Featured Articles:

   Perspective:

Frank L. Meyskens, Jr., Patrick J. Farmer, and Hoda Anton-Culver

Etiologic Pathogenesis of Melanoma: A Unifying Hypothesis for the Missing Attributable Risk
Clin Cancer Res 2004 10: 2581-2583. [Full Text] [PDF]  

   Cooperative Group Bulletin Board:

Brian I. Rini, Susan Halabi, John Taylor, Eric J. Small, and Richard L. Schilsky

Cancer and Leukemia Group B 90206: A Randomized Phase III Trial of Interferon- or Interferon- Plus Anti-Vascular Endothelial Growth Factor Antibody (Bevacizumab) in Metastatic Renal Cell Carcinoma
Clin Cancer Res 2004 10: 2584-2586. [Abstract] [Full Text] [PDF]  

   Clinical Trials:

Louis L. Pisters, Curtis A. Pettaway, Patricia Troncoso, Timothy J. McDonnell, L. Clifton Stephens, Christopher G. Wood, Kim-Anh Do, Shawn M. Brisbay, Xuemei Wang, Elizabeth A. Hossan, Robert B. Evans, Cindy Soto, Marc G. Jacobson, Karen Parker, James A. Merritt, Mitchell S. Steiner, and Christopher J. Logothetis

Evidence That Transfer of Functional p53 Protein Results in Increased Apoptosis in Prostate Cancer
Clin Cancer Res 2004 10: 2587-2593. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Hélène Blons, Sophie Gad, Franck Zinzindohoué, Isabelle Manière, Janie Beauregard, David Tregouet, Daniel Brasnu, Philippe Beaune, Ollivier Laccourreye, and Pierre Laurent-Puig

Matrix Metalloproteinase 3 Polymorphism: A Predictive Factor of Response to Neoadjuvant Chemotherapy in Head and Neck Squamous Cell Carcinoma
Clin Cancer Res 2004 10: 2594-2599. [Abstract] [Full Text] [PDF]  

Djordje Atanackovic, Andreas Block, Andreas de Weerth, Christiane Faltz, Dieter Kurt Hossfeld, and Susanna Hegewisch-Becker

Characterization of Effusion-Infiltrating T Cells: Benign versus Malignant Effusions
Clin Cancer Res 2004 10: 2600-2608. [Abstract] [Full Text] [PDF]  

Yago Nieto, Samia Nawaz, Elizabeth J. Shpall, Scott I. Bearman, James Murphy, and Roy B. Jones

Long-Term Analysis and Prospective Validation of a Prognostic Model for Patients with High-Risk Primary Breast Cancer Receiving High-Dose Chemotherapy
Clin Cancer Res 2004 10: 2609-2617. [Abstract] [Full Text] [PDF]  

M. Fatih Okcu, Mano Selvan, Li-E Wang, Linda Stout, Rodrigo Erana, Gladstone Airewele, Phyllis Adatto, Kenneth Hess, Francis Ali-Osman, Morris Groves, Alfred W. K. Yung, Victor A. Levin, Qingyi Wei, and Melissa Bondy

Glutathione S-Transferase Polymorphisms and Survival in Primary Malignant Glioma
Clin Cancer Res 2004 10: 2618-2625. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Carla M. van Herpen, Maaike Looman, Marijke Zonneveld, Nicole Scharenborg, Peter C. de Wilde, Louis van de Locht, Matthias A. W. Merkx, Gosse J. Adema, and Pieter H. De Mulder

Intratumoral Administration of Recombinant Human Interleukin 12 in Head and Neck Squamous Cell Carcinoma Patients Elicits a T-Helper 1 Profile in the Locoregional Lymph Nodes
Clin Cancer Res 2004 10: 2626-2635. [Abstract] [Full Text] [PDF]  

Helen J. Mackay, Ronald Hoekstra, Ferry A. L. M. Eskens, Walker J. Loos, Donna Crawford, Maurizio Voi, Anne Van Vreckem, T. R. Jeffrey Evans, and Jaap Verweij

A Phase I Pharmacokinetic and Pharmacodynamic Study of the Farnesyl Transferase Inhibitor BMS-214662 in Combination with Cisplatin in Patients with Advanced Solid Tumors
Clin Cancer Res 2004 10: 2636-2644. [Abstract] [Full Text] [PDF]  

