Editorials:

Moving Discovery into Clinical Practice

John Mendelsohn
Clin Cancer Res 2004 10: 8129. [Full Text] [PDF]  

Toward Early Oral Cancer Detection using Gene Expression Profiling of Saliva: A Thoroughfare or Dead End?

William H. Westra and Joseph Califano
Clin Cancer Res 2004 10: 8130-8131. [Full Text] [PDF]  

Review:

Cell Cycle Genes in Ovarian Cancer: Steps Toward Earlier Diagnosis and Novel Therapies

Giuseppina D’Andrilli, Christine Kumar, Giovanni Scambia, and Antonio Giordano
Clin Cancer Res 2004 10: 8132-8141. [Abstract] [Full Text] [PDF]  

Perspective:

Heat Shock Proteins and Their Use as Anticancer Vaccines

Giorgio Parmiani, Alessandro Testori, Michele Maio, Chiara Castelli, Licia Rivoltini, Lorenzo Pilla, Filiberto Belli, Vincenzo Mazzaferro, Jorgelina Coppa, Roberto Patuzzo, Mario R. Sertoli, Axel Hoos, Pramod K. Srivastava, and Mario Santinami
Clin Cancer Res 2004 10: 8142-8146. [Full Text] [PDF]  

Report from the FDA:

Approval Summary: Docetaxel in Combination with Prednisone for the Treatment of Androgen-Independent Hormone-Refractory Prostate Cancer

Ramzi Dagher, Ning Li, Sophia Abraham, Atiqur Rahman, Raji Sridhara, and Richard Pazdur
Clin Cancer Res 2004 10: 8147-8151. [Abstract] [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Circulating Tumor Cells in Patients with Breast Cancer Dormancy

Songdong Meng, Debasish Tripathy, Eugene P. Frenkel, Sanjay Shete, Elizabeth Z. Naftalis, James F. Huth, Peter D. Beitsch, Marilyn Leitch, Susan Hoover, David Euhus, Barbara Haley, Larry Morrison, Timothy P. Fleming, Dorothee Herlyn, Leon W. M. M. Terstappen, Tanja Fehm, Thomas F. Tucker, Nancy Lane, Jianqiang Wang, and Jonathan W. Uhr
Clin Cancer Res 2004 10: 8152-8162. [Abstract] [Full Text] [PDF]  

Down-Regulation of Intratumoral Aromatase Messenger RNA Levels by Docetaxel in Human Breast Cancers

Yasuo Miyoshi, Seung Jin Kim, Kenji Akazawa, Shunji Kamigaki, Satsuki Ueda, Tetsu Yanagisawa, Tomoo Inoue, Tetsuya Taguchi, Yasuhiro Tamaki, and Shinzaburo Noguchi
Clin Cancer Res 2004 10: 8163-8169. [Abstract] [Full Text] [PDF]  

Results of a Multicenter Randomized Phase II Trial of Thalidomide and Prednisone Maintenance Therapy for Multiple Myeloma after Autologous Stem Cell Transplant

A. Keith Stewart, Christine I. Chen, Kang Howson-Jan, Darrell White, Jean Roy, Michael J. Kovacs, Chaim Shustik, Anna Sadura, Lois Shepherd, Keyue Ding, Ralph M. Meyer, and Andrew R. Belch
Clin Cancer Res 2004 10: 8170-8176. [Abstract] [Full Text] [PDF]  

Hypoxia Is Important in the Biology and Aggression of Human Glial Brain Tumors

Sydney M. Evans, Kevin D. Judy, Isolde Dunphy, W. Timothy Jenkins, Wei-Ting Hwang, Peter T. Nelson, Robert A. Lustig, Kevin Jenkins, Deirdre P. Magarelli, Stephen M. Hahn, Ruth A. Collins, M. Sean Grady, and Cameron J. Koch
Clin Cancer Res 2004 10: 8177-8184. [Abstract] [Full Text] [PDF]  

Trastuzumab Administration Can Effectively Target Chemotherapy-Resistant Cytokeratin-19 Messenger RNA–Positive Tumor Cells in the Peripheral Blood and Bone Marrow of Patients With Breast Cancer

Vassiliki Bozionellou, Dimitris Mavroudis, Maria Perraki, Savvas Papadopoulos, Stella Apostolaki, Efstathios Stathopoulos, Aliki Stathopoulou, Evi Lianidou, and Vassilis Georgoulias
Clin Cancer Res 2004 10: 8185-8194. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

High Frequency of Epidermal Growth Factor Receptor Mutations with Complex Patterns in Non–Small Cell Lung Cancers Related to Gefitinib Responsiveness in Taiwan

