Editorials:

Developing New Monoclonal Antibodies for Aggressive Lymphoma: A Challenging Road in the Rituximab Era

Jonathan W. Friedberg
Clin Cancer Res 2004 10: 5297-5298. [Full Text] [PDF]  

Review:

Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Cancer

Roland L. Chu, Dawn E. Post, Fadlo R. Khuri, and Erwin G. Van Meir
Clin Cancer Res 2004 10: 5299-5312. [Abstract] [Full Text] [PDF]  

The Biology Behind:

Arzoxifene: A Promising New Selective Estrogen Receptor Modulator for Clinical Chemoprevention of Breast Cancer: Commentary re C. J. Fabian et al., Breast Cancer Chemoprevention Phase I Evaluation of Biomarker Modulation by Arzoxifene, a Third Generation Selective Estrogen Receptor Modulator. Clin Cancer Res 2004;10:5403–17.

Michael B. Sporn
Clin Cancer Res 2004 10: 5313-5315. [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Clinical Responsiveness of Glioblastoma Multiforme to Chemotherapy after Vaccination

Christopher J. Wheeler, Asha Das, Gentao Liu, John S. Yu, and Keith L. Black
Clin Cancer Res 2004 10: 5316-5326. [Abstract] [Full Text] [PDF]  

Epratuzumab, a Humanized Anti-CD22 Antibody, in Aggressive Non-Hodgkin’s Lymphoma: Phase I/II Clinical Trial Results

John P. Leonard, Morton Coleman, Jamie C. Ketas, Amy Chadburn, Richard Furman, Michael W. Schuster, Eric J. Feldman, Michelle Ashe, Stephen J. Schuster, William A. Wegener, Hans J. Hansen, Heather Ziccardi, Michael Eschenberg, Urte Gayko, Scott Z. Fields, Alessandra Cesano, and David M. Goldenberg
Clin Cancer Res 2004 10: 5327-5334. [Abstract] [Full Text] [PDF]  

Asparaginase Pharmacokinetics After Intensive Polyethylene Glycol-Conjugated L-Asparaginase Therapy for Children with Relapsed Acute Lymphoblastic Leukemia

Douglas S. Hawkins, Julie R. Park, Blythe G. Thomson, Judy L. Felgenhauer, John S. Holcenberg, Eduard H. Panosyan, and Vassilios I. Avramis
Clin Cancer Res 2004 10: 5335-5341. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Isolated Tumor Cells in Bone Marrow Three Years after Diagnosis in Disease-Free Breast Cancer Patients Predict Unfavorable Clinical Outcome¹

Gro Wiedswang, Elin Borgen, Rolf Kåresen, Hanne Qvist, Jan Janbu, Gunnar Kvalheim, Jahn M. Nesland, and Bjørn Naume
Clin Cancer Res 2004 10: 5342-5348. [Abstract] [Full Text] [PDF]  

Nonrandom Distribution of Aberrant Promoter Methylation of Cancer-Related Genes in Sporadic Breast Tumors

Paola Parrella, Maria Luana Poeta, Antonietta Pia Gallo, Maria Prencipe, Marina Scintu, Adolfo Apicella, Raffaele Rossiello, Giuseppina Liguoro, Davide Seripa, Carolina Gravina, Carla Rabitti, Monica Rinaldi, Theresa Nicol, Stefania Tommasi, Angelo Paradiso, Francesco Schittulli, Vittorio Altomare, and Vito Michele Fazio
Clin Cancer Res 2004 10: 5349-5354. [Abstract] [Full Text] [PDF]  

TEL Deletion Analysis Supports a Novel View of Relapse in Childhood Acute Lymphoblastic Leukemia

Jan Zuna, Anthony M. Ford, Martina Peham, Naina Patel, Vaskar Saha, Cornelia Eckert, Joachim Köchling, Renate Panzer-Grümayer, Jan Trka, and Mel Greaves
Clin Cancer Res 2004 10: 5355-5360. [Abstract] [Full Text] [PDF]  

Overexpression of Collagen XVIII Is Associated with Poor Outcome and Elevated Levels of Circulating Serum Endostatin in Non–Small Cell Lung Cancer

