Editorials:

Fritz H. Schröder and Monique J. Roobol

Detection Characteristics in Randomized Prostate Screening
Clin Cancer Res 2004 10: 5641-5642. [Full Text] [PDF]  

Review:

Scott R. Plotkin, Rebecca A. Betensky, Fred H. Hochberg, Stuart A. Grossman, Glenn J. Lesser, L. Burt Nabors, Brian Chon, and Tracy T. Batchelor

Treatment of Relapsed Central Nervous System Lymphoma with High-Dose Methotrexate
Clin Cancer Res 2004 10: 5643-5646. [Abstract] [Full Text] [PDF]  

The Biology Behind:

James F. Holland and Beatriz G. T. Pogo

Mouse Mammary Tumor Virus-Like Viral Infection and Human Breast Cancer
Clin Cancer Res 2004 10: 5647-5649. [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Roberto Gennari, Sylvie Menard, Francesco Fagnoni, Luisa Ponchio, Mario Scelsi, Elda Tagliabue, Fabio Castiglioni, Laura Villani, Cesare Magalotti, Nadia Gibelli, Barbara Oliviero, Bettina Ballardini, Gianantonio Da Prada, Alberto Zambelli, and Alberto Costa

Pilot Study of the Mechanism of Action of Preoperative Trastuzumab in Patients with Primary Operable Breast Tumors Overexpressing HER2
Clin Cancer Res 2004 10: 5650-5655. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Polly R. Etkind, Alexandre F. R. Stewart, Thambi Dorai, Daniel J. Purcell, and Peter H. Wiernik

Clonal Isolation of Different Strains of Mouse Mammary Tumor Virus-Like DNA Sequences from Both the Breast Tumors and Non-Hodgkin’s Lymphomas of Individual Patients Diagnosed with Both Malignancies
Clin Cancer Res 2004 10: 5656-5664. [Abstract] [Full Text] [PDF]  

Benjamin Besse, Céline Candé, Jean-Philippe Spano, Antoine Martin, David Khayat, Thierry Le Chevalier, Thomas Tursz, Laure Sabatier, Jean-Charles Soria, and Guido Kroemer

Nuclear Localization of Apoptosis Protease Activating Factor-1 Predicts Survival after Tumor Resection in Early-Stage Non–Small Cell Lung Cancer
Clin Cancer Res 2004 10: 5665-5669. [Abstract] [Full Text] [PDF]  

Grazia Arpino, Stephanie J. Green, D. Craig Allred, Dannika Lew, Silvana Martino, C. Kent Osborne, and Richard M. Elledge

HER-2 Amplification, HER-1 Expression, and Tamoxifen Response in Estrogen Receptor-Positive Metastatic Breast Cancer: A Southwest Oncology Group Study
Clin Cancer Res 2004 10: 5670-5676. [Abstract] [Full Text] [PDF]  

George A. Mashour, Pablo Hernáiz Driever, Melanie Hartmann, Stephanie N. Drissel, Tingguo Zhang, Bianca Scharf, Ursula Felderhoff-Müser, Sadatoshi Sakuma, Reinhard E. Friedrich, Robert L. Martuza, Victor Felix Mautner, and Andreas Kurtz

Circulating Growth Factor Levels Are Associated with Tumorigenesis in Neurofibromatosis Type 1
Clin Cancer Res 2004 10: 5677-5683. [Abstract] [Full Text] [PDF]  

Paul M. Weinberger, Z. Yu, B.G. Haffty, D. Kowalski, M. Harigopal, C. Sasaki, D. L. Rimm, and A. Psyrri

Prognostic Significance of p16 Protein Levels in Oropharyngeal Squamous Cell Cancer
Clin Cancer Res 2004 10: 5684-5691. [Abstract] [Full Text] [PDF]  

Ann M. Dring, Faith E. Davies, James A. L. Fenton, Philippa L. Roddam, Kathryn Scott, David Gonzalez, Sara Rollinson, Andrew C. Rawstron, Karen S. Rees-Unwin, Cheng Li, Nikhil C. Munshi, Kenneth C. Anderson, and Gareth J. Morgan

