The Biology Behind:

William C. Hahn

Targeting Cancer with Telomerase: Commentary re Q. Huang et al., A Novel Conditionally Replicative Adenovirus Vector Targeting Telomerase-Positive Tumor Cells. Clin. Cancer Res., 10: 1439–1445, 2004.
Clin Cancer Res 2004 10: 1203-1205. [Full Text] [PDF]  

Cooperative Group Bulletin Board:

Joseph A. Sparano, Robert Gray, Bruce Giantonio, Peter O’Dwyer, and Robert L. Comis

Evaluating Antiangiogenesis Agents in the Clinic: The Eastern Cooperative Oncology Group Portfolio of Clinical Trials
Clin Cancer Res 2004 10: 1206-1211. [Abstract] [Full Text] [PDF]  

Report from the FDA:

Martin H. Cohen, Grant A. Williams, Rajeshwari Sridhara, Gang Chen, W. David McGuinn, Jr., David Morse, Sophia Abraham, Atiqur Rahman, Chenyi Liang, Richard Lostritto, Amy Baird, and Richard Pazdur

United States Food and Drug Administration Drug Approval Summary: Gefitinib (ZD1839; Iressa) Tablets
Clin Cancer Res 2004 10: 1212-1218. [Abstract] [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Celestia S. Higano, Nicholas J. Vogelzang, Jeffrey A. Sosman, Anyang Feng, Dania Caron, and Eric J Small

Safety and Biological Activity of Repeated Doses of Recombinant Human Flt3 Ligand in Patients with Bone Scan-Negative Hormone-Refractory Prostate Cancer
Clin Cancer Res 2004 10: 1219-1225. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Sheikh M. Ismail, Monica Puppi, Sheela Prithivirajsingh, Anupama Munshi, Uma Raju, Raymond E. Meyn, Thomas A. Buchholz, Michael D. Story, William A. Brock, Luka Milas, Howard D. Thames, and Craig W. Stevens

Predicting Radiosensitivity Using DNA End-Binding Complex Analysis
Clin Cancer Res 2004 10: 1226-1234. [Abstract] [Full Text] [PDF]  

Maamoun M. Al-Aynati, Nikolina Radulovich, Robert H. Riddell, and Ming-Sound Tsao

Epithelial-Cadherin and ß-Catenin Expression Changes in Pancreatic Intraepithelial Neoplasia
Clin Cancer Res 2004 10: 1235-1240. [Abstract] [Full Text] [PDF]  

Carsten Müller-Tidow, Joachim Schwäble, Björn Steffen, Nicola Tidow, Burkhardt Brandt, Kerstin Becker, Eric Schulze-Bahr, Hartmut Halfter, Ulf Vogt, Ralf Metzger, Paul M. Schneider, Thomas Büchner, Christian Brandts, Wolfgang E. Berdel, and Hubert Serve

High-Throughput Analysis of Genome-Wide Receptor Tyrosine Kinase Expression in Human Cancers Identifies Potential Novel Drug Targets
Clin Cancer Res 2004 10: 1241-1249. [Abstract] [Full Text] [PDF]  

Mark E. Robson, Emily Glogowski, Gunhild Sommer, Cristina R. Antonescu, Khedoudja Nafa, Robert G. Maki, Nathan Ellis, Peter Besmer, Murray Brennan, and Kenneth Offit

Pleomorphic Characteristics of a Germ-Line KIT Mutation in a Large Kindred with Gastrointestinal Stromal Tumors, Hyperpigmentation, and Dysphagia
Clin Cancer Res 2004 10: 1250-1254. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Nils Ole Schmidt, Mateo Ziu, Giorgio Carrabba, Carlo Giussani, Lorenzo Bello, Yanping Sun, Karl Schmidt, Mitchel Albert, Peter Mcl. Black, and Rona S. Carroll

Antiangiogenic Therapy by Local Intracerebral Microinfusion Improves Treatment Efficiency and Survival in an Orthotopic Human Glioblastoma Model
Clin Cancer Res 2004 10: 1255-1262. [Abstract] [Full Text] [PDF]  

