Perspective:

The Potential Role of Neutrophils in Promoting the Metastatic Phenotype of Tumors Releasing Interleukin-8

Joseph E. De Larco, Beverly R. K. Wuertz, and Leo T. Furcht
Clin Cancer Res 2004 10: 4895-4900. [Abstract] [Full Text] [PDF]  

Review:

Biological Relevance of Adduct Detection to the Chemoprevention of Cancer

Ricky A. Sharma and Peter B. Farmer
Clin Cancer Res 2004 10: 4901-4912. [Abstract] [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Phase I and Pharmacokinetic Study of the Oral Fluoropyrimidine S-1 on a Once-Daily-for-28-Day Schedule in Patients with Advanced Malignancies

Quincy Siu-Chung Chu, Lisa A. Hammond, Garry Schwartz, Leonel Ochoa, Sun-Young Rha, Louis Denis, Kathleen Molpus, Brian Roedig, Stephen P. Letrent, Bharat Damle, Arthur P. DeCillis, and Eric K. Rowinsky
Clin Cancer Res 2004 10: 4913-4921. [Abstract] [Full Text] [PDF]  

Phase I Study of Concomitant Chemoradiotherapy with Paclitaxel, Fluorouracil, Gemcitabine, and Twice-Daily Radiation in Patients with Poor-Prognosis Cancer of the Head and Neck

Michael T. Milano, Daniel J. Haraf, Kerstin M. Stenson, Mary Ellyn Witt, Cathy Eng, Bharat B. Mittal, Athanassios Argiris, Harold Pelzer, Mark F. Kozloff, and Everett E. Vokes
Clin Cancer Res 2004 10: 4922-4932. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

CpG Island Hypermethylation of the DNA Repair Enzyme Methyltransferase Predicts Response to Temozolomide in Primary Gliomas

Maria F. Paz, Ricard Yaya-Tur, Iñigo Rojas-Marcos, Gaspar Reynes, Marina Pollan, Lucinda Aguirre-Cruz, Jose Luis García-Lopez, Jose Piquer, María-Jose Safont, Carmen Balaña, Montserrat Sanchez-Cespedes, Mercedes García-Villanueva, Leoncio Arribas, and Manel Esteller
Clin Cancer Res 2004 10: 4933-4938. [Abstract] [Full Text] [PDF]  

Excision Repair Cross-Complementation Group 1 Polymorphism Predicts Overall Survival in Advanced Non-Small Cell Lung Cancer Patients Treated With Platinum-Based Chemotherapy

Wei Zhou, Sarada Gurubhagavatula, Geoffrey Liu, Sohee Park, Donna S. Neuberg, John C. Wain, Thomas J. Lynch, Li Su, and David C. Christiani
Clin Cancer Res 2004 10: 4939-4943. [Abstract] [Full Text] [PDF]  

Global Gene Expression Profile of Nasopharyngeal Carcinoma by Laser Capture Microdissection and Complementary DNA Microarrays

Virote Sriuranpong, Apiwat Mutirangura, John W. Gillespie, Vyomesh Patel, Panomwat Amornphimoltham, Alfredo A. Molinolo, Veerachai Kerekhanjanarong, Siripornchai Supanakorn, Pakpoom Supiyaphun, Samreung Rangdaeng, Narin Voravud, and J. Silvio Gutkind
Clin Cancer Res 2004 10: 4944-4958. [Abstract] [Full Text] [PDF] Supplementary Data  

Imiquimod Treatment Induces Expression of Opioid Growth Factor Receptor: A Novel Tumor Antigen Induced by Interferon-?

Mirjana Urosevic, Patrick A. Oberholzer, Tanja Maier, Jürg Hafner, Elisabeth Laine, Herbert Slade, Bernd Benninghoff, Günter Burg, and Reinhard Dummer
Clin Cancer Res 2004 10: 4959-4970. [Abstract] [Full Text] [PDF]  

Expression Profiling of T-Cell Lymphomas Differentiates Peripheral and Lymphoblastic Lymphomas and Defines Survival Related Genes