A Global Expression-based Analysis of the Consequences of the t(4;14) Translocation in Myeloma
Clin Cancer Res 2004 10: 5692-5701. [Abstract] [Full Text] [PDF]  

Keiji Yoshinaga, Hiroshi Inoue, Tohru Utsunomiya, Hideto Sonoda, Takaaki Masuda, Koshi Mimori, Yoichi Tanaka, and Masaki Mori

N-Cadherin Is Regulated by Activin A and Associated with Tumor Aggressiveness in Esophageal Carcinoma
Clin Cancer Res 2004 10: 5702-5707. [Abstract] [Full Text] [PDF]  

Jules Lin, Lin Lin, Dafydd G. Thomas, Joel K. Greenson, Thomas J. Giordano, Gregory S. Robinson, Ruteja A. Barve, Frank A. Weishaar, Jeremy M. G. Taylor, Mark B. Orringer, and David G. Beer

Melanoma-Associated Antigens in Esophageal Adenocarcinoma: Identification of Novel MAGE-A10 Splice Variants
Clin Cancer Res 2004 10: 5708-5716. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Paul E. Goss, Shangle Qi, Angela M. Cheung, Haiqing Hu, Maria Mendes, and Kenneth P. H. Pritzker

Effects of the Steroidal Aromatase Inhibitor Exemestane and the Nonsteroidal Aromatase Inhibitor Letrozole on Bone and Lipid Metabolism in Ovariectomized Rats
Clin Cancer Res 2004 10: 5717-5723. [Abstract] [Full Text] [PDF]  

Michael Hagan, Adly Yacoub, and Paul Dent

Ionizing Radiation Causes a Dose-Dependent Release of Transforming Growth Factor In vitro from Irradiated Xenografts and during Palliative Treatment of Hormone-Refractory Prostate Carcinoma
Clin Cancer Res 2004 10: 5724-5731. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

John V. Heymach, Jayesh Desai, Judith Manola, Darren W. Davis, David J. McConkey, David Harmon, David P. Ryan, Geraldine Goss, Travis Quigley, Annick D. Van den Abbeele, Stuart G. Silverman, Susan Connors, Judah Folkman, Christopher D. M. Fletcher, and George D. Demetri

Phase II Study of the Antiangiogenic Agent SU5416 in Patients with Advanced Soft Tissue Sarcomas
Clin Cancer Res 2004 10: 5732-5740. [Abstract] [Full Text] [PDF]  

Reiko Imai, Tadashi Kamada, Hiroshi Tsuji, Takeshi Yanagi, Masayuki Baba, Tadaaki Miyamoto, Shingo Kato, Susumu Kandatsu, Jun-etsu Mizoe, Hirohiko Tsujii, and Shin-ichiro Tatezaki

Carbon Ion Radiotherapy for Unresectable Sacral Chordomas
Clin Cancer Res 2004 10: 5741-5746. [Abstract] [Full Text] [PDF]  

Arno J. Mundt, Srinivasan Vijayakumar, John Nemunaitis, Alan Sandler, Herbert Schwartz, Nader Hanna, Terrence Peabody, Neil Senzer, Karen Chu, Camilla S. Rasmussen, Paul D. Kessler, Henrik S. Rasmussen, Michael Warso, Donald W. Kufe, Tapas Das Gupta, and Ralph R. Weichselbaum

A Phase I Trial of TNFerade Biologic in Patients with Soft Tissue Sarcoma in the Extremities
Clin Cancer Res 2004 10: 5747-5753. [Abstract] [Full Text] [PDF]  

Chau T. Dang, Gabriella M. D’Andrea, Mary E. Moynahan, Maura N. Dickler, Andrew D. Seidman, Monica Fornier, Mark E. Robson, Maria Theodoulou, Diana Lake, Violante E. Currie, Arti Hurria, Katherine S. Panageas, Larry Norton, and Clifford A. Hudis

Phase II Study of Feasibility of Dose-Dense FEC Followed by Alternating Weekly Taxanes in High-Risk, Four or More Node-Positive Breast Cancer
Clin Cancer Res 2004 10: 5754-5761. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Christopher B. Umbricht, George T. Conrad, Douglas P. Clark, William H. Westra, Dañelle C. Smith, Marianna Zahurak, Motoyasu Saji, Robert C. Smallridge, Steven Goodman, and Martha A. Zeiger

