Perspective:

Evaluating the Efficiency of Targeted Designs for Randomized Clinical Trials

Richard Simon and Aboubakar Maitournam
Clin Cancer Res 2004 10: 6759-6763. [Abstract] [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

A Phase II Trial of Neoadjuvant Docetaxel and Capecitabine for Locally Advanced Breast Cancer

Peter F. Lebowitz, Jennifer Eng-Wong, Sandra M. Swain, Arlene Berman, Maria J. Merino, Catherine K. Chow, David Venzon, Farah Zia, David Danforth, Edison Liu, and JoAnne Zujewski
Clin Cancer Res 2004 10: 6764-6769. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Clinical and Biomarker Correlates of Androgen-Independent, Locally Aggressive Prostate Cancer with Limited Metastatic Potential

Vasily J. Assikis, Kim-Anh Do, Sijin Wen, Xuemei Wang, Jeong Hee Cho-Vega, Shawn Brisbay, Remigio Lopez, Christopher J. Logothetis, Patricia Troncoso, Christos N. Papandreou, and Timothy J. McDonnell
Clin Cancer Res 2004 10: 6770-6778. [Abstract] [Full Text] [PDF]  

Activation of the Akt/Mammalian Target of Rapamycin/4E-BP1 Pathway by ErbB2 Overexpression Predicts Tumor Progression in Breast Cancers

Xiaoyan Zhou, Ming Tan, Valerie Stone Hawthorne, Kristine S. Klos, Keng-Hsueh Lan, Ying Yang, Wentao Yang, Terry L. Smith, Daren Shi, and Dihua Yu
Clin Cancer Res 2004 10: 6779-6788. [Abstract] [Full Text] [PDF]  

Molecular Profiling of Inflammatory Breast Cancer: Identification of a Poor-Prognosis Gene Expression Signature

Ivan Bièche, Florence Lerebours, Sengül Tozlu, Marc Espie, Michel Marty, and Rosette Lidereau
Clin Cancer Res 2004 10: 6789-6795. [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data  

Variability in the Degree of Expression of Phosphorylated IB in Chronic Lymphocytic Leukemia Cases With Nodal Involvement

Antonia Rodríguez, Nerea Martínez, Francisca I. Camacho, Elena Ruíz-Ballesteros, Patrocinio Algara, Juan-Fernando García, Javier Menárguez, Tomás Alvaro, Manuel F. Fresno, Fernando Solano, Manuela Mollejo, Carmen Martin, and Miguel A. Piris
Clin Cancer Res 2004 10: 6796-6806. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Components of the Cell Death Machine and Drug Sensitivity of the National Cancer Institute Cell Line Panel

Phyllis A. Svingen, David Loegering, Joe Rodriquez, Xue Wei Meng, Peter W. Mesner, Jr., Susan Holbeck, Anne Monks, Stan Krajewski, Dominic A. Scudiero, Edward A. Sausville, John C. Reed, Yuri A. Lazebnik, and Scott H. Kaufmann
Clin Cancer Res 2004 10: 6807-6820. [Abstract] [Full Text] [PDF]  

Induction of Thyroid Cancer Cell Apoptosis by a Novel Nuclear Factor B Inhibitor, Dehydroxymethylepoxyquinomicin

Dmitriy V. Starenki, Hiroyuki Namba, Vladimir A. Saenko, Akira Ohtsuru, Shigeto Maeda, Kazuo Umezawa, and Shunichi Yamashita
Clin Cancer Res 2004 10: 6821-6829. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

A Phase I and Pharmacodynamic Study of Fludarabine, Carboplatin, and Topotecan in Patients With Relapsed, Refractory, or High-Risk Acute Leukemia

Brenda W. Cooper, Gareth J. Veal, Tomas Radivoyevitch, Michael J. Tilby, Howard J. Meyerson, Hillard M. Lazarus, Omer N. Koc, Richard J. Creger, Graham Pearson, Geoff M. Nowell, David Gosky, Stephen T. Ingalls, Charles L. Hoppel, and Stanton L. Gerson
Clin Cancer Res 2004 10: 6830-6839. [Abstract] [Full Text] [PDF]  

Effects of ₁-Acid Glycoprotein on the Clinical Pharmacokinetics of 7-Hydroxystaurosporine

Alex Sparreboom, Huachen Chen, Milin R. Acharya, Adrian M. Senderowicz, Richard A. Messmann, Takashi Kuwabara, David J. Venzon, Anthony J. Murgo, Donna Headlee, Edward A. Sausville, and William D. Figg
Clin Cancer Res 2004 10: 6840-6846. [Abstract] [Full Text] [PDF]  

