Editorials:

Combined Targeting of the Epidermal Growth Factor Receptor and Cyclooxygenase-2 Pathways

Scott M. Lippman, Neil Gibson, Kotha Subbaramaiah, and Andrew J. Dannenberg
Clin Cancer Res 2005 11: 6097-6099. [Full Text] [PDF]  

The Biology Behind:

ERCC1 and Clinical Resistance to Platinum-Based Therapy

Eddie Reed
Clin Cancer Res 2005 11: 6100-6102. [Full Text] [PDF]  

Perspective:

Translational Crossroads for Biomarkers

Robert C. Bast, Jr., Hans Lilja, Nicole Urban, David L. Rimm, Herbert Fritsche, Joe Gray, Robert Veltri, George Klee, Andrew Allen, Nam Kim, Steven Gutman, Mark A. Rubin, and Andrew Hruszkewycz
Clin Cancer Res 2005 11: 6103-6108. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Malignant B-Lymphoid Cells with Bone Lesions Express Receptor Activator of Nuclear Factor-B Ligand and Vascular Endothelial Growth Factor to Enhance Osteoclastogenesis

Hironobu Shibata, Masahiro Abe, Kenji Hiura, Javier Wilde, Keiji Moriyama, Toshiaki Sano, Ken-ichi Kitazoe, Toshihiro Hashimoto, Shuji Ozaki, Shingo Wakatsuki, Shinsuke Kido, Daisuke Inoue, and Toshio Matsumoto
Clin Cancer Res 2005 11: 6109-6115. [Abstract] [Full Text] [PDF]  

Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate with Those in Normal Fallopian Tube, Endometrium, and Colon

Rebecca T. Marquez, Keith A. Baggerly, Andrea P. Patterson, Jinsong Liu, Russell Broaddus, Michael Frumovitz, Edward N. Atkinson, David I. Smith, Lynn Hartmann, David Fishman, Andrew Berchuck, Regina Whitaker, David M. Gershenson, Gordon B. Mills, Robert C. Bast, Jr., and Karen H. Lu
Clin Cancer Res 2005 11: 6116-6126. [Abstract] [Full Text] [PDF]  

Enhanced Production of Interleukin 6 in Peripheral Blood Monocytes Stimulated with Mucins Secreted into the Bloodstream

Norio Yokoigawa, Noriko Takeuchi, Munetoyo Toda, Mizue Inoue, Masaki Kaibori, Hidesuke Yanagida, Hironori Tanaka, Tokuhiro Ogura, Hideho Takada, Tadayoshi Okumura, A-H Kwon, Yasuo Kamiyama, and Hiroshi Nakada
Clin Cancer Res 2005 11: 6127-6132. [Abstract] [Full Text] [PDF]  

BRAF Mutation in Endometrial Carcinoma and Hyperplasia: Correlation with KRAS and p53 Mutations and Mismatch Repair Protein Expression

Yu-Zhen Feng, Tanri Shiozawa, Tsutomu Miyamoto, Hiroyasu Kashima, Miyuki Kurai, Akihisa Suzuki, and Ikuo Konishi
Clin Cancer Res 2005 11: 6133-6138. [Abstract] [Full Text] [PDF]  

Estrogen Receptor Binds to Peroxisome Proliferator–Activated Receptor Response Element and Negatively Interferes with Peroxisome Proliferator–Activated Receptor Signaling in Breast Cancer Cells

Daniela Bonofiglio, Sabrina Gabriele, Saveria Aquila, Stefania Catalano, Mariaelena Gentile, Emilia Middea, Francesca Giordano, and Sebastiano Andò
Clin Cancer Res 2005 11: 6139-6147. [Abstract] [Full Text] [PDF]  

Estrogen-Responsive Finger Protein as a New Potential Biomarker for Breast Cancer

Takashi Suzuki, Tomohiko Urano, Tohru Tsukui, Kuniko Horie-Inoue, Takuya Moriya, Takanori Ishida, Masami Muramatsu, Yasuyoshi Ouchi, Hironobu Sasano, and Satoshi Inoue
Clin Cancer Res 2005 11: 6148-6154. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor–Induced Cyclooxygenase-2 Expression Is Mediated through Phosphatidylinositol-3 Kinase, Not Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase, in Recurrent Respiratory Papillomas

Rong Wu, Allan L. Abramson, Mark J. Shikowitz, Andrew J. Dannenberg, and Bettie M. Steinberg
Clin Cancer Res 2005 11: 6155-6161. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Expression of Cdx2 and Hepatocyte Antigen in Gastric Carcinoma: Correlation with Histologic Type and Implications for Prognosis