Human Telomerase Reverse Transcriptase Gene Expression and the Surgical Management of Suspicious Thyroid Tumors
Clin Cancer Res 2004 10: 5762-5768. [Abstract] [Full Text] [PDF]  

Majida Esslimani-Sahla, Joelle Simony-Lafontaine, Andrew Kramar, Roselyne Lavaill, Caroline Mollevi, Margaret Warner, Jan-Åke Gustafsson, and Henri Rochefort

Estrogen Receptor ß (ERß) Level but Not Its ERßcx Variant Helps to Predict Tamoxifen Resistance in Breast Cancer
Clin Cancer Res 2004 10: 5769-5776. [Abstract] [Full Text] [PDF]  

Samuel B. Ho, Ann Hyslop, Richard Albrecht, Amanda Jacobson, Michael Spencer, David A. Rothenberger, Gloria A. Niehans, John D’Cunha, and Robert A. Kratzke

Quantification of Colorectal Cancer Micrometastases in Lymph Nodes by Nested and Real-Time Reverse Transcriptase-PCR Analysis for Carcinoembryonic Antigen
Clin Cancer Res 2004 10: 5777-5784. [Abstract] [Full Text] [PDF]  

Carmen Rodriguez, Luke Hughes-Davies, Hélène Vallès, Béatrice Orsetti, Marguerite Cuny, Lisa Ursule, Tony Kouzarides, and Charles Theillet

Amplification of the BRCA2 Pathway Gene EMSY in Sporadic Breast Cancer Is Related to Negative Outcome
Clin Cancer Res 2004 10: 5785-5791. [Abstract] [Full Text] [PDF]  

Pornchai O-charoenrat, Valerie Rusch, Simon G. Talbot, Inderpal Sarkaria, Agnes Viale, Nicholas Socci, Ivan Ngai, Pulivarthi Rao, and Bhuvanesh Singh

Casein Kinase II Alpha Subunit and C1-Inhibitor Are Independent Predictors of Outcome in Patients with Squamous Cell Carcinoma of the Lung
Clin Cancer Res 2004 10: 5792-5803. [Abstract] [Full Text] [PDF]  

Tetsuji Yamamoto, Toshihiro Akisue, Takashi Marui, Ikuo Fujita, Keiji Matsumoto, Toshiaki Hitora, Teruya Kawamoto, Keiko Nagira, Tetsuya Nakatani, and Masahiro Kurosaka

Expression of Transforming Growth Factor ß Isoforms and Their Receptors in Malignant Fibrous Histiocytoma of Soft Tissues
Clin Cancer Res 2004 10: 5804-5807. [Abstract] [Full Text] [PDF]  

Ralf Kurek, German Nunez, Nikolaos Tselis, Lutz Konrad, Thomas Martin, Sandra Roeddiger, Gerd Aumüller, Nikolaos Zamboglou, Daniel W. Lin, Ulf W. Tunn, and Heiner Renneberg

Prognostic Value of Combined "Triple"-Reverse Transcription-PCR Analysis for Prostate-Specific Antigen, Human Kallikrein 2, and Prostate-Specific Membrane Antigen mRNA in Peripheral Blood and Lymph Nodes of Prostate Cancer Patients
Clin Cancer Res 2004 10: 5808-5814. [Abstract] [Full Text] [PDF]  

Colette Charpin, Jean-Philippe Dales, Stéphane Garcia, Séverine Carpentier, Amina Djemli, Lucile Andrac, Marie-Noëlle Lavaut, Claude Allasia, and Pascal Bonnier

Tumor Neoangiogenesis by CD31 and CD105 Expression Evaluation in Breast Carcinoma Tissue Microarrays
Clin Cancer Res 2004 10: 5815-5819. [Abstract] [Full Text] [PDF]  

Cherie-Ann O. Nathan, Nazanin Amirghahari, Fleurette Abreo, Xiaohua Rong, Gloria Caldito, M. Lamar Jones, Huijuan Zhou, Melanie Smith, Donnellan Kimberly, and Jonathan Glass

