Editorials:

Is the Gene Expression Pattern of Lung Cancer Detected by Screening With Spiral Computed Tomography Different from That of Symptom-Detected Lung Cancer?

James L. Mulshine and John N. Weinstein
Clin Cancer Res 2004 10: 5973-5974. [Full Text] [PDF]  

Featured Articles:

   Molecular Oncology, Markers, Clinical Correlates:

Truncating BRCA1 Mutations Are Uncommon in a Cohort of Hereditary Prostate Cancer Families with Evidence of Linkage to 17q Markers

Kimberly A. Zuhlke, Jennifer J. Madeoy, Jennifer Beebe-Dimmer, Kirsten A. White, Angela Griffin, Ethan M. Lange, Stephen B. Gruber, Elaine A. Ostrander, and Kathleen A. Cooney
Clin Cancer Res 2004 10: 5975-5980. [Abstract] [Full Text] [PDF]  

Circulating Nucleosomes Predict the Response to Chemotherapy in Patients with Advanced Non–Small Cell Lung Cancer

Stefan Holdenrieder, Petra Stieber, Joachim von Pawel, Hannelore Raith, Dorothea Nagel, Knut Feldmann, and Dietrich Seidel
Clin Cancer Res 2004 10: 5981-5987. [Abstract] [Full Text] [PDF]  

Molecular Cytogenetic Identification of Subgroups of Grade III Invasive Ductal Breast Carcinomas with Different Clinical Outcomes

Chris Jones, Emily Ford, Cheryl Gillett, Ken Ryder, Samantha Merrett, Jorge S. Reis-Filho, Laura G. Fulford, Andrew Hanby, and Sunil R. Lakhani
Clin Cancer Res 2004 10: 5988-5997. [Abstract] [Full Text] [PDF] Supplementary Data  

Hypermethylation in Histologically Distinct Classes of Breast Cancer

Young Kyung Bae, Amy Brown, Elizabeth Garrett, Daniel Bornman, Mary Jo Fackler, Saraswati Sukumar, James G. Herman, and Edward Gabrielson
Clin Cancer Res 2004 10: 5998-6005. [Abstract] [Full Text] [PDF]  

Effects of Gefitinib on Serum Epidermal Growth Factor Receptor and HER2 in Patients with Advanced Non-Small Cell Lung Cancer

Vanesa Gregorc, Giovanni Luca Ceresoli, Irene Floriani, Anna Spreafico, Katia Bruna Bencardino, Vienna Ludovini, Lorenza Pistola, Zhasmina Mihaylova, Francesca Romana Tofanetti, Massimiliano Ferraldeschi, Valter Torri, Federico Cappuzzo, Lucio Crinò, Maurizio Tonato, and Eugenio Villa
Clin Cancer Res 2004 10: 6006-6012. [Abstract] [Full Text] [PDF]  

Comprehensive Characterization of Annexin I Alterations in Esophageal Squamous Cell Carcinoma

Nan Hu, Michael J. Flaig, Hua Su, Jian-Zhong Shou, Mark J. Roth, Wen-Jun Li, Chaoyu Wang, Alisa M. Goldstein, Guang Li, Michael R. Emmert-Buck, and Philip R. Taylor
Clin Cancer Res 2004 10: 6013-6022. [Abstract] [Full Text] [PDF]  

Lung Cancers Detected by Screening with Spiral Computed Tomography Have a Malignant Phenotype when Analyzed by cDNA Microarray

Fabrizio Bianchi, Jiangting Hu, Giuseppe Pelosi, Rosalia Cirincione, Mary Ferguson, Cathy Ratcliffe, Pier Paolo Di Fiore, Kevin Gatter, Francesco Pezzella, and Ugo Pastorino
Clin Cancer Res 2004 10: 6023-6028. [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Prediction of Response to 5-Fluorouracil and Interferon- Combination Chemotherapy in Advanced Hepatocellular Carcinoma