Ko-Jiunn Liu, Chuan-Cheng Wang, Li-Tzong Chen, Ann-Lii Cheng, Dong-Tsamn Lin, Yu-Chen Wu, Wei-Lan Yu, Yi-Mei Hung, Hui-Yu Yang, Shin-Hun Juang, and Jacqueline Whang-Peng

Generation of Carcinoembryonic Antigen (CEA)-Specific T-Cell Responses in HLA-A*0201 and HLA-A*2402 Late-Stage Colorectal Cancer Patients after Vaccination with Dendritic Cells Loaded with CEA Peptides
Clin Cancer Res 2004 10: 2645-2651. [Abstract] [Full Text] [PDF]  

Lori K. Mattison, Hany Ezzeldin, Mark Carpenter, Anil Modak, Martin R. Johnson, and Robert B. Diasio

Rapid Identification of Dihydropyrimidine Dehydrogenase Deficiency by Using a Novel 2-¹³C-Uracil Breath Test
Clin Cancer Res 2004 10: 2652-2658. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

David B. Seligson, Allan J. Pantuck, Xueli Liu, Yunda Huang, Steven Horvath, Matthew H. T. Bui, Ken-ryu Han, Adrian J. L. Correa, Mervi Eeva, Sheila Tze, Arie S. Belldegrun, and Robert A. Figlin

Epithelial Cell Adhesion Molecule (KSA) Expression: Pathobiology and Its Role as an Independent Predictor of Survival in Renal Cell Carcinoma
Clin Cancer Res 2004 10: 2659-2669. [Abstract] [Full Text] [PDF]  

Ute Woelfle, Guido Sauter, Sonja Santjer, Ruud Brakenhoff, and Klaus Pantel

Down-Regulated Expression of Cytokeratin 18 Promotes Progression of Human Breast Cancer
Clin Cancer Res 2004 10: 2670-2674. [Abstract] [Full Text] [PDF]  

Claire Seedhouse, Rowena Faulkner, Nadia Ashraf, Emma Das-Gupta, and Nigel Russell

Polymorphisms in Genes Involved in Homologous Recombination Repair Interact to Increase the Risk of Developing Acute Myeloid Leukemia
Clin Cancer Res 2004 10: 2675-2680. [Abstract] [Full Text] [PDF]  

Mory Nouriani, Afshin Bahador, Jonathan S. Berek, Joan P. Cheng, Dennis S. Chi, William A. Cliby, Giuseppe Del Priore, Mark K. Dodson, Bridgette D. Duggan, David M. Gershenson, Scott E. Lentz, Richard T. Penson, William R. Robinson, Mildred Rodriguez, Lynda D. Roman, Mimi C. Yu, Karen Zempolich, and Louis Dubeau

Detection of Residual Subclinical Ovarian Carcinoma after Completion of Adjuvant Chemotherapy
Clin Cancer Res 2004 10: 2681-2686. [Abstract] [Full Text] [PDF]  

Jun-ichi Akahira, Youko Sugihashi, Takashi Suzuki, Kiyoshi Ito, Hitoshi Niikura, Takuya Moriya, Makoto Nitta, Hitoshi Okamura, Satoshi Inoue, Hironobu Sasano, Kunihiro Okamura, and Nobuo Yaegashi

Decreased Expression of 14-3-3 Is Associated with Advanced Disease in Human Epithelial Ovarian Cancer: Its Correlation with Aberrant DNA Methylation
Clin Cancer Res 2004 10: 2687-2693. [Abstract] [Full Text] [PDF]  

Fabio Cianchi, Camillo Cortesini, Ornella Fantappiè, Luca Messerini, Iacopo Sardi, Nadia Lasagna, Federico Perna, Valentina Fabbroni, Annamaria Di Felice, Giuliano Perigli, Roberto Mazzanti, and Emanuela Masini

Cyclooxygenase-2 Activation Mediates the Proangiogenic Effect of Nitric Oxide in Colorectal Cancer
Clin Cancer Res 2004 10: 2694-2704. [Abstract] [Full Text] [PDF]  