Overexpressed eIF4E Is Functionally Active in Surgical Margins of Head and Neck Cancer Patients via Activation of the Akt/Mammalian Target of Rapamycin Pathway
Clin Cancer Res 2004 10: 5820-5827. [Abstract] [Full Text] [PDF]  

Shigeki Shichijo, Kouichi Azuma, Nobukazu Komatsu, Masaaki Ito, Yoshiaki Maeda, Yuki Ishihara, and Kyogo Itoh

Two Proliferation-Related Proteins, TYMS and PGK1, Could Be New Cytotoxic T Lymphocyte-Directed Tumor-Associated Antigens of HLA-A2⁺ Colon Cancer
Clin Cancer Res 2004 10: 5828-5836. [Abstract] [Full Text] [PDF]  

Xao X. Tang, Marjorie E. Robinson, Justin S. Riceberg, David Y. Kim, Bing Kung, Tracy B. Titus, Satoshi Hayashi, Alan W. Flake, David Carpentieri, and Naohiko Ikegaki

Favorable Neuroblastoma Genes and Molecular Therapeutics of Neuroblastoma
Clin Cancer Res 2004 10: 5837-5844. [Abstract] [Full Text] [PDF]  

J. Shawn Jones, Xuedong Chi, Xiangjun Gu, Patrick M. Lynch, Christopher I. Amos, and Marsha L. Frazier

p53 Polymorphism and Age of Onset of Hereditary Nonpolyposis Colorectal Cancer in a Caucasian Population
Clin Cancer Res 2004 10: 5845-5849. [Abstract] [Full Text] [PDF]  

Hiroki Utsunomiya, Kiyoshi Ito, Takashi Suzuki, Takako Kitamura, Chika Kaneko, Taisuke Nakata, Hitoshi Niikura, Kunihiro Okamura, Nobuo Yaegashi, and Hironobu Sasano

Steroid Sulfatase and Estrogen Sulfotransferase in Human Endometrial Carcinoma
Clin Cancer Res 2004 10: 5850-5856. [Abstract] [Full Text] [PDF]  

Paola Granelli, Monica Cattaneo, Stefano Ferrero, Luca Bottiglieri, Silvano Bosari, Giuseppe Fichera, and Ida Biunno

SEL1L and Squamous Cell Carcinoma of the Esophagus
Clin Cancer Res 2004 10: 5857-5861. [Abstract] [Full Text] [PDF]  

Constance L. Monitto, Seung-Myung Dong, Jin Jen, and David Sidransky

Characterization of a Human Homologue of Proteolysis-Inducing Factor and Its Role in Cancer Cachexia
Clin Cancer Res 2004 10: 5862-5869. [Abstract] [Full Text] [PDF]  

Patrick A. Adegboyega, Omiyosoye Ololade, Jamal Saada, Randy Mifflin, John F. Di Mari, and Don W. Powell

Subepithelial Myofibroblasts Express Cyclooxygenase-2 in Colorectal Tubular Adenomas
Clin Cancer Res 2004 10: 5870-5879. [Abstract] [Full Text] [PDF]  

Thierry Lecomte, Jean-Marc Ferraz, Franck Zinzindohoué, Marie-Anne Loriot, David-Alexandre Tregouet, Bruno Landi, Anne Berger, Paul-Henri Cugnenc, Raymond Jian, Philippe Beaune, and Pierre Laurent-Puig

Thymidylate Synthase Gene Polymorphism Predicts Toxicity in Colorectal Cancer Patients Receiving 5-Fluorouracil-based Chemotherapy
Clin Cancer Res 2004 10: 5880-5888. [Abstract] [Full Text] [PDF]  

Floris A. de Jong, Sharon Marsh, Ron H. J. Mathijssen, Cristi King, Jaap Verweij, Alex Sparreboom, and Howard L. McLeod

ABCG2 Pharmacogenetics: Ethnic Differences in Allele Frequency and Assessment of Influence on Irinotecan Disposition
Clin Cancer Res 2004 10: 5889-5894. [Abstract] [Full Text] [PDF]  