Toshihiko Iizasa, Hao Chang, Makoto Suzuki, Mizuto Otsuji, Sana Yokoi, Masako Chiyo, Shinichiro Motohashi, Kazuhiro Yasufuku, Yasuo Sekine, Akira Iyoda, Kiyoshi Shibuya, Kenzo Hiroshima, and Takehiko Fujisawa
Clin Cancer Res 2004 10: 5361-5366. [Abstract] [Full Text] [PDF]  

Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma

Torsten O. Nielsen, Forrest D. Hsu, Kristin Jensen, Maggie Cheang, Gamze Karaca, Zhiyuan Hu, Tina Hernandez-Boussard, Chad Livasy, Dave Cowan, Lynn Dressler, Lars A. Akslen, Joseph Ragaz, Allen M. Gown, C. Blake Gilks, Matt van de Rijn, and Charles M. Perou
Clin Cancer Res 2004 10: 5367-5374. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Effects of the Antiestrogen Tamoxifen and the Aromatase Inhibitor Letrozole on Serum Hormones and Bone Characteristics in a Preclinical Tumor Model for Breast Cancer

Nomelí P. Núñez, Danijela Jelovac, Luciana Macedo, David Berrigan, Susan N. Perkins, Stephen D. Hursting, J. Carl Barrett, and Angela Brodie
Clin Cancer Res 2004 10: 5375-5380. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Boosting T Cell-Mediated Immunity to Tyrosinase by Vaccinia Virus-Transduced, CD34⁺-Derived Dendritic Cell Vaccination: A Phase I Trial in Metastatic Melanoma

Massimo Di Nicola, Carmelo Carlo-Stella, Roberta Mortarini, Paola Baldassari, Anna Guidetti, Gian Francesco Gallino, Michele Del Vecchio, Fernando Ravagnani, Michele Magni, Paul Chaplin, Natale Cascinelli, Giorgio Parmiani, Alessandro M. Gianni, and Andrea Anichini
Clin Cancer Res 2004 10: 5381-5390. [Abstract] [Full Text] [PDF]  

Vaccination with Ep-CAM Protein or Anti-Idiotypic Antibody Induces Th1-Biased Response against MHC Class I- and II-Restricted Ep-CAM Epitopes in Colorectal Carcinoma Patients

Szilvia Mosolits, Katja Markovic, Jan-Erik Frödin, Lena Virving, Carl G. M. Magnusson, Michael Steinitz, Jan Fagerberg, and Håkan Mellstedt
Clin Cancer Res 2004 10: 5391-5402. [Abstract] [Full Text] [PDF]  

Breast Cancer Chemoprevention Phase I Evaluation of Biomarker Modulation by Arzoxifene, a Third Generation Selective Estrogen Receptor Modulator

Carol J. Fabian, Bruce F. Kimler, Julie Anderson, Ossama W. Tawfik, Matthew S. Mayo, William E. Burak, Jr., Joyce A. O’Shaughnessy, Kathy S. Albain, David M. Hyams, G. Thomas Budd, Patricia A. Ganz, Edward R. Sauter, Samuel W. Beenken, William E. Grizzle, John P. Fruehauf, Dora W. Arneson, James W. Bacus, Michael D. Lagios, Karen A. Johnson, and Doris Browne
Clin Cancer Res 2004 10: 5403-5417. [Abstract] [Full Text] [PDF]  

Phase I Study of Tirapazamine Plus Cisplatin/Etoposide and Concurrent Thoracic Radiotherapy in Limited-Stage Small Cell Lung Cancer (S0004): A Southwest Oncology Group Study

Quynh-Thu Le, Jason McCoy, Stephen Williamson, Janice Ryu, Laurie E. Gaspar, Martin J. Edelman, Shaker R. Dakhil, Stanley D. Sides, John J. Crowley, and David R. Gandara
Clin Cancer Res 2004 10: 5418-5424. [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacokinetic Study of TAS-108 in Postmenopausal Female Patients with Locally Advanced, Locally Recurrent Inoperable, or Progressive Metastatic Breast Cancer

