The Biology Behind:

The Pathway to Biomarker Discovery: Carbonic Anhydrase IX and the Prediction of Immune Responsiveness

Monica C. Panelli, Ena Wang, and Francesco M. Marincola
Clin Cancer Res 2005 11: 3601-3603. [Full Text] [PDF]  

Report from the FDA:

Approval Summary: Azacitidine for Treatment of Myelodysplastic Syndrome Subtypes

Edvardas Kaminskas, Ann Farrell, Sophia Abraham, Amy Baird, Li-Shan Hsieh, Shwu-Luan Lee, John K. Leighton, Hasmukh Patel, Atiqur Rahman, Rajeshwara Sridhara, Yong-Cheng Wang, and Richard Pazdur
Clin Cancer Res 2005 11: 3604-3608. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

DDEF1 Is Located in an Amplified Region of Chromosome 8q and Is Overexpressed in Uveal Melanoma

Justis P. Ehlers, Lori Worley, Michael D. Onken, and J. William Harbour
Clin Cancer Res 2005 11: 3609-3613. [Abstract] [Full Text] [PDF]  

A Rare Transporter Associated with Antigen Processing Polymorphism Overpresented in HLA^low Colon Cancer Reveals the Functional Significance of the Signature Domain in Antigen Processing

Tianyu Yang, Philip E. Lapinski, Haotian Zhao, Qunmin Zhou, Huiming Zhang, Malini Raghavan, Yang Liu, and Pan Zheng
Clin Cancer Res 2005 11: 3614-3623. [Abstract] [Full Text] [PDF]  

Proteins and Protein Pattern Differences between Glioma Cell Lines and Glioblastoma Multiforme

Timothy W. Vogel, Zhengping Zhuang, Jie Li, Hiroaki Okamoto, Makoto Furuta, Youn-Soo Lee, Weifen Zeng, Edward H. Oldfield, Alexander O. Vortmeyer, and Robert J. Weil
Clin Cancer Res 2005 11: 3624-3632. [Abstract] [Full Text] [PDF]  

In vivo Target Modulation and Biological Activity of CHIR-258, a Multitargeted Growth Factor Receptor Kinase Inhibitor, in Colon Cancer Models

Sang Hoon Lee, Daniel Lopes de Menezes, Jayesh Vora, Alex Harris, Helen Ye, Lara Nordahl, Evelyn Garrett, Emil Samara, Sharon Lea Aukerman, Arnold B. Gelb, and Carla Heise
Clin Cancer Res 2005 11: 3633-3641. [Abstract] [Full Text] [PDF]  

Association of Visceral Fat Accumulation and Plasma Adiponectin with Colorectal Adenoma: Evidence for Participation of Insulin Resistance

Sayaka Otake, Hiroaki Takeda, Yasukuni Suzuki, Tadahisa Fukui, Shinichiro Watanabe, Katsuyoshi Ishihama, Takafumi Saito, Hitoshi Togashi, Tadashi Nakamura, Yuji Matsuzawa, and Sumio Kawata
Clin Cancer Res 2005 11: 3642-3646. [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Polymorphisms in Relation to Breast Cancer Development and Prognosis

Qianren Jin, Kari Hemminki, Kerstin Enquist, Per Lenner, Ewa Grzybowska, Rüdiger Klaes, Roger Henriksson, Bowang Chen, Jolanta Pamula, Wioletta Pekala, Helena Zientek, Jadwiga Rogozinska-Szczepka, Beata Utracka-Hutka, Göran Hallmans, and Asta Försti
Clin Cancer Res 2005 11: 3647-3653. [Abstract] [Full Text] [PDF]  

Distinct Methylation Patterns of Benign and Malignant Liver Tumors Revealed by Quantitative Methylation Profiling

Ulrich Lehmann, Ina Berg-Ribbe, Luzie U. Wingen, Kai Brakensiek, Thomas Becker, Jürgen Klempnauer, Brigitte Schlegelberger, Hans Kreipe, and Peer Flemming
Clin Cancer Res 2005 11: 3654-3660. [Abstract] [Full Text] [PDF]  