Yukinori Kurokawa, Ryo Matoba, Hiroaki Nagano, Masato Sakon, Ichiro Takemasa, Shoji Nakamori, Keizo Dono, Koji Umeshita, Noriko Ueno, Shin Ishii, Kikuya Kato, and Morito Monden
Clin Cancer Res 2004 10: 6029-6038. [Abstract] [Full Text] [PDF]  

Mammaglobin Expression in Leukapheresis Products Is a Predictive Marker of Poor Prognosis in Women with High-Risk Breast Cancer

Pier Francesco Ferrucci, Cristina Rabascio, Chiara Mazzetta, Emilia Cocorocchio, Alberto Agazzi, Anna Vanazzi, Saverio Cinieri, Fedro A. Peccatori, Mara Paolucci, Francesco Bertolini, and Giovanni Martinelli
Clin Cancer Res 2004 10: 6039-6046. [Abstract] [Full Text] [PDF]  

Identification of a Novel Human Cancer/Testis Antigen, KM-HN-1, Recognized by Cellular and Humoral Immune Responses

Mikio Monji, Tetsuya Nakatsura, Satoru Senju, Yoshihiro Yoshitake, Motohiro Sawatsubashi, Masanori Shinohara, Toshiro Kageshita, Tomomichi Ono, Akira Inokuchi, and Yasuharu Nishimura
Clin Cancer Res 2004 10: 6047-6057. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Low-Dose Suramin Enhanced Paclitaxel Activity in Chemotherapy-Naïve and Paclitaxel-Pretreated Human Breast Xenograft Tumors

SaeHeum Song, Bei Yu, Yong Wei, M. Guillaume Wientjes, and Jessie L.-S. Au
Clin Cancer Res 2004 10: 6058-6065. [Abstract] [Full Text] [PDF]  

Enhancement of Xenograft Tumor Radiosensitivity by the Histone Deacetylase Inhibitor MS-275 and Correlation with Histone Hyperacetylation

Kevin Camphausen, Tamalee Scott, Mary Sproull, and Philip J. Tofilon
Clin Cancer Res 2004 10: 6066-6071. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Cyclophosphamide Dose Intensification during Induction Therapy for Intermediate-Risk Pediatric Rhabdomyosarcoma Is Feasible but Does Not Improve Outcome: A Report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group

Sheri L. Spunt, Lynette M. Smith, Frederick B. Ruymann, Stephen J. Qualman, Sarah S. Donaldson, David A. Rodeberg, James R. Anderson, William M. Crist, and Michael P. Link
Clin Cancer Res 2004 10: 6072-6079. [Abstract] [Full Text] [PDF]  

Sequential Intraperitoneal Topotecan and Oral Etoposide Chemotherapy in Recurrent Platinum-Resistant Ovarian Carcinoma: Results of a Phase II Trial

Anil K. Sood, Richard Lush, John P. Geisler, Mark S. Shahin, Linda Sanders, Dan Sullivan, Richard E. Buller, and Joel I. Sorosky
Clin Cancer Res 2004 10: 6080-6085. [Abstract] [Full Text] [PDF]  

A Phase I/II Study of LY900003, an Antisense Inhibitor of Protein Kinase C-, in Combination with Cisplatin and Gemcitabine in Patients with Advanced Non–Small Cell Lung Cancer

Miguel A. Villalona-Calero, Paul Ritch, Jose A. Figueroa, Gregory A. Otterson, Robert Belt, Edward Dow, Sebastian George, James Leonardo, Spence McCachren, G. Lance Miller, Manuel Modiano, Manuel Valdivieso, Richard Geary, Jennifer W. Oliver, and Jon Holmlund
Clin Cancer Res 2004 10: 6086-6093. [Abstract] [Full Text] [PDF]  

Vaccination of Patients with Small-Cell Lung Cancer with Synthetic Fucosyl GM-1 Conjugated to Keyhole Limpet Hemocyanin

Lee M. Krug, Govind Ragupathi, Chandra Hood, Mark G. Kris, Vincent A. Miller, Jennifer R. Allen, Stacy J. Keding, Samuel J. Danishefsky, Jorge Gomez, Leslie Tyson, Barbara Pizzo, Valerie Baez, and Philip O. Livingston
Clin Cancer Res 2004 10: 6094-6100. [Abstract] [Full Text] [PDF]  

