian, Douglas S. Scherr, and Lorraine J. Gudas
Clin Cancer Res 2005 11: 8570-8576. [Abstract] [Full Text] [PDF]  

The Accumulation of Specific Amplifications Characterizes Two Different Genomic Pathways of Evolution of Familial Breast Tumors

Lorenzo Melchor, Sara Álvarez, Emiliano Honrado, José Palacios, Alicia Barroso, Orland Díez, Ana Osorio, and Javier Benítez
Clin Cancer Res 2005 11: 8577-8584. [Abstract] [Full Text] [PDF] Supplementary Data  

Perturbation of the Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Cascade in Ovarian Cancer: Overexpression of FLIP_L and Deregulation of the Functional Receptors DR4 and DR5

Peter Horak, Dietmar Pils, Alexandra Kaider, Alexander Pinter, Katarzyna Elandt, Cornelia Sax, Christoph C. Zielinski, Reinhard Horvat, Robert Zeillinger, Alexander Reinthaller, and Michael Krainer
Clin Cancer Res 2005 11: 8585-8591. [Abstract] [Full Text] [PDF]  

Two Single-Nucleotide Polymorphisms with Linkage Disequilibrium in the Human Programmed Cell Death 5 Gene 5' Regulatory Region Affect Promoter Activity and the Susceptibility of Chronic Myelogenous Leukemia in Chinese Population

Xi Ma, Guorui Ruan, Ying Wang, Qiyan Li, Ping Zhu, Ya-Zhen Qin, Jin-Lan Li, Yan-Rong Liu, Dalong Ma, and Hongshan Zhao
Clin Cancer Res 2005 11: 8592-8599. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Magnetic Resonance Imaging Characteristics Predict Epidermal Growth Factor Receptor Amplification Status in Glioblastoma

Manish Aghi, Paola Gaviani, John W. Henson, Tracy T. Batchelor, David N. Louis, and Fred G. Barker, II
Clin Cancer Res 2005 11: 8600-8605. [Abstract] [Full Text] [PDF]  

Importance of P-Cadherin, ß-Catenin, and Wnt5a/Frizzled for Progression of Melanocytic Tumors and Prognosis in Cutaneous Melanoma

Ingeborg M. Bachmann, Oddbjørn Straume, Hanne E. Puntervoll, May Britt Kalvenes, and Lars A. Akslen
Clin Cancer Res 2005 11: 8606-8614. [Abstract] [Full Text] [PDF]  

Tumor ß-1,4-Galactosyltransferase IV Overexpression Is Closely Associated with Colorectal Cancer Metastasis and Poor Prognosis

Wei-Shone Chen, Hong-Yi Chang, Chung-Pin Li, Jacqueline Ming Liu, and Tze-Sing Huang
Clin Cancer Res 2005 11: 8615-8622. [Abstract] [Full Text] [PDF]  

Tumor Gene Expression and Prognosis in Breast Cancer Patients with 10 or More Positive Lymph Nodes

Melody A. Cobleigh, Bita Tabesh, Pincas Bitterman, Joffre Baker, Maureen Cronin, Mei-Lan Liu, Russell Borchik, Juan-Miguel Mosquera, Michael G. Walker, and Steven Shak
Clin Cancer Res 2005 11: 8623-8631. [Abstract] [Full Text] [PDF]  

Mcl-1, Vascular Endothelial Growth Factor-R2, and 14-3-3 Expression Might Predict Primary Response against Radiotherapy and Chemotherapy in Patients with Locally Advanced Squamous Cell Carcinomas of the Head and Neck

Boban M. Erovic, Martina Pelzmann, Matthäus Ch. Grasl, Johannes Pammer, Gabriela Kornek, Werner Brannath, Edgar Selzer, and Dietmar Thurnher
Clin Cancer Res 2005 11: 8632-8636. [Abstract] [Full Text] [PDF]  