L. Johnetta Blakely, Aman Buzdar, Hsiu-Yin Chang, Debra Frye, Richard Theriault, Vicente Valero, Edgardo Rivera, Daniel Booser, Jun Kuritani, and Masuhiro Tsuda
Clin Cancer Res 2004 10: 5425-5431. [Abstract] [Full Text] [PDF]  

Phase II Clinical Trial of Interleukin-12 in Patients with Relapsed and Refractory Non-Hodgkin’s Lymphoma and Hodgkin’s Disease

Anas Younes, Barbara Pro, Michael J. Robertson, Ian W. Flinn, Jorge E. Romaguera, Fredrick Hagemeister, Nam H. Dang, Paolo Fiumara, Evelyne M. Loyer, Fernando F. Cabanillas, Peter W. McLaughlin, Maria Alma Rodriguez, and Felipe Samaniego
Clin Cancer Res 2004 10: 5432-5438. [Abstract] [Full Text] [PDF]  

Phase II Study of Pemetrexed-Gemcitabine Combination in Patients with Advanced-Stage Non-Small Cell Lung Cancer

Christian Monnerat, Thierry Le Chevalier, Karen Kelly, Coleman K. Obasaju, Julie Brahmer, Silvia Novello, Takashi Nakamura, Astra M. Liepa, Laurence Bozec, Paul A. Bunn, Jr, and David S. Ettinger
Clin Cancer Res 2004 10: 5439-5446. [Abstract] [Full Text] [PDF]  

A Phase I Trial of the Dual Farnesyltransferase and Geranylgeranyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Pancreatic Cancer

Neil E. Martin, Thomas B. Brunner, Krystina D. Kiel, Thomas F. DeLaney, William F. Regine, Mohammed Mohiuddin, Ernest F. Rosato, Daniel G. Haller, James P. Stevenson, Debbie Smith, Barnali Pramanik, Joel Tepper, Wesley K. Tanaka, Briggs Morrison, Paul Deutsch, Anjali K. Gupta, Ruth J. Muschel, W. Gillies McKenna, Eric J. Bernhard, and Stephen M. Hahn
Clin Cancer Res 2004 10: 5447-5454. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Invasion and Metastasis of Oral Cancer Cells Require Methylation of E-Cadherin and/or Degradation of Membranous ß-Catenin

Yasusei Kudo, Shojiro Kitajima, Ikuko Ogawa, Masae Hiraoka, Soodabeh Sargolzaei, Mohammad Reza Keikhaee, Sunao Sato, Mutsumi Miyauchi, and Takashi Takata
Clin Cancer Res 2004 10: 5455-5463. [Abstract] [Full Text] [PDF]  

Using Protein Expressions to Predict Survival in Clear Cell Renal Carcinoma

Hyung L. Kim, David Seligson, Xueli Liu, Nicolette Janzen, Matthew H. T. Bui, Hong Yu, Tao Shi, Robert A. Figlin, Steve Horvath, and Arie S. Belldegrun
Clin Cancer Res 2004 10: 5464-5471. [Abstract] [Full Text] [PDF]  

Vitamin D Receptor Gene Polymorphisms and Breast Cancer Risk

Michelle Guy, Lorraine C. Lowe, Deborah Bretherton-Watt, Janine L. Mansi, Clare Peckitt, Judith Bliss, Rosalind Given Wilson, Valerie Thomas, and Kay W. Colston
Clin Cancer Res 2004 10: 5472-5481. [Abstract] [Full Text] [PDF]  

Combined Histopathological and Molecular Cytogenetic Stratification of Medulloblastoma Patients

Jayne M. Lamont, Charles S. McManamy, Andrew D. Pearson, Steven C. Clifford, and David W. Ellison
Clin Cancer Res 2004 10: 5482-5493. [Abstract] [Full Text] [PDF]  

CXC Chemokine Receptor 3 and CC Chemokine Receptor 4 Expression in T-Cell and NK-Cell Lymphomas with Special Reference to Clinicopathological Significance for Peripheral T-Cell Lymphoma, Unspecified

Takashi Ishida, Hiroshi Inagaki, Atae Utsunomiya, Yoshifusa Takatsuka, Hirokazu Komatsu, Shinsuke Iida, Genji Takeuchi, Tadaaki Eimoto, Shigeo Nakamura, and Ryuzo Ueda
Clin Cancer Res 2004 10: 5494-5500. [Abstract] [Full Text] [PDF]  