Combination Immunotherapy of B-Cell Non-Hodgkin’s Lymphoma with Rituximab and Interleukin-2: A Preclinical and Phase I Study

Charles F. Eisenbeis, Andrew Grainger, Beth Fischer, Robert A. Baiocchi, Lester Carrodeguas, Sameek Roychowdhury, Lei Chen, Amy L. Banks, Thomas Davis, Donn Young, Nicole Kelbick, Julie Stephens, John C. Byrd, Michael R. Grever, Michael A. Caligiuri, and Pierluigi Porcu
Clin Cancer Res 2004 10: 6101-6110. [Abstract] [Full Text] [PDF]  

Phase II Study of the Proteasome Inhibitor Bortezomib (PS-341) in Patients with Metastatic Neuroendocrine Tumors

Manisha H. Shah, Donn Young, Hedy L. Kindler, Iain Webb, Barbara Kleiber, John Wright, and Michael Grever
Clin Cancer Res 2004 10: 6111-6118. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Value of p16^INK4a and RASSF1A Promoter Hypermethylation in Prognosis of Patients with Resectable Non–Small Cell Lung Cancer

Jie Wang, J. Jack Lee, Luo Wang, Diane D. Liu, Charles Lu, You-Hong Fan, Waun Ki Hong, and Li Mao
Clin Cancer Res 2004 10: 6119-6125. [Abstract] [Full Text] [PDF]  

Aberrant Promoter Hypermethylation of Multiple Genes in Gallbladder Carcinoma and Chronic Cholecystitis

Takao Takahashi, Narayan Shivapurkar, Erick Riquelme, Hisayuki Shigematsu, Jyotsna Reddy, Makoto Suzuki, Kuniharu Miyajima, Xian Zhou, B. Nebiyou Bekele, Adi F. Gazdar, and Ignacio I. Wistuba
Clin Cancer Res 2004 10: 6126-6133. [Abstract] [Full Text] [PDF]  

Overexpression of the Nuclear Receptor Coactivator AIB1 (SRC-3) during Progression of Pancreatic Adenocarcinoma

Ralf Thorsten Henke, Bassem R. Haddad, Sung Eun Kim, Janice Dalby Rone, Aparna Mani, John Milburn Jessup, Anton Wellstein, Anirban Maitra, and Anna Tate Riegel
Clin Cancer Res 2004 10: 6134-6142. [Abstract] [Full Text] [PDF]  

Hierarchical Clustering Analysis of Tissue Microarray Immunostaining Data Identifies Prognostically Significant Groups of Breast Carcinoma

Nikita A. Makretsov, David G. Huntsman, Torsten O. Nielsen, Erika Yorida, Michael Peacock, Maggie C. U. Cheang, Sandra E. Dunn, Malcolm Hayes, Matt van de Rijn, Chris Bajdik, and C. Blake Gilks
Clin Cancer Res 2004 10: 6143-6151. [Abstract] [Full Text] [PDF]  

Met Proto-Oncogene and Insulin-Like Growth Factor Binding Protein 3 Overexpression Correlates with Metastatic Ability in Well-Differentiated Pancreatic Endocrine Neoplasms

Donna E. Hansel, Ayman Rahman, Michael House, Raheela Ashfaq, Karin Berg, Charles J. Yeo, and Anirban Maitra
Clin Cancer Res 2004 10: 6152-6158. [Abstract] [Full Text] [PDF]  

Characterization of Mutator Phenotype in Familial Colorectal Cancer Patients Not Fulfilling Amsterdam Criteria

Jin C. Kim, Kang H. Lee, In H. Ka, Kum H. Koo, Seon A. Roh, Hee C. Kim, Chang S. Yu, Tae W. Kim, Heung M. Chang, Gyeong Y. Gong, and Jung S. Kim
Clin Cancer Res 2004 10: 6159-6168. [Abstract] [Full Text] [PDF]  