Zhuo Zhang, Hui Wang, Gautam Prasad, Mao Li, Dong Yu, James A. Bonner, Sudhir Agrawal, and Ruiwen Zhang

Radiosensitization by Antisense Anti-MDM2 Mixed-Backbone Oligonucleotide in in Vitro and in Vivo Human Cancer Models
Clin Cancer Res 2004 10: 1263-1273. [Abstract] [Full Text] [PDF]  

Ruiqi Meng, Joan E. Smallshaw, Laurentiu M. Pop, Michael Yen, Xiaoyun Liu, Lien Le, Maria-Ana Ghetie, Ellen S. Vitetta, and Victor Ghetie

The Evaluation of Recombinant, Chimeric, Tetravalent Antihuman CD22 Antibodies
Clin Cancer Res 2004 10: 1274-1281. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Bruce J. Giantonio, Christine Derry, Cecilia McAleer, Joseph J. McPhillips, and Peter J. O’Dwyer

Phase I and Pharmacokinetic Study of the Cytotoxic Ether Lipid Ilmofosine Administered by Weekly Two-Hour Infusion in Patients with Advanced Solid Tumors
Clin Cancer Res 2004 10: 1282-1288. [Abstract] [Full Text] [PDF]  

Sridhar Mani, Hayley McDaid, Anne Hamilton, Howard Hochster, Marvin B. Cohen, Dineo Khabelle, Tom Griffin, David E. Lebwohl, Leonard Liebes, Franco Muggia, and Susan Band Horwitz

Phase I Clinical and Pharmacokinetic Study of BMS-247550, a Novel Derivative of Epothilone B, in Solid Tumors
Clin Cancer Res 2004 10: 1289-1298. [Abstract] [Full Text] [PDF]  

Miklos Pless, Karim Belhadj, Hans D. Menssen, Wolfgang Kern, Bertrand Coiffier, Jürgen Wolf, Richard Herrmann, Eckhard Thiel, Doug Bootle, Ivo Sklenar, Christian Müller, Les Choi, Carl Porter, and Renaud Capdeville

Clinical Efficacy, Tolerability, and Safety of SAM486A, a Novel Polyamine Biosynthesis Inhibitor, in Patients with Relapsed or Refractory Non-Hodgkin’s Lymphoma: Results from a Phase II Multicenter Study
Clin Cancer Res 2004 10: 1299-1305. [Abstract] [Full Text] [PDF]  

Tomasz M. Beer, Mark Garzotto, Bruce A. Lowe, William J. Ellis, Michelle A. Montalto, Paul H. Lange, and Celestia S. Higano

Phase I Study of Weekly Mitoxantrone and Docetaxel before Prostatectomy in Patients with High-Risk Localized Prostate Cancer
Clin Cancer Res 2004 10: 1306-1311. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Francesca L. Sciacca, Emilio Ciusani, Antonio Silvani, Elena Corsini, Simona Frigerio, Simona Pogliani, Eugenio Parati, Danilo Croci, Amerigo Boiardi, and Andrea Salmaggi

Genetic and Plasma Markers of Venous Thromboembolism in Patients with High Grade Glioma
Clin Cancer Res 2004 10: 1312-1317. [Abstract] [Full Text] [PDF]  

Rafael Rosell, Kathleen D. Danenberg, Vincente Alberola, Gerold Bepler, Jose Javier Sanchez, Carlos Camps, Mariano Provencio, Dolores Isla, Miquel Taron, Pilar Diz, and Angel Artal

Ribonucleotide Reductase Messenger RNA Expression and Survival in Gemcitabine/Cisplatin-Treated Advanced Non-Small Cell Lung Cancer Patients
Clin Cancer Res 2004 10: 1318-1325. [Abstract] [Full Text] [PDF]  

Lee-Yung Shih, Chein-Fuang Huang, Jin-Hou Wu, Po-Nan Wang, Tung-Liang Lin, Po Dunn, Meng-Chu Chou, Ming-Chung Kuo, and Chung-Chih Tang

