The Biology Behind:

Chronic Lymphocytic Leukemia: A Niche for Flavopiridol?

Jennifer R. Brown
Clin Cancer Res 2005 11: 3971-3973. [Full Text] [PDF]  

Reviews:

Prognostic Implications of Cell Cycle, Apoptosis, and Angiogenesis Biomarkers in Non–Small Cell Lung Cancer: A Review

Sunil Singhal, Anil Vachani, Danielle Antin-Ozerkis, Larry R. Kaiser, and Steven M. Albelda
Clin Cancer Res 2005 11: 3974-3986. [Abstract] [Full Text] [PDF]  

Boron Neutron Capture Therapy of Cancer: Current Status and Future Prospects

Rolf F. Barth, Jeffrey A. Coderre, M. Graça H. Vicente, and Thomas E. Blue
Clin Cancer Res 2005 11: 3987-4002. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Placental Cadherin and the Basal Epithelial Phenotype of BRCA1-Related Breast Cancer

Jarle B. Arnes, Jean-Sébastien Brunet, Ingunn Stefansson, Louis R. Bégin, Nora Wong, Pierre O. Chappuis, Lars A. Akslen, and William D. Foulkes
Clin Cancer Res 2005 11: 4003-4011. [Abstract] [Full Text] [PDF]  

Critical Role of Peroxisome Proliferator-Activated Receptor on Anoikis and Invasion of Squamous Cell Carcinoma

Tomotake Masuda, Koichiro Wada, Atsushi Nakajima, Masaya Okura, Chiho Kudo, Takashi Kadowaki, Mikihiko Kogo, and Yoshinori Kamisaki
Clin Cancer Res 2005 11: 4012-4021. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Radiolabeled Small-Molecule Ligands for Prostate-Specific Membrane Antigen: In vivo Imaging in Experimental Models of Prostate Cancer

Catherine A. Foss, Ronnie C. Mease, Hong Fan, Yuchuan Wang, Hayden T. Ravert, Robert F. Dannals, Rafal T. Olszewski, Warren D. Heston, Alan P. Kozikowski, and Martin G. Pomper
Clin Cancer Res 2005 11: 4022-4028. [Abstract] [Full Text] [PDF]  

A Molecular Signature in Superficial Bladder Carcinoma Predicts Clinical Outcome

Lars Dyrskjøt, Karsten Zieger, Mogens Kruhøffer, Thomas Thykjaer, Jens L. Jensen, Hanne Primdahl, Natasha Aziz, Niels Marcussen, Klaus Møller, and Torben F. Ørntoft
Clin Cancer Res 2005 11: 4029-4036. [Abstract] [Full Text] [PDF] Supplementary Data  

Preoperative Serum DNA GSTP1 CpG Island Hypermethylation and the Risk of Early Prostate-Specific Antigen Recurrence Following Radical Prostatectomy

Patrick J. Bastian, Ganesh S. Palapattu, Xiaohui Lin, Srinivasan Yegnasubramanian, Leslie A. Mangold, Bruce Trock, Mario A. Eisenberger, Alan W. Partin, and William G. Nelson
Clin Cancer Res 2005 11: 4037-4043. [Abstract] [Full Text] [PDF]  

Bladder Cancer Outcome and Subtype Classification by Gene Expression

Ekaterini Blaveri, Jeff P. Simko, James E. Korkola, Jeremy L. Brewer, Frederick Baehner, Kshama Mehta, Sandy DeVries, Theresa Koppie, Sunanda Pejavar, Peter Carroll, and Frederic M. Waldman
Clin Cancer Res 2005 11: 4044-4055. [Abstract] [Full Text] [PDF] Supplementary Data  

Microarray Analysis of Endometrial Carcinomas and Mixed Mullerian Tumors Reveals Distinct Gene Expression Profiles Associated with Different Histologic Types of Uterine Cancer

G. Larry Maxwell, G.V.R. Chandramouli, Lou Dainty, Tracy J. Litzi, Andrew Berchuck, J. Carl Barrett, and John I. Risinger
Clin Cancer Res 2005 11: 4056-4066. [Abstract] [Full Text] [PDF]  