Genetic Abnormalities and Patterns of Antigenic Expression in Multiple Myeloma

Gema Mateo, Mariana Castellanos, Ana Rasillo, Norma C. Gutiérrez, Ma. Angeles Montalbán, Ma. Luisa Martín, Jesús Ma. Hernández, Ma. Consuelo López-Berges, Laura Montejano, Joan Bladé, Ma. Victoria Mateos, Anna Sureda, Javier de la Rubia, Joaquín Díaz-Mediavilla, Atanasio Pandiella, Juan José Lahuerta, Alberto Orfao, and Jesús F. San Miguel
Clin Cancer Res 2005 11: 3661-3667. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Analysis of KIT Mutations in Sporadic and Familial Gastrointestinal Stromal Tumors: Therapeutic Implications through Protein Modeling

Chi Tarn, Erin Merkel, Adrian A. Canutescu, Wei Shen, Yuliya Skorobogatko, Martin J. Heslin, Burton Eisenberg, Ruth Birbe, Arthur Patchefsky, Roland Dunbrack, J. Pablo Arnoletti, Margaret von Mehren, and Andrew K. Godwin
Clin Cancer Res 2005 11: 3668-3677. [Abstract] [Full Text] [PDF]  

Circulating Tumor Cells in Breast Cancer: Correlation to Bone Marrow Micrometastases, Heterogeneous Response to Systemic Therapy and Low Proliferative Activity

Volkmar Müller, Nicole Stahmann, Sabine Riethdorf, Thomas Rau, Tanja Zabel, Alexander Goetz, Fritz Jänicke, and Klaus Pantel
Clin Cancer Res 2005 11: 3678-3685. [Abstract] [Full Text] [PDF]  

Patterns of Gene Expression That Characterize Long-term Survival in Advanced Stage Serous Ovarian Cancers

Andrew Berchuck, Edwin S. Iversen, Johnathan M. Lancaster, Jennifer Pittman, Jingqin Luo, Paula Lee, Susan Murphy, Holly K. Dressman, Phillip G. Febbo, Mike West, Joseph R. Nevins, and Jeffrey R. Marks
Clin Cancer Res 2005 11: 3686-3696. [Abstract] [Full Text] [PDF]  

An Innovative Microarray Strategy Identities Informative Molecular Markers for the Detection of Micrometastatic Breast Cancer

Kaidi Mikhitarian, William E. Gillanders, Jonas S. Almeida, Renee Hebert Martin, Juan C. Varela, John S. Metcalf, David J. Cole, and Michael Mitas
Clin Cancer Res 2005 11: 3697-3704. [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor Dose Response to the Vascular Disrupting Agent, 5,6-Dimethylxanthenone-4-Acetic Acid, Using In vivo Magnetic Resonance Spectroscopy

Lesley D. McPhail, Yuen-Li Chung, Basetti Madhu, Simon Clark, John R. Griffiths, Lloyd R. Kelland, and Simon P. Robinson
Clin Cancer Res 2005 11: 3705-3713. [Abstract] [Full Text] [PDF]  

Carbonic Anhydrase IX Expression Predicts Outcome of Interleukin 2 Therapy for Renal Cancer

Michael Atkins, Meredith Regan, David McDermott, James Mier, Eric Stanbridge, Amanda Youmans, Philip Febbo, Melissa Upton, Mirna Lechpammer, and Sabina Signoretti
Clin Cancer Res 2005 11: 3714-3721. [Abstract] [Full Text] [PDF]  

Evaluation of a Panel of Tumor Markers for Molecular Detection of Circulating Cancer Cells in Women with Suspected Breast Cancer

Monica M. Reinholz, Andrea Nibbe, Leslie M. Jonart, Kathleen Kitzmann, Vera J. Suman, James N. Ingle, Raymond Houghton, Barbara Zehentner, Patrick C. Roche, and Wilma L. Lingle
Clin Cancer Res 2005 11: 3722-3732. [Abstract] [Full Text] [PDF]  

The Relationship of Molecular Markers of p53 Function and Angiogenesis to Prognosis of Stage I Epithelial Ovarian Cancer

Michael J. Goodheart, Justine M. Ritchie, Stephen L. Rose, John P. Fruehauf, Barry R. De Young, and Richard E. Buller
Clin Cancer Res 2005 11: 3733-3742. [Abstract] [Full Text] [PDF]  

Functionality of Androgen Receptor–Based Gene Expression Imaging in Hormone Refractory Prostate Cancer

Makoto Sato, Mai Johnson, Liqun Zhang, Sanjiv S. Gambhir, Michael Carey, and Lily Wu
Clin Cancer Res 2005 11: 3743-3749. [Abstract] [Full Text] [PDF]  

