The Biology Behind:

Imaging Molecular Signatures in Oligodendroglioma: Commentary on Walker et al., pages 7182-7191

J. Gregory Cairncross
Clin Cancer Res 2004 10: 7109-7111. [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Administration of CI-1033, an Irreversible Pan-erbB Tyrosine Kinase Inhibitor, Is Feasible on a 7-Day On, 7-Day Off Schedule: A Phase I Pharmacokinetic and Food Effect Study

Emiliano Calvo, Anthony W. Tolcher, Lisa A. Hammond, Amita Patnaik, Johan S. de Bono, Irene A. Eiseman, Stephen C. Olson, Peter F. Lenehan, Heather McCreery, Patricia LoRusso, and Eric K. Rowinsky
Clin Cancer Res 2004 10: 7112-7120. [Abstract] [Full Text] [PDF]  

The Influence of Androgen Deprivation Therapy on Dihydrotestosterone Levels in the Prostatic Tissue of Patients with Prostate Cancer

Tsutomu Nishiyama, Yutaka Hashimoto, and Kota Takahashi
Clin Cancer Res 2004 10: 7121-7126. [Abstract] [Full Text] [PDF]  

A Phase I Open Label Study of the Farnesyltransferase Inhibitor CP-609,754 in Patients with Advanced Malignant Tumors

Stacy L. Moulder, John J. Mahany, Richard Lush, Caio Rocha-Lima, Michael Langevin, Karen J. Ferrante, Lisa Michele Bartkowski, Shama M. Kajiji, Dennis A. Noe, Simone Paillet, and Daniel M. Sullivan
Clin Cancer Res 2004 10: 7127-7135. [Abstract] [Full Text] [PDF]  

Phase II Feasibility and Pharmacokinetic Study of Concurrent Administration of Trastuzumab and High-Dose Chemotherapy in Advanced HER2+ Breast Cancer

Yago Nieto, James J. Vredenburgh, Elizabeth J. Shpall, Scott I. Bearman, Peter A. McSweeney, Nelson Chao, David Rizzieri, Christina Gasparetto, Steve Matthes, Anna E. Barón, and Roy B. Jones
Clin Cancer Res 2004 10: 7136-7143. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

High LYVE-1–Positive Lymphatic Vessel Numbers Are Associated with Poor Outcome in Breast Cancer

Petri Bono, Veli-Matti Wasenius, Päivi Heikkilä, Johan Lundin, David G. Jackson, and Heikki Joensuu
Clin Cancer Res 2004 10: 7144-7149. [Abstract] [Full Text] [PDF]  

Genetic Analysis of the RNASEL Gene in Hereditary, Familial, and Sporadic Prostate Cancer

Fredrik Wiklund, Björn-Anders Jonsson, Anthony J. Brookes, Linda Strömqvist, Jan Adolfsson, Monica Emanuelsson, Hans-Olov Adami, Katarina Augustsson-Bälter, and Henrik Grönberg
Clin Cancer Res 2004 10: 7150-7156. [Abstract] [Full Text] [PDF]  

Increased Serum Interleukin-8 in Patients with Early and Metastatic Breast Cancer Correlates with Early Dissemination and Survival

Ina H. Benoy, Roberto Salgado, Peter Van Dam, Katrien Geboers, Eric Van Marck, Simon Scharpé, Peter B. Vermeulen, and Luc Y. Dirix
Clin Cancer Res 2004 10: 7157-7162. [Abstract] [Full Text] [PDF]  

Delineation of Brain Tumor Extent with [¹¹C]L-Methionine Positron Emission Tomography: Local Comparison with Stereotactic Histopathology

Lutz W. Kracht, Hrvoje Miletic, Susanne Busch, Andreas H. Jacobs, Jurgen Voges, Moritz Hoevels, Johannes C. Klein, Karl Herholz, and Wolf-D. Heiss
Clin Cancer Res 2004 10: 7163-7170. [Abstract] [Full Text] [PDF]  

Angiogenic Profile of Breast Carcinoma Determines Leukocyte Infiltration

Jessica C. A. Bouma-ter Steege, Coen I. M. Baeten, Victor L. J. L. Thijssen, Sietske A. Satijn, Inge C. L. Verhoeven, Harry F. P. Hillen, John Wagstaff, and Arjan W. Griffioen
Clin Cancer Res 2004 10: 7171-7178. [Abstract] [Full Text] [PDF]  