Effect of Epidermal Growth Factor Receptor Expression Level on Survival in Patients with Epithelial Ovarian Cancer

Amanda Psyrri, Mohamad Kassar, Ziwei Yu, Aris Bamias, Paul M. Weinberger, Sonia Markakis, Diane Kowalski, Robert L. Camp, David L. Rimm, and Meletios A. Dimopoulos
Clin Cancer Res 2005 11: 8637-8643. [Abstract] [Full Text] [PDF]  

High Serum Concentration of YKL-40 Is Associated with Short Survival in Patients with Acute Myeloid Leukemia

Olav J. Bergmann, Julia S. Johansen, Tobias W. Klausen, Anne K. Mylin, Jørgen S. Kristensen, Eigil Kjeldsen, and Hans E. Johnsen
Clin Cancer Res 2005 11: 8644-8652. [Abstract] [Full Text] [PDF]  

Inclusion of Vasculature-Related Variables in the Dukes Staging System of Colon Cancer

Michael I. Koukourakis, Alexandra Giatromanolaki, Efthimios Sivridis, Kevin C. Gatter, Adrian L. Harris for Tumour and Angiogenesis Research Group
Clin Cancer Res 2005 11: 8653-8660. [Abstract] [Full Text] [PDF]  

Expression of Multidrug Resistance–Associated Proteins Predicts Prognosis in Childhood and Adult Acute Lymphoblastic Leukemia

Sabine L.A. Plasschaert, Eveline S.J.M. de Bont, Marike Boezen, Dorina M. vander Kolk, Simon M.J.G. Daenen, Klaas Nico Faber, Willem A. Kamps, Elisabeth G.E. de Vries, and Edo Vellenga
Clin Cancer Res 2005 11: 8661-8668. [Abstract] [Full Text] [PDF]  

Time to Detectable Metastatic Disease in Patients with Rising Prostate-Specific Antigen Values following Surgery or Radiation Therapy

Susan F. Slovin, Andrew S. Wilton, Glenn Heller, and Howard I. Scher
Clin Cancer Res 2005 11: 8669-8673. [Abstract] [Full Text] [PDF]  

Circulating Aminopeptidase N/CD13 Is an Independent Prognostic Factor in Patients with Non–Small Cell Lung Cancer

Haruyasu Murakami, Akihito Yokoyama, Keiichi Kondo, Shuhei Nakanishi, Nobuoki Kohno, and Masayuki Miyake
Clin Cancer Res 2005 11: 8674-8679. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Phase I/II Study of 19-nor-1-25-Dihydroxyvitamin D₂ (Paricalcitol) in Advanced, Androgen-Insensitive Prostate Cancer

Gary G. Schwartz, M. Craig Hall, Diana Stindt, Suzanne Patton, James Lovato, and Frank M. Torti
Clin Cancer Res 2005 11: 8680-8685. [Abstract] [Full Text] [PDF]  

Epithelial versus Mesenchymal Phenotype Determines In vitro Sensitivity and Predicts Clinical Activity of Erlotinib in Lung Cancer Patients

Robert L. Yauch, Thomas Januario, David A. Eberhard, Guy Cavet, Wenjing Zhu, Ling Fu, Thinh Q. Pham, Robert Soriano, Jeremy Stinson, Somasekar Seshagiri, Zora Modrusan, Chin-Yu Lin, Vincent O'Neill, and Lukas C. Amler
Clin Cancer Res 2005 11: 8686-8698. [Abstract] [Full Text] [PDF]  

Methylation of the DPYD Promoter: An Alternative Mechanism for Dihydropyrimidine Dehydrogenase Deficiency in Cancer Patients

Hany H. Ezzeldin, Adam M. Lee, Lori K. Mattison, and Robert B. Diasio
Clin Cancer Res 2005 11: 8699-8705. [Abstract] [Full Text] [PDF]  

Serum Free Light Chain Analysis and Urine Immunofixation Electrophoresis in Patients with Multiple Myeloma