Mutation in the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor Is a Predictive and Prognostic Factor for Gefitinib Treatment in Patients with Non–Small Cell Lung Cancer

Teh-Ying Chou, Chao-Hua Chiu, Ling-Hui Li, Chun-Yen Hsiao, Chin-Yuan Tzen, Kuo-Ting Chang, Yuh-Min Chen, Reury-Perng Perng, Shih-Feng Tsai, and Chun-Ming Tsai
Clin Cancer Res 2005 11: 3750-3757. [Abstract] [Full Text] [PDF]  

Cytochrome P450 Profile of Colorectal Cancer: Identification of Markers of Prognosis

Meera Kumarakulasingham, Patrick H. Rooney, Sinclair R. Dundas, Colin Telfer, William T. Melvin, Stephanie Curran, and Graeme I. Murray
Clin Cancer Res 2005 11: 3758-3765. [Abstract] [Full Text] [PDF]  

Markers of Adenocarcinoma Characteristic of the Site of Origin: Development of a Diagnostic Algorithm

Jayne L. Dennis, Torgeir R. Hvidsten, Ernst C. Wit, Jan Komorowski, Alexandra K. Bell, Ian Downie, Jacqueline Mooney, Caroline Verbeke, Christopher Bellamy, W. Nicol Keith, and Karin A. Oien
Clin Cancer Res 2005 11: 3766-3772. [Abstract] [Full Text] [PDF] Supplementary Data  

Detection of Micrometastases in Pelvic Lymph Nodes in Patients Undergoing Radical Cystectomy for Focally Invasive Bladder Cancer by Real-time Reverse Transcriptase-PCR for Cytokeratin 19 and Uroplakin II

Toshifumi Kurahashi, Isao Hara, Nobutoshi Oka, Sadao Kamidono, Hiroshi Eto, and Hideaki Miyake
Clin Cancer Res 2005 11: 3773-3777. [Abstract] [Full Text] [PDF]  

Prognostic Role of Thymidylate Synthase Polymorphisms in Gastric Cancer Patients Treated with Surgery and Adjuvant Chemotherapy

Kazuyuki Kawakami, Francesco Graziano, Go Watanabe, Annamaria Ruzzo, Daniele Santini, Vincenzo Catalano, Renato Bisonni, Federica Arduini, Italo Bearzi, Stefano Cascinu, Pietro Muretto, Giuseppe Perrone, Carla Rabitti, Lucio Giustini, Giuseppe Tonini, Francesca Pizzagalli, and Mauro Magnani
Clin Cancer Res 2005 11: 3778-3783. [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Overexpression Is Associated with a Poor Outcome in Resected Ampullary Cancer Patients

Daniele Santini, Bruno Vincenzi, Giuseppe Tonini, Susanna Scarpa, Fortunata Vasaturo, Carolina Malacrino, Fabio Vecchio, Domenico Borzomati, Sergio Valeri, Roberto Coppola, Paolo Magistrelli, Gennaro Nuzzo, and Aurelio Picciocchi
Clin Cancer Res 2005 11: 3784-3789. [Abstract] [Full Text] [PDF]  

Inhibition of Heme Oxygenase-1 Increases Responsiveness of Pancreatic Cancer Cells to Anticancer Treatment

Pascal O. Berberat, Zilvinas Dambrauskas, Antanas Gulbinas, Thomas Giese, Nathalia Giese, Beat Künzli, Frank Autschbach, Stefen Meuer, Markus W. Büchler, and Helmut Friess
Clin Cancer Res 2005 11: 3790-3798. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Proton Beam Therapy for Hepatocellular Carcinoma: A Retrospective Review of 162 Patients

Toshiya Chiba, Koichi Tokuuye, Yasushi Matsuzaki, Shinji Sugahara, Yoshimichi Chuganji, Kenji Kagei, Junichi Shoda, Masaharu Hata, Masato Abei, Hiroshi Igaki, Naomi Tanaka, and Yasuyuki Akine
Clin Cancer Res 2005 11: 3799-3805. [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetic Study of the Dolastatin 10 Analogue TZT-1027, Given on Days 1 and 8 of a 3-Week Cycle in Patients with Advanced Solid Tumors

Maja J.A. de Jonge, Ate van der Gaast, André S.T. Planting, Leny van Doorn, Aletta Lems, Inge Boot, Jantien Wanders, Masahiko Satomi, and Jaap Verweij
Clin Cancer Res 2005 11: 3806-3813. [Abstract] [Full Text] [PDF]  