Phase I Clinical Trial of Oral Curcumin: Biomarkers of Systemic Activity and Compliance

Ricky A. Sharma, Stephanie A. Euden, Sharon L. Platton, Darren N. Cooke, Aisha Shafayat, Heather R. Hewitt, Timothy H. Marczylo, Bruno Morgan, David Hemingway, Simon M. Plummer, Munir Pirmohamed, Andreas J. Gescher, and William P. Steward
Clin Cancer Res 2004 10: 6847-6854. [Abstract] [Full Text] [PDF]  

Effects of Recombinant Erythropoietin in Palliative Treatment of Unselected Cancer Patients

Elisabet Lindholm, Peter Daneryd, Ulla Körner, Anders Hyltander, Marita Fouladiun, and Kent Lundholm
Clin Cancer Res 2004 10: 6855-6864. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Phospho-Akt Overexpression in Non–Small Cell Lung Cancer Confers Significant Stage-Independent Survival Disadvantage

Odile David, James Jett, Helena LeBeau, Grace Dy, Janet Hughes, Mitchell Friedman, and Arnold R. Brody
Clin Cancer Res 2004 10: 6865-6871. [Abstract] [Full Text] [PDF]  

Modulation of Pulmonary Leukotriene B₄ Production by Cyclooxygenase-2 Inhibitors and Lipopolysaccharide

Jenny T. Mao, I-Hsien Tsu, Steven M. Dubinett, Bradley Adams, Theodore Sarafian, Felicita Baratelli, Michael D. Roth, and Kenneth J. Serio
Clin Cancer Res 2004 10: 6872-6878. [Abstract] [Full Text] [PDF]  

Induction of Endothelial Nitric Oxide Synthase Expression by Melanoma Sensitizes Endothelial Cells to Tumor Necrosis Factor-Driven Cytotoxicity

Simone Mocellin, Maurizio Provenzano, Carlo Riccardo Rossi, Pierluigi Pilati, Romano Scalerta, Mario Lise, and Donato Nitti
Clin Cancer Res 2004 10: 6879-6886. [Abstract] [Full Text] [PDF]  

Proteomic Analysis of Human Acute Leukemia Cells: Insight into Their Classification

Jiu-Wei Cui, Jie Wang, Kun He, Bao-Feng Jin, Hong-Xia Wang, Wei Li, Li-Hua Kang, Mei-Ru Hu, Hui-Yan Li, Ming Yu, Bei-fen Shen, Guan-Jun Wang, and Xue-Min Zhang
Clin Cancer Res 2004 10: 6887-6896. [Abstract] [Full Text] [PDF]  

Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases

W. Jeffrey Allard, Jeri Matera, M. Craig Miller, Madeline Repollet, Mark C. Connelly, Chandra Rao, Arjan G. J. Tibbe, Jonathan W. Uhr, and Leon W. M. M. Terstappen
Clin Cancer Res 2004 10: 6897-6904. [Abstract] [Full Text] [PDF] Supplementary Data  

Expression of Np73 Predicts Poor Prognosis in Lung Cancer

Hidetaka Uramoto, Kenji Sugio, Tsunehiro Oyama, Shoji Nakata, Kenji Ono, Masaru Morita, Keiko Funa, and Kosei Yasumoto
Clin Cancer Res 2004 10: 6905-6911. [Abstract] [Full Text] [PDF]  

Is a Lymph Node Detected by the Dye-Guided Method a True Sentinel Node in Gastric Cancer?

Hirohisa Osaka, Masakazu Yashiro, Tetsuji Sawada, Kei Katsuragi, and Kosei Hirakawa
Clin Cancer Res 2004 10: 6912-6918. [Abstract] [Full Text] [PDF]  

Lymphatic Vessel Density and Vascular Endothelial Growth Factor-C Expression Correlate with Malignant Behavior in Human Pancreatic Endocrine Tumors

Laura Rubbia-Brandt, Benoit Terris, Emile Giostra, Bertrand Dousset, Philippe Morel, and Michael S. Pepper
Clin Cancer Res 2004 10: 6919-6928. [Abstract] [Full Text] [PDF]  

Effect of Human Papillomavirus-16 Infection on CD8+ T-Cell Recognition of a Wild-Type Sequence p53_264–272 Peptide in Patients with Squamous Cell Carcinoma of the Head and Neck

Nicky Sirianni, Patrick K. Ha, Mattias Oelke, Joseph Califano, William Gooding, William Westra, Theresa L. Whiteside, Wayne M. Koch, Jonathan P. Schneck, Albert DeLeo, and Robert L. Ferris
Clin Cancer Res 2004 10: 6929-6937. [Abstract] [Full Text] [PDF]  

