Editorials:

Epidermal Growth Factor Receptor Inhibitors: A Moving Target?

Susan E. Bates and Tito Fojo
Clin Cancer Res 2005 11: 7203-7205. [Full Text] [PDF]  

The Biology Behind:

Multifocal Renal Cancer: Genetic Basis and Its Medical Relevance

Donald P. Bottaro and W. Marston Linehan
Clin Cancer Res 2005 11: 7206-7208. [Full Text] [PDF]  

Human Cancer Biology:

Gene Expression Profiles of B-lineage Adult Acute Lymphocytic Leukemia Reveal Genetic Patterns that Identify Lineage Derivation and Distinct Mechanisms of Transformation

Sabina Chiaretti, Xiaochun Li, Robert Gentleman, Antonella Vitale, Kathy S. Wang, Franco Mandelli, Robin Foà, and Jerome Ritz
Clin Cancer Res 2005 11: 7209-7219. [Abstract] [Full Text] [PDF] Supplementary Data  

Carbonic Anhydrase IX Expression and Tumor Oxygenation Status Do Not Correlate at the Microregional Level in Locally Advanced Cancers of the Uterine Cervix

Arnulf Mayer, Michael Höckel, and Peter Vaupel
Clin Cancer Res 2005 11: 7220-7225. [Abstract] [Full Text] [PDF]  

Molecular Genetic Evidence for the Independent Origin of Multifocal Papillary Tumors in Patients with Papillary Renal Cell Carcinomas

Timothy D. Jones, John N. Eble, Mingsheng Wang, Gregory T. MacLennan, Brett Delahunt, Matteo Brunelli, Guido Martignoni, Antonio Lopez-Beltran, Stephen M. Bonsib, Thomas M. Ulbright, Shaobo Zhang, Kelly Nigro, and Liang Cheng
Clin Cancer Res 2005 11: 7226-7233. [Abstract] [Full Text] [PDF]  

Novel Genes Associated with Malignant Melanoma but not Benign Melanocytic Lesions

Dmitri Talantov, Abhijit Mazumder, Jack X. Yu, Thomas Briggs, Yuqiu Jiang, John Backus, David Atkins, and Yixin Wang
Clin Cancer Res 2005 11: 7234-7242. [Abstract] [Full Text] [PDF] Supplementary Data  

Ovarian Carcinomas: CCN Genes Are Aberrantly Expressed and CCN1 Promotes Proliferation of these Cells

Sigal Gery, Dong Xie, Dong Yin, Hani Gabra, Carl Miller, Heming Wang, Diane Scott, William S. Yi, Miriam L. Popoviciu, Johathan W. Said, and H. Phillip Koeffler
Clin Cancer Res 2005 11: 7243-7254. [Abstract] [Full Text] [PDF]  

Expression of Phosphorylated Ser⁷⁰ of Bcl-2 Correlates with Malignancy in Human Colorectal Neoplasms

Eisaku Kondo, Takayoshi Miyake, Masao Shibata, Toshikazu Kimura, Hiromi Iwagaki, Shin-ichi Nakamura, Takehiro Tanaka, Nobuya Ohara, Koichi Ichimura, Takashi Oka, Hiroyuki Yanai, Futoshi Shibasaki, and Tadashi Yoshino
Clin Cancer Res 2005 11: 7255-7263. [Abstract] [Full Text] [PDF]  

Macrophage Migration Inhibitory Factor Is a Determinant of Hypoxia-Induced Apoptosis in Colon Cancer Cell Lines

Kangshen Yao, Seiichiro Shida, Muthu Selvakumaran, Robert Zimmerman, Ephraim Simon, Jonathan Schick, Naomi B. Haas, Marge Balke, Howard Ross, Steven W. Johnson, and Peter J. O'Dwyer
Clin Cancer Res 2005 11: 7264-7272. [Abstract] [Full Text] [PDF]  

Molecular Pathogenesis of Ovarian Borderline Tumors: New Insights and Old Challenges

Ie-Ming Shih and Robert J. Kurman
Clin Cancer Res 2005 11: 7273-7279. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Nuclear Estrogen Receptor ß in Lung Cancer: Expression and Survival Differences by Sex

Ann G. Schwartz, Geoffrey M. Prysak, Valerie Murphy, Fulvio Lonardo, Harvey Pass, Jan Schwartz, and Sam Brooks
Clin Cancer Res 2005 11: 7280-7287. [Abstract] [Full Text] [PDF]  