Nuclear Factor-B Is Constitutively Activated in Prostate Cancer In vitro and Is Overexpressed in Prostatic Intraepithelial Neoplasia and Adenocarcinoma of the Prostate

Christopher Sweeney, Lang Li, Rajasubramaniam Shanmugam, Poornima Bhat-Nakshatri, Vetrichelvan Jayaprakasan, Lee Ann Baldridge, Thomas Gardner, Martin Smith, Harikrishna Nakshatri, and Liang Cheng
Clin Cancer Res 2004 10: 5501-5507. [Abstract] [Full Text] [PDF]  

Conservation of Breast Cancer Molecular Subtypes and Transcriptional Patterns of Tumor Progression Across Distinct Ethnic Populations

Kun Yu, Chee How Lee, Puay Hoon Tan, and Patrick Tan
Clin Cancer Res 2004 10: 5508-5517. [Abstract] [Full Text] [PDF] Supplementary Data  

Optimal Use of a Panel of Methylation Markers with GSTP1 Hypermethylation in the Diagnosis of Prostate Adenocarcinoma

Yutaka Tokumaru, Susan V. Harden, Dong-Il Sun, Keishi Yamashita, Jonathan I. Epstein, and David Sidransky
Clin Cancer Res 2004 10: 5518-5522. [Abstract] [Full Text] [PDF]  

Procholecystokinin as Marker of Human Ewing Sarcomas

Jean Claude Reubi, Pernille Koefoed, Thomas v. O. Hansen, Edouard Stauffer, Daniel Rauch, Finn C. Nielsen, and Jens F. Rehfeld
Clin Cancer Res 2004 10: 5523-5530. [Abstract] [Full Text] [PDF]  

Expression of Thyrotropin-Releasing Hormone by Human Melanoma and Nevi

Julie A. Ellerhorst, Aresu A. Naderi, Marilyn K. Johnson, Pauline Pelletier, Victor G. Prieto, A. Hafeez Diwan, Marcella M. Johnson, Debra C. Gunn, Sandra Yekell, and Elizabeth A. Grimm
Clin Cancer Res 2004 10: 5531-5536. [Abstract] [Full Text] [PDF]  

The Contribution of Genetic and Epigenetic Changes in Granulosa Cell Tumors of Ovarian Origin

Varinderpal S. Dhillon, Mohammad Aslam, and Syed Akhtar Husain
Clin Cancer Res 2004 10: 5537-5545. [Abstract] [Full Text] [PDF]  

Prognostic Significance of E-Cadherin Protein Expression in Pathological Stage I-III Endometrial Cancer

Loren K. Mell, Jeffrey J. Meyer, Maria Tretiakova, Andrey Khramtsov, Can Gong, S. Diane Yamada, Anthony G. Montag, and Arno J. Mundt
Clin Cancer Res 2004 10: 5546-5553. [Abstract] [Full Text] [PDF]  

Loss of Fhit Expression in Head and Neck Squamous Cell Carcinoma and Its Potential Clinical Implication

Shyh-Kuan Tai, Janet I. Lee, K. Kian Ang, Adel K. El-Naggar, Khaled A. Hassan, Diane Liu, J. Jack Lee, Hening Ren, Waun K. Hong, and Li Mao
Clin Cancer Res 2004 10: 5554-5557. [Abstract] [Full Text] [PDF]  

Expression Level of Valosin-Containing Protein (p97) Is Associated with Prognosis of Esophageal Carcinoma

Shinji Yamamoto, Yasuhiko Tomita, Yoshihiko Hoshida, Norishige Iizuka, Shinya Kidogami, Hiroshi Miyata, Shuji Takiguchi, Yoshiyuki Fujiwara, Takushi Yasuda, Masahiko Yano, Shoji Nakamori, Masato Sakon, Morito Monden, and Katsuyuki Aozasa
Clin Cancer Res 2004 10: 5558-5565. [Abstract] [Full Text] [PDF]  

BNIP3 Expression Is Linked with Hypoxia-Regulated Protein Expression and with Poor Prognosis in Non–Small Cell Lung Cancer