Concomitant Overexpression of Cyclooxygenase-2 in HER-2–Positive on Smad4-Reduced Human Gastric Carcinomas Is Associated with a Poor Patient Outcome

Hirokazu Okano, Hisashi Shinohara, Akiko Miyamoto, Kyoichi Takaori, and Nobuhiko Tanigawa
Clin Cancer Res 2004 10: 6938-6945. [Abstract] [Full Text] [PDF]  

The Spontaneous CD8⁺ T-Cell Response to HLA-A2-Restricted NY-ESO-1b Peptide in Hepatocellular Carcinoma Patients

Xiao-Ying Shang, Hong-Song Chen, Hua-Gang Zhang, Xue-Wen Pang, Huan Qiao, Ji-Run Peng, Li-Ling Qin, Ran Fei, Ming-Hui Mei, Xi-Sheng Leng, Sacha Gnjatic, Gerd Ritter, Andrew J. G. Simpson, Lloyd J. Old, and Wei-Feng Chen
Clin Cancer Res 2004 10: 6946-6955. [Abstract] [Full Text] [PDF]  

The Absence of Human Equilibrative Nucleoside Transporter 1 Is Associated with Reduced Survival in Patients With Gemcitabine-Treated Pancreas Adenocarcinoma

Jennifer Spratlin, Randeep Sangha, Darryl Glubrecht, Laith Dabbagh, James D. Young, Charles Dumontet, Carol Cass, Raymond Lai, and John R. Mackey
Clin Cancer Res 2004 10: 6956-6961. [Abstract] [Full Text] [PDF]  

HDAC6 Expression Is Correlated with Better Survival in Breast Cancer

Zhenhuan Zhang, Hiroko Yamashita, Tatsuya Toyama, Hiroshi Sugiura, Yoko Omoto, Yoshiaki Ando, Keiko Mita, Maho Hamaguchi, Shin-ichi Hayashi, and Hirotaka Iwase
Clin Cancer Res 2004 10: 6962-6968. [Abstract] [Full Text] [PDF]  

Rat Sodium Iodide Symporter for Radioiodide Therapy of Cancer

Elena Mitrofanova, Robert Unfer, Nick Vahanian, Wayne Daniels, Erica Roberson, Tatiana Seregina, Prem Seth, and Charles Link, Jr.
Clin Cancer Res 2004 10: 6969-6976. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Monitoring the Response of Orthotopic Bladder Tumors to Granulocyte Macrophage Colony-Stimulating Factor Therapy Using the Prostate-Specific Antigen Gene as a Reporter

Qinghui Wu, Kesavan Esuvaranathan, and Ratha Mahendran
Clin Cancer Res 2004 10: 6977-6984. [Abstract] [Full Text] [PDF]  

Treatment of Neuroblastoma Meningeal Carcinomatosis with Intrathecal Application of -Emitting Atomic Nanogenerators Targeting Disialo-Ganglioside GD2

Matthias Miederer, Michael R. McDevitt, Paul Borchardt, Ira Bergman, Kim Kramer, Nai-Kong V. Cheung, and David A. Scheinberg
Clin Cancer Res 2004 10: 6985-6992. [Abstract] [Full Text] [PDF]  

Effect of Rapamycin Alone and in Combination with Antiangiogenesis Therapy in an Orthotopic Model of Human Pancreatic Cancer

Susann Stephan, Kaustubh Datta, Enfeng Wang, Jinping Li, Rolf A. Brekken, Sareh Parangi, Philip E. Thorpe, and Debabrata Mukhopadhyay
Clin Cancer Res 2004 10: 6993-7000. [Abstract] [Full Text] [PDF]  

Fibrinogen-Coated Droplets of Olive Oil for Delivery of Docetaxel to a Fibrin(ogen)-Rich Ascites Form of a Murine Mammary Tumor

Charity M. Einhaus, Andrew C. Retzinger, Andre O. Perrotta, Michael D. Dentler, Abhijeet S. Jakate, Pankaj B. Desai, and Gregory S. Retzinger
Clin Cancer Res 2004 10: 7001-7010. [Abstract] [Full Text] [PDF]  

The In vitro and In vivo Effects of Re-Expressing Methylated von Hippel-Lindau Tumor Suppressor Gene in Clear Cell Renal Carcinoma with 5-Aza-2'-deoxycytidine