In vitro and In vivo Targeting Properties of Iodine-123- or Iodine-131–Labeled Monoclonal Antibody 14C5 in a Non–Small Cell Lung Cancer and Colon Carcinoma Model

Ingrid Burvenich, Steve Schoonooghe, Bart Cornelissen, Peter Blanckaert, Elisabeth Coene, Claude Cuvelier, Nico Mertens, and Guido Slegers
Clin Cancer Res 2005 11: 7288-7296. [Abstract] [Full Text] [PDF]  

Total Soluble HLA Class I and Soluble HLA-G in Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance

Xavier Leleu, Gaëlle Le Friec, Thierry Facon, Laurence Amiot, Renée Fauchet, Bernadette Hennache, Valérie Coiteux, Ibrahim Yakoub-Agha, Sylvain Dubucquoi, Hervé Avet-Loiseau, Claire Mathiot, Régis Bataille, Jean-Yves Mary on behalf of the Intergroupe Francophone du Myélome
Clin Cancer Res 2005 11: 7297-7303. [Abstract] [Full Text] [PDF]  

Differential Features of Colorectal Cancers Fulfilling Amsterdam Criteria without Involvement of the Mutator Pathway

Xavier Llor, Elisenda Pons, Rosa M. Xicola, Antoni Castells, Cristina Alenda, Virgínia Piñol, Montserrat Andreu, Sergi Castellví-Bel, Artemio Payá, Rodrigo Jover, Xavier Bessa, Anna Girós, Anna Roca, Miquel A. Gassull for the Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Clin Cancer Res 2005 11: 7304-7310. [Abstract] [Full Text] [PDF]  

How ADAM-9 and ADAM-11 Differentially From Estrogen Receptor Predict Response to Tamoxifen Treatment in Patients with Recurrent Breast Cancer: a Retrospective Study

Anieta M. Sieuwerts, Marion E. Meijer-van Gelder, Mieke Timmermans, Anita M.A.C. Trapman, Roberto Rodriguez Garcia, Miranda Arnold, Anneke J.W. Goedheer, Henk Portengen, Jan G.M. Klijn, and John A. Foekens
Clin Cancer Res 2005 11: 7311-7321. [Abstract] [Full Text] [PDF]  

Increased Intratumor V24-Positive Natural Killer T Cells: A Prognostic Factor for Primary Colorectal Carcinomas

Tsuyoshi Tachibana, Hisashi Onodera, Tatsuaki Tsuruyama, Akira Mori, Satoshi Nagayama, Hiroshi Hiai, and Masayuki Imamura
Clin Cancer Res 2005 11: 7322-7327. [Abstract] [Full Text] [PDF]  

p53 Codon 72 Polymorphism Predicts the Pathologic Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer

Ye Xu, Lihua Yao, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Benyao Lin, Youyong Lu, and Yuntao Xie
Clin Cancer Res 2005 11: 7328-7333. [Abstract] [Full Text] [PDF]  

Expressions of Nuclear Factor B, Inducible Nitric Oxide Synthase, and Vascular Endothelial Growth Factor in Adenoid Cystic Carcinoma of Salivary Glands: Correlations with the Angiogenesis and Clinical Outcome

Jiali Zhang, Bin Peng, and Xinming Chen
Clin Cancer Res 2005 11: 7334-7343. [Abstract] [Full Text] [PDF]  

Lymphangiogenesis Correlates with Lymph Node Metastasis, Prognosis, and Angiogenic Phenotype in Human Non–Small Cell Lung Cancer

Ferenc Renyi-Vamos, Jozsef Tovari, Janos Fillinger, Jozsef Timar, Sandor Paku, Istvan Kenessey, Gyula Ostoros, Laszlo Agocs, Ibolya Soltesz, and Balazs Dome
Clin Cancer Res 2005 11: 7344-7353. [Abstract] [Full Text] [PDF]  

The Up-Regulation of Y-Box Binding Proteins (DNA Binding Protein A and Y-Box Binding Protein-1) as Prognostic Markers of Hepatocellular Carcinoma

Mahmut Yasen, Kazunori Kajino, Sayaka Kano, Hiroshi Tobita, Junji Yamamoto, Takeshi Uchiumi, Shigeyuki Kon, Masahiro Maeda, Gulanbar Obulhasim, Shigeki Arii, and Okio Hino
Clin Cancer Res 2005 11: 7354-7361. [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Is an Independent Prognostic Factor in Gastric Cancer and Its Expression Is Regulated by the Messenger RNA Stability Factor HuR