Shiu-Feng Huang, Hui-Ping Liu, Ling-Hui Li, Yuan-Chieh Ku, Yu-Ning Fu, Hsien-Yu Tsai, Ya-Ting Chen, Yung-Feng Lin, Wen-Cheng Chang, Han-Pin Kuo, Yi-Cheng Wu, Yi-Rong Chen, and Shih-Feng Tsai
Clin Cancer Res 2004 10: 8195-8203. [Abstract] [Full Text] [PDF]  

Genetic and Expression Profiles of Squamous Cell Carcinoma of the Head and Neck Correlate with Cisplatin Sensitivity and Resistance in Cell Lines and Patients

Jan Akervall, Xiang Guo, Chao-Nan Qian, Jacqueline Schoumans, Brandon Leeser, Eric Kort, Andrew Cole, James Resau, Carol Bradford, Thomas Carey, Johan Wennerberg, Harald Anderson, Jan Tennvall, and Bin T. Teh
Clin Cancer Res 2004 10: 8204-8213. [Abstract] [Full Text] [PDF]  

Detection of Overexpressed and Phosphorylated Wild-Type Kit Receptor in Surgical Specimens of Small Cell Lung Cancer

Elena Tamborini, Lorena Bonadiman, Tiziana Negri, Angela Greco, Samantha Staurengo, Paolo Bidoli, Ugo Pastorino, Marco A. Pierotti, and Silvana Pilotti
Clin Cancer Res 2004 10: 8214-8219. [Abstract] [Full Text] [PDF]  

Noninvasive Magnetic Resonance Spectroscopic Imaging Biomarkers to Predict the Clinical Grade of Pediatric Brain Tumors

Loukas G. Astrakas, David Zurakowski, A. Aria Tzika, Maria K. Zarifi, Douglas C. Anthony, Umberto De Girolami, Nancy J. Tarbell, and Peter McLaren Black
Clin Cancer Res 2004 10: 8220-8228. [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinase/Tissue Inhibitors of Matrix Metalloproteinase Phenotype Identifies Poor Prognosis Colorectal Cancers

Stephanie Curran, Sinclair R. Dundas, Jenny Buxton, Matthew F. Leeman, Robin Ramsay, and Graeme I. Murray
Clin Cancer Res 2004 10: 8229-8234. [Abstract] [Full Text] [PDF]  

Immunocytochemical Identification of VPAC₁, VPAC₂, and PAC₁ Receptors in Normal and Neoplastic Human Tissues with Subtype-Specific Antibodies

Solveig Schulz, Christoph Röcken, Christian Mawrin, Wolfgang Weise, Volker Höllt, and Stefan Schulz
Clin Cancer Res 2004 10: 8235-8242. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Coexpression of Matrix Metalloproteinase-7 (MMP-7) and Epidermal Growth Factor (EGF) Receptor in Colorectal Cancer: An EGF Receptor Tyrosine Kinase Inhibitor Is Effective against MMP-7–Expressing Cancer Cells

Koshi Mimori, Keishi Yamashita, Mitsuhiko Ohta, Keiji Yoshinaga, Kenji Ishikawa, Hideshi Ishii, Tohru Utsunomiya, Graham F. Barnard, Hiroshi Inoue, and Masaki Mori
Clin Cancer Res 2004 10: 8243-8249. [Abstract] [Full Text] [PDF]  

Characterization of Gastrin-Induced Proangiogenic Effects In vivo in Orthotopic U373 Experimental Human Glioblastomas and In vitro in Human Umbilical Vein Endothelial Cells

Florence Lefranc, Tatjana Mijatovic, Véronique Mathieu, Sandrine Rorive, Christine Decaestecker, Olivier Debeir, Jacques Brotchi, Philippe Van Ham, Isabelle Salmon, and Robert Kiss
Clin Cancer Res 2004 10: 8250-8265. [Abstract] [Full Text] [PDF]  

Pseudolaric Acid B Inhibits Angiogenesis and Reduces Hypoxia-Inducible Factor 1 by Promoting Proteasome-Mediated Degradation

Mei-Hong Li, Ze-Hong Miao, Wen-Fu Tan, Jian-Min Yue, Chao Zhang, Li-Ping Lin, Xiong-Wen Zhang, and Jian Ding
Clin Cancer Res 2004 10: 8266-8274. [Abstract] [Full Text] [PDF]  

Differential Effects of Delivery of Omega-3 Fatty Acids to Human Cancer Cells by Low-Density Lipoproteins versus Albumin