Monoclonal Immunoglobulin Production Is a Frequent Event in Patients with Mucosa-Associated Lymphoid Tissue Lymphoma

Stefan Wöhrer, Berthold Streubel, Rupert Bartsch, Andreas Chott, and Markus Raderer
Clin Cancer Res 2004 10: 7179-7181. [Abstract] [Full Text] [PDF]  

Correlation of Molecular Genetics with Molecular and Morphological Imaging in Gliomas with an Oligodendroglial Component

Carol Walker, Daniel G. du Plessis, Diane Fildes, Brian Haylock, David Husband, Michael D. Jenkinson, Kathy A. Joyce, John Broome, Klaus Kopitski, Joanne Prosser, Trevor Smith, Sobhan Vinjamuri, and Peter C. Warnke
Clin Cancer Res 2004 10: 7182-7191. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

7-Hydroxystaurosporine (UCN-01) Inhibition of Akt Thr³⁰⁸ but not Ser⁴⁷³ Phosphorylation: A Basis for Decreased Insulin-Stimulated Glucose Transport

Sudhir B. Kondapaka, MaryJane Zarnowski, Dena R. Yver, Edward A. Sausville, and Samuel W. Cushman
Clin Cancer Res 2004 10: 7192-7198. [Abstract] [Full Text] [PDF]  

Impact of Human Neutralizing Antibodies on Antitumor Efficacy of an Oncolytic Adenovirus in a Murine Model

Van Tsai, Duane E. Johnson, Amena Rahman, Shu Fen Wen, Drake LaFace, Jennifer Philopena, Jonathan Nery, Monica Zepeda, Daniel C. Maneval, G. William Demers, and Robert Ralston
Clin Cancer Res 2004 10: 7199-7206. [Abstract] [Full Text] [PDF]  

In vitro Stimulation with WT1 Peptide-Loaded Epstein-Barr Virus-Positive B Cells Elicits High Frequencies of WT1 Peptide-Specific T Cells with In vitro and In vivo Tumoricidal Activity

Ekaterina S. Doubrovina, Mikhail M. Doubrovin, Sangyull Lee, Jae-Hung Shieh, Glen Heller, Eric Pamer, and Richard J. O’Reilly
Clin Cancer Res 2004 10: 7207-7219. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Phase I Study of Docetaxel in Combination with the P-Glycoprotein Inhibitor, Zosuquidar, in Resistant Malignancies

Paula M. Fracasso, Lori J. Goldstein, Dinesh P. de Alwis, Janet S. Rader, Matthew A. Arquette, Sherry A. Goodner, Lisa P. Wright, Carole L. Fears, Robert J. Gazak, Valerie A. M. Andre, Michael F. Burgess, Christopher A. Slapak, and Jan H. M. Schellens
Clin Cancer Res 2004 10: 7220-7228. [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacokinetic Study of Exisulind and Docetaxel in Patients with Advanced Solid Tumors

Samir E. Witta, Daniel L. Gustafson, A. Scott Pierson, Alexander Menter, Scott N. Holden, Michele Basche, Martha Persky, Cindy L. O’Bryant, Chan Zeng, Anna Baron, Michael E. Long, Amy Gibbs, Karen Kelly, Paul A. Bunn, Jr., Daniel C. Chan, Patrick Pallansch, and S. Gail Eckhardt
Clin Cancer Res 2004 10: 7229-7237. [Abstract] [Full Text] [PDF]  

Plasma Coagulation Markers in Patients with Solid Tumors and Venous Thromboembolic Disease Receiving Oral Anticoagulation Therapy

Sabah Sallah, Aisha Husain, Vaia Sigounas, Jim Wan, Francesco Turturro, George Sigounas, and Nam P. Nguyen
Clin Cancer Res 2004 10: 7238-7243. [Abstract] [Full Text] [PDF]  

Delivery of a Liposomal c-raf-1 Antisense Oligonucleotide by Weekly Bolus Dosing in Patients with Advanced Solid Tumors: A Phase I Study

Charles M. Rudin, John L. Marshall, Chao Hui Huang, Hedy L. Kindler, Chuanbo Zhang, Deepak Kumar, Prafulla C. Gokhale, Joyce Steinberg, Steve Wanaski, Usha N. Kasid, and Mark J. Ratain
Clin Cancer Res 2004 10: 7244-7251. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

X-Tile: A New Bio-Informatics Tool for Biomarker Assessment and Outcome-Based Cut-Point Optimization