Johanna Mrena, Jan-Patrik Wiksten, Alexandra Thiel, Arto Kokkola, Leena Pohjola, Johan Lundin, Stig Nordling, Ari Ristimäki, and Caj Haglund
Clin Cancer Res 2005 11: 7362-7368. [Abstract] [Full Text] [PDF]  

Profiling Cytochrome P450 Expression in Ovarian Cancer: Identification of Prognostic Markers

Diane Downie, Morag C.E. McFadyen, Patrick H. Rooney, Margaret E. Cruickshank, David E. Parkin, Iain D. Miller, Colin Telfer, William T. Melvin, and Graeme I. Murray
Clin Cancer Res 2005 11: 7369-7375. [Abstract] [Full Text] [PDF]  

Hypermethylation of 18S and 28S Ribosomal DNAs Predicts Progression-Free Survival in Patients with Ovarian Cancer

Michael W.Y. Chan, Susan H. Wei, Ping Wen, Zailong Wang, Daniela E. Matei, Joseph C. Liu, Sandya Liyanarachchi, Robert Brown, Kenneth P. Nephew, Pearlly S. Yan, and Tim H-M. Huang
Clin Cancer Res 2005 11: 7376-7383. [Abstract] [Full Text] [PDF]  

14-3-3 in Endometrial Cancer–A Possible Prognostic Marker in Early-Stage Cancer

Kiyoshi Ito, Takashi Suzuki, Jun-ichi Akahira, Michiko Sakuma, Sumika Saitou, Satoshi Okamoto, Hitoshi Niikura, Kunihiro Okamura, Nobuo Yaegashi, Hironobu Sasano, and Satoshi Inoue
Clin Cancer Res 2005 11: 7384-7391. [Abstract] [Full Text] [PDF]  

Reduction of Raf-1 Kinase Inhibitor Protein Expression Correlates with Breast Cancer Metastasis

Suzanne Hagan, Fahd Al-Mulla, Elizabeth Mallon, Karin Oien, Rhona Ferrier, Barry Gusterson, Jorge J. Curto García, and Walter Kolch
Clin Cancer Res 2005 11: 7392-7397. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Effect of Common CYP3A4 and CYP3A5 Variants on the Pharmacokinetics of the Cytochrome P450 3A Phenotyping Probe Midazolam in Cancer Patients

Erin R. Lepper, Sharyn D. Baker, Matt Permenter, Nicole Ries, Ron H.N. van Schaik, Paul W. Schenk, Douglas K. Price, Danielle Ahn, Nicola F. Smith, George Cusatis, Roxann G. Ingersoll, Susan E. Bates, Ron H.J. Mathijssen, Jaap Verweij, William D. Figg, and Alex Sparreboom
Clin Cancer Res 2005 11: 7398-7404. [Abstract] [Full Text] [PDF]  

Apurinic/Apyrimidinic Endonuclease Activity Is Associated with Response to Radiation and Chemotherapy in Medulloblastoma and Primitive Neuroectodermal Tumors

Michael S. Bobola, Laura S. Finn, Richard G. Ellenbogen, J. Russell Geyer, Mitchel S. Berger, Justin M. Braga, Elizabeth H. Meade, Mary E. Gross, and John R. Silber
Clin Cancer Res 2005 11: 7405-7414. [Abstract] [Full Text] [PDF]  

Modeling the Pharmacodynamics of Highly Schedule-Dependent Agents: Exemplified by Cytarabine-Based Regimens in Acute Myeloid Leukemia

Jan Braess, Michael Fiegl, Isolde Lorenz, Karin Waxenberger, and Wolfgang Hiddemann
Clin Cancer Res 2005 11: 7415-7425. [Abstract] [Full Text] [PDF] Supplementary Data  

CD4 and CD8 T-Lymphocyte Apoptosis Can Predict Radiation-Induced Late Toxicity: A Prospective Study in 399 Patients

Mahmut Ozsahin, Nigel E.A. Crompton, Sophie Gourgou, Andrew Kramar, Ling Li, YuQuan Shi, Wendy Jeanneret Sozzi, Abderrahim Zouhair, René O. Mirimanoff, and David Azria
Clin Cancer Res 2005 11: 7426-7433. [Abstract] [Full Text] [PDF]  

Gene Expression Profile Associated with Response to Doxorubicin-Based Therapy in Breast Cancer