Iris J. Edwards, Isabelle M. Berquin, Haiguo Sun, Joseph T. O’Flaherty, Larry W. Daniel, Michael J. Thomas, Lawrence L. Rudel, Robert L. Wykle, and Yong Q. Chen
Clin Cancer Res 2004 10: 8275-8283. [Abstract] [Full Text] [PDF]  

Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis Is Inhibited by Bcl-2 but Restored by the Small Molecule Bcl-2 Inhibitor, HA 14-1, in Human Colon Cancer Cells

Frank A. Sinicrope, Robert C. Penington, and Xi Ming Tang
Clin Cancer Res 2004 10: 8284-8292. [Abstract] [Full Text] [PDF]  

Functionalization of Tumor Necrosis Factor- Using Phage Display Technique and PEGylation Improves Its Antitumor Therapeutic Window

Hiroko Shibata, Yasuo Yoshioka, Shinji Ikemizu, Kyoko Kobayashi, Yoko Yamamoto, Yohei Mukai, Takayuki Okamoto, Madoka Taniai, Maki Kawamura, Yasuhiro Abe, Shinsaku Nakagawa, Takao Hayakawa, Satoshi Nagata, Yuriko Yamagata, Tadanori Mayumi, Haruhiko Kamada, and Yasuo Tsutsumi
Clin Cancer Res 2004 10: 8293-8300. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Phase I Clinical Trial of the Inosine Monophosphate Dehydrogenase Inhibitor Mycophenolate Mofetil (Cellcept) in Advanced Multiple Myeloma Patients

Naoko Takebe, Xiangfei Cheng, Suhlan Wu, Kenneth Bauer, Olga G. Goloubeva, Robert G. Fenton, Meyer Heyman, Aaron P. Rapoport, Ashraf Badros, John Shaughnessy, Douglas Ross, Barry Meisenberg, and Guido Tricot
Clin Cancer Res 2004 10: 8301-8308. [Abstract] [Full Text] [PDF]  

Human Autologous Tumor-Specific T-Cell Responses Induced by Liposomal Delivery of a Lymphoma Antigen

Sattva S. Neelapu, Sivasubramanian Baskar, Barry L. Gause, Carol B. Kobrin, Thelma M. Watson, Andrea Robin Frye, Robin Pennington, Linda Harvey, Elaine S. Jaffe, Richard J. Robb, Mircea C. Popescu, and Larry W. Kwak
Clin Cancer Res 2004 10: 8309-8317. [Abstract] [Full Text] [PDF]  

Phase I/II Randomized Trial Evaluating the Safety and Clinical Effects of Repifermin Administered to Reduce Mucositis in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation

Cesar O. Freytes, Voravit Ratanatharathorn, Charles Taylor, Camille Abboud, Nancy Chesser, Alejandro Restrepo, Jorge Arango, and Daniel Odenheimer
Clin Cancer Res 2004 10: 8318-8324. [Abstract] [Full Text] [PDF]  

Prospective Evaluation of Body Surface Area as a Determinant of Paclitaxel Pharmacokinetics and Pharmacodynamics in Women with Solid Tumors: Cancer and Leukemia Group B Study 9763

Antonius A. Miller, Gary L. Rosner, Merrill J. Egorin, Donna Hollis, Stuart M. Lichtman, Mark J. Ratain for the Cancer and Leukemia Group B
Clin Cancer Res 2004 10: 8325-8331. [Abstract] [Full Text] [PDF]  

A Pilot Study to Establish a Clinical Model to Perform Phase II Studies of Breast Cancer Chemopreventive Agents in Women at High Risk with Biomarkers as Surrogate Endpoints for Activity

Vered Stearns, Ann Gallagher, Celina G. Kleer, Baljit Singh, Matthew Freedman, Bassem R. Haddad, Claudine Isaacs, Robert Warren, Martha Brown, Jennifer Cullen, Bruce Trock, and Daniel F. Hayes
Clin Cancer Res 2004 10: 8332-8340. [Abstract] [Full Text] [PDF]  

Factors Affecting Cytochrome P-450 3A Activity in Cancer Patients

Sharyn D. Baker, Ron H. N. van Schaik, Laurent P. Rivory, Albert J. ten Tije, Kimberly Dinh, Wilfried J. Graveland, Paul W. Schenk, Kellie A. Charles, Stephen J. Clarke, Michael A. Carducci, William P. McGuire, Fitzroy Dawkins, Hans Gelderblom, Jaap Verweij, and Alex Sparreboom
Clin Cancer Res 2004 10: 8341-8350. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Antibody-Based Profiling of the Phosphoinositide 3-Kinase Pathway in Clinical Prostate Cancer

