The Biology Behind:

More than a Marker... Phosphorylated Akt in Prostate Carcinoma

David F. Stern
Clin Cancer Res 2004 10: 6407-6410. [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

A Phase I Study of Topical Tempol for the Prevention of Alopecia Induced by Whole Brain Radiotherapy

James M. Metz, Debbie Smith, Rosemarie Mick, Robert Lustig, James Mitchell, Murali Cherakuri, Eli Glatstein, and Stephen M. Hahn
Clin Cancer Res 2004 10: 6411-6417. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Immediate Gene Expression Changes After the First Course of Neoadjuvant Chemotherapy in Patients with Primary Breast Cancer Disease

Olga Modlich, Hans-Bernd Prisack, Marc Munnes, Werner Audretsch, and Hans Bojar
Clin Cancer Res 2004 10: 6418-6431. [Abstract] [Full Text] [PDF]  

Characterization of Active Mitogen-Activated Protein Kinase in Ovarian Serous Carcinomas

Chih-Yi Hsu, Robert Bristow, Moon Seok Cha, Brant G. Wang, Chung-Liang Ho, Robert J. Kurman, Tian-Li Wang, and Ie-Ming Shih
Clin Cancer Res 2004 10: 6432-6436. [Abstract] [Full Text] [PDF]  

Proliferation Potential-Related Protein, an Ideal Esophageal Cancer Antigen for Immunotherapy, Identified Using Complementary DNA Microarray Analysis

Yoshihiro Yoshitake, Tetsuya Nakatsura, Mikio Monji, Satoru Senju, Hidetake Matsuyoshi, Hirotake Tsukamoto, Seiji Hosaka, Hiroyuki Komori, Daiki Fukuma, Yoshiaki Ikuta, Toyomasa Katagiri, Yoichi Furukawa, Hiromi Ito, Masanori Shinohara, Yusuke Nakamura, and Yasuharu Nishimura
Clin Cancer Res 2004 10: 6437-6448. [Abstract] [Full Text] [PDF]  

Centrosome Hyperamplification Predicts Progression and Tumor Recurrence in Bladder Cancer

Yoshiaki Yamamoto, Hideyasu Matsuyama, Tomoko Furuya, Atsunori Oga, Satoru Yoshihiro, Masaru Okuda, Shigeto Kawauchi, Kohsuke Sasaki, and Katsusuke Naito
Clin Cancer Res 2004 10: 6449-6455. [Abstract] [Full Text] [PDF]  

[¹⁸F]Fluoro-2-deoxy-D-glucose Positron Emission Tomography Detects Gastric Carcinoma in an Early Stage in an Asymptomatic E-Cadherin Mutation Carrier

Mariette C. A. van Kouwen, Joost P. H. Drenth, Wim J. G. Oyen, Joyce H. F. M. de Bruin, Marjolijn J. Ligtenberg, J. J. (Han) Bonenkamp, J. Han J. M. van Krieken, and Fokko M. Nagengast
Clin Cancer Res 2004 10: 6456-6459. [Abstract] [Full Text] [PDF]  

Overexpression of Matrix Metalloproteinase-1 and -9 mRNA Is Associated with Progression of Oral Dysplasia to Cancer

Richard C. K. Jordan, Maricris Macabeo-Ong, Caroline H. Shiboski, Nusi Dekker, David G. Ginzinger, David T. W. Wong, and Brian L. Schmidt
Clin Cancer Res 2004 10: 6460-6465. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Leptin Interferes with the Effects of the Antiestrogen ICI 182,780 in MCF-7 Breast Cancer Cells

Cecilia Garofalo, Diego Sisci, and Eva Surmacz
Clin Cancer Res 2004 10: 6466-6475. [Abstract] [Full Text] [PDF]  

Modulation of DNA Repair In vitro after Treatment with Chemotherapeutic Agents by the Epidermal Growth Factor Receptor Inhibitor Gefitinib (ZD1839)

Benjamin Friedmann, Martyn Caplin, John A. Hartley, and Daniel Hochhauser
Clin Cancer Res 2004 10: 6476-6486. [Abstract] [Full Text] [PDF]  

Combined Epidermal Growth Factor Receptor Targeting with the Tyrosine Kinase Inhibitor Gefitinib (ZD1839) and the Monoclonal Antibody Cetuximab (IMC-C225): Superiority Over Single-Agent Receptor Targeting

Pablo Matar, Federico Rojo, Raúl Cassia, Gema Moreno-Bueno, Serena Di Cosimo, José Tabernero, Marta Guzmán, Sonia Rodriguez, Joaquín Arribas, José Palacios, and José Baselga
Clin Cancer Res 2004 10: 6487-6501. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

