Supplement Articles:

Conference Participants
Clin Cancer Res 2004 10: I. [Full Text] [PDF]  

Sponsorship and CME Credit
Clin Cancer Res 2004 10: II. [Full Text] [PDF]  

Thomas J. Lynch, Alex A. Adjei, Paul A. Bunn, Jr., Raymond N. DuBois, David R. Gandara, Giuseppe Giaccone, Ramaswamy Govindan, Roy S. Herbst, Bruce E. Johnson, Fadlo R. Khuri, Roman Perez-Soler, Rafael Rosell, Eric K. Rowinsky, Alan B. Sandler, Giorgio V. Scagliotti, Joan H. Schiller, Geoffrey I. Shapiro, Mark A. Socinski, and Carol S. Hart

Novel Agents in the Treatment of Lung Cancer: Conference Summary Statement
Clin Cancer Res 2004 10: 4199S-4204S. [Full Text] [PDF]  

David R. Gandara, Howard West, Kari Chansky, Angela M. Davies, Derick H. M. Lau, John Crowley, Paul H. Gumerlock, Fred R. Hirsch, and Wilbur A. Franklin

Bronchioloalveolar Carcinoma: A Model for Investigating the Biology of Epidermal Growth Factor Receptor Inhibition
Clin Cancer Res 2004 10: 4205S-4209S. [Abstract] [Full Text] [PDF]  

Mark A. Socinski

Cytotoxic Chemotherapy in Advanced Non-Small Cell Lung Cancer: A Review of Standard Treatment Paradigms
Clin Cancer Res 2004 10: 4210S-4214S. [Abstract] [Full Text] [PDF]  

Rafael Rosell, Enriqueta Felip, Miquel Taron, Joaquim Majo, Pedro Mendez, Maria Sanchez-Ronco, Cristina Queralt, Jose Javier Sanchez, and Jose Maestre

Gene Expression as a Predictive Marker of Outcome in Stage IIB-IIIA-IIIB Non-Small Cell Lung Cancer After Induction Gemcitabine-Based Chemotherapy Followed By Resectional Surgery
Clin Cancer Res 2004 10: 4215S-4219S. [Abstract] [Full Text] [PDF]  

Eric K. Rowinsky

Curtailing the High Rate of Late-Stage Attrition of Investigational Therapeutics Against Unprecedented Targets in Patients with Lung and Other Malignancies
Clin Cancer Res 2004 10: 4220S-4226S. [Abstract] [Full Text] [PDF]  

Giorgio V. Scagliotti, Giovanni Selvaggi, Silvia Novello, and Fred R. Hirsch

The Biology of Epidermal Growth Factor Receptor in Lung Cancer
Clin Cancer Res 2004 10: 4227S-4232S. [Abstract] [Full Text] [PDF]  

Giuseppe Giaccone

The Role of Gefitinib in Lung Cancer Treatment
Clin Cancer Res 2004 10: 4233S-4237S. [Abstract] [Full Text] [PDF]  

Roman Perez-Soler

The Role of Erlotinib (Tarceva, OSI 774) in the Treatment of Non-Small Cell Lung Cancer
Clin Cancer Res 2004 10: 4238S-4240S. [Abstract] [Full Text] [PDF]  

Ramaswamy Govindan

Cetuximab in Advanced Non-Small Cell Lung Cancer
Clin Cancer Res 2004 10: 4241S-4244S. [Abstract] [Full Text] [PDF]  

Roy S. Herbst and Stanley R. Frankel

Oblimersen Sodium (Genasense bcl-2 Antisense Oligonucleotide): A Rational Therapeutic to Enhance Apoptosis in Therapy of Lung Cancer
Clin Cancer Res 2004 10: 4245S-4248S. [Abstract] [Full Text] [PDF]  

Fadlo R. Khuri and Victor Cohen

Molecularly Targeted Approaches to the Chemoprevention of Lung Cancer
Clin Cancer Res 2004 10: 4249S-4253S. [Abstract] [Full Text] [PDF]  

Bruce E. Johnson and John V. Heymach

Farnesyl Transferase Inhibitors for Patients with Lung Cancer
Clin Cancer Res 2004 10: 4254S-4257S. [Abstract] [Full Text] [PDF]  

Alan B. Sandler, David H. Johnson, and Roy S. Herbst

Anti-Vascular Endothelial Growth Factor Monoclonals in Non-Small Cell Lung Cancer
Clin Cancer Res 2004 10: 4258S-4262S. [Abstract] [Full Text] [PDF]  

Paul A. Bunn, Jr.