M. Dror Michaelson, Rose M. Marujo, and Matthew R. Smith

Contribution of Androgen Deprivation Therapy to Elevated Osteoclast Activity in Men with Metastatic Prostate Cancer
Clin Cancer Res 2004 10: 2705-2708. [Abstract] [Full Text] [PDF]  

Ashka Y. Pandya, Lynya I. Talley, Andra R. Frost, Thomas J. Fitzgerald, Vivek Trivedi, Mithun Chakravarthy, David C. Chhieng, William E. Grizzle, Jeffrey A. Engler, Helen Krontiras, Kirby I. Bland, Albert F. LoBuglio, Susan M. Lobo-Ruppert, and J. Michael Ruppert

Nuclear Localization of KLF4 Is Associated with an Aggressive Phenotype in Early-Stage Breast Cancer
Clin Cancer Res 2004 10: 2709-2719. [Abstract] [Full Text] [PDF]  

Maria Cristina Picchio, Eric Santos Martin, Rossano Cesari, George Adrian Calin, Sai Yendamuri, Tamotsu Kuroki, Francesca Pentimalli, Manuela Sarti, Kristine Yoder, Larry R. Kaiser, Richard Fishel, and Carlo Maria Croce

Alterations of the Tumor Suppressor Gene Parkin in Non-Small Cell Lung Cancer
Clin Cancer Res 2004 10: 2720-2724. [Abstract] [Full Text] [PDF]  

Jennifer Listgarten, Sambasivarao Damaraju, Brett Poulin, Lillian Cook, Jennifer Dufour, Adrian Driga, John Mackey, David Wishart, Russ Greiner, and Brent Zanke

Predictive Models for Breast Cancer Susceptibility from Multiple Single Nucleotide Polymorphisms
Clin Cancer Res 2004 10: 2725-2737. [Abstract] [Full Text] [PDF]  

Minoru Fukuchi, Tatsuya Miyazaki, Yasuyuki Fukai, Masanobu Nakajima, Makoto Sohda, Norihiro Masuda, Ryokuhei Manda, Katsuhiko Tsukada, Hiroyuki Kato, and Hiroyuki Kuwano

Plasma Level of Transforming Growth Factor ß1 Measured from the Azygos Vein Predicts Prognosis in Patients with Esophageal Cancer
Clin Cancer Res 2004 10: 2738-2741. [Abstract] [Full Text] [PDF]  

Julien Mazieres, Teresita Antonia, Ghislaine Daste, Carlos Muro-Cacho, Delphine Berchery, Vanessa Tillement, Anne Pradines, Said Sebti, and Gilles Favre

Loss of RhoB Expression in Human Lung Cancer Progression
Clin Cancer Res 2004 10: 2742-2750. [Abstract] [Full Text] [PDF]  

Torsten A. Hopp, Heidi L. Weiss, Susan G. Hilsenbeck, Yukun Cui, D. Craig Allred, Kathryn B. Horwitz, and Suzanne A. W. Fuqua

Breast Cancer Patients with Progesterone Receptor PR-A-Rich Tumors Have Poorer Disease-Free Survival Rates
Clin Cancer Res 2004 10: 2751-2760. [Abstract] [Full Text] [PDF]  

Yoram Cohen, Eli Rosenbaum, Douglas P. Clark, Martha A. Zeiger, Christopher B. Umbricht, Ralph P. Tufano, David Sidransky, and William H. Westra

Mutational Analysis of BRAF in Fine Needle Aspiration Biopsies of the Thyroid: A Potential Application for the Preoperative Assessment of Thyroid Nodules
Clin Cancer Res 2004 10: 2761-2765. [Abstract] [Full Text] [PDF]  

Kazushi Shigemasa, Lijun Gu, Hirotoshi Tanimoto, Timothy J. O’Brien, and Koso Ohama

Human Kallikrein Gene 11 (KLK11) mRNA Overexpression Is Associated with Poor Prognosis in Patients with Epithelial Ovarian Cancer
Clin Cancer Res 2004 10: 2766-2770. [Abstract] [Full Text] [PDF]  

Ponniah Selvakumar, Ashakumary Lakshmikuttyamma, Rani Kanthan, Selliah Chandra Kanthan, Jonathan R. Dimmock, and Rajendra K. Sharma