Alexandra Giatromanolaki, Michael I. Koukourakis, Heidi M. Sowter, Efthimios Sivridis, Spencer Gibson, Kevin C. Gatter, and Adrian L. Harris
Clin Cancer Res 2004 10: 5566-5571. [Abstract] [Full Text] [PDF]  

The Membrane-Anchored Matrix Metalloproteinase (MMP) Regulator RECK in Combination with MMP-9 Serves as an Informative Prognostic Indicator for Colorectal Cancer

Taku Takeuchi, Michiyoshi Hisanaga, Mitsuo Nagao, Naoya Ikeda, Hisao Fujii, Fumikazu Koyama, Tomohide Mukogawa, Hiroshi Matsumoto, Shunya Kondo, Chiaki Takahashi, Makoto Noda, and Yoshiyuki Nakajima
Clin Cancer Res 2004 10: 5572-5579. [Abstract] [Full Text] [PDF]  

Expression of the ELAV-Like Protein HuR Is Associated with Higher Tumor Grade and Increased Cyclooxygenase-2 Expression in Human Breast Carcinoma

Carsten Denkert, Wilko Weichert, Klaus-Jürgen Winzer, Berit-Maria Müller, Aurelia Noske, Silvia Niesporek, Glen Kristiansen, Hans Guski, Manfred Dietel, and Steffen Hauptmann
Clin Cancer Res 2004 10: 5580-5586. [Abstract] [Full Text] [PDF]  

Degree of CD25 Expression in T-Cell Lymphoma Is Dependent on Tissue Site: Implications for Targeted Therapy

Dan Jones, Sherif Ibrahim, Kaushali Patel, Rajyalakshmi Luthra, Madeleine Duvic, and L. Jeffrey Medeiros
Clin Cancer Res 2004 10: 5587-5594. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

In vitro and In vivo Activity of the Nuclear Factor-B Inhibitor Sulfasalazine in Human Glioblastomas

Pierre A. Robe, Mohamed Bentires-Alj, Marianne Bonif, Bernard Rogister, Manuel Deprez, Heddi Haddada, Minh-Tuan Nguyen Khac, Olivier Jolois, Kadir Erkmen, Marie-Paule Merville, Peter M. Black, and Vincent Bours
Clin Cancer Res 2004 10: 5595-5603. [Abstract] [Full Text] [PDF]  

Irofulven Cytotoxicity Depends on Transcription-Coupled Nucleotide Excision Repair and Is Correlated with XPG Expression in Solid Tumor Cells

Florence Koeppel, Virginie Poindessous, Vladimir Lazar, Eric Raymond, Alain Sarasin, and Annette K. Larsen
Clin Cancer Res 2004 10: 5604-5613. [Abstract] [Full Text] [PDF]  

Characterization of a Gemcitabine-Resistant Murine Leukemic Cell Line: Reversion of In vitro Resistance by a Mononucleotide Prodrug

Lars Petter Jordheim, Emeline Cros, Marie-Hélène Gouy, Carlos M. Galmarini, Suzanne Peyrottes, John Mackey, Christian Perigaud, and Charles Dumontet
Clin Cancer Res 2004 10: 5614-5621. [Abstract] [Full Text] [PDF]  

Antiangiogenic and Proapoptotic Effects of Dietary Restriction on Experimental Mouse and Human Brain Tumors

Purna Mukherjee, Laura E. Abate, and Thomas N. Seyfried
Clin Cancer Res 2004 10: 5622-5629. [Abstract] [Full Text] [PDF]  

CXCR4 and CXCL12 (SDF-1) in Prostate Cancer: Inhibitory Effects of Human Single Chain Fv Antibodies

Gayle G. Vaday, Shao-Bing Hua, Donna M. Peehl, Michelle H. Pauling, Yu-Huei Lin, Li Zhu, Diana M. Lawrence, Hussein D. Foda, and Stanley Zucker
Clin Cancer Res 2004 10: 5630-5639. [Abstract] [Full Text] [PDF]  

Corrections:

Correction: Article on Safety and Efficacy of Oral Vitamin A

Clin Cancer Res 2004 10: 5640. [Full Text] [PDF]  

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