Editorials:

Radioimmunotherapy for Non-Hodgkin’s Lymphoma

Jonathan W. Friedberg
Clin Cancer Res 2004 10: 7789-7791. [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

The Radioisotope Contributes Significantly to the Activity of Radioimmunotherapy

Thomas A. Davis, Mark S. Kaminski, John P. Leonard, Frank J. Hsu, Mary Wilkinson, Andrew Zelenetz, Richard L. Wahl, Stewart Kroll, Morton Coleman, Michael Goris, Ronald Levy, and Susan J. Knox
Clin Cancer Res 2004 10: 7792-7798. [Abstract] [Full Text] [PDF]  

Allogeneic Hematopoietic Cell Transplantation for Metastatic Renal Cell Carcinoma after Nonmyeloablative Conditioning: Toxicity, Clinical Response, and Immunological Response to Minor Histocompatibility Antigens

Scott S. Tykodi, Edus H. Warren, John A. Thompson, Stanley R. Riddell, Richard W. Childs, Brith E. Otterud, Mark F. Leppert, Rainer Storb, and Brenda M. Sandmaier
Clin Cancer Res 2004 10: 7799-7811. [Abstract] [Full Text] [PDF]  

A Phase II Trial of Gefitinib (Iressa, ZD1839) in Stage IV and Recurrent Renal Cell Carcinoma

Nancy A. Dawson, Chuanfo Guo, Richard Zak, Brenda Dorsey, Jeanne Smoot, Jade Wong, and Arif Hussain
Clin Cancer Res 2004 10: 7812-7819. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Molecular Stratification of Diagnostically Challenging High-Grade Gliomas Composed of Small Cells: The Utility of Fluorescence In situ Hybridization

Andrey Korshunov, Regina Sycheva, and Andrey Golanov
Clin Cancer Res 2004 10: 7820-7826. [Abstract] [Full Text] [PDF]  

Clinical Significance of Micrometastatic Cells Detected by E48 (Ly-6D) Reverse Transcription-Polymerase Chain Reaction in Bone Marrow of Head and Neck Cancer Patients

David R. Colnot, Eline J. C. Nieuwenhuis, Dirk J. Kuik, C. René Leemans, Janny Dijkstra, Gordon B. Snow, Guus A. M. S. van Dongen, and Ruud H. Brakenhoff
Clin Cancer Res 2004 10: 7827-7833. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Targeting of HER2 Antigen for the Treatment of Disseminated Peritoneal Disease

Diane E. Milenic, Kayhan Garmestani, Erik D. Brady, Paul S. Albert, Dangshe Ma, Alia Abdulla, and Martin W. Brechbiel
Clin Cancer Res 2004 10: 7834-7841. [Abstract] [Full Text] [PDF]  

Efficient Elimination of B-Lineage Lymphomas by Anti-CD20–Auristatin Conjugates

Che-Leung Law, Charles G. Cerveny, Kristine A. Gordon, Kerry Klussman, Bruce J. Mixan, Dana F. Chace, Damon L. Meyer, Svetlana O. Doronina, Clay B. Siegall, Joseph A. Francisco, Peter D. Senter, and Alan F. Wahl
Clin Cancer Res 2004 10: 7842-7851. [Abstract] [Full Text] [PDF]  

Therapeutic Efficacy of DTI-015 using Diffusion Magnetic Resonance Imaging as an Early Surrogate Marker

Daniel E. Hall, Bradford A. Moffat, Jadranka Stojanovska, Timothy D. Johnson, Zhuolin Li, Daniel A. Hamstra, Alnawaz Rehemtulla, Thomas L. Chenevert, Julie Carter, Dennis Pietronigro, and Brian D. Ross
Clin Cancer Res 2004 10: 7852-7859. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

S-1 Plus Cisplatin Combination Chemotherapy in Patients with Advanced Non–Small Cell Lung Cancer: A Multi-Institutional Phase II Trial

Yukito Ichinose, Kozo Yoshimori, Hiroshi Sakai, Yushi Nakai, Takahiko Sugiura, Masaaki Kawahara, and Hisanobu Niitani
Clin Cancer Res 2004 10: 7860-7864. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Proteinase Activity in Human and Murine Saliva as a Biomarker for Proteinase Inhibitor Efficacy

Barbara Fingleton, Ramkumar Menon, Kathy J. Carter, P. Dawn Overstreet, David L. Hachey, Lynn M. Matrisian, and J. Oliver McIntyre
Clin Cancer Res 2004 10: 7865-7874. [Abstract] [Full Text] [PDF]  

Apurinic Endonuclease Activity in Adult Gliomas and Time to Tumor Progression after Alkylating Agent-Based Chemotherapy and after Radiotherapy