Mohammad R. Nowrousian, Dieter Brandhorst, Christiane Sammet, Michaela Kellert, Rainer Daniels, Philipp Schuett, Miriam Poser, Siemke Mueller, Peter Ebeling, Anja Welt, Arthur R. Bradwell, Ulrike Buttkereit, Bertram Opalka, Michael Flasshove, Thomas Moritz, and Siegfried Seeber
Clin Cancer Res 2005 11: 8706-8714. [Abstract] [Full Text] [PDF]  

Feasibility and Tolerability of Sequential Doxorubicin/Paclitaxel Followed by Cyclophosphamide, Methotrexate, and Fluorouracil and Its Effects on Tumor Response as Preoperative Therapy

Luca Gianni, José Baselga, Wolfgang Eiermann, Vicente Guillem Porta, Vladimir Semiglazov, Aña Lluch, Milvia Zambetti, Dolores Sabadell, Günther Raab, Antonio Llombart Cussac, Alla Bozhok, Angel Martinez-Agulló, Marco Greco, Mikhail Byakhov, Juan Josè Lopez Lopez, Mauro Mansutti, Pinuccia Valagussa, Gianni Bonadonna European Cooperative Trial in Operable Breast Cancer Study Group
Clin Cancer Res 2005 11: 8715-8721. [Abstract] [Full Text] [PDF]  

Effect of Exemestane on Tamoxifen Pharmacokinetics in Postmenopausal Women Treated for Breast Cancer

Paul R. Hutson, Richard R. Love, Thomas C. Havighurst, Eric Rogers, and James F. Cleary
Clin Cancer Res 2005 11: 8722-8727. [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetic Study of Sequences of the Rebeccamycin Analogue NSC 655649 and Cisplatin in Patients with Advanced Solid Tumors

Alejandro D. Ricart, Lisa A. Hammond, John G. Kuhn, Chris H. Takimoto, Andrew Goetz, Bahram Forouzesh, Leonardo Forero, Jose L. Ochoa-Bayona, Kristin Berg, Anthony W. Tolcher, and Eric K. Rowinsky
Clin Cancer Res 2005 11: 8728-8736. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Pigment Epithelium–Derived Factor Gene Therapy Inhibits Human Pancreatic Cancer in Mice

Ryunosuke Hase, Masaki Miyamoto, Hirofumi Uehara, Masatoshi Kadoya, Yuma Ebihara, Yoshihiro Murakami, Ryo Takahashi, Seiji Mega, Li Li, Toshiaki Shichinohe, Yo Kawarada, and Satoshi Kondo
Clin Cancer Res 2005 11: 8737-8744. [Abstract] [Full Text] [PDF]  

Neamine Inhibits Xenografic Human Tumor Growth and Angiogenesis in Athymic Mice

Saori Hirukawa, Karen A. Olson, Takanori Tsuji, and Guo-fu Hu
Clin Cancer Res 2005 11: 8745-8752. [Abstract] [Full Text] [PDF]  

Overexpression of Stefin A in Human Esophageal Squamous Cell Carcinoma Cells Inhibits Tumor Cell Growth, Angiogenesis, Invasion, and Metastasis

Wendong Li, Fang Ding, Liyong Zhang, Zhongmin Liu, Yu Wu, Aiping Luo, Min Wu, Mingrong Wang, Qimin Zhan, and Zhihua Liu
Clin Cancer Res 2005 11: 8753-8762. [Abstract] [Full Text] [PDF]  

Natural Killer Cells License Dendritic Cell Cross-Presentation of B Lymphoma Cell–Associated Antigens

Tao Dao, Marta Gomez-Nunez, Christophe Antczak, Barry Kappel, Jaspreet Singh Jaggi, Tatyana Korontsvit, Victoriya Zakhaleva, and David A. Scheinberg
Clin Cancer Res 2005 11: 8763-8772. [Abstract] [Full Text] [PDF]  