Beatriz Martinez-Delgado, Barbara Meléndez, Marta Cuadros, Javier Alvarez, Jose Maria Castrillo, Ana Ruiz de la Parte, Manuela Mollejo, Carmen Bellas, Ramon Diaz, Luis Lombardía, Fatima Al-Shahrour, Orlando Domínguez, Alberto Cascon, Mercedes Robledo, Carmen Rivas, and Javier Benitez
Clin Cancer Res 2004 10: 4971-4982. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Antitumor Activity of Systemically Delivered Ribozymes Targeting Murine Telomerase RNA

Mehdi Nosrati, Shang Li, Sepideh Bagheri, David Ginzinger, Elizabeth H. Blackburn, Robert J. Debs, and Mohammed Kashani-Sabet
Clin Cancer Res 2004 10: 4983-4990. [Abstract] [Full Text] [PDF]  

Superior Activity of the Combination of Histone Deacetylase Inhibitor LAQ824 and the FLT-3 Kinase Inhibitor PKC412 against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3

Purva Bali, Prince George, Pamela Cohen, Jianguo Tao, Fei Guo, Celia Sigua, Anasuya Vishvanath, Anna Scuto, Srinivas Annavarapu, Warren Fiskus, Lynn Moscinski, Peter Atadja, and Kapil Bhalla
Clin Cancer Res 2004 10: 4991-4997. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

The Effects of Standard Anthracycline-Based Chemotherapy on Soluble ICAM-1 and Vascular Endothelial Growth Factor Levels in Breast Cancer

Paul J. Mills, Barbara Parker, Vicky Jones, Karen A. Adler, Christy J. Perez, Sherella Johnson, Mairav Cohen-Zion, Matthew Marler, Georgia R. Sadler, Joel E. Dimsdale, and Sonia Ancoli-Israel
Clin Cancer Res 2004 10: 4998-5003. [Abstract] [Full Text] [PDF]  

Immune Responses to a Class II Helper Peptide Epitope in Patients with Stage III/IV Resected Melanoma

Raymond Wong, Roy Lau, Jenny Chang, Tina Kuus-Reichel, Vincent Brichard, Claudine Bruck, and Jeffrey Weber
Clin Cancer Res 2004 10: 5004-5013. [Abstract] [Full Text] [PDF]  

Pilot Trial Evaluating an ¹²³I-Labeled 80-Kilodalton Engineered Anticarcinoembryonic Antigen Antibody Fragment (cT84.66 Minibody) in Patients with Colorectal Cancer

Jeffrey Y. C. Wong, David Z. Chu, Lawrence E. Williams, Dave M. Yamauchi, David N. Ikle, Cheuk S. Kwok, An Liu, Sharon Wilczynski, David Colcher, Paul J. Yazaki, John E. Shively, Anna M. Wu, and Andrew A. Raubitschek
Clin Cancer Res 2004 10: 5014-5021. [Abstract] [Full Text] [PDF]  

Randomized Phase II Trial of Sequential Chemotherapy in Advanced Non-Small Cell Lung Cancer (SWOG 9806): Carboplatin/Gemcitabine followed by Paclitaxel or Cisplatin/Vinorelbine followed by Docetaxel

Martin J. Edelman, Joseph I. Clark, Kari Chansky, Kathy Albain, Nirmala Bhoopalam, Geoffrey R. Weiss, Jeffrey K. Giguere, Karen Kelly, John Crowley, and David R. Gandara
Clin Cancer Res 2004 10: 5022-5026. [Abstract] [Full Text] [PDF]  

A Phase I Study of Interleukin 12 with Trastuzumab in Patients with Human Epidermal Growth Factor Receptor-2-Overexpressing Malignancies: Analysis of Sustained Interferon Production in a Subset of Patients

Robin Parihar, Padma Nadella, Adrian Lewis, Rhonda Jensen, Carrie De Hoff, Julie E. Dierksheide, Anne M. VanBuskirk, Cynthia M. Magro, Donn C. Young, Charles L. Shapiro, and William E. Carson, III
Clin Cancer Res 2004 10: 5027-5037. [Abstract] [Full Text] [PDF]  

Phase I Trial of the Cyclin-Dependent Kinase Inhibitor Flavopiridol in Combination with Docetaxel in Patients with Metastatic Breast Cancer

Antoinette R. Tan, Xiaowei Yang, Arlene Berman, Suoping Zhai, Alex Sparreboom, Allyson L. Parr, Catherine Chow, Jaime S. Brahim, Seth M. Steinberg, William D. Figg, and Sandra M. Swain
Clin Cancer Res 2004 10: 5038-5047. [Abstract] [Full Text] [PDF]  