Michael S. Bobola, Mary J. Emond, A. Blank, Elizabeth H. Meade, Douglas D. Kolstoe, Mitchel S. Berger, Robert C. Rostomily, Daniel L. Silbergeld, Alexander M. Spence, and John R. Silber
Clin Cancer Res 2004 10: 7875-7883. [Abstract] [Full Text] [PDF]  

Partial Contribution of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)/TRAIL Receptor Pathway to Antitumor Effects of Interferon-/5-Fluorouracil against Hepatocellular Carcinoma

Tameyoshi Yamamoto, Hiroaki Nagano, Masato Sakon, Hisashi Wada, Hidetoshi Eguchi, Motoi Kondo, Bazarragchaa Damdinsuren, Hideo Ota, Masato Nakamura, Hiroshi Wada, Shigeru Marubashi, Atsushi Miyamoto, Keizo Dono, Koji Umeshita, Shoji Nakamori, Hideo Yagita, and Morito Monden
Clin Cancer Res 2004 10: 7884-7895. [Abstract] [Full Text] [PDF]  

Breast Cancer Resistance Protein and P-Glycoprotein in 149 Adult Acute Myeloid Leukemias

Zineb Benderra, Anne-Marie Faussat, Lydia Sayada, Jean-Yves Perrot, Driss Chaoui, Jean-Pierre Marie, and Ollivier Legrand
Clin Cancer Res 2004 10: 7896-7902. [Abstract] [Full Text] [PDF]  

Thymidylate Synthase 5'- and 3'-Untranslated Region Polymorphisms Associated with Risk and Progression of Squamous Cell Carcinoma of the Head and Neck

Zhengdong Zhang, Qiuling Shi, Erich M. Sturgis, Margaret R. Spitz, Waun Ki Hong, and Qingyi Wei
Clin Cancer Res 2004 10: 7903-7910. [Abstract] [Full Text] [PDF]  

Fas Ligand Expression in Metastatic Renal Cell Carcinoma During Interleukin-2 Based Immunotherapy: No In vivo Effect of Fas Ligand Tumor Counterattack

Frede Donskov, Hans von der Maase, Niels Marcussen, Stephen Hamilton-Dutoit, Hans Henrik Torp Madsen, Jens Jorgen Jensen, and Marianne Hokland
Clin Cancer Res 2004 10: 7911-7916. [Abstract] [Full Text] [PDF]  

Hypermethylation of the GATA Genes in Lung Cancer

Mingzhou Guo, Yoshimitsu Akiyama, Michael G. House, Craig M. Hooker, Elizabeth Heath, Edward Gabrielson, Stephen C. Yang, Yu Han, Stephen B. Baylin, James G. Herman, and Malcolm V. Brock
Clin Cancer Res 2004 10: 7917-7924. [Abstract] [Full Text] [PDF]  

Carbonic Anhydrase IX in Early-Stage Non–Small Cell Lung Cancer

Seok Jin Kim, Zahid N. Rabbani, Robin T. Vollmer, Ernst-Gilbert Schreiber, Egbert Oosterwijk, Mark W. Dewhirst, Zeljko Vujaskovic, and Michael J. Kelley
Clin Cancer Res 2004 10: 7925-7933. [Abstract] [Full Text] [PDF]  

Plasma Glutathione S-Transferase P1-1 as a Prognostic Factor in Patients with Advanced Non-Hodgkin’s Lymphoma (Stages III and IV)

Tatsuro Katahira, Tetsuji Takayama, Koji Miyanishi, Tsuyoshi Hayashi, Tatsuru Ikeda, Yasuo Takahashi, Rishu Takimoto, Takuya Matsunaga, Junji Kato, and Yoshiro Niitsu
Clin Cancer Res 2004 10: 7934-7940. [Abstract] [Full Text] [PDF]  

Preradiotherapy Hemoglobin Level but not Microvessel Density Predicts Locoregional Control and Survival in Laryngeal Cancer Treated with Primary Radical Radiotherapy

Hedda Haugen, Bengt Magnusson, Marie Svensson, and Claes Mercke
Clin Cancer Res 2004 10: 7941-7949. [Abstract] [Full Text] [PDF]  

Interplay of Insulin-Like Growth Factor-II, Insulin-Like Growth Factor-I, Insulin-Like Growth Factor-I Receptor, COX-2, and Matrix Metalloproteinase-7, Play Key Roles in the Early Stage of Colorectal Carcinogenesis

Katsuhiko Nosho, Hiroyuki Yamamoto, Hiroaki Taniguchi, Yasushi Adachi, Yukinari Yoshida, Yoshiaki Arimura, Takao Endo, Yuji Hinoda, and Kohzoh Imai
Clin Cancer Res 2004 10: 7950-7957. [Abstract] [Full Text] [PDF]  