A Randomized Phase IIb Trial of Pulmicort Turbuhaler (Budesonide) in People with Dysplasia of the Bronchial Epithelium

Stephen Lam, Jean C. leRiche, Annette McWilliams, Calum MacAulay, Yulia Dyachkova, Eva Szabo, John Mayo, Robert Schellenberg, Andy Coldman, Ernest Hawk, and Adi Gazdar
Clin Cancer Res 2004 10: 6502-6511. [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacokinetic Study of Col-3 (Metastat), an Oral Tetracycline Derivative with Potent Matrix Metalloproteinase and Antitumor Properties

Samira Syed, Chris Takimoto, Manuel Hidalgo, Jinee Rizzo, John G. Kuhn, Lisa A. Hammond, Garry Schwartz, Anthony Tolcher, Amita Patnaik, S. Gail Eckhardt, and Eric K. Rowinsky
Clin Cancer Res 2004 10: 6512-6521. [Abstract] [Full Text] [PDF]  

Phase I Trial of Irinotecan, Infusional 5-Fluorouracil, and Leucovorin (FOLFIRI) with Erlotinib (OSI-774): Early Termination Due To Increased Toxicities

Wells A. Messersmith, Daniel A. Laheru, Neil N. Senzer, Ross C. Donehower, Paula Grouleff, Theresa Rogers, Sean K. Kelley, David A. Ramies, Bert L. Lum, and Manuel Hidalgo
Clin Cancer Res 2004 10: 6522-6527. [Abstract] [Full Text] [PDF]  

A Phase II Study of Etanercept (Enbrel), a Tumor Necrosis Factor Inhibitor in Patients with Metastatic Breast Cancer

Srinivasan Madhusudan, Martin Foster, Sethupathi R. Muthuramalingam, Jeremy P. Braybrooke, Susan Wilner, Kulwinder Kaur, Cheng Han, Susan Hoare, Frances Balkwill, Denis C. Talbot, Trivadi S. Ganesan, and Adrian L. Harris
Clin Cancer Res 2004 10: 6528-6534. [Abstract] [Full Text] [PDF]  

No Long-Term Increase in Sperm Aneuploidy Rates after Anticancer Therapy: Sperm Fluorescence In situ Hybridization Analysis in 26 Patients Treated for Testicular Cancer or Lymphoma

Claire Thomas, Christine Cans, Roberte Pelletier, Christine De Robertis, Mira Hazzouri, Bernard Sele, Sophie Rousseaux, and Sylviane Hennebicq
Clin Cancer Res 2004 10: 6535-6543. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

The Spermatozoa Protein, SLLP1, Is a Novel Cancer–Testis Antigen in Hematologic Malignancies

Zhiqing Wang, Yana Zhang, Arabinda Mandal, Jian Zhang, Francis J. Giles, John C. Herr, and Seah H. Lim
Clin Cancer Res 2004 10: 6544-6550. [Abstract] [Full Text] [PDF]  

NY-ESO-1 Expression and Immunogenicity in Esophageal Cancer

Shoichiro Fujita, Hisashi Wada, Achim A. Jungbluth, Shuichiro Sato, Tetsuya Nakata, Yuji Noguchi, Yuichiro Doki, Masayoshi Yasui, Yurika Sugita, Takushi Yasuda, Masahiko Yano, Toshiro Ono, Yao-Tseng Chen, Masahiko Higashiyama, Sacha Gnjatic, Lloyd J. Old, Eiichi Nakayama, and Morito Monden
Clin Cancer Res 2004 10: 6551-6558. [Abstract] [Full Text] [PDF]  

Expression of the Tumor Suppressor Gene ARHI in Epithelial Ovarian Cancer Is Associated with Increased Expression of p21^WAF1/CIP1 and Prolonged Progression-Free Survival

Daniel G. Rosen, Lin Wang, Ajay N. Jain, Karen H. Lu, Robert Z. Luo, Yinhua Yu, Jinsong Liu, and Robert C. Bast, Jr.
Clin Cancer Res 2004 10: 6559-6566. [Abstract] [Full Text] [PDF]  

Expression of Hypoxia-related Tissue Factors Correlates with Diminished Survival of Adjuvantly Treated Patients with Chromosome 1p Aberrant Oligodendroglial Neoplasms and Therapeutic Implications

Peter Birner, Matthias Preusser, Ellen Gelpi, Johannes Berger, Brigitte Gatterbauer, Inge M. Ambros, Peter F. Ambros, Till Acker, Karl H. Plate, Adrian L. Harris, and Johannes A. Hainfellner
Clin Cancer Res 2004 10: 6567-6571. [Abstract] [Full Text] [PDF]  

High Levels of Phosphorylated Form of Akt-1 in Prostate Cancer and Non-Neoplastic Prostate Tissues Are Strong Predictors of Biochemical Recurrence