Humoral Immune Response to Mesothelin in Mesothelioma and Ovarian Cancer Patients

Mitchell Ho, Raffit Hassan, Jingli Zhang, Qing-cheng Wang, Masanori Onda, Tapan Bera, and Ira Pastan
Clin Cancer Res 2005 11: 3814-3820. [Abstract] [Full Text] [PDF]  

Recombinant Sendai Virus Vector Induces Complete Remission of Established Brain Tumors through Efficient Interleukin-2 Gene Transfer in Vaccinated Rats

Yasuo Iwadate, Makoto Inoue, Takashi Saegusa, Yumiko Tokusumi, Hiroaki Kinoh, Mamoru Hasegawa, Masatoshi Tagawa, Akira Yamaura, and Hideaki Shimada
Clin Cancer Res 2005 11: 3821-3827. [Abstract] [Full Text] [PDF]  

Dietary Flaxseed Alters Tumor Biological Markers in Postmenopausal Breast Cancer

Lilian U. Thompson, Jian Min Chen, Tong Li, Kathrin Strasser-Weippl, and Paul E. Goss
Clin Cancer Res 2005 11: 3828-3835. [Abstract] [Full Text] [PDF]  

A Phase I Clinical Trial of the Sequential Combination of Irinotecan Followed by Flavopiridol

Manish A. Shah, Jeremy Kortmansky, Monica Motwani, Marija Drobnjak, Mithat Gonen, Sandy Yi, Amanda Weyerbacher, Carlos Cordon-Cardo, Robert Lefkowitz, Baruch Brenner, Eileen O'Reilly, Leonard Saltz, William Tong, David P. Kelsen, and Gary K. Schwartz
Clin Cancer Res 2005 11: 3836-3845. [Abstract] [Full Text] [PDF]  

Phase 1 Clinical and Pharmacokinetics Evaluation of Oral CI-1033 in Patients with Refractory Cancer

John Nemunaitis, Irene Eiseman, Casey Cunningham, Neil Senzer, Adrienne Williams, Peter F. Lenehan, Stephen C. Olson, Paul Bycott, Michael Schlicht, Rebecca Zentgraff, Dong M. Shin, and Ralph G. Zinner
Clin Cancer Res 2005 11: 3846-3853. [Abstract] [Full Text] [PDF]  

A Phase II, Pharmacokinetic, and Biological Correlative Study of Oblimersen Sodium and Docetaxel in Patients with Hormone-Refractory Prostate Cancer

Anthony W. Tolcher, Kim Chi, John Kuhn, Martin Gleave, Amita Patnaik, Chris Takimoto, Garry Schwartz, Ian Thompson, Kristin Berg, Susan D'Aloisio, Nevin Murray, Stanley R. Frankel, Elzbieta Izbicka, and Eric Rowinsky
Clin Cancer Res 2005 11: 3854-3861. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Plasma Pharmacokinetics, Oral Bioavailability, and Interspecies Scaling of the DNA Methyltransferase Inhibitor, Zebularine

Julianne L. Holleran, Robert A. Parise, Erin Joseph, Julie L. Eiseman, Joseph M. Covey, Elizabeth R. Glaze, Alexander V. Lyubimov, Ya-Fei Chen, David Z. D'Argenio, and Merrill J. Egorin
Clin Cancer Res 2005 11: 3862-3868. [Abstract] [Full Text] [PDF]  

Recognition of Prostate and Breast Tumor Cells by Helper T Lymphocytes Specific for a Prostate and Breast Tumor-Associated Antigen, TARP

Hiroya Kobayashi, Toshihiro Nagato, Kensuke Oikawa, Keisuke Sato, Shoji Kimura, Naoko Aoki, Ryusuke Omiya, Masatoshi Tateno, and Esteban Celis
Clin Cancer Res 2005 11: 3869-3878. [Abstract] [Full Text] [PDF]  

A Bispecific Recombinant Immunotoxin, DT2219, Targeting Human CD19 and CD22 Receptors in a Mouse Xenograft Model of B-Cell Leukemia/Lymphoma

Daniel A. Vallera, Deborah A. Todhunter, David W. Kuroki, Yanqun Shu, Andy Sicheneder, and Hua Chen
Clin Cancer Res 2005 11: 3879-3888. [Abstract] [Full Text] [PDF]  

Potent Activity of a Novel Dimeric Heat Shock Protein 90 Inhibitor against Head and Neck Squamous Cell Carcinoma In vitro and In vivo