Zhaoqing Fan, Jiyou Li, Bin Dong, and Xinfu Huang
Clin Cancer Res 2005 11: 6162-6170. [Abstract] [Full Text] [PDF]  

Effect of Angiosonography to Monitor Response During Imatinib Treatment in Patients with Metastatic Gastrointestinal Stromal Tumors

Ugo De Giorgi, Camillo Aliberti, Giorgio Benea, Matteo Conti, and Maurizio Marangolo
Clin Cancer Res 2005 11: 6171-6176. [Abstract] [Full Text] [PDF]  

Genetic Classification of Lung Adenocarcinoma Based on Array-Based Comparative Genomic Hybridization Analysis: Its Association with Clinicopathologic Features

Tatsuhiro Shibata, Satomi Uryu, Akiko Kokubu, Fumie Hosoda, Misao Ohki, Tokuki Sakiyama, Yoshihiro Matsuno, Ryosuke Tsuchiya, Yae Kanai, Tadashi Kondo, Issei Imoto, Johji Inazawa, and Setsuo Hirohashi
Clin Cancer Res 2005 11: 6177-6185. [Abstract] [Full Text] [PDF]  

Detection and Staging of Preinvasive Lesions and Occult Lung Cancer in the Central Airways with ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography: A Pilot Study

Arifa Pasic, Hes A. Brokx, Emile F. Comans, Gerarda J. Herder, Elle K. Risse, Otto S. Hoekstra, Pieter E. Postmus, and Tom G. Sutedja
Clin Cancer Res 2005 11: 6186-6189. [Abstract] [Full Text] [PDF]  

Hepatocyte Growth Factor Promotes Cancer Cell Migration and Angiogenic Factors Expression: A Prognostic Marker of Human Esophageal Squamous Cell Carcinomas

Yi Ren, Brian Cao, Simon Law, Yi Xie, Ping Yin Lee, Leo Cheung, Yongxong Chen, Xin Huang, Hiu Man Chan, Ping Zhao, John Luk, George Vande Woude, and John Wong
Clin Cancer Res 2005 11: 6190-6197. [Abstract] [Full Text] [PDF]  

Prognostic Impact of Immunohistochemical Expression of Ezrin in Highly Malignant Soft Tissue Sarcomas

Wen-Hui Weng, Jan Åhlén, Kristina Åström, Weng-Onn Lui, and Catharina Larsson
Clin Cancer Res 2005 11: 6198-6204. [Abstract] [Full Text] [PDF]  

APE1 and XRCC1 Protein Expression Levels Predict Cancer-Specific Survival Following Radical Radiotherapy in Bladder Cancer

Sei C. Sak, Patricia Harnden, Colin F. Johnston, Alan B. Paul, and Anne E. Kiltie
Clin Cancer Res 2005 11: 6205-6211. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

ERCC1 Codon 118 Polymorphism Is a Predictive Factor for the Tumor Response to Oxaliplatin/5-Fluorouracil Combination Chemotherapy in Patients with Advanced Colorectal Cancer

Jérôme Viguier, Valérie Boige, Catherine Miquel, Marc Pocard, Bruno Giraudeau, Jean-Christophe Sabourin, Michel Ducreux, Alain Sarasin, and Françoise Praz
Clin Cancer Res 2005 11: 6212-6217. [Abstract] [Full Text] [PDF]  

In vivo Generation of Angiostatin Isoforms by Administration of a Plasminogen Activator and a Free Sulfhydryl Donor: A Phase I Study of an Angiostatic Cocktail of Tissue Plasminogen Activator and Mesna

Gerald A. Soff, Hao Wang, Deborah L. Cundiff, Keyi Jiang, Brenda Martone, Alfred W. Rademaker, Jennifer A. Doll, and Timothy M. Kuzel
Clin Cancer Res 2005 11: 6218-6225. [Abstract] [Full Text] [PDF]  

Gene Expression Patterns and Profile Changes Pre- and Post-Erlotinib Treatment in Patients with Metastatic Breast Cancer

Sherry X. Yang, Richard M. Simon, Antoinette R. Tan, Diana Nguyen, and Sandra M. Swain
Clin Cancer Res 2005 11: 6226-6232. [Abstract] [Full Text] [PDF]  

Phase I Clinical Trial of BMS-247550, A Derivative of Epothilone B, Using Accelerated Titration 2B Design

Shirish M. Gadgeel, Antoinette Wozniak, Ramesh R. Boinpally, Richard Wiegand, Lance K. Heilbrun, Vikas Jain, Ralph Parchment, Dimitrios Colevas, Marvin B. Cohen, and Patricia M. LoRusso
Clin Cancer Res 2005 11: 6233-6239. [Abstract] [Full Text] [PDF]  