The Potential Role of Proteasome Inhibitors in the Treatment of Lung Cancer
Clin Cancer Res 2004 10: 4263S-4265S. [Abstract] [Full Text] [PDF]  

Joanne R. Brown and Raymond N. DuBois

Cyclooxygenase as a Target in Lung Cancer
Clin Cancer Res 2004 10: 4266S-4269S. [Abstract] [Full Text] [PDF]  

Geoffrey I. Shapiro

Preclinical and Clinical Development of the Cyclin-Dependent Kinase Inhibitor Flavopiridol
Clin Cancer Res 2004 10: 4270S-4275S. [Abstract] [Full Text] [PDF]  

Alex A. Adjei

Pemetrexed (ALIMTA), A Novel Multitargeted Antineoplastic Agent
Clin Cancer Res 2004 10: 4276S-4280S. [Abstract] [Full Text] [PDF]  

Joan H. Schiller

Clinical Trial Design Issues in the Era of Targeted Therapies
Clin Cancer Res 2004 10: 4281S-4282S. [Abstract] [Full Text] [PDF]  

CME Assessment Test
Clin Cancer Res 2004 10: 4283S-4284S. [Full Text] [PDF]  

CME Post-test and Evaluation
Clin Cancer Res 2004 10: 4285S. [Full Text] [PDF]  

Editorials:

Reuben Lotan and Yair Lotan

Retinoic Acid Receptor ß2 Hypermethylation: Implications for Prostate Cancer Detection, Prevention, and Therapy
Clin Cancer Res 2004 10: 3935-3936. [Full Text] [PDF]  

Reviews:

Raffit Hassan, Tapan Bera, and Ira Pastan

Mesothelin: A New Target for Immunotherapy
Clin Cancer Res 2004 10: 3937-3942. [Abstract] [Full Text] [PDF]  

James V. Tricoli, Mason Schoenfeldt, and Barbara A. Conley

Detection of Prostate Cancer and Predicting Progression: Current and Future Diagnostic Markers
Clin Cancer Res 2004 10: 3943-3953. [Abstract] [Full Text] [PDF]  

Report from the FDA:

Peter F. Bross, Robert Kane, Ann T. Farrell, Sophia Abraham, Kimberly Benson, Margaret E. Brower, Sean Bradley, Jogarao V. Gobburu, Anwar Goheer, Shwu-Luan Lee, John Leighton, Cheng Yi Liang, Richard T. Lostritto, William D. McGuinn, David E. Morse, Atiqur Rahman, Lilliam A. Rosario, S. Leigh Verbois, Grant Williams, Yong-Cheng Wang, and Richard Pazdur

Approval Summary for Bortezomib for Injection in the Treatment of Multiple Myeloma
Clin Cancer Res 2004 10: 3954-3964. [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Wolfgang R. Sperr, Maria Piribauer, Friedrich Wimazal, Christa Fonatsch, Renate Thalhammer-Scherrer, Ilse Schwarzinger, Klaus Geissler, Paul Knöbl, Ulrich Jäger, Klaus Lechner, and Peter Valent

A Novel Effective and Safe Consolidation for Patients Over 60 Years with Acute Myeloid Leukemia: Intermediate Dose Cytarabine (2 x 1 g/m² on Days 1, 3, and 5)
Clin Cancer Res 2004 10: 3965-3971. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Essel Dulaimi, Inmaculada Ibanez de Caceres, Robert G. Uzzo, Tahseen Al-Saleem, Richard E. Greenberg, Thomas J. Polascik, James S. Babb, William E. Grizzle, and Paul Cairns

Promoter Hypermethylation Profile of Kidney Cancer
Clin Cancer Res 2004 10: 3972-3979. [Abstract] [Full Text] [PDF]  

Yoon-Pin Lim, Chow Yin Wong, London Lucien Ooi, Brian J. Druker, and Richard J. Epstein

Selective Tyrosine Hyperphosphorylation of Cytoskeletal and Stress Proteins in Primary Human Breast Cancers: Implications for Adjuvant Use of Kinase-Inhibitory Drugs
Clin Cancer Res 2004 10: 3980-3987. [Abstract] [Full Text] [PDF]  

Xifeng Wu, Hua Zhao, Kim-Anh Do, Marcella M. Johnson, Qiong Dong, Waun Ki Hong, and Margaret R. Spitz

Serum Levels of Insulin Growth Factor (IGF-I) and IGF-Binding Protein Predict Risk of Second Primary Tumors in Patients with Head and Neck Cancer
Clin Cancer Res 2004 10: 3988-3995. [Abstract] [Full Text] [PDF]  