Antitumor Efficacy of Capecitabine and Celecoxib in Irradiated and Lead-Shielded, Contralateral Human BxPC-3 Pancreatic Cancer Xenografts: Clinical Implications of Abscopal Effects

Carmelo Blanquicett, M. Wasif Saif, Donald J. Buchsbaum, Mohamad Eloubeidi, Selwyn M. Vickers, David C. Chhieng, Mark D. Carpenter, Jeffrey C. Sellers, Suzanne Russo, Robert B. Diasio, and Martin R. Johnson
Clin Cancer Res 2005 11: 8773-8781. [Abstract] [Full Text] [PDF]  

The Distribution of the Anticancer Drug Doxorubicin in Relation to Blood Vessels in Solid Tumors

Andrew J. Primeau, Augusto Rendon, David Hedley, Lothar Lilge, and Ian F. Tannock
Clin Cancer Res 2005 11: 8782-8788. [Abstract] [Full Text] [PDF]  

Antitumor Vascular Strategy for Controlling Experimental Metastatic Spread of Human Small-Cell Lung Cancer Cells with ZD6474 in Natural Killer Cell–Depleted Severe Combined Immunodeficient Mice

Seiji Yano, Hiroaki Muguruma, Yuka Matsumori, Hisatsugu Goto, Emiko Nakataki, Nobutaka Edakuni, Hideki Tomimoto, Soji Kakiuchi, Akihiko Yamamoto, Hisanori Uehara, Anderson Ryan, and Saburo Sone
Clin Cancer Res 2005 11: 8789-8798. [Abstract] [Full Text] [PDF]  

T-Cell Responses Directed against Multiple HLA-A*0201-Restricted Epitopes Derived from Wilms' Tumor 1 Protein in Patients with Leukemia and Healthy Donors: Identification, Quantification, and Characterization

Katayoun Rezvani, Jason M. Brenchley, David A. Price, Yasemin Kilical, Emma Gostick, Andrew K. Sewell, Jongming Li, Stephan Mielke, Daniel C. Douek, and A. John Barrett
Clin Cancer Res 2005 11: 8799-8807. [Abstract] [Full Text] [PDF]  

Targeting Heat Shock Proteins for Immunotherapy in Multiple Myeloma: Generation of Myeloma-Specific CTLs Using Dendritic Cells Pulsed with Tumor-Derived gp96

Jianfei Qian, Siqing Wang, Jing Yang, Jin Xie, Pei Lin, Muta E. Freeman, III, and Qing Yi
Clin Cancer Res 2005 11: 8808-8815. [Abstract] [Full Text] [PDF]  

AdCD40L Gene Therapy Counteracts T Regulatory Cells and Cures Aggressive Tumors in an Orthotopic Bladder Cancer Model

Angelica S.I. Loskog, Moa E. Fransson, and Thomas T.H. Totterman
Clin Cancer Res 2005 11: 8816-8821. [Abstract] [Full Text] [PDF]  

Reveromycin A Inhibits Osteolytic Bone Metastasis of Small-Cell Lung Cancer Cells, SBC-5, through an Antiosteoclastic Activity

Hiroaki Muguruma, Seiji Yano, Soji Kakiuchi, Hisanori Uehara, Makoto Kawatani, Hiroyuki Osada, and Saburo Sone
Clin Cancer Res 2005 11: 8822-8828. [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data  

Focal Adhesion Kinase Silencing Augments Docetaxel-Mediated Apoptosis in Ovarian Cancer Cells

Jyotsnabaran Halder, Charles N. Landen, Jr., Susan K. Lutgendorf, Yang Li, Nicholas B. Jennings, Dominic Fan, Gina M. Nelkin, Rosemarie Schmandt, Michael D. Schaller, and Anil K. Sood
Clin Cancer Res 2005 11: 8829-8836. [Abstract] [Full Text] [PDF]  