George V. Thomas, Steve Horvath, Bradley L. Smith, Katherine Crosby, Lori A. Lebel, Matthew Schrage, Jonathan Said, Jean De Kernion, Robert E. Reiter, and Charles L. Sawyers
Clin Cancer Res 2004 10: 8351-8356. [Abstract] [Full Text] [PDF] Supplementary Data  

Genetic Polymorphisms of Human Flavin Monooxygenase 3 in Sulindac-Mediated Primary Chemoprevention of Familial Adenomatous Polyposis

Irfan M. Hisamuddin, Mohammad A. Wehbi, Ann Chao, Hadley W. Wyre, Linda M. Hylind, Francis M. Giardiello, and Vincent W. Yang
Clin Cancer Res 2004 10: 8357-8362. [Abstract] [Full Text] [PDF]  

ADAM8 as a Novel Serological and Histochemical Marker for Lung Cancer

Nobuhisa Ishikawa, Yataro Daigo, Wataru Yasui, Kouki Inai, Hitoshi Nishimura, Eiju Tsuchiya, Nobuoki Kohno, and Yusuke Nakamura
Clin Cancer Res 2004 10: 8363-8370. [Abstract] [Full Text] [PDF]  

Relative Bcl-2 Independence of Drug-Induced Cytotoxicity and Resistance in 518A2 Melanoma Cells

Luba Benimetskaya, Johnathan C. Lai, Anastasia Khvorova, Sijian Wu, Emily Hua, Paul Miller, Li-Ming Zhang, and Cy A. Stein
Clin Cancer Res 2004 10: 8371-8379. [Abstract] [Full Text] [PDF]  

Artificial Neural Networks Analysis of Surface-Enhanced Laser Desorption/Ionization Mass Spectra of Serum Protein Pattern Distinguishes Colorectal Cancer from Healthy Population

Yi-ding Chen, Shu Zheng, Jie-kai Yu, and Xun Hu
Clin Cancer Res 2004 10: 8380-8385. [Abstract] [Full Text] [PDF]  

Cancer-Associated Expression of Minichromosome Maintenance 3 Gene in Several Human Cancers and Its Involvement in Tumorigenesis

Seon-Ah Ha, Seung Min Shin, Hong Namkoong, Heejeong Lee, Goang Won Cho, Soo Young Hur, Tae Eung Kim, and Jin Woo Kim
Clin Cancer Res 2004 10: 8386-8395. [Abstract] [Full Text] [PDF]  

Immunohistochemical and Molecular Analysis of Human Melanomas for Expression of the Human Cancer-Testis Antigens NY-ESO-1 and LAGE-1

Hilary A. Vaughan, Suzanne Svobodova, Duncan MacGregor, Sue Sturrock, Achim A. Jungbluth, Judy Browning, Ian D. Davis, Philip Parente, Yao-Tseng Chen, Elisabeth Stockert, Fiona St. Clair, Lloyd J. Old, and Jonathan Cebon
Clin Cancer Res 2004 10: 8396-8404. [Abstract] [Full Text] [PDF]  

Hypoxia-Inducible Factor 1 Expression as an Intrinsic Marker of Hypoxia: Correlation with Tumor Oxygen, Pimonidazole Measurements, and Outcome in Locally Advanced Carcinoma of the Cervix

Gillian J. Hutchison, Helen R. Valentine, Juliette A. Loncaster, Susan E. Davidson, Robert D. Hunter, Stephen A. Roberts, Adrian L. Harris, Ian J. Stratford, Patricia M. Price, and Catharine M. L. West
Clin Cancer Res 2004 10: 8405-8412. [Abstract] [Full Text] [PDF]  

Impact of Vascular Endothelial Growth Factor-C and -D Expression in Human Pancreatic Cancer: Its Relationship to Lymph Node Metastasis

Hiroshi Kurahara, Sonshin Takao, Kousei Maemura, Hiroyuki Shinchi, Shoji Natsugoe, and Takashi Aikou
Clin Cancer Res 2004 10: 8413-8420. [Abstract] [Full Text] [PDF]  

mTOR and P70 S6 Kinase Expression in Primary Liver Neoplasms

Fikret Sahin, Rajesh Kannangai, Onikepe Adegbola, Jianzhou Wang, Gloria Su, and Michael Torbenson
Clin Cancer Res 2004 10: 8421-8425. [Abstract] [Full Text] [PDF]  