Dose-Finding Study of the Multitargeted Tyrosine Kinase Inhibitor SU6668 in Patients with Advanced Malignancies

Bart C. Kuenen, Giuseppe Giaccone, Rita Ruijter, Astrid Kok, Casper Schalkwijk, Klaas Hoekman, and Herbert M. Pinedo
Clin Cancer Res 2005 11: 6240-6246. [Abstract] [Full Text] [PDF]  

Phase I Evaluation of a 40-kDa Branched-Chain Long-Acting Pegylated IFN--2a With and Without Cytarabine in Patients with Chronic Myelogenous Leukemia

Moshe Talpaz, Ashok Rakhit, Karen Rittweger, Susan O'Brien, Jorge Cortes, Scott Fettner, Leon Hooftman, and Hagop Kantarjian
Clin Cancer Res 2005 11: 6247-6255. [Abstract] [Full Text] [PDF]  

Phase I Combining a P-Glycoprotein Inhibitor, MS209, in Combination with Docetaxel in Patients with Advanced Malignancies

Véronique Diéras, Jacques Bonneterre, Valérie Laurence, Marian Degardin, Jean-Yves Pierga, Marie-Edith Bonneterre, Sandrine Marreaud, Denis Lacombe, and Pierre Fumoleau
Clin Cancer Res 2005 11: 6256-6260. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Tumor Growth Inhibition by Simultaneously Blocking Epidermal Growth Factor Receptor and Cyclooxygenase-2 in a Xenograft Model

Xin Zhang, Zhuo (Georgia) Chen, Mi Sun Choe, Yan Lin, Shi-Yong Sun, H. Samuel Wieand, Hyung Ju C. Shin, Amy Chen, Fadlo R. Khuri, and Dong M. Shin
Clin Cancer Res 2005 11: 6261-6269. [Abstract] [Full Text] [PDF]  

Inhibition of _vß₃ Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy

Amir Abdollahi, David W. Griggs, Heike Zieher, Alexandra Roth, Kenneth E. Lipson, Rainer Saffrich, Hermann-Josef Gröne, Dennis E. Hallahan, Ralph A. Reisfeld, Juergen Debus, Andreas G. Niethammer, and Peter E. Huber
Clin Cancer Res 2005 11: 6270-6279. [Abstract] [Full Text] [PDF]  

Targeting the Extracellular Domain of Fibroblast Growth Factor Receptor 3 with Human Single-Chain Fv Antibodies Inhibits Bladder Carcinoma Cell Line Proliferation

Jorge Martínez-Torrecuadrada, Gabriela Cifuentes, Paula López-Serra, Pilar Saenz, Antonio Martínez, and J. Ignacio Casal
Clin Cancer Res 2005 11: 6280-6290. [Abstract] [Full Text] [PDF]  

Antiapoptotic Role of Growth Factors in the Myelodysplastic Syndromes: Concordance Between In vitro and In vivo Observations

Ramin Tehranchi, Bengt Fadeel, Jan Schmidt-Mende, Ann-Mari Forsblom, Emma Emanuelsson, Martin Jadersten, Birger Christensson, Robert Hast, Robert B. Howe, Jan Samuelsson, Boris Zhivotovsky, and Eva Hellström-Lindberg
Clin Cancer Res 2005 11: 6291-6299. [Abstract] [Full Text] [PDF]  

Gene Expression Profiles Associated with Response to Chemotherapy in Epithelial Ovarian Cancers

Amir A. Jazaeri, Christopher S. Awtrey, Gadisetti V.R. Chandramouli, Yao Eric Chuang, Javed Khan, Christos Sotiriou, Olga Aprelikova, Cindy J. Yee, Kristin K. Zorn, Michael J. Birrer, J. Carl Barrett, and Jeff Boyd
Clin Cancer Res 2005 11: 6300-6310. [Abstract] [Full Text] [PDF] Supplementary Data  

SMAD4 Levels and Response to 5-Fluorouracil in Colorectal Cancer

Pia Alhopuro, Hafid Alazzouzi, Heli Sammalkorpi, Verónica Dávalos, Reijo Salovaara, Akseli Hemminki, Heikki Järvinen, Jukka-Pekka Mecklin, Simo Schwartz, Jr., Lauri A. Aaltonen, and Diego Arango
Clin Cancer Res 2005 11: 6311-6316. [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of Tumor Growth by RGD Peptide–Directed Delivery of Truncated Tissue Factor to the Tumor Vasculature