Robert L. Camp, Marisa Dolled-Filhart, and David L. Rimm
Clin Cancer Res 2004 10: 7252-7259. [Abstract] [Full Text] [PDF]  

Increased Levels of Interleukin-10 in Serum from Patients with Hepatocellular Carcinoma Correlate with Profound Numerical Deficiencies and Immature Phenotype of Circulating Dendritic Cell Subsets

Susanne Beckebaum, Xia Zhang, Xiao Chen, Zhengya Yu, Andrea Frilling, Grzegorz Dworacki, Hans Grosse-Wilde, Christoph Erich Broelsch, Guido Gerken, and Vito R. Cicinnati
Clin Cancer Res 2004 10: 7260-7269. [Abstract] [Full Text] [PDF]  

Autoantibody Profiles and Neurological Correlations of Thymoma

Steven Vernino and Vanda A. Lennon
Clin Cancer Res 2004 10: 7270-7275. [Abstract] [Full Text] [PDF]  

Molecular Profiling and Classification of Sporadic Renal Cell Carcinoma by Quantitative Methylation Analysis

Mark L. Gonzalgo, Srinivasan Yegnasubramanian, Gai Yan, Craig G. Rogers, Theresa L. Nicol, William G. Nelson, and Christian P. Pavlovich
Clin Cancer Res 2004 10: 7276-7283. [Abstract] [Full Text] [PDF]  

Mouse Mammary Tumor Virus-like RNA Transcripts and DNA Are Found in Affected Cells of Human Breast Cancer

Caroline E. Ford, Margaret Faedo, and William D. Rawlinson
Clin Cancer Res 2004 10: 7284-7289. [Abstract] [Full Text] [PDF]  

Loss of Methylthioadenosine Phosphorylase and Elevated Ornithine Decarboxylase Is Common in Pancreatic Cancer

Ahmad L. Subhi, Baiqing Tang, Binaifer R. Balsara, Deborah A. Altomare, Joseph R. Testa, Harry S. Cooper, John P. Hoffman, Neal J. Meropol, and Warren D. Kruger
Clin Cancer Res 2004 10: 7290-7296. [Abstract] [Full Text] [PDF]  

Prognostic Value of ERM Gene Expression in Human Primary Breast Cancers

Anne Chotteau-Lelièvre, Françoise Révillion, Valérie Lhotellier, Louis Hornez, Xavier Desbiens, Véronique Cabaret, Yvan de Launoit, and Jean-Philippe Peyrat
Clin Cancer Res 2004 10: 7297-7303. [Abstract] [Full Text] [PDF]  

Overexpression of Aurora-A Contributes to Malignant Development of Human Esophageal Squamous Cell Carcinoma

Tong Tong, Yali Zhong, Jianping Kong, Lijia Dong, Yongmei Song, Ming Fu, Zhihua Liu, Mingrong Wang, Liping Guo, Shixin Lu, Ming Wu, and Qimin Zhan
Clin Cancer Res 2004 10: 7304-7310. [Abstract] [Full Text] [PDF]  

Dominant Papillary Subtype Is a Significant Predictor of the Response to Gefitinib in Adenocarcinoma of the Lung

Young Hak Kim, Genichiro Ishii, Koichi Goto, Kanji Nagai, Koji Tsuta, Satoshi Shiono, Junichi Nitadori, Testuro Kodama, Yutaka Nishiwaki, and Atsushi Ochiai
Clin Cancer Res 2004 10: 7311-7317. [Abstract] [Full Text] [PDF]  

High Expression of PRL-3 Promotes Cancer Cell Motility and Liver Metastasis in Human Colorectal Cancer: A Predictive Molecular Marker of Metachronous Liver and Lung Metastases

Hirotaka Kato, Shuho Semba, Upik A. Miskad, Yasushi Seo, Masato Kasuga, and Hiroshi Yokozaki
Clin Cancer Res 2004 10: 7318-7328. [Abstract] [Full Text] [PDF]  

Absence of a Correlation between the Presence of a Single Nucleotide Polymorphism in the Matrix Metalloproteinase 1 Promoter and Outcome in Patients of Chondrosarcoma

Yi-Chin Fong, Charyl M. Dutton, Stephen S. Cha, Nandor Garamszegi, Franklin H. Sim, and Sean P. Scully
Clin Cancer Res 2004 10: 7329-7334. [Abstract] [Full Text] [PDF]  