High Expression of Neuropeptide Y Receptors in Tumors of the Human Adrenal Gland and Extra-Adrenal Paraganglia

Meike Körner, Beatrice Waser, and Jean Claude Reubi
Clin Cancer Res 2004 10: 8426-8433. [Abstract] [Full Text] [PDF]  

Low Levels of Insulin-Like Growth Factor Type 1 Receptor Expression at Cancer Cell Membrane Predict Liver Metastasis in Dukes’ C Human Colorectal Cancers

Michio Nakamura, Shin’ichi Miyamoto, Hiroyuki Maeda, Shi-chuan Zhang, Takafumi Sangai, Genichiro Ishii, Takahiro Hasebe, Yasushi Endoh, Norio Saito, Masahiro Asaka, and Atsushi Ochiai
Clin Cancer Res 2004 10: 8434-8441. [Abstract] [Full Text] [PDF]  

Salivary Transcriptome Diagnostics for Oral Cancer Detection

Yang Li, Maie A. R. St. John, Xiaofeng Zhou, Yong Kim, Uttam Sinha, Richard C. K. Jordan, David Eisele, Elliot Abemayor, David Elashoff, No-Hee Park, and David T. Wong
Clin Cancer Res 2004 10: 8442-8450. [Abstract] [Full Text] [PDF]  

Correlation of Protease-Activated Receptor-1 With Differentiation Markers in Squamous Cell Carcinoma of the Head and Neck and Its Implication in Lymph Node Metastasis

Xin Zhang, Jennifer L. Hunt, Doug P. Landsittel, Susan Muller, Karen Adler-Storthz, Robert L. Ferris, Dong M. Shin, and Zhuo (Georgia) Chen
Clin Cancer Res 2004 10: 8451-8459. [Abstract] [Full Text] [PDF]  

Nuclear Factor-B Nuclear Localization Is Predictive of Biochemical Recurrence in Patients with Positive Margin Prostate Cancer

Vincent Fradet, Laurent Lessard, Louis R. Bégin, Pierre Karakiewicz, Anne-Marie Mes Masson, and Fred Saad
Clin Cancer Res 2004 10: 8460-8464. [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Expression: A Significant Prognostic Indicator for Patients With Colorectal Cancer

Labile Togba Soumaoro, Hiroyuki Uetake, Tetsuro Higuchi, Yoko Takagi, Masayuki Enomoto, and Kenichi Sugihara
Clin Cancer Res 2004 10: 8465-8471. [Abstract] [Full Text] [PDF]  

A Quantitative Promoter Methylation Profile of Prostate Cancer

Carmen Jerónimo, Rui Henrique, Mohammad O. Hoque, Elizabeth Mambo, Franclim R. Ribeiro, Graça Varzim, Jorge Oliveira, Manuel R. Teixeira, Carlos Lopes, and David Sidransky
Clin Cancer Res 2004 10: 8472-8478. [Abstract] [Full Text] [PDF]  

Loss of Heterozygosity and Immunohistochemistry of Adenocarcinomas of the Esophagus and Gastric Cardia

Willem A. Marsman, Rakesh S. Birjmohun, Bastiaan P. van Rees, Eric Caspers, G. Johan, A. Offerhaus, Piter J. Bosma, J. Jan, and B. van Lanschot
Clin Cancer Res 2004 10: 8479-8485. [Abstract] [Full Text] [PDF]  

Cyclin A as a Predictive Factor for Chemotherapy Response in Advanced Head and Neck Cancer

Maria Rodriguez-Pinilla, Jose L. Rodriguez-Peralto, Ricardo Hitt, Jose J. Sanchez, Claudio Ballestin, Ana Diez, Lydia Sanchez-Verde, Francesc Alameda, and Montserrat Sanchez-Cespedes
Clin Cancer Res 2004 10: 8486-8492. [Abstract] [Full Text] [PDF]  

Association of Epigenetic Inactivation of RASSF1A with Poor Outcome in Human Neuroblastoma

Qiwei Yang, Peter Zage, David Kagan, Yufeng Tian, Roopa Seshadri, Helen R. Salwen, Shuqing Liu, Alexandre Chlenski, and Susan L. Cohn
Clin Cancer Res 2004 10: 8493-8500. [Abstract] [Full Text] [PDF]  

Small Integrin Binding Ligand N-Linked Glycoprotein Gene Family Expression in Different Cancers

Larry W. Fisher, Alka Jain, Matt Tayback, and Neal S. Fedarko
Clin Cancer Res 2004 10: 8501-8511. [Abstract] [Full Text] [PDF]  