High Expression of Methionine Aminopeptidase 2 in Human Colorectal Adenocarcinomas
Clin Cancer Res 2004 10: 2771-2775. [Abstract] [Full Text] [PDF]  

Selina Raguz, Manuela Tamburo De Bella, Gopichani Tripuraneni, Martin J. Slade, Christopher F. Higgins, R. Charles Coombes, and Ernesto Yagüe

Activation of the MDR1 Upstream Promoter in Breast Carcinoma as a Surrogate for Metastatic Invasion
Clin Cancer Res 2004 10: 2776-2783. [Abstract] [Full Text] [PDF]  

Francesco Graziano, Federica Arduini, Annamaria Ruzzo, Italo Bearzi, Bostjan Humar, Helen More, Rosarita Silva, Pietro Muretto, Parry Guilford, Enrica Testa, Davide Mari, Mauro Magnani, and Stefano Cascinu

Prognostic Analysis of E-Cadherin Gene Promoter Hypermethylation in Patients with Surgically Resected, Node-Positive, Diffuse Gastric Cancer
Clin Cancer Res 2004 10: 2784-2789. [Abstract] [Full Text] [PDF]  

Stephan E. Baldus, Stefan P. Mönig, Sandra Huxel, Stephanie Landsberg, Franz-Georg Hanisch, Katja Engelmann, Paul M. Schneider, Jürgen Thiele, Arnulf H. Hölscher, and Hans P. Dienes

MUC1 and Nuclear ß-Catenin Are Coexpressed at the Invasion Front of Colorectal Carcinomas and Are Both Correlated with Tumor Prognosis
Clin Cancer Res 2004 10: 2790-2796. [Abstract] [Full Text] [PDF]  

Zahra Madjd, Lindy G. Durrant, Richard Bradley, Ian Spendlove, Ian O. Ellis, and Sarah E. Pinder

Loss of CD55 Is Associated with Aggressive Breast Tumors
Clin Cancer Res 2004 10: 2797-2803. [Abstract] [Full Text] [PDF]  

Kentaro Nakayama, Atsuko Kanzaki, Kunihiko Terada, Masato Mutoh, Kenji Ogawa, Toshihiro Sugiyama, Seiichi Takenoshita, Kiyoshi Itoh, Nobuo Yaegashi, Kohji Miyazaki, Nouri Neamati, and Yuji Takebayashi

Prognostic Value of the Cu-Transporting ATPase in Ovarian Carcinoma Patients Receiving Cisplatin-Based Chemotherapy
Clin Cancer Res 2004 10: 2804-2811. [Abstract] [Full Text] [PDF]  

Shinji Itoh, Takashi Maeda, Mitsuo Shimada, Shin-ichi Aishima, Ken Shirabe, Shinji Tanaka, and Yoshihiko Maehara

Role of Expression of Focal Adhesion Kinase in Progression of Hepatocellular Carcinoma
Clin Cancer Res 2004 10: 2812-2817. [Abstract] [Full Text] [PDF]  

Yutaka Shimada, Seiji Yamasaki, Yosuke Hashimoto, Tetsuo Ito, Jun-ichiro Kawamura, Toshiya Soma, Yoshinori Ino, Yukihiro Nakanishi, Michiie Sakamoto, Setsuo Hirohashi, and Masayuki Imamura

Clinical Significance of Dysadherin Expression in Gastric Cancer Patients
Clin Cancer Res 2004 10: 2818-2823. [Abstract] [Full Text] [PDF]  

Alessandro Ottaiano, Anna De Chiara, Francesco Perrone, Gerardo Botti, Flavio Fazioli, Vincenzo De Rosa, Nicola Mozzillo, Vincenzo Ravo, Brunello Morrica, Ciro Gallo, Carmela Pisano, Maria Napolitano, Paolo Antonio Ascierto, Rosario Vincenzo Iaffaioli, and Gaetano Apice

Prognostic Value of CD40 in Adult Soft Tissue Sarcomas
Clin Cancer Res 2004 10: 2824-2831. [Abstract] [Full Text] [PDF]  

Lucie E. Jones, Michelle J. Humphreys, Fiona Campbell, John P. Neoptolemos, and Mark T. Boyd