Gain of OGP, an Estrogen-Regulated Oviduct-Specific Glycoprotein, Is Associated with the Development of Endometrial Hyperplasia and Endometrial Cancer

Michelle M. M. Woo, Abdulmohsen Alkushi, Harold G. Verhage, Anthony M. Magliocco, Peter C. K. Leung, C. Blake Gilks, and Nelly Auersperg
Clin Cancer Res 2004 10: 7958-7964. [Abstract] [Full Text] [PDF]  

Increased Angiogenesis and Lymphangiogenesis in Inflammatory versus Noninflammatory Breast Cancer by Real-Time Reverse Transcriptase-PCR Gene Expression Quantification

Ilse Van der Auwera, Steven J. Van Laere, Gert G. Van den Eynden, Ina Benoy, Peter van Dam, Cecile G. Colpaert, Stephen B. Fox, Helen Turley, Adrian L. Harris, Eric A. Van Marck, Peter B. Vermeulen, and Luc Y. Dirix
Clin Cancer Res 2004 10: 7965-7971. [Abstract] [Full Text] [PDF]  

c-erbB-2 Related Aggressiveness in Breast Cancer Is Hypoxia Inducible Factor-1 Dependent

Alexandra Giatromanolaki, Michael I. Koukourakis, Costantinos Simopoulos, Alexandros Polychronidis, Kevin C. Gatter, Adrian L. Harris, and Efthimios Sivridis
Clin Cancer Res 2004 10: 7972-7977. [Abstract] [Full Text] [PDF]  

Detection of Neuroblastoma Cells in Bone Marrow and Peripheral Blood by Different Techniques: Accuracy and Relationship with Clinical Features of Patients

Maria Valeria Corrias, Lawrence B. Faulkner, Angela Pistorio, Cristina Rosanda, Francesco Callea, Maria Serena Lo Piccolo, Paola Scaruffi, Cinzia Marchi, Laura Lacitignola, Marzia Occhino, Claudio Gambini, Gian Paolo Tonini, Riccardo Haupt, Bruno De Bernardi, Vito Pistoia, and Alberto Garaventa
Clin Cancer Res 2004 10: 7978-7985. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Lack of Impact of the Loss of Constitutive Folate Receptor Expression, Achieved by RNA Interference, on the Activity of the New Generation Antifolate Pemetrexed in HeLa Cells

Shrikanta Chattopadhyay, Yanhua Wang, Rongbao Zhao, and I. David Goldman
Clin Cancer Res 2004 10: 7986-7993. [Abstract] [Full Text] [PDF]  

Evaluation of Combination Chemotherapy: Integration of Nonlinear Regression, Curve Shift, Isobologram, and Combination Index Analyses

Liang Zhao, M. Guillaume Wientjes, and Jessie L-S. Au
Clin Cancer Res 2004 10: 7994-8004. [Abstract] [Full Text] [PDF]  

Lack of Microvessels in Well-Differentiated Regions of Human Head and Neck Squamous Cell Carcinoma A253 Associated with Functional Magnetic Resonance Imaging Detectable Hypoxia, Limited Drug Delivery, and Resistance to Irinotecan Therapy

Arup Bhattacharya, Károly Tóth, Richard Mazurchuk, Joseph A. Spernyak, Harry K. Slocum, Lakshmi Pendyala, Rami Azrak, Shousong Cao, Farukh A. Durrani, and Youcef M. Rustum
Clin Cancer Res 2004 10: 8005-8017. [Abstract] [Full Text] [PDF]  

Inhibition of Proliferation and Induction of Apoptosis by 25-Hydroxyvitamin D₃-3ß-(2)-Bromoacetate, a Nontoxic and Vitamin D Receptor-Alkylating Analog of 25-Hydroxyvitamin D₃ in Prostate Cancer Cells

Narasimha Swamy, Tai C. Chen, Sara Peleg, Puneet Dhawan, Sylvia Christakos, LaMonica V. Stewart, Nancy L. Weigel, Rajendra G. Mehta, Michael F. Holick, and Rahul Ray
Clin Cancer Res 2004 10: 8018-8027. [Abstract] [Full Text] [PDF]  

Inhibition of Src Tyrosine Kinase as Treatment for Human Pancreatic Cancer Growing Orthotopically in Nude Mice

Maksim V. Yezhelyev, Gudrun Koehl, Markus Guba, Thomas Brabletz, Karl-Walter Jauch, Anderson Ryan, Alan Barge, Tim Green, Michael Fennell, and Christiane J. Bruns
Clin Cancer Res 2004 10: 8028-8036. [Abstract] [Full Text] [PDF]  