Mitochondrial DNA Quantity Increases with Histopathologic Grade in Premalignant and Malignant Head and Neck Lesions

Michael M. Kim, John D. Clinger, Brett G. Masayesva, Patrick K. Ha, Marianna L. Zahurak, William H. Westra, and Joseph A. Califano
Clin Cancer Res 2004 10: 8512-8515. [Abstract] [Full Text] [PDF]  

MAP2K4/MKK4 Expression in Pancreatic Cancer: Genetic Validation of Immunohistochemistry and Relationship to Disease Course

Wei Xin, Ki J. Yun, Francesca Ricci, Marianna Zahurak, Wanglong Qiu, Gloria H. Su, Charles J. Yeo, Ralph H. Hruban, Scott E. Kern, and Christine A. Iacobuzio-Donahue
Clin Cancer Res 2004 10: 8516-8520. [Abstract] [Full Text] [PDF]  

Transcription Factor AP-2 Is a Developmentally Regulated Marker of Testicular Carcinoma In situ and Germ Cell Tumors

Christina E. Hoei-Hansen, John E. Nielsen, Kristian Almstrup, Si Brask Sonne, Niels Graem, Niels E. Skakkebaek, Henrik Leffers, and Ewa Rajpert-De Meyts
Clin Cancer Res 2004 10: 8521-8530. [Abstract] [Full Text] [PDF]  

Prognostic Relevance of Increased Angiogenesis in Osteosarcoma

Michael Kreuter, Ralf Bieker, Stefan S. Bielack, Tanja Auras, Horst Buerger, Georg Gosheger, Heribert Jurgens, Wolfgang E. Berdel, and Rolf M. Mesters
Clin Cancer Res 2004 10: 8531-8537. [Abstract] [Full Text] [PDF]  

Differences in Prognostic Molecular Markers between Women Over and Under 45 Years of Age with Advanced Ovarian Cancer

John K. Chan, Vera Loizzi, Alessandra Magistris, Fritz Lin, Joanne Rutgers, Kathryn Osann, Philip J. DiSaia, and Michael L. Berman
Clin Cancer Res 2004 10: 8538-8543. [Abstract] [Full Text] [PDF]  

OCT4: A Sensitive and Specific Biomarker for Intratubular Germ Cell Neoplasia of the Testis

Timothy D. Jones, Thomas M. Ulbright, John N. Eble, and Liang Cheng
Clin Cancer Res 2004 10: 8544-8547. [Abstract] [Full Text] [PDF]  

Flt-4–Positive Endothelial Cell Density and Its Clinical Significance in Non–Small Cell Lung Cancer

Fengshi Chen, Kazumasa Takenaka, Eiji Ogawa, Kazuhiro Yanagihara, Yosuke Otake, Hiromi Wada, and Fumihiro Tanaka
Clin Cancer Res 2004 10: 8548-8553. [Abstract] [Full Text] [PDF]  

Prognostic Impact of Hypoxia-Inducible Factors 1 and 2 in Colorectal Cancer Patients: Correlation with Tumor Angiogenesis and Cyclooxygenase-2 Expression

Hiroshi Yoshimura, Dipok Kumar Dhar, Hitoshi Kohno, Hirofumi Kubota, Toshiyuki Fujii, Shuhei Ueda, Shoichi Kinugasa, Mitsuo Tachibana, and Naofumi Nagasue
Clin Cancer Res 2004 10: 8554-8560. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Efficacy and Safety Evaluation of Human Reovirus Type 3 in Immunocompetent Animals: Racine and Nonhuman Primates

Wen Qing Yang, Xueqing Lun, Cheryl Ann Palmer, M. Elizabeth Wilcox, Huong Muzik, Zhong Qiao Shi, Richard Dyck, Matt Coffey, Brad Thompson, Mark Hamilton, Sandra G. Nishikawa, Penny M. A. Brasher, Kevin Fonseca, David George, N. Berry Rewcastle, Randal N. Johnston, Doug Stewart, Patrick W. K. Lee, Donna L. Senger, and Peter A. Forsyth
Clin Cancer Res 2004 10: 8561-8576. [Abstract] [Full Text] [PDF]  

Ring Finger Protein 43 as a New Target for Cancer Immunotherapy

Naotaka Uchida, Takuya Tsunoda, Satoshi Wada, Yoichi Furukawa, Yusuke Nakamura, and Hideaki Tahara
Clin Cancer Res 2004 10: 8577-8586. [Abstract] [Full Text] [PDF]  