A Phase I Pharmacokinetic and Biological Correlative Study of Oblimersen Sodium (Genasense, G3139), an Antisense Oligonucleotide to the Bcl-2 mRNA, and of Docetaxel in Patients with Hormone-Refractory Prostate Cancer

Anthony W. Tolcher, John Kuhn, Garry Schwartz, Amita Patnaik, Lisa A. Hammond, Ian Thompson, Howard Fingert, David Bushnell, Shazli Malik, Jeffrey Kreisberg, Elzbieta Izbicka, Leslie Smetzer, and Eric K. Rowinsky
Clin Cancer Res 2004 10: 5048-5057. [Abstract] [Full Text] [PDF]  

Phase I and Pharmacologic Study of Intermittently Administered 9-Nitrocamptothecin in Patients with Advanced Solid Tumors

William C. Zamboni, Laura L. Jung, Merrill J. Egorin, Douglas M. Potter, David M. Friedland, Chandra P. Belani, Sanjiv S. Agarwala, Michael M. W. Wong, Marwan Fakih, Donald L. Trump, Ruzhi Jin, Sandra Strychor, Michael Vozniak, Monica Troetschel, and Ramesh K. Ramanathan
Clin Cancer Res 2004 10: 5058-5064. [Abstract] [Full Text] [PDF]  

Extended Follow-up of Patients Treated with Imatinib Mesylate (Gleevec) for Chronic Myelogenous Leukemia Relapse after Allogeneic Transplantation: Durable Cytogenetic Remission and Conversion to Complete Donor Chimerism without Graft-versus-Host Disease

Daniel J. DeAngelo, Ephraim P. Hochberg, Edwin P. Alyea, Janina Longtine, Stephanie Lee, Ilene Galinsky, Ben Parekkedon, Jerome Ritz, Joseph H. Antin, Richard M. Stone, and Robert J. Soiffer
Clin Cancer Res 2004 10: 5065-5071. [Abstract] [Full Text] [PDF]  

Pharmacokinetics of O⁶-benzylguanine in Pediatric Patients with Central Nervous System Tumors: A Pediatric Oncology Group Study

Kathleen Neville, Susan Blaney, Mark Bernstein, Patrick Thompson, Denise Adams, Alexander Aleksic, and Stacey Berg
Clin Cancer Res 2004 10: 5072-5075. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Prognostic Analysis of Early Lymphocyte Recovery in Patients with Advanced Breast Cancer Receiving High-Dose Chemotherapy with an Autologous Hematopoietic Progenitor Cell Transplant

Yago Nieto, Elizabeth J. Shpall, Ian K. McNiece, Samia Nawaz, Julie Beaudet, Steve Rosinski, Julie Pellom, Victoria Slat-Vasquez, Peter A. McSweeney, Scott I. Bearman, James Murphy, and Roy B. Jones
Clin Cancer Res 2004 10: 5076-5086. [Abstract] [Full Text] [PDF]  

Methylation of p16 CpG Islands Associated with Malignant Transformation of Gastric Dysplasia in a Population-Based Study

Yu Sun, Dajun Deng, Wei-Cheng You, Hua Bai, Lian Zhang, Jing Zhou, Lin Shen, Jun-Ling Ma, Yu-Quan Xie, and Ji-You Li
Clin Cancer Res 2004 10: 5087-5093. [Abstract] [Full Text] [PDF] Supplementary Data  

B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression

Jun Konishi, Koichi Yamazaki, Miyuki Azuma, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, and Masaharu Nishimura
Clin Cancer Res 2004 10: 5094-5100. [Abstract] [Full Text] [PDF]  

Expression of Pro- and Antiapoptotic Proteins in Circulating CD8+ T Cells of Patients with Squamous Cell Carcinoma of the Head and Neck

Jeong-Whun Kim, Takashi Tsukishiro, Jonas T. Johnson, and Theresa L. Whiteside
Clin Cancer Res 2004 10: 5101-5110. [Abstract] [Full Text] [PDF]  

Primary Acute Lymphoblastic Leukemia Cells Use a Novel Promoter and 5'Noncoding Exon for the Human Reduced Folate Carrier That Encodes a Modified Carrier Translated from an Upstream Translational Start