Comprehensive Analysis of Matrix Metalloproteinase and Tissue Inhibitor Expression in Pancreatic Cancer: Increased Expression of Matrix Metalloproteinase-7 Predicts Poor Survival
Clin Cancer Res 2004 10: 2832-2845. [Abstract] [Full Text] [PDF]  

Shinji Yamamoto, Yasuhiko Tomita, Yoshihiko Hoshida, Takaya Morooka, Hiroaki Nagano, Keizo Dono, Koji Umeshita, Masato Sakon, Osamu Ishikawa, Hiroaki Ohigashi, Shoji Nakamori, Morito Monden, and Katsuyuki Aozasa

Prognostic Significance of Activated Akt Expression in Pancreatic Ductal Adenocarcinoma
Clin Cancer Res 2004 10: 2846-2850. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Jingsong Zhao, Lingyan Huang, Nicole Belmar, Roland Buelow, and Timothy Fong

Oral RDP58 Allows CPT-11 Dose Intensification for Enhanced Tumor Response by Decreasing Gastrointestinal Toxicity
Clin Cancer Res 2004 10: 2851-2859. [Abstract] [Full Text] [PDF]  

Marta Ruiz, Hiroya Kobayashi, Juan José Lasarte, Jesús Prieto, Francisco Borrás-Cuesta, Esteban Celis, and Pablo Sarobe

Identification and Characterization of a T-Helper Peptide from Carcinoembryonic Antigen
Clin Cancer Res 2004 10: 2860-2867. [Abstract] [Full Text] [PDF]  

Rhona Stein, Zhengxing Qu, Susan Chen, Adriane Rosario, Victoria Shi, Marianne Hayes, Ivan D. Horak, Hans J. Hansen, and David M. Goldenberg

Characterization of a New Humanized Anti-CD20 Monoclonal Antibody, IMMU-106, and Its Use in Combination with the Humanized Anti-CD22 Antibody, Epratuzumab, for the Therapy of Non-Hodgkin’s Lymphoma
Clin Cancer Res 2004 10: 2868-2878. [Abstract] [Full Text] [PDF]  

Eugene Maraskovsky, Sigrid Sjölander, Debbie P. Drane, Max Schnurr, Thuy T. T. Le, Luis Mateo, Thomas Luft, Kelly-Anne Masterman, Tsin-Yee Tai, Qiyuan Chen, Simon Green, Anders Sjölander, Martin J. Pearse, Francois A. Lemonnier, Weisan Chen, Jonathan Cebon, and Andreas Suhrbier

NY-ESO-1 Protein Formulated in ISCOMATRIX Adjuvant Is a Potent Anticancer Vaccine Inducing Both Humoral and CD8⁺ T-Cell-Mediated Immunity and Protection against NY-ESO-1⁺ Tumors
Clin Cancer Res 2004 10: 2879-2890. [Abstract] [Full Text] [PDF]  

Seok-Chul Yang, Sven Hillinger, Karen Riedl, Ling Zhang, Li Zhu, Min Huang, Kimberly Atianzar, Brian Y. Kuo, Brian Gardner, Raj K. Batra, Robert M. Strieter, Steven M. Dubinett, and Sherven Sharma

Intratumoral Administration of Dendritic Cells Overexpressing CCL21 Generates Systemic Antitumor Responses and Confers Tumor Immunity
Clin Cancer Res 2004 10: 2891-2901. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Alfredo Cesario, Stefano Margaritora, Domenico Galetta, Venanzio Porziella, Pierluigi Granone, Rolando Maria D’Angelillo, Lucio Trodella, Vittorio Cardaci, Silvia Sterzi, and Patrizia Russo

Correspondence re L. J. Wirth et al., Induction Docetaxel and Carboplatin Followed by Weekly Docetaxel and Carboplatin with Concurrent Radiotherapy, Then Surgery in Stage III Non-Small Cell Lung Cancer: a Phase I Study. Clin Cancer Res 2003;9:1698–704.
Clin Cancer Res 2004 10: 2902-2903. [Full Text] [PDF]  

Lori J. Wirth, Arthur T. Skarin, and David J. Sugarbaker

Reply
Clin Cancer Res 2004 10: 2904. [Full Text] [PDF]  

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