Gustavo Ayala, Timothy Thompson, Guang Yang, Anna Frolov, Rile Li, Peter Scardino, Makoto Ohori, Thomas Wheeler, and Wade Harper
Clin Cancer Res 2004 10: 6572-6578. [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinase-2 Status in Stromal Fibroblasts, Not in Tumor Cells, Is a Significant Prognostic Factor in Non–Small-Cell Lung Cancer

Shinya Ishikawa, Kazumasa Takenaka, Kazuhiro Yanagihara, Ryo Miyahara, Yozo Kawano, Yosuke Otake, Seiki Hasegawa, Hiromi Wada, and Fumihiro Tanaka
Clin Cancer Res 2004 10: 6579-6585. [Abstract] [Full Text] [PDF]  

Gene Expression Profiling of Differentiated Thyroid Neoplasms: Diagnostic and Clinical Implications

Sylvie Chevillard, Nicolas Ugolin, Philippe Vielh, Katherine Ory, Céline Levalois, Danielle Elliott, Gary L. Clayman, and Adel K. El-Naggar
Clin Cancer Res 2004 10: 6586-6597. [Abstract] [Full Text] [PDF]  

Overexpression of G₁-S Cyclins and Cyclin-Dependent Kinases during Multistage Human Pancreatic Duct Cell Carcinogenesis

Maamoun M. Al-Aynati, Nikolina Radulovich, James Ho, and Ming-Sound Tsao
Clin Cancer Res 2004 10: 6598-6605. [Abstract] [Full Text] [PDF]  

CD74 Is Expressed by Multiple Myeloma and Is a Promising Target for Therapy

Jack D. Burton, Scott Ely, Praveen K. Reddy, Rhona Stein, David V. Gold, Thomas M. Cardillo, and David M. Goldenberg
Clin Cancer Res 2004 10: 6606-6611. [Abstract] [Full Text] [PDF]  

Identification of Glypican-3 as a Novel Tumor Marker for Melanoma

Tetsuya Nakatsura, Toshiro Kageshita, Shosuke Ito, Kazumasa Wakamatsu, Mikio Monji, Yoshiaki Ikuta, Satoru Senju, Tomomichi Ono, and Yasuharu Nishimura
Clin Cancer Res 2004 10: 6612-6621. [Abstract] [Full Text] [PDF]  

Chemotherapy Is More Effective in Patients with Breast Cancer Not Expressing Steroid Hormone Receptors: A Study of Preoperative Treatment

Marco Colleoni, Giuseppe Viale, David Zahrieh, Giancarlo Pruneri, Oreste Gentilini, Paolo Veronesi, Richard D. Gelber, Giuseppe Curigliano, Rosalba Torrisi, Alberto Luini, Mattia Intra, Viviana Galimberti, Giuseppe Renne, Franco Nolè, Giulia Peruzzotti, and Aron Goldhirsch
Clin Cancer Res 2004 10: 6622-6628. [Abstract] [Full Text] [PDF]  

Loss of Parafibromin Immunoreactivity Is a Distinguishing Feature of Parathyroid Carcinoma

Min-Han Tan, Carl Morrison, Pengfei Wang, Ximing Yang, Carola J. Haven, Chun Zhang, Ping Zhao, Maria S. Tretiakova, Eeva Korpi-Hyovalti, John R. Burgess, Khee Chee Soo, Wei-Keat Cheah, Brian Cao, James Resau, Hans Morreau, and Bin Tean Teh
Clin Cancer Res 2004 10: 6629-6637. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Liposomal Irinotecan: Formulation Development and Therapeutic Assessment in Murine Xenograft Models of Colorectal Cancer

Corrie Lynn Messerer, Euan C. Ramsay, Dawn Waterhouse, Rebecca Ng, Eva-Maria Simms, Natashia Harasym, Paul Tardi, Lawrence D. Mayer, and Marcel B. Bally
Clin Cancer Res 2004 10: 6638-6649. [Abstract] [Full Text] [PDF]  

Influence of Casein Kinase II in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis in Human Rhabdomyosarcoma Cells

Kamel Izeradjene, Leslie Douglas, Addison Delaney, and Janet A. Houghton
Clin Cancer Res 2004 10: 6650-6660. [Abstract] [Full Text] [PDF]  

Imatinib (STI571)-Mediated Changes in Glucose Metabolism in Human Leukemia BCR-ABL-Positive Cells

Sven Gottschalk, Nora Anderson, Carsten Hainz, S. Gail Eckhardt, and Natalie J. Serkova
Clin Cancer Res 2004 10: 6661-6668. [Abstract] [Full Text] [PDF]  