Guojun Li, Erich M. Sturgis, Li-E. Wang, Robert M. Chamberlain, Margaret R. Spitz, Adel K. El-Naggar, Waun K. Hong, and Qingyi Wei

Association between the V109G Polymorphism of the p27 Gene and the Risk and Progression of Oral Squamous Cell Carcinoma
Clin Cancer Res 2004 10: 3996-4002. [Abstract] [Full Text] [PDF]  

Christian F. Singer, Maurice Mogg, Wolfgang Koestler, Margit Pacher, Erika Marton, Ernst Kubista, and Martin Schreiber

Insulin-Like Growth Factor (IGF)-I and IGF-II Serum Concentrations in Patients with Benign and Malignant Breast Lesions: Free IGF-II Is Correlated with Breast Cancer Size
Clin Cancer Res 2004 10: 4003-4009. [Abstract] [Full Text] [PDF]  

Carmen Jerónimo, Rui Henrique, Mohammad O. Hoque, Franclim R. Ribeiro, Jorge Oliveira, Daniel Fonseca, Manuel R. Teixeira, Carlos Lopes, and David Sidransky

Quantitative RARß2 Hypermethylation: A Promising Prostate Cancer Marker
Clin Cancer Res 2004 10: 4010-4014. [Abstract] [Full Text] [PDF]  

Milo Frattini, Debora Balestra, Simona Suardi, Maria Oggionni, Paola Alberici, Paolo Radice, Aurora Costa, Maria Grazia Daidone, Ermanno Leo, Silvana Pilotti, Lucio Bertario, and Marco A. Pierotti

Different Genetic Features Associated with Colon and Rectal Carcinogenesis
Clin Cancer Res 2004 10: 4015-4021. [Abstract] [Full Text] [PDF]  

Stephane Temam, Odile Casiraghi, Jean-Baptiste Lahaye, Jacques Bosq, Xian Zhou, Morbize Julieron, Gerard Mamelle, J. Jack Lee, Li Mao, Bernard Luboinski, Jean Benard, and Francois Janot

Tetranucleotide Microsatellite Instability in Surgical Margins for Prediction of Local Recurrence of Head and Neck Squamous Cell Carcinoma
Clin Cancer Res 2004 10: 4022-4028. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Panomwat Amornphimoltham, Virote Sriuranpong, Vyomesh Patel, Fernando Benavides, Claudio J. Conti, John Sauk, Edward A. Sausville, Alfredo A. Molinolo, and J. Silvio Gutkind

Persistent Activation of the Akt Pathway in Head and Neck Squamous Cell Carcinoma: A Potential Target for UCN-01
Clin Cancer Res 2004 10: 4029-4037. [Abstract] [Full Text] [PDF]  

Erik Maquoi, Nor Eddine Sounni, Laetitia Devy, Fabrice Olivier, Francis Frankenne, Hans-Willi Krell, Frank Grams, Jean-Michel Foidart, and Agnès Noël

Anti-Invasive, Antitumoral, and Antiangiogenic Efficacy of a Pyrimidine-2,4,6-trione Derivative, an Orally Active and Selective Matrix Metalloproteinases Inhibitor
Clin Cancer Res 2004 10: 4038-4047. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Amy C. Peterson, Susan Swiger, Walter M. Stadler, Milica Medved, Greg Karczmar, and Thomas F. Gajewski

Phase II Study of the Flk-1 Tyrosine Kinase Inhibitor SU5416 in Advanced Melanoma
Clin Cancer Res 2004 10: 4048-4054. [Abstract] [Full Text] [PDF]  

Laurence Gamelin, Michele Boisdron-Celle, Remy Delva, Véronique Guérin-Meyer, Norbert Ifrah, Alain Morel, and Erick Gamelin

Prevention of Oxaliplatin-Related Neurotoxicity by Calcium and Magnesium Infusions: A Retrospective Study of 161 Patients Receiving Oxaliplatin Combined with 5-Fluorouracil and Leucovorin for Advanced Colorectal Cancer
Clin Cancer Res 2004 10: 4055-4061. [Abstract] [Full Text] [PDF]  

Chau T. Dang, Andrew J. Dannenberg, Kotha Subbaramaiah, Maura N. Dickler, Mark M. Moasser, Andrew D. Seidman, Gabriella M. D’Andrea, Maria Theodoulou, Katherine S. Panageas, Larry Norton, and Clifford A. Hudis