Xiaoying Yin, Hong Zhang, Francis Burrows, Lin Zhang, and Carol G. Shores
Clin Cancer Res 2005 11: 3889-3896. [Abstract] [Full Text] [PDF]  

A Neutralizing Anti–Fibroblast Growth Factor 8 Monoclonal Antibody Shows Potent Antitumor Activity against Androgen-Dependent Mouse Mammary Tumors In vivo

Naoki Shimada, Toshihiko Ishii, Teruyoshi Imada, Katsumi Takaba, Yuka Sasaki, Kumiko Maruyama-Takahashi, Yoshimi Maekawa-Tokuda, Hideaki Kusaka, Shiro Akinaga, Akira Tanaka, and Kenya Shitara
Clin Cancer Res 2005 11: 3897-3904. [Abstract] [Full Text] [PDF]  

Characterization of Chemical Constituents in Scutellaria baicalensis with Antiandrogenic and Growth-Inhibitory Activities toward Prostate Carcinoma

Michael Bonham, Jeff Posakony, Ilsa Coleman, Bruce Montgomery, Julian Simon, and Peter S. Nelson
Clin Cancer Res 2005 11: 3905-3914. [Abstract] [Full Text] [PDF] Supplementary Data  

Dexrazoxane Protects against Myelosuppression from the DNA Cleavage–Enhancing Drugs Etoposide and Daunorubicin but not Doxorubicin

Kenneth Francis Hofland, Annemette Vinding Thougaard, Maxwell Sehested, and Peter Buhl Jensen
Clin Cancer Res 2005 11: 3915-3924. [Abstract] [Full Text] [PDF]  

Carbamoylphosphonate Matrix Metalloproteinase Inhibitors 3: In vivo Evaluation of Cyclopentylcarbamoylphosphonic Acid in Experimental Metastasis and Angiogenesis

Reuven Reich, Yiffat Katz, Rivka Hadar, and Eli Breuer
Clin Cancer Res 2005 11: 3925-3929. [Abstract] [Full Text] [PDF]  

In vivo Bioavailability and Pharmacokinetics of a c-MYC Antisense Phosphorodiamidate Morpholino Oligomer, AVI-4126, in Solid Tumors

Gayathri R. Devi, Tomasz M. Beer, Christopher L. Corless, Vikram Arora, Doreen L. Weller, and Patrick L. Iversen
Clin Cancer Res 2005 11: 3930-3938. [Abstract] [Full Text] [PDF]  

p12^CDK2-AP1 Gene Therapy Strategy Inhibits Tumor Growth in an In vivo Mouse Model of Head and Neck Cancer

Marxa L. Figueiredo, Yong Kim, Maie A.R. St. John, and David T.W. Wong
Clin Cancer Res 2005 11: 3939-3948. [Abstract] [Full Text] [PDF]  

Frequent Immune Responses to a Cancer/Testis Antigen, CAGE, in Patients with Microsatellite instability–Positive Endometrial Cancer

Takashi Iwata, Tomonobu Fujita, Nobumaru Hirao, Yuriko Matsuzaki, Tsutomu Okada, Hiroshi Mochimaru, Nobuyuki Susumu, Eri Matsumoto, Kokichi Sugano, Naohide Yamashita, Shiro Nozawa, and Yutaka Kawakami
Clin Cancer Res 2005 11: 3949-3957. [Abstract] [Full Text] [PDF]  

Novel Histone Deacetylase Inhibitors in the Treatment of Thyroid Cancer

Constantine S. Mitsiades, Vassiliki Poulaki, Ciaran McMullan, Joseph Negri, Galinos Fanourakis, Athina Goudopoulou, Victoria M. Richon, Paul A. Marks, and Nicholas Mitsiades
Clin Cancer Res 2005 11: 3958-3965. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Significance of Hypoxia in Malignant Glioma. Re: Evans et al. Hypoxia is important in the biology and aggression of human glial brain tumors. Clin Cancer Res 2004;10:8177–84

Dirk Vordermark, Sydney M. Evans, Stephen M. Hahn, Kevin D. Judy, and Cameron J. Koch
Clin Cancer Res 2005 11: 3966-3968. [Full Text] [PDF]  

Corrections:

Article on Efficient Elimination of B-Lineage Lymphomas by Anti-CD20–Auristatin Conjugates

Clin Cancer Res 2005 11: 3969. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.