Torsten Kessler, Ralf Bieker, Teresa Padró, Christian Schwöppe, Thorsten Persigehl, Christoph Bremer, Michael Kreuter, Wolfgang E. Berdel, and Rolf M. Mesters
Clin Cancer Res 2005 11: 6317-6324. [Abstract] [Full Text] [PDF]  

Glucocorticoids Inhibit Cell Death in Ovarian Cancer and Up-regulate Caspase Inhibitor cIAP2

Ingo B. Runnebaum and Ansgar Brüning
Clin Cancer Res 2005 11: 6325-6332. [Abstract] [Full Text] [PDF]  

Down-Regulation of Signal Transducer and Activator of Transcription 3 Expression Using Vector-Based Small Interfering RNAs Suppresses Growth of Human Prostate Tumor In vivo

Lifang Gao, Ling Zhang, Jiadi Hu, Feng Li, Yueting Shao, Dan Zhao, Dhananjaya V. Kalvakolanu, Dennis J. Kopecko, Xuejian Zhao, and De-Qi Xu
Clin Cancer Res 2005 11: 6333-6341. [Abstract] [Full Text] [PDF]  

Identification of Novel Human CTL Epitopes and Their Agonist Epitopes of Mesothelin

Junko Yokokawa, Claudia Palena, Philip Arlen, Raffit Hassan, Mitchell Ho, Ira Pastan, Jeffrey Schlom, and Kwong Y. Tsang
Clin Cancer Res 2005 11: 6342-6351. [Abstract] [Full Text] [PDF]  

Chromosomal Radiosensitivity in Two Cell Lineages Derived from Clinically Radiosensitive Cancer Patients

Carl N. Sprung, Michael Chao, Trevor Leong, and Michael J. McKay
Clin Cancer Res 2005 11: 6352-6358. [Abstract] [Full Text] [PDF]  

Activation of the Steroid and Xenobiotic Receptor (Human Pregnane X Receptor) by Nontaxane Microtubule-Stabilizing Agents

Sridhar Mani, Haiyan Huang, Sumathy Sundarababu, Wenjing Liu, Ganjam Kalpana, Amos B. Smith, and Susan B. Horwitz
Clin Cancer Res 2005 11: 6359-6369. [Abstract] [Full Text] [PDF]  

Transcriptional Profiling Identifies Altered Intracellular Labile Iron Homeostasis as a Contributing Factor to the Toxicity of Adaphostin: Decreased Vascular Endothelial Growth Factor Secretion Is Independent of Hypoxia-Inducible Factor-1 Regulation

Curtis Hose, Gurmeet Kaur, Edward A. Sausville, and Anne Monks
Clin Cancer Res 2005 11: 6370-6381. [Abstract] [Full Text] [PDF]  

Activity of Suberoylanilide Hydroxamic Acid Against Human Breast Cancer Cells with Amplification of Her-2

Purva Bali, Michael Pranpat, Ramona Swaby, Warren Fiskus, Hirohito Yamaguchi, Maria Balasis, Kathy Rocha, Hong-Gang Wang, Victoria Richon, and Kapil Bhalla
Clin Cancer Res 2005 11: 6382-6389. [Abstract] [Full Text] [PDF]  

Treatment of Human Tumor Xenografts with Monoclonal Antibody 806 in Combination with a Prototypical Epidermal Growth Factor Receptor–Specific Antibody Generates Enhanced Antitumor Activity

Rushika M. Perera, Yoshitaka Narita, Frank B. Furnari, Hui K. Gan, Carmel Murone, Marika Ahlkvist, Rodney B. Luwor, Antony W. Burgess, Elisabeth Stockert, Achim A. Jungbluth, Lloyd J. Old, Webster K. Cavenee, Andrew M. Scott, and Terrance G. Johns
Clin Cancer Res 2005 11: 6390-6399. [Abstract] [Full Text] [PDF]  

Expression of the Apoptosis Inhibitor Protease Inhibitor 9 Predicts Clinical Outcome in Vaccinated Patients with Stage III and IV Melanoma

Inge S. van Houdt, Joost J. Oudejans, Alfonsus J.M. van den Eertwegh, Arnold Baars, Wim Vos, Bellinda A. Bladergroen, Donata Rimoldi, Jettie J.F. Muris, Erik Hooijberg, Chad M. Gundy, Chris J.L.M. Meijer, and Jean A. Kummer
Clin Cancer Res 2005 11: 6400-6407. [Abstract] [Full Text] [PDF]  

Corrections:

Correction: Article on Up-Regulation of the Peripheral Benzodiazepine Receptor during Human Colorectal Carcinogenesis and Tumor Spread

Clin Cancer Res 2005 11: 6408. [Full Text] [PDF]  

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