Altered Expression of Metastasis-Associated and Regulatory Molecules in Effusions from Breast Cancer Patients: A Novel Model for Tumor Progression

Ben Davidson, Sophya Konstantinovsky, Søren Nielsen, Hiep Phuc Dong, Aasmund Berner, Mogens Vyberg, and Reuven Reich
Clin Cancer Res 2004 10: 7335-7346. [Abstract] [Full Text] [PDF]  

Mina53 as a Potential Prognostic Factor for Esophageal Squamous Cell Carcinoma

Makoto Tsuneoka, Hiromasa Fujita, Nobuyuki Arima, Kwesi Teye, Torahiko Okamura, Hiroki Inutsuka, Yoshiro Koda, Kazuo Shirouzu, and Hiroshi Kimura
Clin Cancer Res 2004 10: 7347-7356. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Efficacy of the Novel Camptothecin Gimatecan against Orthotopic and Metastatic Human Tumor Xenograft Models

Michelandrea De Cesare, Graziella Pratesi, Silvia Veneroni, Raffaella Bergottini, and Franco Zunino
Clin Cancer Res 2004 10: 7357-7364. [Abstract] [Full Text] [PDF]  

Potent Antitumor Activity of Novel Iron Chelators Derived from Di-2-Pyridylketone Isonicotinoyl Hydrazone Involves Fenton-Derived Free Radical Generation

Timothy B. Chaston, Ralph N. Watts, Jun Yuan, and Des R. Richardson
Clin Cancer Res 2004 10: 7365-7374. [Abstract] [Full Text] [PDF]  

Effects of Exemestane and Tamoxifen in a Postmenopausal Breast Cancer Model

Danijela Jelovac, Luciana Macedo, Venkatesh Handratta, Brian J. Long, Olga G. Goloubeva, James N. Ingle, and Angela M. H. Brodie
Clin Cancer Res 2004 10: 7375-7381. [Abstract] [Full Text] [PDF]  

Antitumor Activity of Hydrophilic Paclitaxel Copolymer Prodrug Using Locoregional Delivery in Human Orthotopic Non–Small Cell Lung Cancer Xenograft Models

Yiyu Zou, Hao Fu, Sukhen Ghosh, David Farquhar, and Jim Klostergaard
Clin Cancer Res 2004 10: 7382-7391. [Abstract] [Full Text] [PDF]  

Androgen Receptor Is Targeted to Distinct Subcellular Compartments in Response to Different Therapeutic Antiandrogens

Hayley C. Whitaker, Sarah Hanrahan, Nick Totty, Simon C. Gamble, Jonathan Waxman, Andrew C. B. Cato, Helen C. Hurst, and Charlotte L. Bevan
Clin Cancer Res 2004 10: 7392-7401. [Abstract] [Full Text] [PDF]  

Myeloma Cells Are Highly Sensitive to the Granule Exocytosis Pathway Mediated by WT1-Specific Cytotoxic T Lymphocytes

Taichi Azuma, Takemi Otsuki, Kiyotaka Kuzushima, Christopher J. Froelich, Shigeru Fujita, and Masaki Yasukawa
Clin Cancer Res 2004 10: 7402-7412. [Abstract] [Full Text] [PDF]  

Therapeutic Synergy of Oral Taxane BMS-275183 and Cetuximab versus Human Tumor Xenografts

William C. Rose and Robert Wild
Clin Cancer Res 2004 10: 7413-7417. [Abstract] [Full Text] [PDF]  

Antiproliferative Effects of Interferon-Con1 on Ovarian Clear Cell Adenocarcinoma In vitro and In vivo

Yumi Takemoto, Hirohisa Yano, Seiya Momosaki, Sachiko Ogasawara, Naoyo Nishida, Sakiko Kojiro, Toshiharu Kamura, and Masamichi Kojiro
Clin Cancer Res 2004 10: 7418-7426. [Abstract] [Full Text] [PDF]  

   Cancer Biology:

Type I Collagen Promotes the Malignant Phenotype of Pancreatic Ductal Adenocarcinoma

Thomas Armstrong, Graham Packham, Lindsay B. Murphy, Adrian C. Bateman, John A. Conti, David R. Fine, Colin D. Johnson, R. Christopher Benyon, and John P. Iredale
Clin Cancer Res 2004 10: 7427-7437. [Abstract] [Full Text] [PDF]  

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