The Fibroblast Growth Factor Receptor-4 Arg³⁸⁸ Allele Is Associated with Prostate Cancer Initiation and Progression

Jianghua Wang, David W. Stockton, and Michael Ittmann
Clin Cancer Res 2004 10: 6169-6178. [Abstract] [Full Text] [PDF]  

The Antimetastatic Role of Thrombomodulin Expression in Islet Cell-Derived Tumors and Its Diagnostic Value

Satoshi Iino, Kazuhiro Abeyama, Ko-ichi Kawahara, Munekazu Yamakuchi, Teruto Hashiguchi, Sumika Matsukita, Suguru Yonezawa, Shotaro Taniguchi, Masanori Nakata, Sonshin Takao, Takashi Aikou, and Ikuro Maruyama
Clin Cancer Res 2004 10: 6179-6188. [Abstract] [Full Text] [PDF]  

Tumor Suppressor Gene Promoter Hypermethylation in Serum of Breast Cancer Patients

Essel Dulaimi, Jeanne Hillinck, Inmaculada Ibanez de Caceres, Tahseen Al-Saleem, and Paul Cairns
Clin Cancer Res 2004 10: 6189-6193. [Abstract] [Full Text] [PDF]  

The Prognostic Value of BCAR1 in Patients with Primary Breast Cancer

Lambert C. J. Dorssers, Nicolai Grebenchtchikov, Arend Brinkman, Maxime P. Look, Simone P. J. van Broekhoven, Danielle de Jong, Harry A. Peters, Henk Portengen, Marion E. Meijer-van Gelder, Jan G. M. Klijn, Doorlene T. H. van Tienoven, Anneke Geurts-Moespot, Paul N. Span, John A. Foekens, and Fred C. G. J. Sweep
Clin Cancer Res 2004 10: 6194-6202. [Abstract] [Full Text] [PDF]  

Expression of Uncoupling Protein-2 in Human Colon Cancer

Masayoshi Horimoto, Murray B. Resnick, Tamako A. Konkin, Justin Routhier, Jack R. Wands, and György Baffy
Clin Cancer Res 2004 10: 6203-6207. [Abstract] [Full Text] [PDF]  

Prognostic Significance of TP53 Tumor Suppressor Gene Expression and Mutations in Human Osteosarcoma: A Meta-Analysis

Emilios E. Pakos, Panayiotis A. Kyzas, and John P. A. Ioannidis
Clin Cancer Res 2004 10: 6208-6214. [Abstract] [Full Text] [PDF]  

p53 Expression as a Prognostic Marker in Inflammatory Breast Cancer

Ana M. Gonzalez-Angulo, Nour Sneige, Aman U. Buzdar, Vicente Valero, Shu-Wan Kau, Kristine Broglio, Yuko Yamamura, Gabriel N. Hortobagyi, and Massimo Cristofanilli
Clin Cancer Res 2004 10: 6215-6221. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Antiangiogenic Therapy of Cerebral Melanoma Metastases Results in Sustained Tumor Progression via Vessel Co-Option

William P. J. Leenders, Benno Küsters, Kiek Verrijp, Cathy Maass, Pieter Wesseling, Arend Heerschap, Dirk Ruiter, Andy Ryan, and Robert de Waal
Clin Cancer Res 2004 10: 6222-6230. [Abstract] [Full Text] [PDF]  

Analysis of Antitumor Activity of an Interleukin-13 (IL-13) Receptor-Targeted Cytotoxin Composed of IL-13 Antagonist and Pseudomonas Exotoxin

Mitomu Kioi, Koji Kawakami, and Raj K. Puri
Clin Cancer Res 2004 10: 6231-6238. [Abstract] [Full Text] [PDF]  

Reversal of the Malignant Phenotype of Gastric Cancer Cells by Inhibition of RhoA Expression and Activity

Na Liu, Feng Bi, Yanglin Pan, Lijun Sun, Yan Xue, Yongquan Shi, Xuebiao Yao, Yi Zheng, and Daiming Fan
Clin Cancer Res 2004 10: 6239-6247. [Abstract] [Full Text] [PDF]  