Maria Aparecida Azevedo Koike Folgueira, Dirce Maria Carraro, Helena Brentani, Diogo Ferreira da Costa Patrão, Edson Mantovani Barbosa, Mário Mourão Netto, José Roberto Fígaro Caldeira, Maria Lucia Hirata Katayama, Fernando Augusto Soares, Célia Tosello Oliveira, Luiz Fernando Lima Reis, Jane Haruko Lima Kaiano, Luiz Paulo Camargo, Ricardo Zorzetto Nicoliello Vêncio, Igor Moysés Longo Snitcovsky, Fabiana Baroni Alves Makdissi, Paulo José da Silva e Silva, João Carlos Guedes Sampaio Góes, and Maria Mitzi Brentani
Clin Cancer Res 2005 11: 7434-7443. [Abstract] [Full Text] [PDF] Supplementary Data  

Long-term Follow-up of Patients with Malignant Pleural Mesothelioma Receiving High-Dose Adenovirus Herpes Simplex Thymidine Kinase/Ganciclovir Suicide Gene Therapy

Daniel H. Sterman, Adriana Recio, Anil Vachani, Jing Sun, Lumei Cheung, Peter DeLong, Kunjlata M. Amin, Leslie A. Litzky, James M. Wilson, Larry R. Kaiser, and Steven M. Albelda
Clin Cancer Res 2005 11: 7444-7453. [Abstract] [Full Text] [PDF]  

Pilot Trial of Unlabeled and Indium-111–Labeled Anti–Prostate-Specific Membrane Antigen Antibody J591 for Castrate Metastatic Prostate Cancer

Michael J. Morris, Chaitanya R. Divgi, Neeta Pandit-Taskar, Maria Batraki, Nyasha Warren, Angelo Nacca, Peter Smith-Jones, Lawrence Schwartz, W. Kevin Kelly, Susan Slovin, David Solit, Jennifer Halpern, Anthony Delacruz, Tracy Curley, Ronald Finn, Joseph A. O'Donoghue, Philip Livingston, Steven Larson, and Howard I. Scher
Clin Cancer Res 2005 11: 7454-7461. [Abstract] [Full Text] [PDF]  

Association of Pretherapeutic Expression of Chemotherapy-Related Genes with Response to Neoadjuvant Chemotherapy in Barrett Carcinoma

Rupert Langer, Katja Specht, Karen Becker, Philipp Ewald, Melitta Bekesch, Mario Sarbia, Raymonde Busch, Marcus Feith, Hubert J. Stein, Jörg-Rüdiger Siewert, and Heinz Höfler
Clin Cancer Res 2005 11: 7462-7469. [Abstract] [Full Text] [PDF]  

Phase I Clinical Trial of a HER-2/neu Peptide (E75) Vaccine for the Prevention of Prostate-Specific Antigen Recurrence in High-Risk Prostate Cancer Patients

Matthew T. Hueman, Zia A. Dehqanzada, Thomas E. Novak, Jennifer M. Gurney, Michael M. Woll, Gayle B. Ryan, Catherine E. Storrer, Christine Fisher, David G. McLeod, Constantine G. Ioannides, Sathibalan Ponniah, and George E. Peoples
Clin Cancer Res 2005 11: 7470-7479. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Epidermal Growth Factor Receptor Activity Determines Response of Colorectal Cancer Cells to Gefitinib Alone and in Combination with Chemotherapy

Sandra Van Schaeybroeck, Anthi Karaiskou-McCaul, Donal Kelly, Daniel Longley, Leeona Galligan, Eric Van Cutsem, and Patrick Johnston
Clin Cancer Res 2005 11: 7480-7489. [Abstract] [Full Text] [PDF]  

Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-B Pathway in Breast Cancer Cells and Inhibits Lung Metastasis of Human Breast Cancer in Nude Mice

Bharat B. Aggarwal, Shishir Shishodia, Yasunari Takada, Sanjeev Banerjee, Robert A. Newman, Carlos E. Bueso-Ramos, and Janet E. Price
Clin Cancer Res 2005 11: 7490-7498. [Abstract] [Full Text] [PDF]  

Schedule-Dependent Drug Effects of Oral 5-Iodo-2-Pyrimidinone-2'-Deoxyribose as an In vivo Radiosensitizer in U251 Human Glioblastoma Xenografts

Yuji Seo, Tao Yan, Jane E. Schupp, Tomas Radivoyevitch, and Timothy J. Kinsella
Clin Cancer Res 2005 11: 7499-7507. [Abstract] [Full Text] [PDF]  

In vivo Therapeutic Responses Contingent on Fanconi Anemia/BRCA2 Status of the Tumor