Heterogeneous Patterns of FLT3 Asp⁸³⁵ Mutations in Relapsed de Novo Acute Myeloid Leukemia: A Comparative Analysis of 120 Paired Diagnostic and Relapse Bone Marrow Samples
Clin Cancer Res 2004 10: 1326-1332. [Abstract] [Full Text] [PDF]  

Chong-Xian Pan, Michael S. Kinch, Peter A. Kiener, Solomon Langermann, Ginette Serrero, Le Sun, Joseph Corvera, Christopher J. Sweeney, Lang Li, Shaobo Zhang, Lee Ann Baldridge, Timothy D. Jones, Michael O. Koch, Thomas M. Ulbright, John N. Eble, and Liang Cheng

PC Cell-Derived Growth Factor Expression in Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma
Clin Cancer Res 2004 10: 1333-1337. [Abstract] [Full Text] [PDF]  

Antonio Marchetti, Fabio Barassi, Carla Martella, Antonio Chella, Simona Salvatore, Antonio Castrataro, Felice Mucilli, Rocco Sacco, and Fiamma Buttitta

Down Regulation of High in Normal-1 (HIN-1) is a Frequent Event in Stage I Non-Small Cell Lung Cancer and Correlates with Poor Clinical Outcome
Clin Cancer Res 2004 10: 1338-1343. [Abstract] [Full Text] [PDF]  

Bruno Fuchs, Carrie Y. Inwards, and Ralf Janknecht

Vascular Endothelial Growth Factor Expression is Up-Regulated by EWS-ETS Oncoproteins and Sp1 and May Represent an Independent Predictor of Survival in Ewing’s Sarcoma
Clin Cancer Res 2004 10: 1344-1353. [Abstract] [Full Text] [PDF]  

Leigh Murphy, Tracy Cherlet, Adewale Adeyinka, Yulian Niu, Linda Snell, and Peter Watson

Phospho-Serine-118 Estrogen Receptor- Detection in Human Breast Tumors in Vivo
Clin Cancer Res 2004 10: 1354-1359. [Abstract] [Full Text] [PDF]  

Claudio Botti, Simonetta Buglioni, Maria Benevolo, Diana Giannarelli, Paola Papaldo, Francesco Cognetti, Patrizia Vici, Franco Di Filippo, Franca Del Nonno, Franco Maria Venanzi, Pier Giorgio Natali, and Marcella Mottolese

Altered Expression of FAS System Is Related to Adverse Clinical Outcome in Stage I-II Breast Cancer Patients Treated with Adjuvant Anthracycline-Based Chemotherapy
Clin Cancer Res 2004 10: 1360-1365. [Abstract] [Full Text] [PDF]  

Gwi Eon Kim, Yong Bae Kim, Nam Hoon Cho, Hyun-Cheol Chung, Hong Ryull Pyo, Jong Doo Lee, Tchan Kyu Park, Woong Sub Koom, Mison Chun, and Chang Ok Suh

Synchronous Coexpression of Epidermal Growth Factor Receptor and Cyclooxygenase-2 in Carcinomas of the Uterine Cervix: A Potential Predictor of Poor Survival
Clin Cancer Res 2004 10: 1366-1374. [Abstract] [Full Text] [PDF]  

Takumi Sakakibara, Kenji Hibi, Yasuhiro Kodera, Katsuki Ito, Seiji Akiyama, and Akimasa Nakao

Plasminogen Activator Inhibitor-1 as a Potential Marker for the Malignancy of Esophageal Squamous Cell Carcinoma
Clin Cancer Res 2004 10: 1375-1378. [Abstract] [Full Text] [PDF]  

Masahide Ikeguchi, Ken-ichi Yamaguchi, and Nobuaki Kaibara

Clinical Significance of the Loss of KiSS-1 and Orphan G-Protein–Coupled Receptor (hOT7T175) Gene Expression in Esophageal Squamous Cell Carcinoma
Clin Cancer Res 2004 10: 1379-1383. [Abstract] [Full Text] [PDF]  