Enhancement of the Antibody-Dependent Cellular Cytotoxicity of Low-Fucose IgG1 Is Independent of FcRIIIa Functional Polymorphism

Rinpei Niwa, Shigeki Hatanaka, Emi Shoji-Hosaka, Mikiko Sakurada, Yukari Kobayashi, Aya Uehara, Haruhiko Yokoi, Kazuyasu Nakamura, and Kenya Shitara
Clin Cancer Res 2004 10: 6248-6255. [Abstract] [Full Text] [PDF]  

Characterization of a Folate Transporter in HeLa Cells with a Low pH Optimum and High Affinity for Pemetrexed Distinct from the Reduced Folate Carrier

Yanhua Wang, Rongbao Zhao, and I. David Goldman
Clin Cancer Res 2004 10: 6256-6264. [Abstract] [Full Text] [PDF]  

Identification of the Fenretinide Metabolite 4-Oxo-Fenretinide Present in Human Plasma and Formed in Human Ovarian Carcinoma Cells through Induction of Cytochrome P450 26A1

Maria Grazia Villani, Valentina Appierto, Elena Cavadini, Manuela Valsecchi, Sandro Sonnino, Robert W. Curley, and Franca Formelli
Clin Cancer Res 2004 10: 6265-6275. [Abstract] [Full Text] [PDF]  

Supplement Articles:

Innovations and Challenges in Renal Cancer: Consensus Statement from the First International Conference

Michael B. Atkins, David E. Avigan, Ronald M. Bukowski, Richard W. Childs, Janice P. Dutcher, Tim G. Eisen, Robert A. Figlin, James H. Finke, Robert C. Flanigan, Daniel J. George, S. Nahum Goldberg, Michael S. Gordon, Othon Iliopoulos, William G. Kaelin, Jr., W. Marston Linehan, Allan Lipton, Robert J. Motzer, Andrew C. Novick, Walter M. Stadler, Bin Tean Teh, James C. Yang, and Laura King
Clin Cancer Res 2004 10: 6277S-6281S. [Full Text] [PDF]  

Genetic Basis of Cancer of the Kidney: Disease-Specific Approaches to Therapy

W. Marston Linehan, James Vasselli, Ramaprasad Srinivasan, McClellan M. Walther, Maria Merino, Peter Choyke, Cathy Vocke, Laura Schmidt, Jennifer S. Isaacs, Gladys Glenn, Jorge Toro, Berton Zbar, Donald Bottaro, and Len Neckers
Clin Cancer Res 2004 10: 6282S-6289S. [Abstract] [Full Text] [PDF]  

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney Cancer

William G. Kaelin, Jr.
Clin Cancer Res 2004 10: 6290S-6295S. [Abstract] [Full Text] [PDF]  

Molecular Markers for Early Detection of Renal Carcinoma: Investigative Approach

Steven Skates and Othon Iliopoulos
Clin Cancer Res 2004 10: 6296S-6301S. [Abstract] [Full Text] [PDF]  

Prognostic Factors for Survival of Patients with Stage IV Renal Cell Carcinoma: Memorial Sloan-Kettering Cancer Center Experience

Robert J. Motzer, Jennifer Bacik, and Madhu Mazumdar
Clin Cancer Res 2004 10: 6302S-6303S. [Abstract] [Full Text] [PDF]  

Tissue Array-Based Predictions of Pathobiology, Prognosis, and Response to Treatment for Renal Cell Carcinoma Therapy

John S. Lam, Arie S. Belldegrun, and Robert A. Figlin
Clin Cancer Res 2004 10: 6304S-6309S. [Abstract] [Full Text] [PDF]  

Prognostic Factors in Patients with Advanced Renal Cell Carcinoma: Development of an International Kidney Cancer Working Group

Ronald M. Bukowski, Sylvie Negrier, and Paul Elson
Clin Cancer Res 2004 10: 6310S-6314S. [Abstract] [Full Text] [PDF]  