Stefania Gessi, Elena Cattabriga, Arianna Avitabile, Roberta Gafa’, Giovanni Lanza, Luigi Cavazzini, Nicoletta Bianchi, Roberto Gambari, Carlo Feo, Alberto Liboni, Sergio Gullini, Edward Leung, Stephen Mac-Lennan, and Pier Andrea Borea

Elevated Expression of A₃ Adenosine Receptors in Human Colorectal Cancer Is Reflected in Peripheral Blood Cells
Clin Cancer Res 2004 10: 5895-5901. [Abstract] [Full Text] [PDF]  

Leigh C. Murphy, Yulian Niu, Linda Snell, and Peter Watson

Phospho-Serine-118 Estrogen Receptor- Expression Is Associated with Better Disease Outcome in Women Treated with Tamoxifen
Clin Cancer Res 2004 10: 5902-5906. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Eiji Suzuki, Veena Kapoor, H.-Kam Cheung, Leona E. Ling, Peter A. DeLong, Larry R. Kaiser, and Steven M. Albelda

Soluble Type II Transforming Growth Factor-ß Receptor Inhibits Established Murine Malignant Mesothelioma Tumor Growth by Augmenting Host Antitumor Immunity
Clin Cancer Res 2004 10: 5907-5918. [Abstract] [Full Text] [PDF]  

Omar I. Abdel-Wahab, Elizabeth Grubbs, Benjamin L. Viglianti, Tsung-Yen Cheng, Tomio Ueno, SaeHee Ko, Zahid Rabbani, Simon Curtis, Scott K. Pruitt, Mark W. Dewhirst, and Doug S. Tyler

The Role of Hyperthermia in Regional Alkylating Agent Chemotherapy
Clin Cancer Res 2004 10: 5919-5929. [Abstract] [Full Text] [PDF]  

Zhuo Chen, Xin Zhang, Mengfeng Li, Zhiqiang Wang, H. Samuel Wieand, Jennifer R. Grandis, and Dong M. Shin

Simultaneously Targeting Epidermal Growth Factor Receptor Tyrosine Kinase and Cyclooxygenase-2, an Efficient Approach to Inhibition of Squamous Cell Carcinoma of the Head and Neck
Clin Cancer Res 2004 10: 5930-5939. [Abstract] [Full Text] [PDF]  

Yasumichi Kuwahara, Hajime Hosoi, Shinya Osone, Masakazu Kita, Tomoko Iehara, Hiroshi Kuroda, and Tohru Sugimoto

Antitumor Activity of Gefitinib in Malignant Rhabdoid Tumor Cells In vitro and In vivo
Clin Cancer Res 2004 10: 5940-5948. [Abstract] [Full Text] [PDF]  

Francisco Chung, Jun Lu, Brian D. Palmer, Philip Kestell, Peter Browett, Bruce C. Baguley, Malcolm Tingle, and Lai-Ming Ching

Thalidomide Pharmacokinetics and Metabolite Formation in Mice, Rabbits, and Multiple Myeloma Patients
Clin Cancer Res 2004 10: 5949-5956. [Abstract] [Full Text] [PDF]  

Rosana B. Michel, Mary Ellen Castillo, Philip M. Andrews, and M. Jules Mattes

In vitro Toxicity of A-431 Carcinoma Cells with Antibodies to Epidermal Growth Factor Receptor and Epithelial Glycoprotein-1 Conjugated to Radionuclides Emitting Low-Energy Electrons
Clin Cancer Res 2004 10: 5957-5966. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Mary Varterasian, Howard Fingert, Marilyn Agin, Mark Meyer, Matthew Cooney, Tomas Radivoyevitch, Afshin Dowlati, Beth Overmoyer, Nathan Levitan, Kelly Robertson, Scot C. Remick, and Bruce S. Stambler

Consideration of QT/QTc Interval Data in a Phase I Study in Patients with Advanced Cancer
Clin Cancer Res 2004 10: 5967-5969. [Full Text] [PDF]  

Jeremy R. Jass, Gary J. Kelloff, and Richard L. Schilsky

Limitations of the Adenoma–Carcinoma Sequence in Colorectum
Clin Cancer Res 2004 10: 5969-5970. [Full Text] [PDF]  

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