Distribution of 1-(2-Deoxy-2-fluoro-ß-D-arabinofuranosyl) Uracil in Mice Bearing Colorectal Cancer Xenografts: Rationale for Therapeutic Use and as a Positron Emission Tomography Probe for Thymidylate Synthase

Julie L. Eiseman, Clive Brown-Proctor, Paul E. Kinahan, Jerry M. Collins, Lawrence W. Anderson, Erin Joseph, Deborah R. Hamburger, Su-shu Pan, Chester A. Mathis, Merrill J. Egorin, and Raymond W. Klecker
Clin Cancer Res 2004 10: 6669-6676. [Abstract] [Full Text] [PDF]  

Characterization of the Hollow Fiber Assay for the Determination of Microtubule Disruption In vivo

Marie Suggitt, David J. Swaine, George R. Pettit, and Michael C. Bibby
Clin Cancer Res 2004 10: 6677-6685. [Abstract] [Full Text] [PDF]  

A Selective c-Met Inhibitor Blocks an Autocrine Hepatocyte Growth Factor Growth Loop in ANBL-6 Cells and Prevents Migration and Adhesion of Myeloma Cells

Håkon Hov, Randi Utne Holt, Torstein Baade Rø, Unn-Merete Fagerli, Henrik Hjorth-Hansen, Vadim Baykov, James G. Christensen, Anders Waage, Anders Sundan, and Magne Børset
Clin Cancer Res 2004 10: 6686-6694. [Abstract] [Full Text] [PDF]  

Ran, a Small GTPase Gene, Encodes Cytotoxic T Lymphocyte (CTL) Epitopes Capable of Inducing HLA-A33–restricted and Tumor-Reactive CTLs in Cancer Patients

Koichi Azuma, Tetsuro Sasada, Hiroko Takedatsu, Hiroki Shomura, Makoto Koga, Yoshiaki Maeda, Akihisa Yao, Tatsuya Hirai, Arimichi Takabayashi, Shigeki Shichijo, and Kyogo Itoh
Clin Cancer Res 2004 10: 6695-6702. [Abstract] [Full Text] [PDF]  

Overexpression of 5-Lipoxygenase in Rat and Human Esophageal Adenocarcinoma and Inhibitory Effects of Zileuton and Celecoxib on Carcinogenesis

Xiaoxin Chen, Su Wang, Nan Wu, Sandeep Sood, Peng Wang, Zhe Jin, David G. Beer, Thomas J. Giordano, Yong Lin, Wei-chung J. Shih, Ronald A. Lubet, and Chung S. Yang
Clin Cancer Res 2004 10: 6703-6709. [Abstract] [Full Text] [PDF]  

Synergistic Effects of Acyclic Retinoid and OSI-461 on Growth Inhibition and Gene Expression in Human Hepatoma Cells

Masahito Shimizu, Masumi Suzui, Atsuko Deguchi, Jin T. E. Lim, Danhua Xiao, Julia H. Hayes, Kyriakos P. Papadopoulos, and I. Bernard Weinstein
Clin Cancer Res 2004 10: 6710-6721. [Abstract] [Full Text] [PDF]  

A Predictive Model of Human Myelotoxicity Using Five Camptothecin Derivatives and the In vitro Colony-Forming Unit Granulocyte/Macrophage Assay

Noriko Masubuchi, Richard D. May, and Ryo Atsumi
Clin Cancer Res 2004 10: 6722-6731. [Abstract] [Full Text] [PDF]  

Inhibition of the Type III Epidermal Growth Factor Receptor Variant Mutant Receptor by Dominant-Negative EGFR-CD533 Enhances Malignant Glioma Cell Radiosensitivity

Guido Lammering, Theodore H. Hewit, Mathew Holmes, Kristoffer Valerie, William Hawkins, Peck-Sun Lin, Ross B. Mikkelsen, and Rupert K. Schmidt-Ullrich
Clin Cancer Res 2004 10: 6732-6743. [Abstract] [Full Text] [PDF]  

Cisplatin Rapidly Down-regulates Its Own Influx Transporter hCTR1 in Cultured Human Ovarian Carcinoma Cells

Alison K. Holzer, Kuniyuki Katano, Leo W. J. Klomp, and Stephen B. Howell
Clin Cancer Res 2004 10: 6744-6749. [Abstract] [Full Text] [PDF]  

   Cancer Biology:

Sp1-Mediated Transcriptional Control of Fibroblast Growth Factor Receptor 4 in Sarcomas of Skeletal Muscle Lineage

Shun Jiang Yu, Lei Zheng, Marc Ladanyi, Sylvia L. Asa, and Shereen Ezzat
Clin Cancer Res 2004 10: 6750-6758. [Abstract] [Full Text] [PDF]  

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