Robin M. Flatley, Scott G. Payton, Jeffrey W. Taub, and Larry H. Matherly
Clin Cancer Res 2004 10: 5111-5122. [Abstract] [Full Text] [PDF]  

Elevated S-Phase Kinase-Associated Protein 2 Protein Expression in Acute Myelogenous Leukemia: Its Association with Constitutive Phosphorylation of Phosphatase and Tensin Homologue Protein and Poor Prognosis

Yoo Hong Min, June-Won Cheong, Mark Hong Lee, Ji Yeon Kim, Seung Tae Lee, Jee Sook Hahn, and Yun Woong Ko
Clin Cancer Res 2004 10: 5123-5130. [Abstract] [Full Text] [PDF]  

Promoter Hypermethylation of Resected Bronchial Margins: A Field Defect of Changes?

Mingzhou Guo, Michael G. House, Craig Hooker, Yu Han, Elizabeth Heath, Edward Gabrielson, Stephen C. Yang, Stephen B. Baylin, James G. Herman, and Malcolm V. Brock
Clin Cancer Res 2004 10: 5131-5136. [Abstract] [Full Text] [PDF]  

Expression of Vascular Endothelial Growth Factor Receptor-3 by Lymphatic Endothelial Cells Is Associated with Lymph Node Metastasis in Prostate Cancer

Yiping Zeng, Kenneth Opeskin, Megan E. Baldwin, Lisa G. Horvath, Marc G. Achen, Steven A. Stacker, Robert L. Sutherland, and Elizabeth D. Williams
Clin Cancer Res 2004 10: 5137-5144. [Abstract] [Full Text] [PDF]  

EphA2 Expression Is Associated with Aggressive Features in Ovarian Carcinoma

Premal H. Thaker, Michael Deavers, Joseph Celestino, Angela Thornton, Mavis S. Fletcher, Charles N. Landen, Michael S. Kinch, Peter A. Kiener, and Anil K. Sood
Clin Cancer Res 2004 10: 5145-5150. [Abstract] [Full Text] [PDF]  

Relevance of Different UGT1A1 Polymorphisms in Irinotecan-Induced Toxicity: A Molecular and Clinical Study of 75 Patients

Elisabeth Rouits, Michèle Boisdron-Celle, Agnès Dumont, Olivier Guérin, Alain Morel, and Erick Gamelin
Clin Cancer Res 2004 10: 5151-5159. [Abstract] [Full Text] [PDF]  

Patterns of Chromosomal Alterations in Breast Ductal Carcinoma In situ

E. Shelley Hwang, Sandy DeVries, Karen L. Chew, Dan H. Moore, II, Karla Kerlikowske, Ann Thor, Britt-Marie Ljung, and Frederic M. Waldman
Clin Cancer Res 2004 10: 5160-5167. [Abstract] [Full Text] [PDF]  

Cyclin D1, p53, and p21^Waf1/Cip1 Expression Is Predictive of Poor Clinical Outcome in Serous Epithelial Ovarian Cancer

Anish Bali, Philippa M. O’Brien, Lyndal S. Edwards, Robert L. Sutherland, Neville F. Hacker, and Susan M. Henshall
Clin Cancer Res 2004 10: 5168-5177. [Abstract] [Full Text] [PDF]  

Distribution and Clinical Significance of Heparan Sulfate Proteoglycans in Ovarian Cancer

E. June Davies, Fiona H. Blackhall, Jonathan H. Shanks, Guido David, Alan T. McGown, Ric Swindell, Richard J. Slade, Pierre Martin-Hirsch, John T. Gallagher, and Gordon C. Jayson
Clin Cancer Res 2004 10: 5178-5186. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Noscapine Crosses the Blood-Brain Barrier and Inhibits Glioblastoma Growth

Jaren W. Landen, Vincent Hau, Mingshen Wang, Thomas Davis, Brian Ciliax, Bruce H. Wainer, Erwin G. Van Meir, Johnathan D. Glass, Harish C. Joshi, and David R. Archer
Clin Cancer Res 2004 10: 5187-5201. [Abstract] [Full Text] [PDF]  