Gene Expression Profiling of Renal Cell Carcinoma

Min-Han Tan, Craig G. Rogers, Jeffrey T. Cooper, Jonathon A. Ditlev, Thomas J. Maatman, Ximing Yang, Kyle A. Furge, and Bin Tean Teh
Clin Cancer Res 2004 10: 6315S-6321S. [Abstract] [Full Text] [PDF]  

Laparoscopic and Partial Nephrectomy

Andrew C. Novick
Clin Cancer Res 2004 10: 6322S-6327S. [Abstract] [Full Text] [PDF]  

Review of Radiofrequency Ablation for Renal Cell Carcinoma

Andrew Hines-Peralta and S. Nahum Goldberg
Clin Cancer Res 2004 10: 6328S-6334S. [Abstract] [Full Text] [PDF]  

Debulking Nephrectomy in Metastatic Renal Cancer

Robert C. Flanigan
Clin Cancer Res 2004 10: 6335S-6341S. [Abstract] [Full Text] [PDF]  

Update on the Role of Interleukin 2 and Other Cytokines in the Treatment of Patients with Stage IV Renal Carcinoma

Michael B. Atkins, Meredith Regan, and David McDermott
Clin Cancer Res 2004 10: 6342S-6346S. [Abstract] [Full Text] [PDF]  

Dendritic Cell-Tumor Fusion Vaccines for Renal Cell Carcinoma

David Avigan
Clin Cancer Res 2004 10: 6347S-6352S. [Abstract] [Full Text] [PDF]  

Nonmyeloablative Transplantation: An Allogeneic-Based Immunotherapy for Renal Cell Carcinoma

Yoshiyuki Takahashi and Richard W. Childs
Clin Cancer Res 2004 10: 6353S-6359S. [Abstract] [Full Text] [PDF]  

Effect of Renal Cell Carcinomas on the Development of Type 1 T-Cell Responses

Patricia Rayman, Amy K. Wesa, Amy L. Richmond, Tanya Das, Kaushik Biswas, Gira Raval, Walter J. Storkus, Charles Tannenbaum, Andrew Novick, Ronald Bukowski, and James Finke
Clin Cancer Res 2004 10: 6360S-6366S. [Abstract] [Full Text] [PDF]  

Bevacizumab for Patients with Metastatic Renal Cancer: An Update

James C. Yang
Clin Cancer Res 2004 10: 6367S-6370S. [Abstract] [Full Text] [PDF]  

Tyrosine Kinase Inhibitors in Renal Cell Carcinoma

Anil Potti and Daniel J. George
Clin Cancer Res 2004 10: 6371S-6376S. [Abstract] [Full Text] [PDF]  

Novel Antiangiogenic Therapies for Renal Cell Cancer

Michael S. Gordon
Clin Cancer Res 2004 10: 6377S-6381S. [Abstract] [Full Text] [PDF]  

Mammalian Target of Rapamycin Inhibition

Janice P. Dutcher
Clin Cancer Res 2004 10: 6382S-6387S. [Abstract] [Full Text] [PDF]  

Kinase Inhibition with BAY 43–9006 in Renal Cell Carcinoma

Tanya Ahmad and Tim Eisen
Clin Cancer Res 2004 10: 6388S-6392S. [Abstract] [Full Text] [PDF]  

Therapeutic Options for Variant Renal Cancer: A True Orphan Disease

Walter M. Stadler
Clin Cancer Res 2004 10: 6393S-6396S. [Abstract] [Full Text] [PDF]  

Skeletal Complications in Patients with Bone Metastases from Renal Cell Carcinoma and Therapeutic Benefits of Zoledronic Acid

Allan Lipton, Alejandro Colombo-Berra, Ronald M. Bukowski, Lee Rosen, Ming Zheng, and Gladys Urbanowitz
Clin Cancer Res 2004 10: 6397S-6403S. [Abstract] [Full Text] [PDF]  

CME Assessment Test

Clin Cancer Res 2004 10: 6404S-6405S. [Full Text] [PDF]  

Registration and Evaluation Form

Clin Cancer Res 2004 10: 6406S. [Full Text] [PDF]  

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