Inhibition of Cyclooxygenase (COX)-2 Expression by Tet-Inducible COX-2 Antisense cDNA in Hormone-Refractory Prostate Cancer Significantly Slows Tumor Growth and Improves Efficacy of Chemotherapeutic Drugs

Devendra S. Dandekar and Bal L. Lokeshwar
Clin Cancer Res 2004 10: 8037-8047. [Abstract] [Full Text] [PDF]  

Pharmacokinetic Model-Predicted Anticancer Drug Concentrations in Human Tumors

James M. Gallo, Paolo Vicini, Amy Orlansky, Shaolan Li, Feng Zhou, Jianguo Ma, Sharon Pulfer, Michel A. Bookman, and Ping Guo
Clin Cancer Res 2004 10: 8048-8058. [Abstract] [Full Text] [PDF]  

Inhibition of mTOR Activity Restores Tamoxifen Response in Breast Cancer Cells with Aberrant Akt Activity

Linda A. deGraffenried, William E. Friedrichs, Douglas H. Russell, Elissa J. Donzis, Amanda K. Middleton, Jessica M. Silva, Richard A. Roth, and Manuel Hidalgo
Clin Cancer Res 2004 10: 8059-8067. [Abstract] [Full Text] [PDF]  

Prognostic Significance of Tissue Transglutaminase in Drug Resistant and Metastatic Breast Cancer

Kapil Mehta, Jansina Fok, Fred R. Miller, Dimpy Koul, and Aysegul A. Sahin
Clin Cancer Res 2004 10: 8068-8076. [Abstract] [Full Text] [PDF]  

Enhanced Tumor Cell Radiosensitivity and Abrogation of G₂ and S Phase Arrest by the Hsp90 Inhibitor 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin

Elizabeth E. A. Bull, Hideaki Dote, Kristin J. Brady, William E. Burgan, Donna J. Carter, Michael A. Cerra, Kelli A. Oswald, Melinda G. Hollingshead, Kevin Camphausen, and Philip J. Tofilon
Clin Cancer Res 2004 10: 8077-8084. [Abstract] [Full Text] [PDF]  

pRb2/p130 Decreases Sensitivity to Apoptosis Induced by Camptothecin and Doxorubicin but not by Taxol

Tiziana Tonini, Chiara Gabellini, Luigi Bagella, Giuseppina D’Andrilli, Valeria Masciullo, Gaetano Romano, Giovanni Scambia, Gabriella Zupi, and Antonio Giordano
Clin Cancer Res 2004 10: 8085-8093. [Abstract] [Full Text] [PDF]  

Histone Deacetylase Inhibitor Trichostatin A Represses Estrogen Receptor -Dependent Transcription and Promotes Proteasomal Degradation of Cyclin D1 in Human Breast Carcinoma Cell Lines

John Patrick Alao, Eric W-F. Lam, Simak Ali, Laki Buluwela, Walter Bordogna, Peter Lockey, Rana Varshochi, Alexandra V. Stavropoulou, R. Charles Coombes, and David M. Vigushin
Clin Cancer Res 2004 10: 8094-8104. [Abstract] [Full Text] [PDF]  

The Selective Cyclooxygenase-2 Inhibitor Nimesulide Prevents Helicobacter pylori-Associated Gastric Cancer Development in a Mouse Model

Ki Taek Nam, Ki-Baik Hahm, Sang-Yeon Oh, Marie Yeo, Sang-Uk Han, Byeongwoo Ahn, Young-Bae Kim, Jin Seok Kang, Dong Deuk Jang, Ki-Hwa Yang, and Dae-Yong Kim
Clin Cancer Res 2004 10: 8105-8113. [Abstract] [Full Text] [PDF]  

   Cancer Biology:

Increased Fas Expression Reduces the Metastatic Potential of Human Osteosarcoma Cells

Elizabeth A. Lafleur, Nadezhda V. Koshkina, John Stewart, Shu-Fang Jia, Laura L. Worth, Xiaoping Duan, and Eugenie S. Kleinerman
Clin Cancer Res 2004 10: 8114-8119. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Natural Killer Cells Activity and Neuroimmunological Treatment of Cancer

Fuad Lechin, Bertha van der Dijs, Alex E. Lechin, Gabriele Multhoff, Karin Pfister, Ilona Hromadnikova, and Denisa Zlacka
Clin Cancer Res 2004 10: 8120-8121. [Full Text] [PDF]  

Acknowledgment to Reviewers:

Acknowledgment to Reviewers

Clin Cancer Res 2004 10: 8122-8128. [Full Text] [PDF]  

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