CD95-Mediated Apoptosis Is Impaired at Receptor Level by Cellular FLICE-Inhibitory Protein (Long Form) in Wild-Type p53 Human Ovarian Carcinoma

Delia Mezzanzanica, Emanuela Balladore, Fabio Turatti, Elena Luison, Paola Alberti, Marina Bagnoli, Mariangela Figini, Alessandra Mazzoni, Francesco Raspagliesi, Maria Oggionni, Silvana Pilotti, and Silvana Canevari
Clin Cancer Res 2004 10: 5202-5214. [Abstract] [Full Text] [PDF]  

Mifepristone Induces Growth Arrest, Caspase Activation, and Apoptosis of Estrogen Receptor-Expressing, Antiestrogen-Resistant Breast Cancer Cells

Virgil T. Gaddy, John T. Barrett, Jennifer N. Delk, Andre M. Kallab, Alan G. Porter, and Patricia V. Schoenlein
Clin Cancer Res 2004 10: 5215-5225. [Abstract] [Full Text] [PDF]  

The Effect of Megestrol Acetate on Growth of HepG2 Cells In vitro and In vivo

Kai Zhang and Pierce K. H. Chow
Clin Cancer Res 2004 10: 5226-5232. [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Tissue Disposition of Indole-3-carbinol and Its Acid Condensation Products after Oral Administration to Mice

Mark J. Anderton, Margaret M. Manson, Richard D. Verschoyle, Andreas Gescher, John H. Lamb, Peter B. Farmer, William P. Steward, and Marion L. Williams
Clin Cancer Res 2004 10: 5233-5241. [Abstract] [Full Text] [PDF]  

In vitro Combination Treatment with Perifosine and UCN-01 Demonstrates Synergism against Prostate (PC-3) and Lung (A549) Epithelial Adenocarcinoma Cell Lines

Girija P. Dasmahapatra, Parijat Didolkar, Michael C. Alley, Somiranjan Ghosh, Edward A. Sausville, and Krishnendu K. Roy
Clin Cancer Res 2004 10: 5242-5252. [Abstract] [Full Text] [PDF]  

trans-3,4,5'-Trihydroxystibene Inhibits Hypoxia-Inducible Factor 1 and Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

Zongxian Cao, Jing Fang, Chang Xia, Xianglin Shi, and Bing-Hua Jiang
Clin Cancer Res 2004 10: 5253-5263. [Abstract] [Full Text] [PDF]  

Nitric Oxide Accelerates Interleukin-13 Cytotoxin-Mediated Regression in Head and Neck Cancer Animal Model

Koji Kawakami, Mariko Kawakami, and Raj K. Puri
Clin Cancer Res 2004 10: 5264-5270. [Abstract] [Full Text] [PDF]  

Class I Histone Deacetylase-Selective Novel Synthetic Inhibitors Potently Inhibit Human Tumor Proliferation

Jung-Hyun Park, Yeonjoo Jung, Tai Young Kim, Sang Gyun Kim, Hyun-Soon Jong, Jung Weon Lee, Dae-Kee Kim, Jong-Soo Lee, Noe Kyeong Kim, Tae-You Kim, and Yung-Jue Bang
Clin Cancer Res 2004 10: 5271-5281. [Abstract] [Full Text] [PDF]  

A Concentrated Aglycone Isoflavone Preparation (GCP) That Demonstrates Potent Anti-Prostate Cancer Activity In vitro and In vivo

Debra L. Bemis, Jillian L. Capodice, Manisha Desai, Ralph Buttyan, and Aaron E. Katz
Clin Cancer Res 2004 10: 5282-5292. [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Identification of Serum Amyloid A Protein As a Potentially Useful Biomarker for Nasopharyngeal Carcinoma

Eleftherios P. Diamandis, Timothy T. C. Yip, Roger K. C. Ngan, William C. S. Cho, Joseph S. K. Au, Stephen C. K. Law, and Tai-Tung Yip
Clin Cancer Res 2004 10: 5293-5294. [Full Text] [PDF]  

Corrections:

Correction: Article on Analysis of p53 Alterations in Lung Biopsies

Clin Cancer Res 2004 10: 5295. [Full Text] [PDF]  

Correction: Article on Predicting Early Failure in Node-Positive Breast Cancer

Clin Cancer Res 2004 10: 5295. [Full Text] [PDF]  

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