Thu-Suong Van Le, Julie Myers, Badrinath R. Konety, Timothy Barder, and Robert H. Getzenberg

Functional Characterization of the Bladder Cancer Marker, BLCA-4
Clin Cancer Res 2004 10: 1384-1391. [Abstract] [Full Text] [PDF]  

Jean-Yves Pierga, Charlyne Bonneton, Anne Vincent-Salomon, Patricia de Cremoux, Claude Nos, Nathalie Blin, Pierre Pouillart, Jean-Paul Thiery, and Henri Magdelénat

Clinical Significance of Immunocytochemical Detection of Tumor Cells Using Digital Microscopy in Peripheral Blood and Bone Marrow of Breast Cancer Patients
Clin Cancer Res 2004 10: 1392-1400. [Abstract] [Full Text] [PDF]  

Sze Chuen Cesar Wong, Elena Siu Fong Lo, King Chung Lee, John K. C. Chan, and W. L. Wendy Hsiao

Prognostic and Diagnostic Significance of ß-Catenin Nuclear Immunostaining in Colorectal Cancer
Clin Cancer Res 2004 10: 1401-1408. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Athanassios Argiris, Chun-Xia Wang, Steve G. Whalen, and Michael P. DiGiovanna

Synergistic Interactions between Tamoxifen and Trastuzumab (Herceptin)
Clin Cancer Res 2004 10: 1409-1420. [Abstract] [Full Text] [PDF]  

Hideki Mukouyama, Nicolette K. Janzen, Jose M. Hernandez, John S. Lam, Randy Caliliw, Allen Y. Wang, Robert A. Figlin, Arie S. Belldegrun, and Gang Zeng

Generation of Kidney Cancer-Specific Antitumor Immune Responses Using Peripheral Blood Monocytes Transduced With a Recombinant Adenovirus Encoding Carbonic Anhydrase 9
Clin Cancer Res 2004 10: 1421-1429. [Abstract] [Full Text] [PDF]  

Taro Semba, Yasuhiro Funahashi, Naoto Ono, Yuji Yamamoto, Naoko Hata Sugi, Makoto Asada, Kentaro Yoshimatsu, and Toshiaki Wakabayashi

An Angiogenesis Inhibitor E7820 Shows Broad-Spectrum Tumor Growth Inhibition in a Xenograft Model: Possible Value of Integrin 2 on Platelets as a Biological Marker
Clin Cancer Res 2004 10: 1430-1438. [Abstract] [Full Text] [PDF]  

Qian Huang, Xiuwu Zhang, He Wang, Bin Yan, John Kirkpatrick, Mark W. Dewhrist, and Chuan-Yuan Li

A Novel Conditionally Replicative Adenovirus Vector Targeting Telomerase-Positive Tumor Cells
Clin Cancer Res 2004 10: 1439-1445. [Abstract] [Full Text] [PDF]  

Ian G. Kirwan, Paul M. Loadman, David J. Swaine, D. Alan Anthoney, George R. Pettit, John W. Lippert, III, Steve D. Shnyder, Patricia A. Cooper, and Mike C. Bibby

Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate
Clin Cancer Res 2004 10: 1446-1453. [Abstract] [Full Text] [PDF]  

Josep Maria Roig, Miguel Angel Molina, Anna Cascante, Joaquim Calbó, Neus Carbó, Uwe Wirtz, Sunil Sreedharan, Cristina Fillat, and Adela Mazo

Adenovirus-Mediated Retinoblastoma 94 Gene Transfer Induces Human Pancreatic Tumor Regression in a Mouse Xenograft Model
Clin Cancer Res 2004 10: 1454-1462. [Abstract] [Full Text] [PDF]  

Alberto Ballestrero, Alessio Nencioni, Davide Boy, Ilaria Rocco, Anna Garuti, Giuseppe Sandro Mela, Luk Van Parijs, Peter Brossart, Sebastian Wesselborg, and Franco Patrone

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Cooperates with Anticancer Drugs to Overcome Chemoresistance in Antiapoptotic Bcl-2 Family Members Expressing Jurkat Cells
Clin Cancer Res 2004 10: 1463-1470. [Abstract] [Full Text] [PDF]  