Wade G. Alleman, Ray L. Tabios, Gadisetti V. R. Chandramouli, Olga N. Aprelikova, Carlos Torres-Cabala, Arnulfo Mendoza, Craig Rodgers, Nikolai A. Sopko, W. Marston Linehan, and James R. Vasselli
Clin Cancer Res 2004 10: 7011-7021. [Abstract] [Full Text] [PDF]  

Troglitazone Acts on Cellular pH and DNA Synthesis through a Peroxisome Proliferator-Activated Receptor -Independent Mechanism in Breast Cancer-Derived Cell Lines

Francesco Turturro, Ellen Friday, Rocky Fowler, Diya Surie, and Tomas Welbourne
Clin Cancer Res 2004 10: 7022-7030. [Abstract] [Full Text] [PDF]  

Targeting Mammalian Target of Rapamycin Synergistically Enhances Chemotherapy-Induced Cytotoxicity in Breast Cancer Cells

Wallace H. Mondesire, Weiguo Jian, Haixia Zhang, Joe Ensor, Mien-Chie Hung, Gordon B. Mills, and Funda Meric-Bernstam
Clin Cancer Res 2004 10: 7031-7042. [Abstract] [Full Text] [PDF]  

Heteroclitic CD33 Peptide With Enhanced Anti-Acute Myeloid Leukemic Immunogenicity

Jooeun Bae, Jeffrey A. Martinson, and Hans G. Klingemann
Clin Cancer Res 2004 10: 7043-7052. [Abstract] [Full Text] [PDF]  

Recognition of Adult T-Cell Leukemia/Lymphoma Cells by CD4⁺ Helper T Lymphocytes Specific for Human T-Cell Leukemia Virus Type I Envelope Protein

Hiroya Kobayashi, Toshihiro Nagato, Mitsuru Yanai, Kensuke Oikawa, Keisuke Sato, Shoji Kimura, Masatoshi Tateno, Ryusuke Omiya, and Esteban Celis
Clin Cancer Res 2004 10: 7053-7062. [Abstract] [Full Text] [PDF]  

Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate

Kevin J. Hamblett, Peter D. Senter, Dana F. Chace, Michael M. C. Sun, Joel Lenox, Charles G. Cerveny, Kim M. Kissler, Starr X. Bernhardt, Anastasia K. Kopcha, Roger F. Zabinski, Damon L. Meyer, and Joseph A. Francisco
Clin Cancer Res 2004 10: 7063-7070. [Abstract] [Full Text] [PDF]  

HMMC-1: A Humanized Monoclonal Antibody With Therapeutic Potential Against Müllerian Duct-Related Carcinomas

Shiro Nozawa, Daisuke Aoki, Katsumi Tsukazaki, Nobuyuki Susumu, Motoko Sakayori, Nao Suzuki, Atsushi Suzuki, Rie Wakita, Makio Mukai, Yuko Egami, Kyoko Kojima-Aikawa, Isao Ishida, Frederic Belot, Ole Hindsgaul, Minoru Fukuda, and Michiko N. Fukuda
Clin Cancer Res 2004 10: 7071-7078. [Abstract] [Full Text] [PDF]  

Abrogation of Head and Neck Squamous Cell Carcinoma Growth by Epidermal Growth Factor Receptor Ligand Fused to Pseudomonas Exotoxin Transforming Growth Factor -PE38

Sufi M. Thomas, Qing Zeng, Michael W. Epperly, William E. Gooding, Ira Pastan, Qing Cheng Wang, Joel Greenberger, and Jennifer Rubin Grandis
Clin Cancer Res 2004 10: 7079-7087. [Abstract] [Full Text] [PDF]  

Bioactive Suture: A Novel Immunotherapy for Head and Neck Cancer

Terry Y. Shibuya, Sanghun Kim, Kevin Nguyen, Johnny Do, Christine E. McLaren, Kuo-Tung Li, Wen-Pin Chen, Parag Parikh, Ashish Wadhwa, Xiaolin Zi, Vincent Y. Chen, Hau-Sin Wong, William B. Armstrong, and George H. Yoo
Clin Cancer Res 2004 10: 7088-7099. [Abstract] [Full Text] [PDF]  

Aberrant Methylation of DPYD Promoter, DPYD Expression, and Cellular Sensitivity to 5-Fluorouracil in Cancer Cells

Takuya Noguchi, Keiji Tanimoto, Tatsushi Shimokuni, Kei Ukon, Hiroaki Tsujimoto, Masakazu Fukushima, Tsuyoshi Noguchi, Katsunobu Kawahara, Keiko Hiyama, and Masahiko Nishiyama
Clin Cancer Res 2004 10: 7100-7107. [Abstract] [Full Text] [PDF]  

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