ZD6474, a Potent Inhibitor of Vascular Endothelial Growth Factor Signaling, Combined With Radiotherapy: Schedule-Dependent Enhancement of Antitumor Activity

Kaye J. Williams, Brian A. Telfer, Sandra Brave, Jane Kendrew, Lynsey Whittaker, Ian J. Stratford, and Stephen R. Wedge
Clin Cancer Res 2004 10: 8587-8593. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor (EGFR) Is Overexpressed in Anaplastic Thyroid Cancer, and the EGFR Inhibitor Gefitinib Inhibits the Growth of Anaplastic Thyroid Cancer

Bradley A. Schiff, Andrea B. McMurphy, Samar A. Jasser, Maher N. Younes, Dao Doan, Orhan G. Yigitbasi, Seungwon Kim, Ge Zhou, Mahitosh Mandal, Benjamin N. Bekele, F. Christopher Holsinger, Steven I. Sherman, Sai-Ching Yeung, Adel K. El-Naggar, and Jeffrey N. Myers
Clin Cancer Res 2004 10: 8594-8602. [Abstract] [Full Text] [PDF]  

Cancer Therapy with a Replicating Oncolytic Adenovirus Targeting the Hypoxic Microenvironment of Tumors

Dawn E. Post, Narra Sarojini Devi, Zhenchao Li, Daniel J. Brat, Balveen Kaur, Ainsley Nicholson, Jeffrey J. Olson, Zhaobin Zhang, and Erwin G. Van Meir
Clin Cancer Res 2004 10: 8603-8612. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Does Not Improve Paclitaxel Effect in an Orthotopic Mouse Model of Lung Cancer

Amir Onn, Takeshi Isobe, Wenjuan Wu, Satoshi Itasaka, Tomoaki Shintani, Keiko Shibuya, Yokoi Kenji, Michael S. O’Reilly, Isaiah J. Fidler, and Roy S. Herbst
Clin Cancer Res 2004 10: 8613-8619. [Abstract] [Full Text] [PDF]  

Potent and Specific Antitumor Efficacy of CMC-544, a CD22-Targeted Immunoconjugate of Calicheamicin, against Systemically Disseminated B-Cell Lymphoma

John F. DiJoseph, Mary E. Goad, Maureen M. Dougher, Erwin R. Boghaert, Arthur Kunz, Philip R. Hamann, and Nitin K. Damle
Clin Cancer Res 2004 10: 8620-8629. [Abstract] [Full Text] [PDF]  

Mouse Homologue of a Novel Human Oncofetal Antigen, Glypican-3, Evokes T-Cell–Mediated Tumor Rejection without Autoimmune Reactions in Mice

Tetsuya Nakatsura, Hiroyuki Komori, Tatsuko Kubo, Yoshihiro Yoshitake, Satoru Senju, Toyomasa Katagiri, Yoichi Furukawa, Michio Ogawa, Yusuke Nakamura, and Yasuharu Nishimura
Clin Cancer Res 2004 10: 8630-8640. [Abstract] [Full Text] [PDF]  

Oral Silibinin Inhibits Lung Tumor Growth in Athymic Nude Mice and Forms a Novel Chemocombination with Doxorubicin Targeting Nuclear Factor B–Mediated Inducible Chemoresistance

Rana P. Singh, G. U. Mallikarjuna, Girish Sharma, Sivanandhan Dhanalakshmi, Anil K. Tyagi, Daniel C. F. Chan, Chapla Agarwal, and Rajesh Agarwal
Clin Cancer Res 2004 10: 8641-8647. [Abstract] [Full Text] [PDF]  

3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitor, Fluvastatin, as a Novel Agent for Prophylaxis of Renal Cancer Metastasis

Akio Horiguchi, Makoto Sumitomo, Junichi Asakuma, Takako Asano, Tomohiko Asano, and Masamichi Hayakawa
Clin Cancer Res 2004 10: 8648-8655. [Abstract] [Full Text] [PDF]  

A Selective Retinoid X Receptor Agonist Bexarotene (Targretin) Prevents and Overcomes Acquired Paclitaxel (Taxol) Resistance in Human Non–Small Cell Lung Cancer

Wan-Ching Yen, Manny R. Corpuz, Rene Y. Prudente, Tracy A. Cooke, Reid P. Bissonnette, Andrés Negro-Vilar, and William W. Lamph
Clin Cancer Res 2004 10: 8656-8664. [Abstract] [Full Text] [PDF]  

2-Methoxyestradiol Inhibits Hypoxia-Inducible Factor 1, Tumor Growth, and Angiogenesis and Augments Paclitaxel Efficacy in Head and Neck Squamous Cell Carcinoma