Phase II Study of Celecoxib and Trastuzumab in Metastatic Breast Cancer Patients Who Have Progressed after Prior Trastuzumab-Based Treatments
Clin Cancer Res 2004 10: 4062-4067. [Abstract] [Full Text] [PDF]  

Floris A. de Jong, Ron H. J. Mathijssen, Rujia Xie, Jaap Verweij, and Alex Sparreboom

Flat-Fixed Dosing of Irinotecan: Influence on Pharmacokinetic and Pharmacodynamic Variability
Clin Cancer Res 2004 10: 4068-4071. [Abstract] [Full Text] [PDF]  

Godefridus J. Peters, Paul Noordhuis, Cornelis J. van Groeningen, Giuseppe Giaccone, Ulbe Holwerda, Daphne Voorn, Ad Schrijvers, Jan H. Schornagel, Jos H. Beijnen, Pierre Fumoleau, and Jan H. M. Schellens

The Effect of Food on the Pharmacokinetics of S-1 after Single Oral Administration to Patients with Solid Tumors
Clin Cancer Res 2004 10: 4072-4076. [Abstract] [Full Text] [PDF]  

Nozomi Niitsu, Miyuki Hayama, Masataka Okamoto, Mika Khori, Masaaki Higashihara, Jun-ichi Tamaru, and Masami Hirano

Phase I Study of Rituximab-CHOP Regimen in Combination with Granulocyte Colony-Stimulating Factor in Patients with Follicular Lymphoma
Clin Cancer Res 2004 10: 4077-4082. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Kimberly L. Blackwell, Mark W. Dewhirst, Vlayka Liotcheva, Stacey Snyder, Gloria Broadwater, Rex Bentley, Anita Lal, Gregory Riggins, Steve Anderson, Jim Vredenburgh, Alan Proia, and Lyndsay N. Harris

HER-2 Gene Amplification Correlates with Higher Levels of Angiogenesis and Lower Levels of Hypoxia in Primary Breast Tumors
Clin Cancer Res 2004 10: 4083-4088. [Abstract] [Full Text] [PDF]  

Pilar Blay, Aurora Astudillo, José M. Buesa, Elías Campo, Mar Abad, Juan García-García, Rosa Miquel, Vicente Marco, Marta Sierra, Raquel Losa, Angel Lacave, Alejandro Braña, Milagros Balbín, and José M. P. Freije

Protein Kinase C Is Highly Expressed in Gastrointestinal Stromal Tumors But Not in Other Mesenchymal Neoplasias
Clin Cancer Res 2004 10: 4089-4095. [Abstract] [Full Text] [PDF]  

Iman Osman, Herman Yee, Samir S. Taneja, Benjamin Levinson, Anne Zeleniuch-Jacquotte, Caroline Chang, Craig Nobert, and David M. Nanus

Neutral Endopeptidase Protein Expression and Prognosis in Localized Prostate Cancer
Clin Cancer Res 2004 10: 4096-4100. [Abstract] [Full Text] [PDF]  

Laura Boldrini, Silvia Ursino, Silvia Gisfredi, Pinuccia Faviana, Valentina Donati, Tiziano Camacci, Marco Lucchi, Alfredo Mussi, Fulvio Basolo, Raffaele Pingitore, and Gabriella Fontanini

Expression and Mutational Status of c-kit in Small-Cell Lung Cancer: Prognostic Relevance
Clin Cancer Res 2004 10: 4101-4108. [Abstract] [Full Text] [PDF]  

James C. Yao, Liwei Wang, Daoyan Wei, Weida Gong, Manal Hassan, Tsung-Teh Wu, Paul Mansfield, Jaffer Ajani, and Keping Xie

Association between Expression of Transcription Factor Sp1 and Increased Vascular Endothelial Growth Factor Expression, Advanced Stage, and Poor Survival in Patients with Resected Gastric Cancer
Clin Cancer Res 2004 10: 4109-4117. [Abstract] [Full Text] [PDF]  

Rile Li, Kateri Heydon, M. Elizabeth Hammond, David J. Grignon, Mack Roach, III, Harvey B. Wolkov, Howard M. Sandler, William U. Shipley, and Alan Pollack

Ki-67 Staining Index Predicts Distant Metastasis and Survival in Locally Advanced Prostate Cancer Treated With Radiotherapy: An Analysis of Patients in Radiation Therapy Oncology Group Protocol 86-10
Clin Cancer Res 2004 10: 4118-4124. [Abstract] [Full Text] [PDF]  