Michiel S. van der Heijden, Jonathan R. Brody, David A. Dezentje, Eike Gallmeier, Steven C. Cunningham, Michael J. Swartz, Angelo M. DeMarzo, G. Johan A. Offerhaus, William H. Isacoff, Ralph H. Hruban, and Scott E. Kern
Clin Cancer Res 2005 11: 7508-7515. [Abstract] [Full Text] [PDF]  

MHC Class I–Related Chain A Conjugated to Antitumor Antibodies Can Sensitize Tumor Cells to Specific Lysis by Natural Killer Cells

Claire Germain, Christel Larbouret, Valérie Cesson, Alena Donda, Werner Held, Jean-Pierre Mach, André Pèlegrin, and Bruno Robert
Clin Cancer Res 2005 11: 7516-7522. [Abstract] [Full Text] [PDF]  

Stable Suppression of Tumorigenicity by Pin1-Targeted RNA Interference in Prostate Cancer

Akihide Ryo, Hiroji Uemura, Hitoshi Ishiguro, Tatsuya Saitoh, Akira Yamaguchi, Kilian Perrem, Yoshinobu Kubota, Kun Ping Lu, and Ichiro Aoki
Clin Cancer Res 2005 11: 7523-7531. [Abstract] [Full Text] [PDF]  

Complete Tumor Response Following Intratumoral ³²P BioSilicon on Human Hepatocellular and Pancreatic Carcinoma Xenografts in Nude Mice

Kai Zhang, Susan L.E. Loong, Steve Connor, Sidney W.K. Yu, Soo-Yong Tan, Robert T.H. Ng, Khai Mun Lee, Leigh Canham, and Pierce K.H. Chow
Clin Cancer Res 2005 11: 7532-7537. [Abstract] [Full Text] [PDF]  

Optimizing Photodynamic Therapy: In vivo Pharmacokinetics of Liposomal meta-(Tetrahydroxyphenyl)Chlorin in Feline Squamous Cell Carcinoma

Julia Buchholz, Barbara Kaser-Hotz, Tania Khan, Carla Rohrer Bley, Katja Melzer, Reto A. Schwendener, Malgorzata Roos, and Heinrich Walt
Clin Cancer Res 2005 11: 7538-7544. [Abstract] [Full Text] [PDF]  

Silencing of Human Phosphatidylethanolamine-Binding Protein 4 Sensitizes Breast Cancer Cells to Tumor Necrosis Factor-–Induced Apoptosis and Cell Growth Arrest

Xiaojian Wang, Nan Li, Hongzhe Li, Bin Liu, Jianming Qiu, Taoyong Chen, and Xuetao Cao
Clin Cancer Res 2005 11: 7545-7553. [Abstract] [Full Text] [PDF] Supplementary Data  

More Efficient Induction of HLA-A*0201-Restricted and Carcinoembryonic Antigen (CEA)–Specific CTL Response by Immunization with Exosomes Prepared from Heat-Stressed CEA-Positive Tumor Cells

Shengming Dai, Tao Wan, Baomei Wang, Xiangyang Zhou, Fangming Xiu, Taoyong Chen, Yanfeng Wu, and Xuetao Cao
Clin Cancer Res 2005 11: 7554-7563. [Abstract] [Full Text] [PDF]  

Kinetics of Tempol for Prevention of Xerostomia Following Head and Neck Irradiation in a Mouse Model

Ana P. Cotrim, Anastasia L. Sowers, Beatrijs M. Lodde, Joseph M. Vitolo, Albert Kingman, Angelo Russo, James B. Mitchell, and Bruce J. Baum
Clin Cancer Res 2005 11: 7564-7568. [Abstract] [Full Text] [PDF]  

Topotecan Combination Chemotherapy in Two New Rodent Models of Retinoblastoma

Nikia A. Laurie, Jonathan K. Gray, Jiakun Zhang, Mark Leggas, Mary Relling, Merrill Egorin, Clinton Stewart, and Michael A. Dyer
Clin Cancer Res 2005 11: 7569-7578. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Estrogen Receptor –Negative Breast Cancer Tissues Express Significant Levels of Estrogen-Independent Transcription Factors, ERß1 and ERß5: Potential Molecular Targets for Chemoprevention

Indira Poola, Suzanne A.W. Fuqua, Robert L. De Witty, Jessy Abraham, Josephine J. Marshallack, and Aiyi Liu
Clin Cancer Res 2005 11: 7579-7585. [Abstract] [Full Text] [PDF]  

Corrections:

Article on Primary Acute Lymphoblastic Leukemia Cells Using a Novel Promoter

Clin Cancer Res 2005 11: 7586. [Full Text] [PDF]  

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