P53 Mutation Analysis of Colorectal Liver Metastases: Relation to Actual Survival, Angiogenic Status, and p53 Overexpression

Koert P. de Jong, Annette S.H. Gouw, Paul M.J.G. Peeters, Marian Bulthuis, Lorian Menkema, Robert J. Porte, Maarten J.H. Slooff, Harry van Goor, and Anke van den Berg
Clin Cancer Res 2005 11: 4067-4073. [Abstract] [Full Text] [PDF]  

Different Activation of Mitogen-Activated Protein Kinase and Akt Signaling Is Associated with Aggressive Phenotype of Human Meningiomas

Christian Mawrin, Tina Sasse, Elmar Kirches, Siegfried Kropf, Thomas Schneider, Christoph Grimm, Claudia Pambor, Christian K. Vorwerk, Raimund Firsching, Uwe Lendeckel, and Knut Dietzmann
Clin Cancer Res 2005 11: 4074-4082. [Abstract] [Full Text] [PDF]  

Automated Quantitative Analysis of E-Cadherin Expression in Lymph Node Metastases Is Predictive of Survival in Invasive Ductal Breast Cancer

Malini Harigopal, Aaron J. Berger, Robert L. Camp, David L. Rimm, and Harriet M. Kluger
Clin Cancer Res 2005 11: 4083-4089. [Abstract] [Full Text] [PDF]  

Increased Cyclooxygenase-2 Expression in Duodenal Compared with Colonic Tissues in Familial Adenomatous Polyposis and Relationship to the –765G C COX-2 Polymorphism

Lodewijk A.A. Brosens, Christine A. Iacobuzio-Donahue, Josbert J. Keller, Steven R. Hustinx, Ralph Carvalho, Folkert H. Morsink, Linda M. Hylind, G. Johan Offerhaus, Francis M. Giardiello, and Michael Goggins
Clin Cancer Res 2005 11: 4090-4096. [Abstract] [Full Text] [PDF]  

Diagnostic and Prognostic Information in Prostate Cancer with the Help of a Small Set of Hypermethylated Gene Loci

Patrick J. Bastian, Jörg Ellinger, Axel Wellmann, Nicolas Wernert, Lukas C. Heukamp, Stefan C. Müller, and Alexander von Ruecker
Clin Cancer Res 2005 11: 4097-4106. [Abstract] [Full Text] [PDF]  

p14^ARF Protein Expression Is a Predictor of Both Relapse and Survival in Squamous Cell Carcinoma of the Anterior Tongue

Rhonda A. Kwong, Larry H. Kalish, Tuan V. Nguyen, James G. Kench, Ronaldo J. Bova, Ian E. Cole, Elizabeth A. Musgrove, and Robert L. Sutherland
Clin Cancer Res 2005 11: 4107-4116. [Abstract] [Full Text] [PDF]  

Nonapical and Cytoplasmic Expression of Interleukin-8, CXCR1, and CXCR2 Correlates with Cell Proliferation and Microvessel Density in Prostate Cancer

Catherine Murphy, Maryalice McGurk, Johanna Pettigrew, Alfredo Santinelli, Roberta Mazzucchelli, Patrick G. Johnston, Rodolfo Montironi, and David J.J. Waugh
Clin Cancer Res 2005 11: 4117-4127. [Abstract] [Full Text] [PDF]  

Prediction of Lymph Node Metastasis by Analysis of Gene Expression Profiles in Primary Lung Adenocarcinomas

Liqiang Xi, James Lyons-Weiler, Michael C. Coello, Xin Huang, William E. Gooding, James D. Luketich, and Tony E. Godfrey
Clin Cancer Res 2005 11: 4128-4135. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Comparative Preclinical and Clinical Pharmacokinetics of a Cremophor-Free, Nanoparticle Albumin-Bound Paclitaxel (ABI-007) and Paclitaxel Formulated in Cremophor (Taxol)

Alex Sparreboom, Charity D. Scripture, Vuong Trieu, Paul J. Williams, Tapas De, Andrew Yang, Bridget Beals, William D. Figg, Michael Hawkins, and Neil Desai
Clin Cancer Res 2005 11: 4136-4143. [Abstract] [Full Text] [PDF]  