Increased Nuclear Localization of Transcription Factor Y-Box Binding Protein 1 Accompanied by Up-Regulation of P-glycoprotein in Breast Cancer Pretreated with Paclitaxel

Tomoyuki Fujita, Ken-ichi Ito, Hiroto Izumi, Morihiko Kimura, Muneaki Sano, Hiroshi Nakagomi, Kazuma Maeno, Yoshihisa Hama, Kiyoshi Shingu, Shin-ichi Tsuchiya, Kimitoshi Kohno, and Minoru Fujimori
Clin Cancer Res 2005 11: 8837-8844. [Abstract] [Full Text] [PDF]  

Dual Promoter–Controlled Oncolytic Adenovirus CG5757 Has Strong Tumor Selectivity and Significant Antitumor Efficacy in Preclinical Models

Yuanhao Li, Neeraja Idamakanti, Trini Arroyo, Steve Thorne, Tony Reid, Scott Nichols, Melinda VanRoey, Gail Colbern, Natalie Nguyen, Orlena Tam, Peter Working, and De-Chao Yu
Clin Cancer Res 2005 11: 8845-8855. [Abstract] [Full Text] [PDF]  

Effect of Repetitive Administration of Doxorubicin-Containing Liposomes on Plasma Pharmacokinetics and Drug Biodistribution in a Rat Brain Tumor Model

Robert D. Arnold, Donald E. Mager, Jeanine E. Slack, and Robert M. Straubinger
Clin Cancer Res 2005 11: 8856-8865. [Abstract] [Full Text] [PDF]  

Heat-Induced Up-Regulation of NAD(P)H:Quinone Oxidoreductase Potentiates Anticancer Effects of ß-Lapachone

Heon Joo Park, Eun Kyung Choi, Jihyung Choi, Ki-Jung Ahn, Eun Jung Kim, In-Mi Ji, Yeon Hee Kook, Seung-Do Ahn, Brent Williams, Robert Griffin, David A. Boothman, Chung K. Lee, and Chang W. Song
Clin Cancer Res 2005 11: 8866-8871. [Abstract] [Full Text] [PDF]  

Enhancement of Sensitivity to Tumor Necrosis Factor in Non–Small Cell Lung Cancer Cells with Acquired Resistance to Gefitinib

Koichi Ando, Tohru Ohmori, Fumiko Inoue, Tsuyoki Kadofuku, Takamichi Hosaka, Hiroo Ishida, Takao Shirai, Kentaro Okuda, Takashi Hirose, Naoya Horichi, Kazuto Nishio, Nagahiro Saijo, Mitsuru Adachi, and Toshio Kuroki
Clin Cancer Res 2005 11: 8872-8879. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Prediction of Colorectal Neoplasia by Quantitative Methylation Analysis of Estrogen Receptor Gene in Nonneoplastic Epithelium from Patients with Ulcerative Colitis

Keiichi Tominaga, Shigehiko Fujii, Kenichiroh Mukawa, Mikio Fujita, Kazuhito Ichikawa, Shigeki Tomita, Yasuo Imai, Kazunari Kanke, Yuko Ono, Akira Terano, Hideyuki Hiraishi, and Takahiro Fujimori
Clin Cancer Res 2005 11: 8880-8885. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

In vivo Molecular Prediction of Carbonic Anhydrase IX-G250MN Expression on Immunotherapy Outcome in Renal Cancer

Adrienne H. Brouwers, Otto C. Boerman, Wim J.G. Oyen, and Michael B. Atkins
Clin Cancer Res 2005 11: 8886. [Full Text] [PDF]  

Circulating Matrix Metalloproteinase-9 Levels as a Biomarker of Disease

Raquel F. Gerlach, Jose E. Tanus-Santos, and Pia Vihinen
Clin Cancer Res 2005 11: 8887-8888. [Full Text] [PDF]  

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