Sanae Nakajima, Ryuichiro Doi, Eiji Toyoda, Shoichiro Tsuji, Michihiko Wada, Masayuki Koizumi, Sidhartha S. Tulachan, Daisuke Ito, Kazuhiro Kami, Tomohiko Mori, Yoshiya Kawaguchi, Koji Fujimoto, Ryo Hosotani, and Masayuki Imamura

N-Cadherin Expression and Epithelial-Mesenchymal Transition in Pancreatic Carcinoma
Clin Cancer Res 2004 10: 4125-4133. [Abstract] [Full Text] [PDF]  

Ragnar S. Faye, Steinar Aamdal, Hanne K. Høifødt, Erling Jacobsen, Linn Holstad, Eva Skovlund, and Øystein Fodstad

Immunomagnetic Detection and Clinical Significance of Micrometastatic Tumor Cells in Malignant Melanoma Patients
Clin Cancer Res 2004 10: 4134-4139. [Abstract] [Full Text] [PDF]  

Chun-Fung Chan, Tai-On Yau, Dong-Yan Jin, Chun-Ming Wong, Sheung-Tat Fan, and Irene Oi-Lin Ng

Evaluation of Nuclear Factor-B, Urokinase-Type Plasminogen Activator, and HBx and Their Clinicopathological Significance in Hepatocellular Carcinoma
Clin Cancer Res 2004 10: 4140-4149. [Abstract] [Full Text] [PDF]  

Ronnie T. Poon, Ka Kit Chung, Siu Tim Cheung, Cecilia P. Lau, See Wai Tong, Ka Ling Leung, Wan Ching Yu, George P. Tuszynski, and Sheung Tat Fan

Clinical Significance of Thrombospondin 1 Expression in Hepatocellular Carcinoma
Clin Cancer Res 2004 10: 4150-4157. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Sanjeewani T. Palayoor, Melissa A. Burgos, Azadeh Shoaibi, Philip J. Tofilon, and C. Norman Coleman

Effect of Radiation and Ibuprofen on Normoxic Renal Carcinoma Cells Overexpressing Hypoxia-Inducible Factors by Loss of von Hippel–Lindau Tumor Suppressor Gene Function
Clin Cancer Res 2004 10: 4158-4164. [Abstract] [Full Text] [PDF]  

Tomasz Switaj, Ahmad Jalili, Anna B. Jakubowska, Nadzieja Drela, Magdalena Stoksik, Dominika Nowis, Grzegorz Basak, Jakub Golab, Piotr J. Wysocki, Andrzej Mackiewicz, Agata Sasor, Koryna Socha, Marek Jakóbisiak, and Witold Lasek

CpG Immunostimulatory Oligodeoxynucleotide 1826 Enhances Antitumor Effect of Interleukin 12 Gene-Modified Tumor Vaccine in a Melanoma Model in Mice
Clin Cancer Res 2004 10: 4165-4175. [Abstract] [Full Text] [PDF]  

Byong Chul Yoo, Eunkyung Jeon, Sung-Hye Hong, Young-Kyoung Shin, Hee Jin Chang, and Jae-Gahb Park

Metabotropic Glutamate Receptor 4-Mediated 5-Fluorouracil Resistance in a Human Colon Cancer Cell Line
Clin Cancer Res 2004 10: 4176-4184. [Abstract] [Full Text] [PDF]  

Christiane Thallinger, Markus F. Wolschek, Helmut Maierhofer, Hans Skvara, Hubert Pehamberger, Brett P. Monia, Burkhard Jansen, Volker Wacheck, and Edgar Selzer

Mcl-1 Is a Novel Therapeutic Target for Human Sarcoma: Synergistic Inhibition of Human Sarcoma Xenotransplants by a Combination of Mcl-1 Antisense Oligonucleotides with Low-Dose Cyclophosphamide
Clin Cancer Res 2004 10: 4185-4191. [Abstract] [Full Text] [PDF]  

Sylvia S. W. Ng, Gordon R. MacPherson, Michael Gütschow, Kurt Eger, and William D. Figg

Antitumor Effects of Thalidomide Analogs in Human Prostate Cancer Xenografts Implanted in Immunodeficient Mice
Clin Cancer Res 2004 10: 4192-4197. [Abstract] [Full Text] [PDF]  

Corrections:

Correction: Article on Low Frequency on Mutations of ING1 in Human Brain Tumors
Clin Cancer Res 2004 10: 4198. [Full Text] [PDF]  

Correction: Article on Dysadherin Expression in Gastric Cancer
Clin Cancer Res 2004 10: 4198. [Full Text] [PDF]  

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