Joel M. Reid, Denise L. Walker, Jennifer K. Miller, Linda M. Benson, Andrew J. Tomlinson, Stephen Naylor, April L. Blajeski, Patricia M. LoRusso, and Matthew M. Ames

The Metabolism of Pyrazoloacridine (NSC 366140) by Cytochromes P450 and Flavin Monooxygenase in Human Liver Microsomes
Clin Cancer Res 2004 10: 1471-1480. [Abstract] [Full Text] [PDF]  

Andrew M. Evens, Sheila Prachand, Bo Shi, Mary Paniaqua, Leo I. Gordon, and Ronald B. Gartenhaus

Imexon-Induced Apoptosis in Multiple Myeloma Tumor Cells Is Caspase-8 Dependent
Clin Cancer Res 2004 10: 1481-1491. [Abstract] [Full Text] [PDF]  

Ryan A. Dick, Xiang Yu, and Thomas W. Kensler

NADPH Alkenal/One Oxidoreductase Activity Determines Sensitivity of Cancer Cells to the Chemotherapeutic Alkylating Agent Irofulven
Clin Cancer Res 2004 10: 1492-1499. [Abstract] [Full Text] [PDF]  

Wainer Zoli, Luca Ricotti, Anna Tesei, Paola Ulivi, Anna Gasperi Campani, Francesco Fabbri, Roberta Gunelli, Giovanni Luca Frassineti, and Dino Amadori

Schedule-Dependent Cytotoxic Interaction between Epidoxorubicin and Gemcitabine in Human Bladder Cancer Cells in Vitro
Clin Cancer Res 2004 10: 1500-1507. [Abstract] [Full Text] [PDF]  

Takashi Kumagai, Takayuki Ikezoe, Dorina Gui, James O’Kelly, Xiang-Jun Tong, Fredric J. Cohen, Jonathan W. Said, and H. Phillip Koeffler

RWJ-241947 (MCC-555), A Unique Peroxisome Proliferator-Activated Receptor- Ligand with Antitumor Activity against Human Prostate Cancer in Vitro and in Beige/Nude/ X-Linked Immunodeficient Mice and Enhancement of Apoptosis in Myeloma Cells Induced by Arsenic Trioxide
Clin Cancer Res 2004 10: 1508-1520. [Abstract] [Full Text] [PDF]  

Madhu Sudhan Shaik, Abhijit Chatterjee, and Mandip Singh

Effect of a Selective Cyclooxygenase-2 Inhibitor, Nimesulide, on the Growth of Lung Tumors and Their Expression of Cyclooxygenase-2 and Peroxisome Proliferator- Activated Receptor-
Clin Cancer Res 2004 10: 1521-1529. [Abstract] [Full Text] [PDF]  

Lev M. Berstein, Ji-Ping Wang, Hong Zheng, Wei Yue, Mark Conaway, and Richard J. Santen

Long-Term Exposure to Tamoxifen Induces Hypersensitivity to Estradiol
Clin Cancer Res 2004 10: 1530-1534. [Abstract] [Full Text] [PDF]  

Eugene A. Choi, Hanqin Lei, David J. Maron, Rosemarie Mick, James Barsoum, Qian-chun Yu, Douglas L. Fraker, James M. Wilson, and Francis R. Spitz

Combined 5-Fluorouracil/Systemic Interferon-ß Gene Therapy Results in Long-Term Survival in Mice with Established Colorectal Liver Metastases
Clin Cancer Res 2004 10: 1535-1544. [Abstract] [Full Text] [PDF]  

Douglas D. Boyd, Heng Wang, Hector Avila, Nila U. Parikh, Horst Kessler, Victor Magdolen, and Gary E. Gallick

Combination of an Src Kinase Inhibitor with a Novel Pharmacological Antagonist of the Urokinase Receptor Diminishes in Vitro Colon Cancer Invasiveness
Clin Cancer Res 2004 10: 1545-1555. [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.