A Phase I Pharmacologic and Pharmacogenetic Trial of Sequential 24-Hour Infusion of Irinotecan Followed by Leucovorin and a 48-Hour Infusion of Fluorouracil in Adult Patients with Solid Tumors

Maurice A. Wright, Geraldine Morrison, Pengxin Lin, Gregory D. Leonard, Dat Nguyen, Xaiodu Guo, Eva Szabo, Jon L. Hopkins, Jorge P. Leguizamo, Nancy Harold, Suzanne Fioravanti, Barbara Schuler, Brian P. Monahan, M. Wasif Saif, Mary G. Quinn, Janet Pang, and Jean L. Grem
Clin Cancer Res 2005 11: 4144-4150. [Abstract] [Full Text] [PDF]  

Phase I Study of the Farnesyltransferase Inhibitor BMS-214662 Given Weekly in Patients with Solid Tumors

Vali Papadimitrakopoulou, Sofia Agelaki, Hai T. Tran, Merrill Kies, Robert Gagel, Ralph Zinner, Edward Kim, Gregory Ayers, John Wright, and Fadlo Khuri
Clin Cancer Res 2005 11: 4151-4159. [Abstract] [Full Text] [PDF]  

Clinical Evaluation of Dendritic Cell Vaccination for Patients with Recurrent Glioma: Results of a Clinical Phase I/II Trial

Ryuya Yamanaka, Junpei Homma, Naoki Yajima, Naoto Tsuchiya, Masakazu Sano, Tsutomu Kobayashi, Seiichi Yoshida, Takashi Abe, Miwako Narita, Masuhiro Takahashi, and Ryuichi Tanaka
Clin Cancer Res 2005 11: 4160-4167. [Abstract] [Full Text] [PDF]  

Phase I Study of the Intratumoral Administration of Recombinant Canarypox Viruses Expressing B7.1 and Interleukin 12 in Patients with Metastatic Melanoma

Pierre L. Triozzi, Karen O. Allen, Ronda R. Carlisle, Mark Craig, Albert F. LoBuglio, and Robert M. Conry
Clin Cancer Res 2005 11: 4168-4175. [Abstract] [Full Text] [PDF]  

Treatment of Relapsed Chronic Lymphocytic Leukemia by 72-Hour Continuous Infusion or 1-Hour Bolus Infusion of Flavopiridol: Results from Cancer and Leukemia Group B Study 19805

John C. Byrd, Bercedis L. Peterson, Janice Gabrilove, Olatoyosi M. Odenike, Michael R. Grever, Kanti Rai, Richard A. Larson, and the Cancer and Leukemia Group B
Clin Cancer Res 2005 11: 4176-4181. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Acquired Resistance to Imatinib in Gastrointestinal Stromal Tumor Occurs Through Secondary Gene Mutation

Cristina R. Antonescu, Peter Besmer, Tianhua Guo, Knarik Arkun, Glory Hom, Beata Koryotowski, Margaret A. Leversha, Philip D. Jeffrey, Diann Desantis, Samuel Singer, Murray F. Brennan, Robert G. Maki, and Ronald P. DeMatteo
Clin Cancer Res 2005 11: 4182-4190. [Abstract] [Full Text] [PDF]  

Chemotherapy Induces the Expression of Cyclooxygenase-2 in Non–Small Cell Lung Cancer

Nasser K. Altorki, Jeffrey L. Port, Fan Zhang, Dragan Golijanin, Howard T. Thaler, Anna J. Duffield-Lillico, Kotha Subbaramaiah, and Andrew J. Dannenberg
Clin Cancer Res 2005 11: 4191-4197. [Abstract] [Full Text] [PDF]  

Increased Renal Calcium Reabsorption by Parathyroid Hormone–Related Protein Is a Causative Factor in the Development of Humoral Hypercalcemia of Malignancy Refractory to Osteoclastic Bone Resorption Inhibitors