Justin L. Ricker, Zhong Chen, Xin Ping Yang, Victor S. Pribluda, Glenn M. Swartz, and Carter Van Waes
Clin Cancer Res 2004 10: 8665-8673. [Abstract] [Full Text] [PDF]  

Preparation and Biological Evaluation of Copper-64–Labeled Tyr³-Octreotate Using a Cross-Bridged Macrocyclic Chelator

Jennifer E. Sprague, Yijie Peng, Xiankai Sun, Gary R. Weisman, Edward H. Wong, Samuel Achilefu, and Carolyn J. Anderson
Clin Cancer Res 2004 10: 8674-8682. [Abstract] [Full Text] [PDF]  

Lactoferrin Down-Regulates G₁ Cyclin-Dependent Kinases during Growth Arrest of Head and Neck Cancer Cells

Yan Xiao, Constance L. Monitto, Khalid M. Minhas, and David Sidransky
Clin Cancer Res 2004 10: 8683-8686. [Abstract] [Full Text] [PDF]  

Selective Induction of Apoptosis with Proton Pump Inhibitor in Gastric Cancer Cells

Marie Yeo, Dong-Kyu Kim, Young-Bae Kim, Tae Young Oh, Jong-Eun Lee, Sung Won Cho, Hugh Chul Kim, and Ki-Baik Hahm
Clin Cancer Res 2004 10: 8687-8696. [Abstract] [Full Text] [PDF]  

A Novel Ex vivo Model System for Evaluation of Conditionally Replicative Adenoviruses Therapeutic Efficacy and Toxicity

Tyler O. Kirby, Angel Rivera, Daniel Rein, Minghui Wang, Ilya Ulasov, Martina Breidenbach, Manjula Kataram, Juan L. Contreras, Carlos Krumdieck, Masato Yamamoto, Marianne G. Rots, Hidde J. Haisma, Ronald D. Alvarez, Parameshwar J. Mahasreshti, and David T. Curiel
Clin Cancer Res 2004 10: 8697-8703. [Abstract] [Full Text] [PDF]  

Induction of Apoptosis by Flavopiridol in Human Neuroblastoma Cells Is Enhanced under Hypoxia and Associated With N-myc Proto-oncogene Down-Regulation

Maura Puppo, Sandra Pastorino, Giovanni Melillo, Annalisa Pezzolo, Luigi Varesio, and Maria Carla Bosco
Clin Cancer Res 2004 10: 8704-8719. [Abstract] [Full Text] [PDF]  

Intermittent Hypoxia Induces Proteasome-Dependent Down-Regulation of Estrogen Receptor in Human Breast Carcinoma

Charlton Cooper, Guang-Yu Liu, Yu-Lian Niu, Sylvia Santos, Leigh C. Murphy, and Peter H. Watson
Clin Cancer Res 2004 10: 8720-8727. [Abstract] [Full Text] [PDF]  

Combination Antiangiogenic and Androgen Deprivation Therapy for Prostate Cancer: A Promising Therapeutic Approach

Brian Nicholson, Kathryn Gulding, Mark Conaway, Stephen R. Wedge, and Dan Theodorescu
Clin Cancer Res 2004 10: 8728-8734. [Abstract] [Full Text] [PDF]  

Antifolate Resistance in a HeLa Cell Line Associated With Impaired Transport Independent of the Reduced Folate Carrier

Rongbao Zhao, Shrikanta Chattopadhyay, Marie Hanscom, and I. David Goldman
Clin Cancer Res 2004 10: 8735-8742. [Abstract] [Full Text] [PDF]  

   Cancer Biology:

Expression and Functional Role of CCR9 in Prostate Cancer Cell Migration and Invasion

Shailesh Singh, Udai P. Singh, Jonathan K. Stiles, William E. Grizzle, and James W. Lillard, Jr.
Clin Cancer Res 2004 10: 8743-8750. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Mesothelin: A New Target for Immunotherapy

Denise R. Shaw, Zhanat E. Muminova, Theresa V. Strong, Raffit Hassan, Tapan Bera, Mitchell Ho, and Ira Pastan
Clin Cancer Res 2004 10: 8751. [Full Text] [PDF]  

Vascular Endothelial Growth Factor in Predicting Outcome in Breast Cancer

Peter Krippl, Uwe Langsenlehner, Hellmut Samonigg, Wilfried Renner, and Herwig Köppel
Clin Cancer Res 2004 10: 8752-8753. [Full Text] [PDF]  

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