Etsuro Onuma, Yumiko Azuma, Hidemi Saito, Toshiaki Tsunenari, Toshihiko Watanabe, Manabu Hirabayashi, Koh Sato, Hisafumi Yamada-Okabe, and Etsuro Ogata
Clin Cancer Res 2005 11: 4198-4203. [Abstract] [Full Text] [PDF]  

Intraprostatic Chemotherapy: Distribution and Transport Mechanisms

M. Guillaume Wientjes, Jenny H. Zheng, Leijun Hu, Yuebo Gan, and Jessie L-S. Au
Clin Cancer Res 2005 11: 4204-4211. [Abstract] [Full Text] [PDF]  

Tirapazamine Administered as a Neoadjuvant to Radiotherapy Reduces Metastatic Dissemination

Sarah Jane Lunt, Brian A. Telfer, Richard J. Fitzmaurice, Ian J. Stratford, and Kaye J. Williams
Clin Cancer Res 2005 11: 4212-4216. [Abstract] [Full Text] [PDF]  

Improved Therapeutic Effectiveness by Combining Recombinant CXC Chemokine Ligand 10 with Cisplatin in Solid Tumors

Gang Li, Ling Tian, Jian-mei Hou, Zhen-yu Ding, Qiu-ming He, Ping Feng, Yan-jun Wen, Fei Xiao, Bing Yao, Ru Zhang, Feng Peng, Yu Jiang, Feng Luo, Xia Zhao, Lin Zhang, Qiao Zhou, and Yu-quan Wei
Clin Cancer Res 2005 11: 4217-4224. [Abstract] [Full Text] [PDF]  

Preclinical Evaluation of Gemcitabine Combination Regimens for Application in Acute Myeloid Leukemia

Ryan H. Shanks, David A. Rizzieri, James L. Flowers, O. Michael Colvin, and David J. Adams
Clin Cancer Res 2005 11: 4225-4233. [Abstract] [Full Text] [PDF]  

High Thymidylate Synthase Expression in Colorectal Cancer with Microsatellite Instability: Implications for Chemotherapeutic Strategies

Luigi Ricciardiello, Claudio Ceccarelli, Graziella Angiolini, Milena Pariali, Pasquale Chieco, Paola Paterini, Guido Biasco, Giuseppe N. Martinelli, Enrico Roda, and Franco Bazzoli
Clin Cancer Res 2005 11: 4234-4240. [Abstract] [Full Text] [PDF]  

Tumor Vascular Response to Photodynamic Therapy and the Antivascular Agent 5,6-Dimethylxanthenone-4-Acetic Acid: Implications for Combination Therapy

Mukund Seshadri, Joseph A. Spernyak, Richard Mazurchuk, Susan H. Camacho, Allan R. Oseroff, Richard T. Cheney, and David A. Bellnier
Clin Cancer Res 2005 11: 4241-4250. [Abstract] [Full Text] [PDF]  

Combination Therapy with Interleukin-6 Receptor Superantagonist Sant7 and Dexamethasone Induces Antitumor Effects in a Novel SCID-hu In vivo Model of Human Multiple Myeloma

Pierfrancesco Tassone, Paola Neri, Renate Burger, Rocco Savino, Masood Shammas, Laurence Catley, Klaus Podar, Dharminder Chauhan, Serena Masciari, Antonella Gozzini, Pierosandro Tagliaferri, Salvatore Venuta, Nikhil C. Munshi, and Kenneth C. Anderson
Clin Cancer Res 2005 11: 4251-4258. [Abstract] [Full Text] [PDF]  

Cooperative Cytotoxicity of Proteasome Inhibitors and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand in Chemoresistant Bcl-2-Overexpressing Cells

Alessio Nencioni, Lucia Wille, Giovanna Dal Bello, Davide Boy, Gabriella Cirmena, Sebastian Wesselborg, Claus Belka, Peter Brossart, Franco Patrone, and Alberto Ballestrero
Clin Cancer Res 2005 11: 4259-4265. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Farnesyltransferase Inhibitor, ABT-100, Is a Potent Liver Cancer Chemopreventive Agent

Vinicio Carloni, Francesco Vizzutti, and Pietro Pantaleo
Clin Cancer Res 2005 11: 4266-4274. [Abstract] [Full Text] [PDF]  

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